Immune checkpoints are among the maintenance regulators of immune responses. In this book, all inhibitory checkpoint molecules in the immune system will explain. In the first part, immune checkpoint molecules will be categorized and described in terms of structure, mechanisms, cellular expression, and genetics in detail. The next part will describe the role of these receptors in tumors and the therapeutic approach in cancers. Eventually, the role of immune checkpoints in other clinical situations, such as transplantation, autoimmunity, and other diseases will be discussed.
It is worth mentioning many sources have described inhibitory checkpoint molecules in cancers since there are poor sources that collected all inhibitory checkpoint molecules. This book tries to categorize and introduce all these molecules based on their application and importance in health and disease. It aims to provide general information about immune checkpoints that will be useful for scientists and clinicians.
1.Overview of immune system regulation.-
2. Immune checkpoint molecules:
structure, function, expression.-
3. Genetics of immune checkpoints.-
4.
Immune checkpoints overexpression in cancer.-
5. Cancer immunotherapy using
immune checkpoint blockade.-
6. Adverse effects of immune checkpoint
blockade.-
7. Autoimmune diseases.-
8. Allergy.-
9. Pregnancy.-
10. Organ
transplantation.-
11. Infection: COVID-19.
Dr. Lobat Tayebi is the Batten Endowed Professor and Director of the Institute for Engineering in Medicine, Health, & Human Performance (EnMed) in the College of Engineering and Technology at Old Dominion University. Her research is at the interface of biology and engineering, and she has authored over 400 peer-reviewed articles as well as several issued patents and books in the field.
Dr. Mohsen Abdolmaleki holds a PhD in Immunology. His research focuses on immune regulation, cancer, and inflammatory diseases. He has authored several peer-reviewed scientific publications. This book draws on his academic and research expertise in immunology.
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