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E-raamat: Improving Cancer Diagnosis and Care: Clinical Application of Computational Methods in Precision Oncology: Proceedings of a Workshop

  • Formaat: 92 pages
  • Ilmumisaeg: 15-Jul-2019
  • Kirjastus: National Academies Press
  • Keel: eng
  • ISBN-13: 9780309490849
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  • Formaat: 92 pages
  • Ilmumisaeg: 15-Jul-2019
  • Kirjastus: National Academies Press
  • Keel: eng
  • ISBN-13: 9780309490849
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A hallmark of high-quality cancer care is the delivery of the right treatment to the right patient at the right time. Precision oncology therapies, which target specific genetic changes in a patient's cancer, are changing the nature of cancer treatment by allowing clinicians to select therapies that are most likely to benefit individual patients. In current clinical practice, oncologists are increasingly formulating cancer treatment plans using results from complex laboratory and imaging tests that characterize the molecular underpinnings of an individual patient's cancer. These molecular fingerprints can be quite complex and heterogeneous, even within a single patient. To enable these molecular tumor characterizations to effectively and safely inform cancer care, the cancer community is working to develop and validate multiparameter omics tests and imaging tests as well as software and computational methods for interpretation of the resulting datasets.





To examine opportunities to improve cancer diagnosis and care in the new precision oncology era, the National Cancer Policy Forum developed a two-workshop series. The first workshop focused on patient access to expertise and technologies in oncologic imaging and pathology and was held in February 2018. The second workshop, conducted in collaboration with the Board on Mathematical Sciences and Analytics, was held in October 2018 to examine the use of multidimensional data derived from patients with cancer, and the computational methods that analyze these data to inform cancer treatment decisions. This publication summarizes the presentations and discussions from the second workshop.

Table of Contents



Front Matter Proceedings of a Workshop Appendix A: Statement of Task Appendix B: Workshop Agenda
Acronyms and Abbreviations xix
Proceedings of a Workshop
1(1)
Workshop Overview
1(1)
New Paradigm in Cancer Diagnosis and Care
2(11)
Computational Technologies
10(3)
Machine Learning
10(2)
Machine Learning Applications in Radiology
12(1)
Health Apps
12(1)
Translation Challenges
13(25)
Data Quality and Completeness
13(4)
Risk of Bias
15(2)
Validation of Computational Precision Oncology
17(6)
Test Development and Analytical Validation Steps
17(1)
Statistical Validation
18(2)
Clinical Validation
20(1)
Face Validity
21(1)
Gaps in Reproducibility
21(2)
Regulatory Oversight
23(7)
Digital Data Standards
23(1)
Devices
24(1)
Software as a Medical Device
25(3)
Quantitative Imaging Devices
28(1)
Laboratory Developed Tests
29(1)
Patient Privacy
30(4)
General Data Protection Regulation
31(1)
California Consumer Privacy Act of 2018
32(2)
Communicating Results and Risks to Patients
34(2)
Challenges for Payers
36(2)
Research Needed
38(2)
Examples of Care Delivery Models for Computational Precision Medicine
40(6)
Moffitt Cancer Center Precision Oncology Program
40(1)
Intermountain Healthcare Precision Oncology Program
41(2)
Department of Veterans Affairs' National Precision Oncology Program
43(1)
University of California
44(2)
Vanderbilt-Ingram Cancer Center's My Cancer Genome
46(1)
Lessons Learned from Implementing Computational Precision Oncology Care
46(12)
Financial Support
46(1)
Patient-Centered and Clinician-Friendly Design
47(1)
Informed Consent
48(1)
Improve Clinician Understanding of Omics and Analytics
49(1)
Standards
49(2)
Data Sharing
51(5)
Large-Scale Public Databases
51(1)
Incentives for Sharing Data
52(1)
Enabling Patient Sharing of Data
52(4)
Data Protection
56(1)
Multidisciplinary Teamwork
56(2)
Wrap-Up
58(1)
References 59(6)
Appendix A Statement Of Task 65(2)
Appendix B Workshop Agenda 67