Preface |
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iii | |
Contributors |
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xiii | |
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SECTION I: ANATOMY AND PHYSIOLOGY |
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1 | (20) |
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1 | (1) |
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1 | (1) |
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2 | (1) |
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3 | (2) |
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5 | (1) |
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Mediobasal Temporal Lobe AVMs |
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5 | (4) |
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Interhemispheric Parafalcine and Callosal Region AVMs |
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9 | (2) |
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Basal Ganglia Region AVMs |
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11 | (7) |
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AVMs of the Posterior Fossa |
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18 | (1) |
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19 | (2) |
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Pathology and Genetic Factors |
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21 | (10) |
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21 | (4) |
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25 | (2) |
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27 | (4) |
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31 | (18) |
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31 | (1) |
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Hemodynamic Effect within the Interstices of an AVM |
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32 | (1) |
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Hemodynamic Effect on Cerebral Blood Vessels in the Presence of an AVM |
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33 | (4) |
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Hemodynamic Effect on the Microcirculation of the Brain Associated with an AVM |
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37 | (1) |
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Autoregulation and Reactivity to Changes in PaCO2 |
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38 | (2) |
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Hemodynamic Effect on Cerebral Blood Vessels at the Time of AVM Ablation |
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40 | (1) |
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Hemodynamic Effect on the Brain at the Time of AVM Ablation |
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40 | (1) |
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Arterio-Capillary-Venous Hypertensive Syndromes |
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41 | (1) |
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42 | (7) |
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Use of Modeling for the Study of Cerebral Arteriovenous Malformations |
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49 | (24) |
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49 | (1) |
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Importance of Modeling for AVMs |
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49 | (1) |
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Specific Modeling Attempts-Model Construction |
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50 | (5) |
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55 | (3) |
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Long-Term Objectives of Computational Modeling |
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58 | (1) |
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59 | (2) |
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61 | (1) |
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Appendix 1. Description of a Computational AVM Model |
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61 | (2) |
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Appendix 2. Mathematical and Computational Approach |
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63 | (4) |
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Appendix 3. Vascular Stress |
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67 | (1) |
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68 | (5) |
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SECTION II: CLINICAL PRESENTATION AND DIAGNOSTIC EVALUATION |
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73 | (8) |
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73 | (1) |
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73 | (2) |
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Morbidity and Mortality Related to Hemorrhage |
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75 | (2) |
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77 | (1) |
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Anatomical Factors Influencing the Natural History of AVMs |
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77 | (1) |
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78 | (1) |
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79 | (2) |
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Classification and Grading Systems |
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81 | (14) |
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81 | (1) |
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Classification and Grading Parameters |
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81 | (3) |
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84 | (7) |
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91 | (1) |
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92 | (3) |
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95 | (20) |
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95 | (1) |
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Epidemiology and Natural History |
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95 | (1) |
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Therapeutic Options and Classification |
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96 | (1) |
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97 | (1) |
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Magnetic Resonance Imaging and Angiography |
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98 | (7) |
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105 | (4) |
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Angiographically Occult AVMs |
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109 | (1) |
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109 | (1) |
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110 | (5) |
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Functional Evaluation and Diagnosis |
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115 | (8) |
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115 | (1) |
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115 | (3) |
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118 | (1) |
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Blood Pressure and Flow Analysis |
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119 | (1) |
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120 | (1) |
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120 | (1) |
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120 | (3) |
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SECTION III: BASIC CONSIDERATIONS |
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Decision Analysis for Asymptomatic Lesions |
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123 | (12) |
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123 | (1) |
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Decision Analysis and Markov Modeling for the Treatment of Asymptomatic AVMs |
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124 | (3) |
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127 | (3) |
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130 | (2) |
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132 | (3) |
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133 | (2) |
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Multimodality Therapy: Treatment Algorithms |
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135 | (10) |
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135 | (1) |
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135 | (1) |
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136 | (1) |
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136 | (1) |
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137 | (1) |
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137 | (1) |
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138 | (2) |
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Decision Analysis for the Management of Unruptured AVMs |
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140 | (1) |
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Decision Analysis for the Management of Ruptured AVMs |
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140 | (1) |
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141 | (1) |
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141 | (4) |
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145 | (14) |
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145 | (1) |
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145 | (4) |
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149 | (1) |
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149 | (2) |
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Neurosurgical Emergency: Intracranial Hemorrhage Related to AVM Rupture |
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151 | (1) |
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152 | (5) |
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157 | (1) |
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157 | (2) |
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159 | (18) |
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159 | (1) |
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159 | (1) |
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Role of Endovascular Therapy |
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160 | (5) |
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Hemodynamic Considerations and Staging of Embolization |
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165 | (1) |
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Anesthetic Considerations and Monitoring |
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166 | (1) |
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167 | (1) |
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168 | (3) |
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171 | (1) |
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172 | (1) |
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Complications and Complication Avoidance |
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172 | (2) |
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174 | (1) |
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174 | (3) |
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177 | (12) |
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177 | (1) |
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History of Radiosurgery for AVMs |
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177 | (1) |
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Radiobiology of AVM Radiosurgery |
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177 | (1) |
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Pathologic Changes of AVMs After Radiosurgery |
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178 | (1) |
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178 | (1) |
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Stereotactic Radiosurgery Technique |
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178 | (4) |
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Evaluation of Treatment Response |
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182 | (1) |
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183 | (1) |
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Combined Modality Management of AVMs |
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183 | (1) |
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Single Fraction Versus Fractionated Therapy |
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183 | (1) |
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Future Directions for AVM Radiosurgery |
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184 | (1) |
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184 | (5) |
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Combined Therapy: The Team Approach |
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189 | (12) |
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189 | (1) |
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189 | (1) |
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190 | (6) |
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196 | (2) |
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198 | (1) |
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198 | (3) |
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SECTION IV: THERAPEUTIC MANAGEMENT |
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Anesthetic Considerations |
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201 | (14) |
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201 | (1) |
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Cerebral Circulatory Changes in Patients with AVMs |
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202 | (1) |
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Anesthetic Management During Surgery |
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203 | (3) |
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Anesthetic Management During Interventional Neuroradiologic Procedures |
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206 | (5) |
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211 | (4) |
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Supratentorial Lobar Arteriovenous Malformations |
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215 | (28) |
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215 | (1) |
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215 | (13) |
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228 | (3) |
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231 | (2) |
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233 | (2) |
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235 | (2) |
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237 | (6) |
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Perisylvian Arteriovenous Malformations |
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243 | (16) |
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243 | (1) |
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244 | (1) |
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244 | (2) |
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246 | (8) |
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254 | (1) |
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254 | (5) |
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Supratentorial Periventricular Arteriovenous Malformations |
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259 | (14) |
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259 | (1) |
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Epidemiology, Presentation, and Natural History |
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259 | (1) |
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Anatomical Considerations |
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260 | (2) |
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Evaluation of Patients with Periventricular AVMs |
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262 | (1) |
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263 | (1) |
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264 | (5) |
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269 | (1) |
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270 | (3) |
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Corpus Callosum Arteriovenous Malformations |
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273 | (12) |
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273 | (1) |
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273 | (1) |
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Anatomy of the Corpus Callosum |
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274 | (1) |
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Functions of the Corpus Callosum and Callosal Syndromes |
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275 | (1) |
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275 | (2) |
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Classification/Grading Systems for AVMs of the Corpus Callosum |
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277 | (1) |
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278 | (4) |
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282 | (1) |
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283 | (2) |
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Arteriovenous Malformations of the Cerebellar Vermis and Hemispheres |
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285 | (14) |
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285 | (1) |
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Cerebellar Surface Anatomy and Vascular Supply |
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285 | (3) |
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Cerebellar Functional Anatomy |
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288 | (1) |
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289 | (1) |
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Classification and Risk Stratification |
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289 | (1) |
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290 | (5) |
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295 | (1) |
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296 | (3) |
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Infratentorial Cerebellopontine Angle Arteriovenous Malformations |
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299 | (16) |
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299 | (1) |
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299 | (3) |
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302 | (1) |
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303 | (1) |
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304 | (1) |
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305 | (5) |
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310 | (1) |
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311 | (1) |
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312 | (3) |
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Brainstem Arteriovenous Malformations |
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315 | (14) |
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315 | (1) |
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315 | (1) |
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Classification of Brainstem AVMs |
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315 | (1) |
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Arterial Supply and Venous Drainage |
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316 | (1) |
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316 | (1) |
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Indications and Contraindications for Surgery |
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316 | (1) |
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317 | (1) |
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317 | (1) |
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317 | (2) |
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Surgical Approaches and Positioning |
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319 | (4) |
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Closure Techniques and Postoperative Management |
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323 | (1) |
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Special Perioperative Equipment/Techniques |
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323 | (1) |
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Stereotactic Radiosurgery |
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324 | (1) |
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324 | (2) |
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326 | (1) |
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Complications and Complication Avoidance |
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327 | (1) |
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327 | (1) |
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327 | (2) |
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Intraoperative and Postoperative Angiography |
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329 | (14) |
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329 | (1) |
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Intraoperative Angiography |
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329 | (7) |
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Intraoperative Embolization |
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336 | (1) |
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Postoperative Angiography |
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337 | (4) |
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341 | (2) |
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343 | (8) |
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343 | (1) |
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343 | (1) |
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343 | (1) |
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344 | (1) |
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344 | (1) |
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344 | (4) |
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348 | (1) |
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349 | (2) |
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Arteriovenous Malformations in Pregnancy |
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351 | (8) |
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351 | (1) |
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351 | (1) |
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Physiologic Changes Associated with Pregnancy |
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351 | (1) |
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Radiologic Diagnosis of AVM in Pregnancy |
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352 | (1) |
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353 | (1) |
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354 | (1) |
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Embolization and Radiosurgical Procedures |
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355 | (1) |
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355 | (1) |
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355 | (1) |
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356 | (3) |
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Diagnosis and Management of Pediatric Arteriovenous Malformations |
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359 | (12) |
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359 | (1) |
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359 | (1) |
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Developmental Biology of AVMs in Children |
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359 | (1) |
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360 | (1) |
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Presentation and Evaluation of AVMs in Children |
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361 | (2) |
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Considerations for Intervention |
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363 | (1) |
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363 | (1) |
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Preoperative Embolization |
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364 | (1) |
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Stereotactic Radiosurgery |
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365 | (1) |
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366 | (1) |
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366 | (1) |
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367 | (1) |
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368 | (3) |
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Management of Residual Arteriovenous Malformations |
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371 | (12) |
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371 | (1) |
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Residual Malformations after Endovascular Embolization |
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372 | (3) |
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Residual Malformations after Radiosurgery |
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375 | (3) |
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Residual Malformations after Microsurgical Resection |
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378 | (2) |
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380 | (1) |
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380 | (3) |
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SECTION V: SPECIAL PROBLEMS |
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383 | (10) |
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383 | (1) |
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Neurological Monitoring and Imaging |
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383 | (1) |
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Perioperative Cerebral Edema |
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384 | (2) |
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Cardiovascular Management |
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386 | (1) |
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387 | (1) |
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387 | (1) |
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Nutrition and Diabetic Management |
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388 | (1) |
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389 | (1) |
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389 | (1) |
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390 | (1) |
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390 | (1) |
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Seizure Prophylaxis and Treatment |
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390 | (1) |
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390 | (3) |
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393 | (14) |
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393 | (1) |
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Preoperative Considerations |
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393 | (2) |
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Intraoperative Considerations |
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395 | (5) |
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Postoperative Considerations |
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400 | (3) |
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403 | (1) |
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403 | (4) |
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Endovascular Therapy: Indications, Complications, and Outcome |
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407 | (22) |
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407 | (1) |
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Cerebrovascular Malformations |
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407 | (1) |
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408 | (1) |
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Indications for Treatment |
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408 | (9) |
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Management Principles for Endovascular Treatment |
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417 | (5) |
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Complications: Avoidance and Management |
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422 | (2) |
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The Jefferson Hospital for Neuroscience Experience |
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424 | (1) |
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424 | (1) |
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424 | (5) |
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Radiosurgical Complications |
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429 | (22) |
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429 | (1) |
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430 | (4) |
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Transient Effects on Normal Brain Tissue |
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434 | (6) |
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Radionecrosis and Other Long-Term Effects |
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440 | (6) |
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446 | (1) |
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447 | (4) |
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SECTION VI: FUTURE CONSIDERATIONS |
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451 | (6) |
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451 | (1) |
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452 | (1) |
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452 | (2) |
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Reduction of Complications |
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454 | (1) |
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455 | (1) |
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455 | (2) |
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457 | (12) |
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457 | (1) |
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Radiobiology of Vascular Malformation Radiosurgery |
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457 | (1) |
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Indications for AVM Radiosurgery |
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458 | (1) |
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458 | (1) |
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Stereotactic Radiosurgery Technique |
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458 | (3) |
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461 | (1) |
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461 | (2) |
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463 | (1) |
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Staged Volume Radiosurgery |
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463 | (1) |
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Future Roles for AVM Radiosurgery |
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463 | (2) |
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465 | (1) |
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465 | (4) |
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Molecular Biology of Arteriovenous Malformations |
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469 | (14) |
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469 | (1) |
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Angiogenesis and Vasculogenesis |
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469 | (2) |
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471 | (4) |
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Molecular Information on Sporadic AVMs |
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475 | (4) |
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479 | (1) |
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479 | (4) |
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483 | (8) |
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483 | (1) |
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483 | (1) |
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484 | (2) |
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Anatomical, Physiological and Operatively Integrated Imaging |
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486 | (2) |
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488 | (1) |
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489 | (1) |
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489 | (2) |
Index |
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491 | |