Klienditugi: 7440010 (E-R 10-18)

E-raamat: Hyaluronan Signaling and Turnover

Melanie Simpson (Department of Biochemistry, University of Nebraska, USA), Paraskevi Heldin (Ludwig Institute for Cancer Research Ltd, Sweden)

Formaat: PDF+DRM
Sari: Advances in Cancer Research
Ilmumisaeg: 26-Jul-2014
Kirjastus: Academic Press Inc
Keel: eng
ISBN-13: 9780128003930

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Oncology

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Formaat: PDF+DRM
Sari: Advances in Cancer Research
Ilmumisaeg: 26-Jul-2014
Kirjastus: Academic Press Inc
Keel: eng
ISBN-13: 9780128003930

Teised raamatud teemal:

Oncology

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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume covers hyaluronan signaling and turnover.

Provides information on cancer research
Outstanding and original reviews
Suitable for researchers and students

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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Contributors

Preface

Pt 1 Emerging Roles for Hyaluronidase in Cancer Metastasis and Therapy

(34)

Caitlin O. McAtee

Joseph J. Barycki

Melanie A. Simpson

1 Introduction

(1)

2 Of Mole Rats and Men: Insights About HA and Cancer

(3)

3 Hyaluronidase Expression in Cancer

(5)

4 Hyaluronidase Function and the Metastatic Process

(7)

5 Hyaluronidase Targeting in Cancer Therapy and Imaging

(8)

6 Conclusions and Future Perspective

(1)

Acknowledgments

(1)

References

(8)

Pt 2 Targeting Hyaluronic Acid Family for Cancer Chemoprevention and Therapy

(32)

Vinata B. Lokeshwar

Summan Mirza

Andre Jordan

1 Introduction

(2)

2 Targeting HA Production

(5)

3 Targeting HA Signaling

(2)

4 HA as a Carrier for Drug Delivery

(3)

5 Targeting HA Receptors

(5)

6 Targeting HAase

(1)

7 Conclusion

(1)

Acknowledgments

(1)

References

(12)

Pt 3 Aberrant, Posttranscriptional Processing of Hyaluronan Synthase 1 in Malignant Transformation and Tumor Progression

(28)

Sophia Adamia

Jitra Kriangkum

Andrew R. Belch

Linda M. Pilarski

1 Splicing and Cancer

(1)

2 Control of Pre-mRNA Splicing

(2)

3 Impact on Cancer of Alterations in Splicing Machinery

(1)

4 Aberrant Splicing of Hyaluronan Synthase 1

(3)

5 Clinical Impact of Aberrant HAS1 Splicing

(1)

6 Genetic Variations in HAS1

(1)

7 Functional Impact of HAS1Vs

(4)

8 Functional Outcomes of HAS1Vs in Transfectants

(3)

9 HAS1Vs and Mitotic Catastrophe

(5)

10 Conclusion

(1)

Acknowledgments

(1)

References

(7)

Pt 4 Hyaluronan Synthases Posttranslational Regulation in Cancer

(26)

Davide Vigetti

Alberto Passi

1 Introduction

(2)

2 HA Synthesis

(3)

3 HA Catabolism

101

(2)

4 HAS2 Phosphorylation, AMPK, and Its Dual Effects on Tumors

103

(5)

5 O-GIcNAcylation and Cancer

108

(5)

6 Conclusions

113

(1)

Acknowledgment

113

(1)

References

113

(8)

Pt 5 Hyaluronan-Coated Extracellular Vesicles-A Novel Link Between Hyaluronan and Cancer

121

(28)

Kirsi Rilla

Hanna Siiskonen

Markku Tammi

Raija Tammi

1 Introduction

122

(2)

2 Extracellular Vesicles as Novel Communicators Between Cells

124

(2)

3 EVs Promote Tumor Progression

126

(3)

4 HA Synthesis Enhances Shedding of Extracellular Vesicles

129

(8)

5 HA-EVs as Predictors, Targets, and Carriers of Therapy

137

(2)

6 Conclusions

139

(1)

Acknowledgments

139

(1)

References

140

(9)

Pt 6 Hyaluronan in the Healthy and Malignant Hematopoietic Microenvironment

149

(42)

Sophia K. Khaldoyanidi

Valentina Goncharova

Barbara Mueller

Ingrid U. Schraufstatter

1 Introduction

151

(2)

2 BM MSC, Their Derivatives, and HA

153

(10)

3 Macrophages and HA in the BM

163

(3)

4 Endothelial Cells and HA in BM

166

(7)

5 Nerve Cells and HA in BM

173

(1)

6 Role of HA in the BM Microenvironment in Hematological Malignancies

174

(3)

7 Conclusion

177

(1)

References

178

(13)

Pt 7 Hyaluronan Regulation of Endothelial Barrier Function in Cancer

191

(20)

Patrick A. Singleton

1 Introduction

192

(2)

2 HA Regulation of Vascular Integrity

194

(3)

3 HA Regulation of Endothelial Barrier Function During Tumor Angiogenesis

197

(1)

4 HA Regulation of Endothelial Barrier Function During Cancer Metastasis

198

(2)

5 Potential Therapeutic Effects of HMW-HA in Inhibiting Endothelial Barrier Disruption During Cancer Progression

200

(1)

6 Conclusions

201

(2)

Acknowledgments

203

(1)

References

203

(8)

Pt 8 HAS2 and CD44 in Breast Tumorigenesis

211

(20)

Paraskevi Heldin

Kaustuv Basu

Inna Kozlova

Helena Porsch

1 Introduction

211

(2)

2 Molecular Classification of Breast Cancer

213

(2)

3 Role of Stromal HA in Tumor Progression

215

(3)

4 Expression of HAS Genes and Breast Cancer Malignancy

218

(2)

5 HA-CD44 Interactions: A Regulatory Network During TGFp-Mediated EMT

220

(3)

6 Conclusions

223

(1)

Acknowledgments

223

(1)

References

224

(7)

Pt 9 CD44 is a Multidomain Signaling Platform that Integrates Extracellular Matrix Cues with Growth Factor and Cytokine Signals

231

(24)

Veronique Orian-Rousseau

Jonathan Sleeman

1 Introduction

232

(2)

2 Ligation of ECM Components by CD44

234

(4)

3 CD44: Coreceptor for Cell-Surface Receptors

238

(6)

4 CD44 as a Multidomain Signal Integration Platform

244

(4)

5 Concluding Remarks

248

(1)

References

249

(6)

Pt 10 Hyaluronan-CD44 Interaction Promotes Oncogenic Signaling, microRNA Functions, Chemoresistance, and Radiation Resistance in Cancer Stem Cells Leading to Tumor Progression

255

(22)

Lilly Y.W. Bourguignon

Marisa Shiina

Jian-Jian Li

1 Introduction

256

(2)

2 Regulation of Tumor Progression by HA/CD44

258

(3)

3 Activation of CSCs by HA/CD44

261

(8)

4 Conclusion

269

(1)

Acknowledgments

269

(1)

References

270

(7)

Pt 11 Advances and Advantages of Nanomedicine in the Pharmacological Targeting of Hyaluronan-CD44 Interactions and Signaling in Cancer

277

(42)

Spyros S. Skandalis

Chrisostomi Gialeli

Achilleas D. Theocharis

Nikos K. Karamanos

1 Introduction

278

(1)

2 Importance of Targeting Hyaluronan-CD44 in Tumors

279

(5)

3 Therapeutic Interventions/Strategies That Target Hyaluronan and/or CD44 to Perturb Hyaluronan-CD44 Interactions in Tumors

284

(11)

4 Advances in Nanomedicine Related with Hyaluronan-CD44 Targeting

295

(9)

5 Concluding Remarks/Conclusions

304

(1)

Acknowledgments

304

(1)

References

305

(14)

Pt 12 Hyaluronan/RHAMM Interactions in Mesenchymal Tumor Pathogenesis: Role of Growth Factors

319

(32)

Katerina Kouvidi

Dragana Nikitovic

Aikaterini Berdiaki

George N. Tzanakakis

1 Introduction

320

(3)

2 The Role of Hyaluronan and Its Receptors in Fibrosarcoma

323

(9)

3 GF Signaling and ECM Organization in Fibrosarcoma Pathogenesis

332

(5)

4 Concluding Remarks

337

(1)

References

338

(13)

Pt 13 CD147: Regulator of Hyaluronan Signaling in Invasiveness and Chemoresistance

351

(24)

G. Daniel Grass

Lu Dai

Zhiqiang Qin

Chris Parsons

Bryan P. Toole

1 Introduction

352

(1)

2 Structure and Pleiotropic Functions of CD147

353

(3)

3 CD147-Induced HA Synthesis and Signaling

356

(1)

4 CD147-HA Axis in Cellular Invasion

356

(5)

5 CD147-HA Axis in Chemoresistance

361

(2)

6 Induction of the CD147-HA Axis by Kaposi's Sarcoma-Associated Herpesvirus

363

(1)

7 Conclusions

364

(2)

References

366

(9)

Index

375

Paraskevi Heldin, Ph.D., received her B.Sci. exam (Chemistry/Biochemistry Mathematics), Uppsala University in 1979 and her Ph.D., in Medical and Physiological Chemistry for studies on regulatory phosphorylation of proteins, Faculty of Medicine, Uppsala University, in 1987. After dissertation she changed research area and focused on the biology of hyaluronan under the supervision of Professor T.C. Laurent, Uppsala University. She worked at Department of Medical and Physiological Chemistry during 1987- 2000, and was awarded Docent appointment in Medical and Physiological Chemistry and Scientist Position from The Göran Gustafsson Foundation. Since 2001, she is Adjunct Associate Professor at the Department of Medical Biochemistry and Microbiology, and Associate Investigator and Head of the Matrix Biology Group in Ludwig Institute for Cancer Research, Uppsala, Sweden. Year 2013, she has appointed Adjunct Professor at the Department of Medical Biochemistry and Microbiology, Uppsala Unversity, Sweden. Dr Heldins interests are focused on understanding the mechanisms of how hyaluronan-CD44 complexes interact with the receptors for the growth factors PDGF and TGF for modulation of the proliferative and invasive behavior of malignant cells.

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