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E-raamat: Lung Growth and Development

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Lung Growth and DevelopmentSuurem pilt
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Highlights new developments in research in lung development, reviewing basic concepts of lung development, offering comparative information on different species, and explaining the pathophysiology of abnormalities. After early chapters on structural development and gene transcription, five chapters deal with cytodifferentiation and the development of specific tissues, and the remaining eight chapters address the control of lung growth and cytodifferentiation, looking at specific critical biomaterials and the role of neuropeptides, other hormones, and injury in modulating lung structure and function. Annotation c. by Book News, Inc., Portland, Or.

Reflects the explosion of information and technological breakthroughs that have facilitated investigations into the development of the lung-including recombinant DNA technology, molecular genetics, transgenics, and advances in lung cell and mo-lecular biology. Provides nearly 2800 bibliographic citations and over 170 tables, drawings, and x-rays to help clarify specific discussions.

Arvustused

" McDonald is to be commended for producing a text that includes both in-depth coverage of major advances in lung development and an assessment of important research areas that remain unexplored. "-The Physiologist

Introduction iii(2) Claude Lenfant Preface v(4) Contributors ix
1. Structural Aspects of Prenatal and Postnatal Development and Growth of the Lung 1(36) Peter H. Burri I. Introduction 1(2) II. Prenatal Lung Development 3(9) III. Postnatal Lung Development 12(10) IV. Disturbances of Alveolization 22(1) V. Growth of the Lung 23(7) VI. Final Dimensions of the Adult Lung 30(2) References 32(5)
2. Respiratory Epithelial Cell Gene Transcription 37(18) Jeffrey A. Whitsett Zvjezdana Sever I. Introduction 37(2) II. Regulation of Surfactant Protein Gene Expression 39(1) III. The SP-B Gene as a Model System of Analysis of Lung Epithelial Gene Transcription and Function 39(1) IV. In Vitro Models for Analysis of Respiratory Epithelial Gene Transcription (MLE Cells) 40(1) V. Genetic Analysis of the SP-B Promoter/Enhancer Elements 40(1) VI. TTF-1 Binds to and Activates Transcription at the SP-B(F1) Binding Site 41(3) VII. Regulation of TTF-1 Gene Expression 44(1) VIII. TTF-1 Binds and Activates SP-A, SP-B, SP-C, and CCSP Promoter Elements 44(2) IX. Role of HNF Family Members in the Regulation of Gene Expression in the Lung 46(1) X. Regulation of HNF-3 Family Members Expression in Lung 47(1) XI. The Role of HNF-3 Family Factors in CCSP Gene Expression 48(1) XII. Regulation of TTF-1 by HNF-3 Family Members in Lung Epithelial Cells 49(1) XIII. Summary 49(2) References 51(4)
3. Role of Transcription Factors in the Development of the Pulmonary Epithelium 55(26) Brian P. Hackett Jonathan D. Gitlin I. Introduction 55(1) II. Cellular Differentiation During Development 56(5) III. Transcription Factors in Developing Pulmonary Epithelium 61(14) IV. Summary 75(1) References 75(6)
4. Epithelial-Mesenchymal Interactions in Lung Development 81(2) John M. Shannon Robin R. Deterding I. Introduction 81(1) II. Concepts and Definitions 82(1) III. Epithelial-Mesenchymal Interactions in the Developing Lung 83(6) IV. Molecular Mechanisms Mediating Epithelial-Mesenchymal Interactions in the Developing Lung 89(1) V. Influence of Extracellular Matrix 89(5) VI. Soluble Factors as Mediators of Epithelial-Mesenchymal Interactions in the Developing Lung 94(11) VII. Proliferation and Differentiation of Lung Epithelial Cells in the Absence of Mesenchyme 105(1) VIII. Summary and Conclusions 106(1) References 106(13)
5. Differentiation of the Alveolar Epithelium in the Fetal Lung 119(44) Rama K. Mallampalli Michael J. Accaregui Jeanne M. Snyder I. Introduction 119(4) II. Morphological Aspects of the Differentiation of the Alveolar Epithelium 123(12) III. Biochemical Aspects of the Differentiation of the Alveolar Epithelium 135(14) IV. Summary 149(1) References 149(14)
6. Airway Gland Growth and Differentiation 163(18) Carol Basbaum J.-D. Li Melissa Lim I. Introduction 163(1) II. Basic Principles of Gland Growth 164(9) References 173(8)
7. Clara Cells 181(30) Charles G. Plopper I. Introduction-Defining a Clara Cell 181(1) II. Bronchiolar Microenvironment in Adults 182(2) III. Bronchiolar Morphogenesis 184(1) IV. Phenotypic Markers for Differentiated Cells 185(6) V. Role as the Bronchiolar Progenitor Cell 191(3) VI. Patterns of Expression of Phenotypic Markers During Cytodifferentiation 194(6) VII. Extracellular Matrix 200(1) VIII. Regulation of Differentiation 200(2) References 202(9)
8. Growth and Differentiation of Tracheobronchial Epithelial Cells 211(32) Reen Wu I. Introduction 211(2) II. Growth Regulation in Tracheobronchial Epithelium 213(8) III. Regulation of Mucociliary Differentiation 221(4) IV. Role of Vitamin A in Airway Mucociliary Cell Differentiation 225(8) V. Summary and Future Studies 233(1) References 234(9)
9. Development of Innervation in the Lung 243(26) Richard D. Dey Kuen-Shan Hung I. Introduction 243(1) II. Embryonic Precursors of the Pulmonary Nervous System 244(9) III. Development of Lung Innervation 253(10) IV. Summary 263(1) References 264(5)
10. Development of Airway Smooth Muscle 269(32) Paul B. McCray, Jr. Kenneth T. Nakamura I. Introduction 269(1) II. Developmental Biology of Airway Smooth Muscle 270(4) III. Physiology 274(11) IV. Relavance to Disease in the Premature and Newborn Infant 285(4) V. Areas for Future Research 289(1) References 290(11)
11. Laminin in Lung Development 301(26) Lucia Schuger I. Introduction 301(1) II. Molecular Structure of Laminin 302(2) III. Biosynthesis and Glycosylation 304(1) IV. Functions of Laminin 304(3) V. Laminin Expression in the Mouse Developing Lung 307(1) VI. Laminin Role in the Mouse Developing Lung 307(5) VII. Basic Morphogenic Cell Behaviors Modulated by Laminin 312(8) VIII. Laminin in Lung Cell Differentiation 320(1) IX. Summary and Conclusions 320(1) References 321(6)
18. Hormonal Control of Compensatory Lung Growth 627(34) Kirk A. Gilbert Lidija Petrovic-Dovat D. Eugene Rannels I. Introduction 627(1) II. Characteristics of Compensatory Lung Growth Following Pneumonectomy 628(6) III. Regulation of Compensatory Lung Growth 634(5) IV. Role of Solubel Factors in Compensatory Lung Growth 639(11) V. Current Status of the Fields 650(2) VI. Conclusions 652(1) References 652(9) Author Index 661(68) Subject Index 729
12. Collagens and Elastic Fiber Proteins in Lung Development 327(38) Edmond C. Crouch Robert P. Mecham Rosa M. Davila Akihiko Noguchi I. Introduction 327(1) II. Matrix Alterations in Lung Development 328(2) III. Collagens 330(7) IV. Involvement of Collagens in Lung Development 337(7) V. Elastic Fibres 344(3) VI. Microfibrils 347(2) VII. Expression of Elastic Fiber Proteins in Developing Lung 349(7) VIII. Questions and Future Strategies 356(1) References 356(9)
13. Cell-Cell and Cell-Matrix Interactions in Development of the Lung Vasculature 365(36) Jesse Roman I. Introduction 365(3) II. Development of the Pulmonary Circulation 368(2) III. Basic Mechanisms of Vessel Formation 370(2) IV. Role of Cell-Matrix Interactions in Vessel Formation 372(7) V. Role of Cell-Cell Interactions in Vessel Formation 379(2) VI. Role of Growth Factors in Vessel Formation 381(1) VII. Development of the Vasculature in Developing Lungs 382(4) VIII. Summary and Research Needs 386(3) References 389(2)
14. Neuropeptides and Lung Development 401(94) Mary E. Sunday I. Introduction 401(11) II. Pulmonary Neuroendocrine Cells 412(39) III. Non-PNEC Neuropeptides in Fetal Lung 451(4) IV. PNECs in Developmental Lung Disorders: Clinical Associations and Animal Models 455(9) V. Summary and Conclusions 464(4) References 468(27)
15. Developmental and Hormonal Regulation of the Surfactant System 495(81) Michael W. Odom Philip L. Ballard I. Introduction 495(82) II. Components of Surfactant 496(6) III. Ontogeny of Surfactant Phospholipids and Proteins 502(4) IV. Hormonal Effects on the Surfactant System 506(48) V. Summary and Conclusions 554(2) References 556(21)
16. Lung Injury When Development Is Interrupted by Premature Birth 577(34) Stuart Horowitz Jonathan M. Davis I. Introduction 577(1) II. Respiratory Distress Syndrome 578(1) III. Bronchopulmonary Dysplasia 579(20) IV. Summary and Conclusions 599(1) References 600(11)
17. In Vitro Models of Lung Development and Cytodifferentiation 611(16) S. Robert Hilfer Robert L. Searls I. Introduction 611(2) II. Branching Morphogenesis 613(5) III. Cytodifferentiation 618(4) References 622(5)
John A. McDonald
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