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E-raamat: Human Pathogenic Microbes: Diseases and Concerns

(Department of Bioresources, School of Biological Sciences, University of Kashmir, Srinagar, India)
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Human Pathogenic Microbes: Diseases and ConcernsSuurem pilt
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Considering the global emerging human pathogenic microbial diseases and trends, Human Pathogenic Microbes is framed to provide deep insights into the epidemic and emerging bacterial and fungal infections and diseases in humans. It presents novel, up-to-date, and cutting-edge knowledge regarding various human pathogenic microbes, their associated drug resistance mechanisms, and different diseases caused by them.

Human Pathogenic Microbes reflects the current research and development on the evolution of bacterial and fungal drug resistance: different bacterial and fungal antimicrobial drug resistance mechanisms along with their biological and molecular aspects.

In a nutshell, Human Pathogenic Microbes describes a various bacterial and fungal diseases caused by different human pathogenic microbes employing different drug resistance mechanisms and processes. It also highlights the novel emerging approaches (Immunological and combinatorial) that will aid to fight against such bacterial and fungal pathogens.

  • Provides a brief but thorough and recent knowledge of various human pathogenic microbes, their associated drug resistance mechanisms, and different diseases caused by them
  • Describes the different aspects of fungal, bacterial and antimicrobial resistance
  • Addresses novel antimicrobial agents and approaches
List of contributors
ix
Preface xi
Acknowledgments xiii
Abbreviation list xv
Glossary xix
1 Human pathogenic microbes (bacterial and fungal) and associated diseases
Manzoor Ahmad Mir
Ubaid Rasool
Shariqa Aisha
Bader Alshehri
Syed Suhail Hamadani
1.1 Introduction
1(3)
1.2 Human--pathogen interaction
4(3)
1.3 Human pathogenic fungal microorganisms
7(3)
1.4 Human pathogenic fungal diseases
10(5)
1.5 Human pathogenic bacterial microorganisms
15(4)
1.6 Human pathogenic bacterial diseases
19(6)
1.7 Summary and future perspectives
25(1)
References
26(5)
2 Evolution of antimicrobial drug resistance in human pathogenic bacteria
Manzoor Ahmad Mir
Shariqa Aisha
Hafsa Qadri
Ulfat Jan
Abrar Yousuf
Nusrat Jan
2.1 Introduction
31(2)
2.2 Current status of resistance to antibacterial drugs
33(1)
2.3 Surveillance of antibacterial resistance / tolerance
34(1)
2.4 Molecular mechanisms of antimicrobial drug resistance in human pathogenic bacteria
35(2)
2.5 Resistance to antibacterial drugs in selected bacteria of international concern
37(5)
2.6 Economic burden of antibacterial resistance and its impacts on human health
42(2)
2.7 Surveillance of antimicrobial drug resistance in disease-specific programs
44(2)
2.8 Evolution of drug resistance in mycobacterium tuberclosis
46(1)
2.9 Future perspectives
47(1)
References
48(5)
3 Evolution of antimicrobial drug resistance in human pathogenic fungi
Manzoor Ahmad Mir
3.1 Introduction
53(2)
3.2 Molecular mechanisms governing antimicrobial drug resistance phenomenon in the human pathogenic fungi
55(9)
3.3 Conclusions
64(1)
References
65(6)
4 Combating human bacterial infections: need for new antibacterial drugs and therapeutics
Manzoor Ahmad Mir
Bilkees Nabi
Sushma Ahlawat
Manoj Kumawat
Shariqa Aisha
4.1 Introduction
71(1)
4.2 Common human bacterial infections
71(1)
4.3 Salmonellosis
72(12)
4.4 Tuberculosis
84(5)
4.5 Cholera
89(2)
4.6 Development of new antimicrobial agents
91(2)
4.7 Future perspectives
93(1)
References
93(8)
Further reading
101(2)
5 Combating human fungal infections: need for new antifungal drugs and therapies
Manzoor Ahmad Mir
Hafsa Qadri
Shariqa Aisha
Abdul Haseeb Shah
5.1 Introduction
103(4)
5.2 Different classes of antifungals
107(3)
5.3 Need for new antifungal drugs and therapies
110(2)
5.4 Potential alternative antifungals to combat drug resistance in pathogenic fungi
112(8)
5.5 Future perspectives
120(1)
References
121(8)
6 Significance of immunotherapy for human bacterial diseases and antibacterial drug discovery
Manzoor Ahmad Mir
Syed Suhail Hamdani
Hafsa Qadri
6.1 Introduction
129(3)
6.2 Immunotherapy and its types
132(4)
6.3 Immunotherapies for bacterial infections
136(10)
6.4 Emerging technologies against bacterial pathogens
146(1)
6.5 Adjuvant immunotherapies as novel strategies to bacterial infection
147(5)
6.6 Development of therapeutic antibodies
152(3)
6.7 Future perspectives
155(1)
References
155(6)
Further readings
161(2)
7 Significance of immunotherapy for human fungal diseases and antifungal drug discovery
Manzoor Ahmad Mir
Ulfat Jan
Hafsa Qadri
7.1 Introduction
163(3)
7.2 Human fungal infections
166(5)
7.3 Potential immunotherapies for fungal diseases
171(2)
7.4 Different immunotherapeutic approaches against human fungal infections
173(5)
7.5 Advantages of immunotherapies for fungal diseases
178(3)
7.6 Future perspectives
181(1)
References
182(5)
8 Combinatorial approach to combat drug resistance in human pathogenic bacteria
Manzoor Ahmad Mir
Manoj Kumawat
Bilkees Nabi
Manoj Kumar
8.1 Introduction
187(1)
8.2 Food-borne bacterial infections
188(4)
8.3 Antibiotic treatment and their efficiency analysis
192(1)
8.4 Antibiotic resistance and antimicrobial resistance shown by Salmonella
193(4)
8.5 Future approach to fight salmonellosis
197(1)
8.6 Combinatorial approach in tuberculosis
197(1)
8.7 Therapeutics and their efficiency analysis
198(1)
8.8 Advanced therapeutics for tuberculosis
199(1)
8.9 Current therapeutics for treatment of cholera
200(1)
8.10 Advanced therapies against human pathogenic bacteria
201(1)
8.11 Future perspectives
201(1)
References
202(5)
9 Combinatorial approach to combat drug resistance in human pathogenic fungi
Manzoor Ahmad Mir
Hafsa Qadri
Shariqa Aisha
Abdul Haseeb Shah
9.1 Introduction
207(5)
9.2 Major classes of antifungal drugs
212(4)
9.3 Overview of combination therapy
216(3)
9.4 Mechanism of drug interactions
219(3)
9.5 Benefits of using drug combinations/applications of combinatorial approach
222(4)
9.6 Future perspectives
226(1)
References
226(7)
10 Recent trends in the development of bacterial and fungal vaccines
Manzoor Abmad Mir
Muhammad Usman
Hafsa Qadri
Shariqa Aisha
10.1 Introduction
233(7)
10.2 Understanding host--pathogen interaction
240(5)
10.3 Immunity and vaccination
245(5)
10.4 Vaccine development against bacterial pathogens
250(2)
10.5 Understanding vaccine development against fungal pathogens
252(2)
10.6 Future perspectives
254(1)
References
255(6)
Index 261
Dr. Manzoor Ahmad Mir holds a Masters Degree in Zoology from HNBG Central University and completed his Ph.D. in Immunology at Jawaharlal Nehru University, New Delhi, and CSIR-Institute of Microbial Technology, Chandigarh. His research focuses on Cancer Biology, Combination Therapy in Breast Cancer, and Tuberculosis Immunology. Dr. Mir has published over 50 high-impact research papers and book chapters, earning multiple awards and royalties. He has authored more than 15 books with international publishers like Elsevier and Springer-Nature. Dr. Mir serves on the editorial boards of prestigious journals and has been an invited speaker at numerous scientific conferences. He is a member of several scientific organizations, including the American Association of Cancer Research and the Royal British Society. He has received the TARE Fellowship and the SRFP-2019 from Indian science academies. Dr. Mir teaches Cancer Biology and Immunology at the University of Kashmir, where he heads the Department of Bioresources.
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