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E-raamat: Liver Metabolism and Fatty Liver Disease

Edited by (Hebrew University of Jerusalem, Israel)
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Nonalcoholic fatty liver disease is one of the most common liver diseases worldwide affecting patients from all ages, races, and ethnic backgrounds. It comprises a spectrum of hepatic pathology ranging from simple steatosis, in which there is an increase of fat accumulation in hepatocytes, to nonalcoholic steatohepatitis and cirrhosis. The significant prevalence of this diseasebetween 15 and 45 percent of the general populationmeans that it contributes to an increased burden of ill health both today and in the future.

Liver Metabolism and Fatty Liver Disease addresses the current understanding of the development of nonalcoholic fatty liver disease as well as the clinical aspects of the disease by examining the current knowledge surrounding metabolism in the liver. The book discusses various topics including the involvement of oxidative stress, metabolic effects, and inflammation as well as the effect of nutrition on the development and progression of the disease.
Series Preface ix
Preface xiii
Editor xv
Contributors xvii
SECTION I Introduction to Fatty Liver Disease and Consequences
Chapter 1 Clinical Aspects of Nonalcoholic Fatty Liver Disease
3(24)
Noa Mashav
Oren Shibolet
SECTION II Fatty Liver Disease and Consequences
Chapter 2 Fatty Liver Vulnerability to Hypoxic and Inflammatory Stress
27(26)
Rabindra Dhital
Oren Tirosh
Chapter 3 Development of Hepatocellular Carcinoma
53(26)
A. Ruth He
Lopa Mishra
Chapter 4 Cellular Stress Responses in the Regulation of Drug-Induced Liver Steatosis
79(12)
Dotan Uzi
Duah Alkam
Boaz Tirosh
Chapter 5 The Role of the Keapl/Nrf2 Pathway in the Development and Progression of Nonalcoholic Fatty Liver Disease
91(12)
Dionysios V. Chartoumpekis
Thomas W. Kensler
Chapter 6 Methionine Adenosyltransferase Genes in Liver Health and Disease
103(22)
Komal Ramani
Shelly C. Lu
Chapter 7 Role and Modulation of Nitric Oxide in the Cirrhotic Liver
125(12)
Jordi Gracia-Sancho
Juan Carlos Garcia-Pagan
Jaime Bosch
Chapter 8 Role of Mitochondria in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease
137(22)
Nicole Rubin
Ho Leung
Jacob E. Valk
Stephen M. Wertheimer
Derick Han
SECTION III Nutrition Role in Liver Protection and Damage
Chapter 9 Nutritional Induction of Nonalcoholic Fatty Liver Disease
159(32)
Noga Budick-Harmelin
Michal Aharoni-Simon
Zecharia Madar
Chapter 10 The Double-Edged Sword of Hepatic Iron Metabolism in Health and Diseases
191(18)
Guiliano Ramadori
Ihtzaz Ahmed Malik
Chapter 11 Diet and Lifestyle Changes as Treatment for Nonalcoholic Fatty Liver Disease
209(22)
Shira Zelber-Sagi
Chapter 12 Role of Antioxidants in the Nonalcoholic Fatty Liver Disease Spectrum
231(16)
Tommy Pacana
Arun J. Sanyal
Chapter 13 ω-3 Fatty Acids and Nonalcoholic Fatty Liver Disease
247(34)
Christopher M. Depner
Kelli A. Lytle
Sasmita Tripathy
Donald B. Jump
Chapter 14 Nutraceuticals in the Prevention and Treatment of Fatty Liver Disease
281(22)
Anna Aronis
Index 303
Oren Tirosh is an associate professor at the School of Nutrition Science in the Institute of Biochemistry, Food Science and Nutrition at The Hebrew University of Jerusalem. He received his PhD from the School of Pharmacy at The Hebrew University of Jerusalem and completed a postdoctoral fellowship at the University of California, Berkeley. Dr. Tirosh is a lifetime honorary member in the Oxygen Club of California and is active in the board of The Israel Society for Oxygen and Free Radical Research. His research interests include nitric oxide and redox biology, oxidative stress and liver pathology, and lipid metabolism under liver disease conditions.