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E-raamat: Hydrogen Sulfide in Redox Biology Part B

Volume editor (Pharmacology & Pharmaceutical Sciences, School of Pharmacy, University of Southern California, USA), Volume editor (Department of Molecular Pharmacology and Toxicology, School of Pharmaceutical Sciences, University of Southern California, USA)
  • Formaat: PDF+DRM
  • Sari: Methods in Enzymology
  • Ilmumisaeg: 03-Mar-2015
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128016220
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Hydrogen Sulfide in Redox Biology Part BSuurem pilt
  • Formaat: PDF+DRM
  • Sari: Methods in Enzymology
  • Ilmumisaeg: 03-Mar-2015
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128016220
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These new volumes of Methods in Enzymology (554 and 555) on Hydrogen Sulfide Signaling continue the legacy established by previous volumes on another gasotransmitter, nitric oxide (Methods in Enzymology volumes 359, 396, 440, and 441), with quality chapters authored by leaders in the field of hydrogen sulfide research. These volumes ofMethods in Enzymology were designed as a compendium for hydrogen sulfide detection methods, the pharmacological activity of hydrogen sulfide donors, the redox biochemistry of hydrogen sulfide and its metabolism in mammalian tissues, the mechanisms inherent in hydrogen sulfide cell signaling and transcriptional pathways, and cell signaling in specific systems, such as cardiovascular and nervous system as well as its function in inflammatory responses. Two chapters are also devoted to hydrogen sulfide in plants and a newcomer, molecular hydrogen, its function as a novel antioxidant.
  • Continues the legacy of this premier serial with quality chapters on hydrogen sulfide research authored by leaders in the field
  • Covers conventional and new hydrogen sulfide detection methods
  • Covers the pharmacological activity of hydrogen sulfide donors
  • Contains chapters on important topics on hydrogen sulfide modulation of cell signaling and transcriptional pathways, and the role of hydrogen sulfide in the cardiovascular and nervous systems and in inflammation

Arvustused

Praise for the Series: "Should be on the shelves of all libraries in the world as a whole collection." --Chemistry in Industry "The work most often consulted in the lab." --Enzymologia "The Methods in Enzymology series represents the gold-standard." --Neuroscience

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Continues the legacy of this premier serial with quality chapters authored by leaders in the field.
Contributors xi
Preface xv
Section I The Redox Biochemistry of Hydrogen Sulfide
1 Investigating the Role of H2S in 4-HNE Scavenging
3(16)
Hilde Laggner
Bernhard M.K. Gmeiner
1 Introduction
4(1)
2 Experimental Compounds and Considerations
5(9)
3 Conclusions and Perspectives
14(5)
Acknowledgment
16(1)
References
16(3)
2 Inhalation Exposure Model of Hydrogen Sulfide (H2S)-Induced Hypometabolism in the Male Sprague-Dawley Rats
19(20)
Asaf Stein
David W. Kraus
Jeannette E. Doeller
Shannon M. Bailey
1 Introduction
20(1)
2 Exposure Protocol for H2S-lnduced Hypometabolism in Rats
21(10)
3 Other Considerations for H2S Exposure Studies
31(1)
4 Summary
32(7)
Acknowledgments
33(1)
References
33(6)
Section II Mechanisms of H2S Cell Signaling and Transcriptional Pathways
3 Use of the Tag-Switch" Method for the Detection of Protein S-Sulfhydration
39(18)
Chung-Min Park
Igor Macinkovic
Milos R. Filipovic
Ming Xian
1 Introduction
40(1)
2 The Design of Tag-Switch" Method
40(1)
3 Chemistry Validation Using Small-Molecule Substrates
41(5)
4 Tag-Switch" Assay on Bovine Serum Albumin and GAPDH as Model Proteins
46(3)
5 "Tag-Switch Assay for the Detection on intracellular protein Persulfides
49(2)
6 Tag-Switch" Assay for the Detection of Intracellular S-Sulfhydration by Fluorescence Microscopy
51(3)
7 Conclusions
54(3)
Acknowledgments
55(1)
References
55(2)
4 Real-Time Assays for Monitoring the Influence of Sulfide and Sulfane Sulfur Species on Protein Thiol Redox States
57(22)
Romy Greiner
Tobias P. Dick
1 Introduction
58(1)
2 PTEN Activity Assay
59(2)
3 roGF P2 Redox Assay
61(3)
4 Application of "H2S Donors" and Polysulfides
64(3)
5 Quantitation of Sulfane Sulfur by Cold Cyanolysis
67(4)
6 Elimination of Sulfane Sulfur by Cold Cyanolysis
71(8)
Acknowledgments
76(1)
References
76(3)
5 Protein Sulfhydration
79(14)
Bindu D. Paul
Solomon H. Snyder
1 Introduction
80(1)
2 Detection of Sulfhydration Using the Modified Biotin Switch Assay
81(5)
3 Detection of Sulfhydration Using the Maleimide Assay
86(2)
4 Summary
88(5)
Acknowledgments
89(1)
References
89(4)
Section III H2S in Cell Signaling in the Cardiovascular and Nervous System and Inflammatory Processes
6 Intravital Microscopic Methods to Evaluate Anti-inflammatory Effects and Signaling Mechanisms Evoked by Hydrogen Sulfide
93(34)
Mozow Y. Zuidema
Ronald J. Korthuis
1 Introduction
94(1)
2 Molecular Determinants of Neutrophil/Endothelial Cell Adhesive Interactions
94(4)
3 Intravital Microscopic Approaches to Study Leukocyte/Endothelial Cell Adhesive Interactions
98(5)
4 Assessing Leukocyte Rolling, Adhesion, and Emigration in the Intact Microcirculation
103(5)
5 Detection of Chemokine and Adhesion Molecule Expression using Intravital Microscopy
108(1)
6 Intravital Microscopic Methods to Assess Changes in Microvascular Permeability
109(2)
7 Assessment of Reactive Oxygen Species Generation Using Intravital Microscopy
111(2)
8 Fluorescence Detection of Cell Injury using Intravital Microscopy
113(1)
9 Perfused Capillary Density Assessment with Intravital Microscopy
113(1)
10 Acute and Preconditioning-Induced Anti-inflammatory Actions of Hydrogen Sulfide: Assessment Using Intravital Microscopy
114(5)
11 Conclusion and Perspectives
119(8)
Acknowledgment
121(1)
References
121(6)
7 Attenuation of Inflammatory Responses by Hydrogen Sulfide (H2S) in Ischemia/Reperfusion Injury
127(18)
Neel R. Sodha
Frank W. Sellke
1 Introduction
128(1)
2 Ischemia--Reperfusion Injury
128(2)
3 Central Nervous System
130(1)
4 Respiratory System
131(2)
5 Cardiovascular System
133(2)
6 Gastrointestinal System
135(3)
7 Hepatobiliary System
138(1)
8 Renal System
139(2)
9 Musculoskeletal
141(1)
10 Summary
142(3)
References
143(2)
8 CD47-Dependent Regulation of H2S Biosynthesis and Signaling in T Cells
145(24)
Sukhbir Kaur
Anthony L. Schwartz
Thomas W. Miller
David D. Roberts
1 Introduction
146(2)
2 Regulation of H2S Biosynthesis in T Cells
148(1)
3 Catabolism of H2S
149(1)
4 Regulation of T Cell Activation by H2S Signaling
150(3)
5 Autocrine and Paracrine Roles of H2S in T Cell Activation
153(2)
6 Role of H2S in the Cytoskeleton
155(1)
7 T Cell Regulation by TSP1/CD47 Signaling
156(1)
8 H2S Regulation of Leukocyte Adhesion
157(1)
9 Role of H2S in Diseases Associated with Altered T Cell Immunity
158(2)
10 Future Prospective
160(9)
Acknowledgments
162(1)
References
162(7)
9 Anti-inflammatory and Cytoprotective Properties of Hydrogen Sulfide
169(26)
Burcu Gemici
John L. Wallace
1 Introduction
170(1)
2 Enzymatic Synthesis of H2S
170(2)
3 Healing and Resolution of Inflammation
172(1)
4 Mechanisms of Anti-inflammatory Effects of H2S
173(3)
5 Effects of H2S on Visceral Pain
176(1)
6 Cytoprotective Actions of H2S
176(4)
7 Therapeutic Applications of H2S-Releasing Drugs
180(15)
Acknowledgments
188(1)
References
188(7)
10 H2S and Substance P in Inflammation
195(12)
Madhav Bhatia
1 Introduction
195(1)
2 Disease Models Used to Study the Role of H2S and Substance P
196(5)
3 H2S and Substance P---What Are They Doing Together?
201(1)
4 Summary
202(5)
Acknowledgments
202(1)
References
202(5)
11 Role of Hydrogen Sulfide in Brain Synaptic Remodeling
207(26)
Pradip Kumar Kamat
Anuradha Kalani
Neetu Tyagi
1 Introduction
208(2)
2 Pharmacological and Physiological Effect of H2S
210(2)
3 Effect of H2S on the CNS
212(2)
4 Effect of H2S on Brain Cells (Astrocyte, Microglia, and Oligodendrocyte)
214(2)
5 Synapse
216(1)
6 Glia and Neurons Interactions
217(1)
7 Effect of H2S on Neuronal Redox Stress
218(1)
8 Effect of H2S on Glutamate Neurotransmission
219(1)
9 Effect of H2S on NMDA Receptor Regulation
220(1)
10 Effect of H2S on GABA-Mediated Neurotransmission
221(1)
11 Effect of H2S on Calmodulin Kinase
222(1)
12 Conclusion
222(11)
Conflict of Interest
223(1)
Acknowledgment
223(1)
References
223(10)
Section IV H2S in Plants
12 Detection of Thiol Modifications by Hydrogen Sulfide
233(20)
E. Williams
S. Pead
M. Whiteman
M.E. Wood
I.D. Wilson
M.R. Ladomery
T. Teklic
M. Lisjak
J.T. Hancock
1 Introduction
234(1)
2 Hydrogen Sulfide Acts as a Signal in Cells
235(1)
3 Modification of Thiols by Signaling Molecules
236(2)
4 Identification of Modified Thiols by Other Methods
238(1)
5 Experimental Protocols
239(1)
6 Caenorhabditis elegans as a Model Organism
239(1)
7 Growth of C. elegans
240(1)
8 Treatment of Samples with H2S
240(1)
9 Estimation of Toxicity of H2S Compounds
241(1)
10 Treatment of Samples with Thiol Tag
242(2)
11 Isolation and Analysis of Modified Proteins
244(1)
12 Estimation of Protein Concentrations in Samples
245(1)
13 Further Analysis and Identification of Modified Proteins
246(1)
14 Concluding Remarks
247(6)
References
248(5)
13 Analysis of Some Enzymes Activities of Hydrogen Sulfide Metabolism in Plants
253(18)
Zhong-Guang Li
1 Theory
254(2)
2 Equipment
256(1)
3 Materials
256(4)
4 Protocol 1
260(1)
5 Step 1: Analyze of L-/D Cysteine Desulfhydrase Activity
261(2)
6 Protocol 2
263(1)
7 Step 1: Analyze of Sulfite Reductase Activity
263(2)
8 Protocol 3
265(1)
9 Step 1: Analyze of β-Cyano-L-Alanine Synthase Activity
266(1)
10 Protocol 4
267(1)
11 Step 1: Analyze of L-Cysteine Synthase Activity
268(3)
Acknowledgment
269(1)
References
269(2)
14 Sulfide Detoxification in Plant Mitochondria
271(18)
Hannah Birke
Tatjana M. Hildebrandt
Markus Wirtz
Rudiger Hell
1 Introduction
272(3)
2 Methods
275(8)
3 Summary
283(6)
Acknowledgments
283(1)
References
284(5)
Section V Molecular Hydrogen
15 Molecular Hydrogen as a Novel Antioxidant: Overview of the Advantages of Hydrogen for Medical Applications
289(30)
Shigeo Ohta
1 Introduction
290(1)
2 Comparison of H2 with Other Medical Gasses
291(1)
3 Oxidative Stress as Pathogenic Sources
292(2)
4 Physiological Roles of H2O2
294(1)
5 Measurement of H2 Gas Concentration
295(1)
6 Advantages of Hydrogen in Medical Applications
296(5)
7 Methods of Ingesting Molecular Hydrogen
301(3)
8 Medical Effects of H2
304(2)
9 Possible Molecular Mechanisms Underlying Various Effects of Molecular Hydrogen
306(3)
10 Unresolved Questions and Closing Remarks
309(10)
References
310(9)
Author Index 319(26)
Subject Index 345
ENRIQUE CADENAS, MD, PhD, received his PhD in biochemistry from the University of Buenos Aires, School of Medicine. He is professor of pharmacology and pharmaceutical sciences at the University of Southern California School of Pharmacy and of biochemistry and molecular biology at the University of Southern California Keck School of Medicine, and doctor honoris causa (medicine) at the University of Linköping, Sweden. Cadenas was president of the Society for Free Radical Research International (SFRRI) and is fellow of the Society for Free Radical Biology & Medicine. He served the scientific community by participating on NIH study sections (2002-2006; chair 2006-2008). His research interests include energy and redox metabolism in brain aging and the coordinated inflammatory-metabolic responses in brain and neurodegenerative diseases. Lester Packer received a PhD in Microbiology and Biochemistry in 1956 from Yale University. In 1961, he joined the University of California at Berkeley serving as Professor of Cell and Molecular Biology until 2000, and then was appointed Adjunct Professor, Pharmacology and Pharmaceutical Sciences, School of Pharmacy at the University of Southern California. Dr Packer received numerous distinctions including three honorary doctoral degrees, several distinguished Professor appointments. He was awarded Chevalier de lOrdre National du Merite (Knight of the French National Order of Merit) and later promoted to the rank of Officier. He served as President of the Society for Free Radical Research International (SFRRI), founder and Honorary President of the Oxygen Club of California. He has edited numerous books and published research; some of the most cited articles have become classics in the field of free radical biology: Dr Packer is a member of many professional societies and editorial boards. His research elucidated - the Antioxidant Network concept. Exogenous lipoic acid was discovered to be one of the most potent natural antioxidants and placed as the ultimate reductant or in the pecking order of the Antioxidant Network” regenerating vitamins C and E and stimulating glutathione synthesis, thereby improving the overall cellular antioxidant defense. The Antioxidant Network is a concept addressing the cells redox status. He established a world-wide network of research programs by supporting and co-organizing conferences on free radical research and redox biology in Asia, Europe, and America.
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