| Contributors |
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| Preface |
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xv | |
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1 Mechanism of initiation of meiosis in mouse germ cells |
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1 | (26) |
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2 | (1) |
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2 STRA8 plays a key role in the initiation of meiosis |
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2 | (2) |
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3 MEIOSIN interacts with STRA8 during meiotic initiation |
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4 | (2) |
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4 MEIOSIN and STRA8 direct the switch from mitosis to meiosis |
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6 | (3) |
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5 MEIOSIN together with STRA8 determines meiotic entry |
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9 | (1) |
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6 MEIOSIN and STRA8 activate meiotic prophase program |
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10 | (3) |
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7 MEIOSIN and STRA8 boost the transcription of the meiotic genes |
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13 | (1) |
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8 Sexual difference of meiotic initiation |
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14 | (3) |
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9 Evolutionary conservation and divergence in the meiotic entry system |
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17 | (1) |
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18 | (1) |
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19 | (1) |
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Conflict of interest statement |
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19 | (1) |
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20 | (7) |
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2 Orchestrating recombination initiation in mice and men |
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27 | (16) |
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1 Introduction---Orchestrating the critical stages of recombination initiation |
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28 | (1) |
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2 Germline replication timing affects broad-scale recombination patterning |
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28 | (1) |
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3 Chromatin loop array formation and loop extrusion |
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29 | (1) |
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4 Creating an accessible local chromatin environment |
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30 | (2) |
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5 Chromatin opening meiosis-specific Pioneer Complex |
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32 | (2) |
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6 Associate putative hotspot sites in the DNA loops with the chromosomal axis |
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34 | (1) |
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7 Facilitating efficient homology engagement and DSB repair |
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35 | (1) |
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8 PRDM9 redundant meiotic recombination initiation |
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36 | (1) |
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37 | (1) |
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38 | (5) |
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3 Cancer and meiotic gene expression: Two sides of the same coin? |
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43 | (26) |
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44 | (3) |
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2 Global DNA demethylation |
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47 | (2) |
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49 | (2) |
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51 | (3) |
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5 Higher-order of chromatin structure |
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54 | (7) |
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61 | (1) |
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62 | (1) |
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62 | (1) |
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62 | (7) |
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4 Phase separation in controlling meiotic chromosome dynamics |
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69 | (22) |
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1 Chromosome dynamics during meiosis |
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70 | (2) |
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2 Phase separation to form biomolecular condensates in cells |
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72 | (3) |
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3 Phase separation in controlling chromatin organization and activities |
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75 | (1) |
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4 Phase separation in meiotic recombination initiation |
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76 | (1) |
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5 Phase separation in homologous chromosome pairing |
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77 | (4) |
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6 Phase separation in synapsis |
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81 | (2) |
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7 Potential phase separation in mammalian sex body formation |
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83 | (1) |
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84 | (2) |
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86 | (1) |
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86 | (5) |
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5 Meiotic chromosome organization and its role in recombination and cancer |
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91 | (36) |
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1 Chromatin and chromosome organization during meiosis |
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92 | (11) |
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2 Evolution of the core axis proteins and the synaptonemal complex |
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103 | (2) |
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3 Morphogenesis and remodeling of the chromosome axis |
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105 | (2) |
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4 Roles of chromosomal axis proteins in DSB and crossover formation during meiosis |
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107 | (2) |
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5 Does the chromosome axis play a role in CO interference? |
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109 | (3) |
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6 Temperature-based regulation of axis proteins and the impact on recombination |
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112 | (3) |
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7 Aberrant expression of the HORMADs and SC proteins regulates intrinsic DNA repair activities in somatic cancer cells |
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115 | (2) |
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117 | (1) |
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117 | (10) |
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6 Chromosome-specific behaviors during early meiosis |
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127 | (28) |
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Katherine Kretovich Billmyre |
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128 | (1) |
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128 | (2) |
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3 How do chromosomes differ from each other? |
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130 | (2) |
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4 Association between meiotic errors and chromosome structure in humans |
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132 | (2) |
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5 Regulation of crossing over on different chromosomes |
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134 | (5) |
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6 Chromatin composition can influence multiple aspects of meiosis |
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139 | (2) |
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7 Aspects of chromosome biology that alter meiotic nuclear organization |
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141 | (3) |
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8 Other examples of chromosome-specific defects |
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144 | (1) |
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145 | (1) |
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145 | (1) |
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145 | (10) |
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7 Emerging mechanisms and roles of meiotic crossover repression at centromeres |
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155 | (36) |
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156 | (6) |
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2 The "centromere" effect |
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162 | (2) |
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3 Mechanisms of meiotic crossover repression at centromeres |
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164 | (1) |
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4 Saccharomyces cerevisiae |
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165 | (3) |
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5 Schizosaccharomyces pombe |
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168 | (1) |
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169 | (2) |
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7 Drosophila melanogaster |
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171 | (2) |
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173 | (1) |
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174 | (4) |
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10 Pericentric crossovers and chromosomal mis-segregation |
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178 | (1) |
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11 Role of pericentric crossovers in human diseases |
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179 | (2) |
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181 | (1) |
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182 | (1) |
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182 | (9) |
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8 Unwinding during stressful times: Mechanisms of helicases in meiotic recombination |
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191 | (26) |
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192 | (3) |
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2 Helicases and meiotic recombination |
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195 | (11) |
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206 | (1) |
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207 | (1) |
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207 | (10) |
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9 Meiotic crossover interference: Methods of analysis and mechanisms of action |
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217 | (28) |
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218 | (2) |
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2 Methods for measuring crossover interference |
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220 | (4) |
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3 Complications in interpreting interference data |
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224 | (4) |
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4 Proteins required for crossover interference |
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228 | (3) |
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5 Models of crossover interference |
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231 | (6) |
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6 Conclusions and future research |
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237 | (1) |
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238 | (1) |
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238 | (6) |
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244 | (1) |
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10 Small RNAs and their protein partners in animal meiosis |
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245 | (36) |
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Maria De Las Mercedes Carro |
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246 | (1) |
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2 RNA binding proteins in non-coding RNA pathways |
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247 | (7) |
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3 Roles for small RNAs and associated RBPs in the germline |
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254 | (2) |
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4 Meiotic silencing of unpaired chromatin |
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256 | (3) |
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5 Meiotic silencing of sex chromatin |
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259 | (2) |
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6 Pericentromeric heterochromatin remodeling during meiosis |
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261 | (3) |
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7 Regulation of meiotic recombination and double strand break repair |
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264 | (2) |
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266 | (2) |
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268 | (1) |
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269 | (12) |
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11 Checkpoint control in meiotic prophase: Idiosyncratic demands require unique characteristics |
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281 | (36) |
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1 Mitotic and meiotic checkpoints |
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282 | (1) |
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2 Unique requirements of meiotic prophase |
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283 | (1) |
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3 The meiotic prophase checkpoint |
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284 | (6) |
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4 The logic of the spindle assembly checkpoint |
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290 | (4) |
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5 The meiotic prophase checkpoint: Logic and open questions in light of the SAC |
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294 | (5) |
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6 Meiotic checkpoint factors in cancer? |
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299 | (2) |
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301 | (1) |
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301 | (16) |
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12 PCH-2 and meiotic HORMADs: A module for evolutionary innovation in meiosis? |
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317 | (28) |
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318 | (1) |
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2 The PCH-2/HORMAD module |
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319 | (2) |
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3 The role of meiotic HORMADs |
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321 | (2) |
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4 PCH-2/Pch2/PCH2/TRIP13 in meiosis |
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323 | (1) |
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324 | (2) |
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6 Role in pairing and synapsis |
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326 | (1) |
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327 | (3) |
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8 Role in regulating meiotic progression |
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330 | (3) |
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9 Requirement for a cofactor |
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333 | (1) |
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10 A unified model of PCH-2's role in meiotic prophase |
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333 | (4) |
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337 | (1) |
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338 | (7) |
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13 In vitro spermatogenesis: Why meiotic checkpoints matter |
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345 | |
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346 | (2) |
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2 Key meiotic events during meiosis |
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348 | (12) |
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3 Meiotic checkpoint mechanisms |
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360 | (3) |
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4 Prospects of in vitro spermatogenesis for research or clinical use |
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363 | (2) |
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365 | (1) |
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365 | |
Lisainfo e-raamatute kohta