This book reviews stem cell behavior in the lung as it relates to regenerative medicine and stem cell therapeutics. Topics ranging from basic developmental mechanisms of various types of lung stem cells through the identification and properties of stem cell behavior and their potential applications in lung repair and regeneration, are discussed by an expert in the field. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding of developmental lung stem cell biology and behavior and their potential applications. Lung Stem Cell Behavior is essential reading for researchers in stem cell biology and regenerative medicine, patient advocates, undergraduate students, graduate students, and clinicians interested in cellular therapy and tissue engineering therapies.
Introduction.- Brief Overview of the Human Respiratory System Structure
and Development.- Diversity of Lung Stem and Progenitor Cell Types.- Signals
and Molecular Mechanisms Controlling Lung Stem/ Progenitor Cell Development
and Behavior.- Signals and Molecular Mechanisms Regulating Stem Cell Behavior
in Other Systems (E.G. Hematopoietic Stem Cells).- Mode of Cell Division as A
Regulatory Mechanism for Lung Stem Cell Behavior Comared to Other
Systems.- Lung Stem Cell Plasticity.- Lung Stem Cells in Lung Repair and
Regeneration.- Stem Cell-Based Organoid Models in Lung Development and
Diseases.- Concluding Remarks and Future
Perspectives.- References.- Biography.
Professor Ahmed Hashash has completed his PhD from Manchester University, UK. He is a fellow of the California Institute of Regenerative Medicine (CIRM) and New York University Medical School (MSSM), USA. Prof. Ahmed Hashash worked as a senior biomedical research scientist at Mount Sinai School of Medicine of New York University and Childrens Hospital Los Angeles. He was Assistant Professor and Principal Investigator of Stem Cell & Regenerative Medicine at Keck School of Medicine and Ostrow School of Dentistry of The University of Southern California, USA. Prof. Hashash has joined The University of Edinburgh, Edinburgh Medical School and Zhejiang International Campus, (ZJU) as Tenure-Track Associate Professor and Senior Principal Investigator of Biomedicine, Stem Cell & Regenerative Medicine. He is also adjunct Professor and Senior Principle Investigator at the School of Basic Medical Science and School of Medicine, Zhejiang University. Prof. Hashash has several breakthrough discoveries in genes/enzymes that control stem cell behavior and regenerative medicine. He has published more than 25 papers in reputed international journals and serving as an editorial board member of repute. Prof. El-Hashash acts as a discussion leader at the prestigious Gordon Research Seminar/Conference in USA, and a Peer Reviewer/ International Extramural Review for The Medical Research Council (MRC) grant applications, London, UK. He is invited to speak at several international conferences in USA, Spain, Germany, Greece, Egypt, Japan and China. He is the editor or author of several books on stem cell and regenerative medicine.
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