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E-raamat: Ketamine: Use and Abuse

Edited by (Chinese University of Hong Kong, Institute of Chinese Medicine)
  • Formaat: PDF+DRM
  • Ilmumisaeg: 16-Mar-2015
  • Kirjastus: CRC Press Inc
  • Keel: eng
  • ISBN-13: 9781466583405
  • Formaat - PDF+DRM
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  • Formaat: PDF+DRM
  • Ilmumisaeg: 16-Mar-2015
  • Kirjastus: CRC Press Inc
  • Keel: eng
  • ISBN-13: 9781466583405

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Increasing use of ketamine as a recreational drug in Asia, Europe, and America is a great burden on society at large, leading to aspirational strain, unemployment, and crime. These societal effects have led to growing interest among researchers and clinicians in ketamines effects on various systems of the body. Ketamine: Use and Abuse reviews the acute and chronic effects of ketamine on both adult and developing animals and humans.

Providing an exhaustive review of the literature, the book is supplemented by the introduction of new data and research. Topics include:











The pharmacological properties of ketamine The impact of ketamine on various organ systems, including the central nervous system and the gastrointestinal, respiratory, adrenal, and renal systems Developmental neurotoxicity in the developing brain Postmortem toxicology The epidemiology of misuse and patterns of acute and chronic toxicity The psychosocial aspects of ketamine addiction Clinical applications at acceptable doses, including possible contribution to the treatment of depression

The contributions in this book represent an initiative to investigate the different facets of ketamine beyond the known psychosocial factors related to addiction and its traditional use as an anesthetic agent. The broad-based coverage is designed to promote heightened attention on the subject and encourage further research into beneficial clinical uses.
Preface vii
Editor ix
Contributors xi
Chapter 1 Ketamine use and misuse---Impacts on the nervous system: An overview
1(12)
David T. Yew
Chapter 2 Clinical applications and side effects of ketamine
13(24)
Ou Sha
Yue Hao
Eric Yu-Pang Cho
Li Zhou
Chapter 3 Diverse pharmacological properties of ketamine
37(28)
Ismail Laher
Xin Zhang
Ping Chung Leung
Willmann Liang
Chapter 4 Developmental neurotoxicity of ketamine in the developing brain
65(38)
Chaoxuan Dong
Chapter 5 Ketamine---Epidemiology of misuse and patterns of acute and chronic toxicity
103(42)
Shwetha S. Rao
David M. Wood
Paul I. Dargan
Chapter 6 Imaging the effects of ketamine use and abuse in the brain
145(28)
Qi Li
Sherry K.W. Chan
Lin Sun
Wai-Chi Chan
Eric Y.H. Chen
Pak C. Sham
Chapter 7 Does sniffing drugs affect the respiratory system?: An example being ketamine
173(14)
Maria S.M. Wai
Jacqueline C. Lam
Lawrence K. Hui
David T. Yew
Chapter 8 Long-term ketamine use causes damage to the pancreas and adrenal glands
187(20)
Wai Ping Lam
Tan Sijie
Lok Hang Lam
Yeak Wan Wong
Chun-Mei Wang
Chapter 9 Ketamine uropathy: Hong Kong experience
207(20)
Peggy Sau Kwan Chu
Chi Fai Ng
Wai Kit Ma
Chapter 10 Ketamine and the lower urinary tract: Summary of pathophysiological evidence in humans and animal models
227(16)
Hong Chai Tang
Phoebe Y.H. Lam
Willmann Liang
Chapter 11 Postmortem toxicology of ketamine
243(6)
James Watterson
Chapter 12 The antidepressant effects of ketamine and the underlying mechanisms
249(32)
Nan Wang
Jian-Jun Yang
Chapter 13 Social correlates of ketamine and other psychoactive drug abuse in Hong Kong
281(20)
Yuet-Wah Cheung
Chapter 14 Mechanisms of ketamine-induced neuroplasticity: Potential effects on brain and behavior
301(24)
Vincenzo Tedesco
Ginetta Collo
Cristiano Chiamulera
Chapter 15 The influence of ketamine on our understanding of depression
325(16)
Andrew M. Perez
Chapter 16 Clinical testing for ketamine: How it inspires the need to develop emerging drugs-of-abuse analysis in a clinical laboratory
341(48)
Magdalene H.Y. Tang
Calvin Y.K. Chong
Doris C.K. Ching
Tony W.L. Mak
Index 389
Professor David T. Yew is the professor emeritus of anatomy in the School of Biomedical Sciences, Chinese University of Hong Kong. He has engaged in research of human and animal neuroscience, drug discovery, and drug toxicology, using various techniques of pathology, immunocytochemistry, cytochemistry, and imaging. Professor Yews area of specialty is research on neurodegeneration, particularly damage to the nervous system brought about by ketamine abuse, and is now one of the major global leaders in this area.