Wiart presents evidence that natural products are not only able to protect neurons and boost their activities, but also to induce neuritogenesis, raising the possibility that flowering plants helped apes evolve into Homo sapiens during the Tertiary period. In the near future, he says, they may also allow complete victory over neurodegenerative diseases such as Alzheimer's and Parkinson's and neuronal injuries, and perhaps even boost human intelligence. In chapters on alkaloids, terpenes, and phenolics, he identifies particular compounds and the plants they can be derived from. Annotation ©2014 Ringgold, Inc., Portland, OR (protoview.com)
Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases is the second volume in the series,Pharmaceutical Leads from Medicinal Plants. This book includes key pharmacological and chemical evidence to support the selection of promising pre-clinical candidates for the treatment of neurodegenerative diseases.
This important addition to the natural product and drug discovery literature contains the history, synonyms, medicinal uses, phytopharmacology, pre-clinical potential, and rationale for each plant selected. By providing critical evaluation of pharmacological data, mechanisms of action, and structural requirements for the development of future neuroprotective agents, this comprehensive reference is a beneficial resource for industry and academic scientists whose research focuses on neurodegenerative drug discovery and development.
- Incorporates compelling biological activity data and preclinical structure-activity relationships to help you choose promising lead molecules for further research
- Includes primary source references to the most recent natural product discoveries in the field of neuroprotection in order to promote new drug discovery in this area
- Contains detailed discussions of important neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease
- Each plant section includes a critical evaluation of pharmacological, chemical, and toxicological evidence to support the use of the compound in drug discovery research in neurodegeneration
Arvustused
"Wiart presents evidence that natural products are not only able to protect neurons and boost their activities, but also to induce neuritogenesis, raising the possibility that flowering plants helped apes evolve into Homo sapiens during the Tertiary period. In the near future, he says, they may also allow complete victory over neurodegenerative diseases" --ProtoView.com, April 2014
Muu info
Provides significant pharmacological and chemical evidence to help researchers identify preclinical candidates for the treatment of neurodegenerative diseases
| Foreword |
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ix | |
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| Foreword |
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xi | |
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| Foreword |
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xiii | |
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Cornelis J. Van der Schyf |
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| Preface |
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xv | |
| About the Author |
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xvii | |
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1 | (188) |
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1 | (2) |
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Topic 1.1 Amide, Piperine, and Pyridine Alkaloids |
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3 | (29) |
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1.1.1 Polyalthia suberosa (Roxb.) Thwaites |
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3 | (4) |
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1.1.2 Piper kadsura (Choisy) Ohwi |
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7 | (5) |
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1.1.3 Sophora flavescens Aiton |
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12 | (12) |
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24 | (8) |
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Topic 1.2 Indole Alkaloids |
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32 | (61) |
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1.2.1 Scorodocarpus borneensis (Baill.) Becc |
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32 | (6) |
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1.2.2 Peganum nigellastrum Bunge |
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38 | (3) |
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1.2.3 Tetradium daniellii (Benn.) T.G. Hartley |
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41 | (3) |
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1.2.4 Cryptolepis sinensis (Lour.) Merr |
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44 | (2) |
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1.2.5 Clausena lansium (Lour.) Skeels |
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46 | (9) |
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1.2.6 Melodinus fusiformis Champ. ex Benth |
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55 | (26) |
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81 | (12) |
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Topic 1.3 Isoquinoline Alkaloids |
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93 | (59) |
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1.3.1 Phellodendron amurense Rupr |
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93 | (10) |
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1.3.2 Macleaya cordata (Willd.) R. Br |
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103 | (3) |
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1.3.3 Nandina domestica Thunb |
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106 | (4) |
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1.3.4 Stephania tetrandra S. Moore |
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110 | (2) |
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1.3.5 Corydalis stricta Stephan ex Fisch |
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112 | (4) |
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1.3.6 Sinomenium acutum (Thunb.) Rehder & E.H. Wilson |
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116 | (3) |
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1.3.7 Crinum latifolium L. |
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119 | (4) |
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1.3.8 Saururus chinensis (Lour.) Baill |
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123 | (4) |
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1.3.9 Dictamnus dasycarpus Turcz |
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127 | (11) |
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138 | (14) |
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Topic 1.4 Terpene Alkaloids |
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152 | (37) |
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1.4.1 Dendrobium catenatum Lindl |
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152 | (7) |
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1.4.2 Aconitum kongboense Lauener |
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159 | (5) |
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1.4.3 Cynanchum wilfordii (Maxim.) Maxim. ex Hook. f. |
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164 | (20) |
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184 | (5) |
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189 | (96) |
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189 | (1) |
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190 | (15) |
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190 | (10) |
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200 | (5) |
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205 | (21) |
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2.2.1 Illicium jiadifengpi B.N. Chang |
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205 | (16) |
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221 | (5) |
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226 | (32) |
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2.3.1 Ajuga ciliata Bunge |
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226 | (26) |
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252 | (6) |
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258 | (27) |
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2.4.1 Boswellia serrata Roxb. ex Colebr |
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258 | (22) |
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280 | (5) |
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285 | (90) |
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285 | (2) |
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287 | (44) |
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3.1.1 Astragalus mongholicus Bunge |
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287 | (15) |
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3.1.2 Citrus trifoliata L. |
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302 | (11) |
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3.1.3 Polygala caudata Rehder & E.H. Wilson |
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313 | (9) |
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322 | (9) |
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331 | (23) |
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3.2.1 Petroselinum crispum (Mill.) Nyman ex A. W. Hill |
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331 | (8) |
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339 | (11) |
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350 | (4) |
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354 | (21) |
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3.3.1 Machilus thunbergii Sieb. et Zucc |
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354 | (17) |
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371 | (4) |
| Index of Natural Products |
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375 | (6) |
| Index of Pharmacological Terms |
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381 | (6) |
| Index of Plants |
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387 | (4) |
| Subject Index |
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391 | |
Dr. Christophe Wiart is a French pharmacist who for the last 25 years has traveled in various parts of Asia to study in situ the botany, the ancient traditional knowledge, and ethnopharmacology of medicinal plants to bring global awareness both in public and academia on the tremendous pharmaceutical value of medicinal plants of Asia and the Pacific. He has authored more than 14 academic books on this subject as well as peer-reviewed research papers. He was recently interviewed by BBC Radio Crowd Science (2020). He appeared on HBO's Vice (TV Series) in season 3, episode 6 (episode 28 of the series), titled "The Post-Antibiotic World & Indonesia's Palm Bomb." aired on April 17, 2015. Dr. Wiart was a guest in Aljazeera Inside Story " For only the fourth time in its 70-year history, the United Nations is holding a special meeting devoted to a health crisis." Dr. Christophe Wiart is a French pharmacist who for the last 25 years has traveled in various parts of Asia to study in situ the botany, the ancient traditional knowledge, and ethnopharmacology of medicinal plants to bring global awareness both in public and academia on the tremendous pharmaceutical value of medicinal plants of Asia and the Pacific. He has authored more than 14 academic books on this subject as well as peer-reviewed research papers. He was recently interviewed by BBC Radio Crowd Science (2020). He appeared on HBO's Vice (TV Series) in season 3, episode 6 (episode 28 of the series), titled "The Post-Antibiotic World & Indonesia's Palm Bomb." aired on April 17, 2015. Dr. Wiart was a guest in Aljazeera Inside Story " For only the fourth time in its 70-year history, the United Nations is holding a special meeting devoted to a health crisis."
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