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E-raamat: Imaging in Photodynamic Therapy

Edited by (Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, USA), Edited by (Harvard University, Boston, Massachusetts, USA)
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This book covers the broad field of cellular, molecular, preclinical, and clinical imaging either associated with or combined with photodynamic therapy (PDT). It showcases how this approach is used clinically for cancer, infections, and diseases characterized by unwanted tissue such as atherosclerosis or blindness. Because the photosensitizers are also fluorescent, the book also addresses various imaging systems such as confocal microscopy and small animal imaging systems, and highlights how they have been used to follow and optimize treatment, and to answer important mechanistic questions. Chapters also discuss how imaging has made important contributions to clinical outcomes in skin, bladder, and brain cancers, as well as in the development of theranostic agents for detection and treatment of disease. This book provides a resource for physicians and research scientists in cell biology, microscopy, optics, molecular imaging, oncology, and drug discovery.

Arvustused

"The editors have skillfully compiled a wide and comprehensive spectrum from contributors around the world on up-to-date imaging technologies for photodynamic therapy (PDT), with a wealth of clinical images." Optics & Photonics News "The editors have skillfully compiled a wide and comprehensive spectrum from contributors around the world on up-to-date imaging technologies for photodynamic therapy (PDT), with a wealth of clinical images." Optics & Photonics News

Series preface ix
Preface xi
Acknowledgment xiii
Editors xv
Contributors xvii
Part 1: Introduction 1(48)
1 Looking out the optical window: Physical principles and instrumentation of imaging in photodynamic therapy
3(26)
Hui Liu
Jonathan P. Celli
2 Photochemistry and photophysics of PDT and photosensitizers
29(20)
Marcin Ptaszek
Part 2: In Vitro Microscopy For Photosensitizer Localization In Cells 49(68)
3 Phthalocyanines in photodynamic therapy
51(16)
Heidi Abrahamse
4 Singlet oxygen luminescence imaging: A prospective tool in bioscience?
67(22)
Michael Pfitzner
Jan C. Schlothauer
Lisheng Lin
Buhong Li
Beate Roder
5 Microbial biofilms and antimicrobial photodynamic therapy
89(14)
Anil Kishen
6 High-content imaging for photosensitizer screening
103(14)
Gisela M.F. Vaz
Mathias O. Senge
Sarah-Louise Ryan
Anthony Davies
Part 3: In Vitro Microscopy Of Cell Damage And Death Processes After PDT 117(66)
7 Enhanced efficacy of photodynamic therapy via an iron-lysosome-mitochondria connection: Studies with phthalocyanine 4
119(12)
Anna-Liisa Nieminen
Hsin-I. Hung
John J. Lemasters
8 Role of cell death pathways in response to photodynamic therapy in gliomas
131(18)
Leonardo Barcelos de Paula
Fernando Lucas Primo
Antonio Claudio Tedesco
9 In search of specific PDT photosensitizers: Subcellular localization and cell death pathways
149(34)
Tayana M. Tsubone
Christiane Pavani
Isabel O.L. Bacellar
Mauricio S. Baptista
Part 4: Theranostic Agents And Nanotechnology 183(92)
10 Quantum dots in PDT
185(26)
Ricardas Rotomskis
Giedre Streckyte
11 Tetrapyrrole-based theranostic combinations of photodynamic action and magnetic resonance imaging
211(38)
Duygu Aydin Tekdas
Devrim Atilla
Vefa Ahsen
Ayse Gul Gurek
12 Theranostic applications of photodynamic molecular beacons
249(10)
Wentao Song
Yang Zhou
Jonathan F. Lovell
13 Tumor-specific imaging and photodynamic therapy targeting the urokinase receptor
259(16)
Zafar lqbal
Longguang Jiang
Zhuo Chen
Cai Yuan
Rui Li
Ke Zheng
Xiaolei Zhou
Jincan Chen
Ping Hu
Mingdong Huang
Part 5: Small Animal Imaging 275(48)
14 Vascular imaging in photodynamic therapy
277(16)
Bin Chen
15 Photosensitizer activity imaging on the microscopic scale
293(20)
Steffen Hackbarth
16 Bioluminescence imaging for monitoring the effectiveness of photodynamic therapy for infections in animal models
313(10)
Pawel Mroz
Michael R. Hamblin
Part 6: Clinical Imaging 323(146)
17 Imaging of photosensitizers in skin
325(22)
Marica B. Ericson
Danni Wang
Despoina Kantere
John Paoli
Ann-Marie Wennberg
18 Brain tumor imaging with ALA
347(38)
Herbert Stepp
Oliver Schnell
19 PDT of non-muscle-invasive bladder cancer with Hexylester Aminolevulinate: Optimization of the illumination wavelengths by fluorescence spectroscopy and imaging
385(10)
Matthieu Zellweger
Claude-Andre Porret
Norbert Lange
Patrice Jichlinski
Hubert van den Bergh
Georges Wagnieres
20 Endoscopic imaging and photodynamic therapy
395(24)
Harubumi Kato
Kinya Furukawa
Yasufumi Kato
Jitsuo Usuda
Kuniharu Miyajima
Keishi Ohtani
21 Spectroscopic imaging in prostate PDT
419(36)
Rozhin Penjweini
Brian C. Wilson
Timothy C. Zhu
22 Fluorescent-guided resection in clinical oncology
455(14)
Ron R. Allison
Index 469
Michael R Hamblin Ph.D. is a Principal Investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital, an Associate Professor of Dermatology at Harvard Medical School and is a member of the affiliated faculty of the Harvard-MIT Division of Health Science and Technology. His research interests lie in the areas of photodynamic therapy (PDT) for infections, cancer, and stimulation of the immune system, and in low-level light therapy (LLLT) for wound healing, arthritis, traumatic brain injury, neurodegenerative diseases and psychiatric disorders. He directs a laboratory of around a dozen post-doctoral fellows, visiting scientists and graduate students. His research program is supported by NIH, CDMRP, USAFOSR and CIMIT among other funding agencies. He has published 272 peer-reviewed articles, over 150 conference proceedings, book chapters and International abstracts and holds 8 patents. He is Associate Editor for 7 journals, on the editorial board of a further 12 journals and serves on NIH Study Sections. For the past 10 years Dr Hamblin has chaired an annual conference at SPIE Photonics West entitled "Mechanisms for low level light therapy" and he has edited the 10 proceedings volumes together with four other major textbooks on PDT and photomedicine. He has several other book projects in progress at various stages of completion. In 2011 Dr Hamblin was honored by election as a Fellow of SPIE.

Ying-Ying Huang, M.D., is a scientist in Dr. Michael Hamblins lab in Wellman Center for Photomedicine at Massachusetts General Hospital, an Instructor of Dermatology at Harvard Medical School. She was trained as a dermatologist in China. She has been at MGH Wellman Center for 5 years. Her research interests lie in the areas of photodynamic therapy (PDT) for infections, cancer and mechanism of low level light therapy (LLLT) for traumatic brain injury. She has published 48 peer review articles and 15 conference proceedings and book chapters. She is the co-editor of newly released Handbook of Photomedicine