"The second edition of the book "Metal Ions in Biochemistry" deals exhaustively with the role of metal and non-metal ions in biochemical reactions, and also the effect of deficiency of metal ions, toxic effects of metal ions and use of metal complexes intherapeutics. As the nature of binding of the metal ions with the biochemicals and further progress of biochemical reactions, depends on the basic concepts of thermodynamics and kinetics of the metal ligand binding, the first two chapters have been devoted to understanding the structure of biochemicals and their metal coordinating sites, and the factors affecting the thermodynamic and kinetic stability of the complexes. Role of mixed ligand complexes and macrocyclic ligand complexes in biochemicals, has also been emphasized. The new aspects in the book are the additional information about role of alkali metal ions in brain chemistry in chapter 3, and various roles of zinc proteins, zinc fingers, zinc signals, in insulin activity and cascade effect in fourth chapter, in the fifth chapter on iron, the addition is of the details of synthesis and break down of haemoglobin. In the seventh chapter the role of vitamin B12 in the synthesis of RBC has been discussed in detail. Chapter 10 of the book presents the role of vanadium and chromium as antidiabetic materials in detail, and also the presence of lanthanides in biochemical systems and their relevance. The last chapter 13 has a novelty that it deals in detail with the role of non metal anions in biochemical systems. The special feature of the book is its simplified and lucid approach, which makes it easy for the students to understand the complex interdisciplinary subject of Bioinorganic chemistry"--
The second edition of the book "Metal Ions in Biochemistry" deals exhaustively with the role of metal and non-metal ions in biochemical reactions, and also the effect of deficiency of metal ions, toxic effects of metal ions and use of metal complexes in therapeutics. As the nature of binding of the metal ions with the biochemicals and further progress of biochemical reactions, depends on the basic concepts of thermodynamics and kinetics of the metal ligand binding, the first two chapters have been devoted to understanding the structure of biochemicals and their metal coordinating sites, and the factors affecting the thermodynamic and kinetic stability of the complexes. Role of mixed ligand complexes and macrocyclic ligand complexes in biochemicals, has also been emphasized. The new aspects in the book are the additional information about role of alkali metal ions in brain chemistry in chapter 3, and various roles of zinc proteins, zinc fingers, zinc signals, in insulin activity and cascade effect in fourth chapter, in the fifth chapter on iron, the addition is of the details of synthesis and break down of haemoglobin. In the seventh chapter the role of vitamin B12 in the synthesis of RBC has been discussed in detail.
Chapter 10 of the book presents the role of vanadium and chromium as antidiabetic materials in detail, and also the presence of lanthanides in biochemical systems and their relevance. The last chapter 13 has a novelty that it deals in detail with the role of non metal anions in biochemical systems. The special feature of the book is its simplified and lucid approach, which makes it easy for the students to understand the complex interdisciplinary subject of Bioinorganic chemistry.
1. Structure of Cells and Introduction to Bioinorganic Chemistry
................................................. 1
2. Thermodynamic and Kinetic Properties of Metal Complexes
....................................................17
3 Alkali and Alkaline Earth Metal Ions in Biochemical Systems
................................................. 63
4. Zinc in Biochemical Systems
.......................................................................................................... 83
5. Iron in Biochemical Systems
........................................................................................................ 103
6. Copper in Biochemical Systems
................................................................................................... 139
7. Cobalt in Vitamin B12 in Biochemical System
............................................................................ 157
8. Molybdenum in Nitrogen Fixation in Plants
...............................................................................167
9. Magnesium and Manganese in Photosynthesis in Plants
...........................................................177
10. Less Common Trace Metal Ions in Biochemical Systems
..........................................................187
11. Metal Ion Toxicity in Biochemical Systems
................................................................................ 209
12. Metal Complexes in Therapeutics
................................................................................................219
13. Role of Trace Nonmetals in Biochemical Systems
......................................................................231
Pabitra Krishna Bhattacharya retired as Professor and Head, Department of Chemistry, M S University of Baroda, 9m 2001, after serving for thirty four years. Prior to that, he served in Kurukshetra University, University of Rajasthan (Jaipur), and Vikram University (Ujjain). Prof Bhattacharya obtained MSc and PhD degrees from University of Saugor, MP. He was awarded senior fellowship under Fulbright Hayes programme to carry out post doctoral work in Ohio state University Columbus USA during 1976 77. He also worked in University of Sheffield UK in 1987 under INSA Royal Society Exchange Programme. Prof Bhattacharyas teaching and research interests involved quantum chemistry, spectroscopy, coordination chemistry, bioinorganic chemistry and homogeneous catalysis. Thirty seven students obtained PhD degree under his supervision. He presented papers and delivered lectures at various Indian and foreign conferences. He was invited as a speaker at international conference in coordination chemistry, held at Gera, Germany in 1990. Prof Bhattacharya was awarded Prof P Ray memorial medal of Indian Chemical Society in 2000, Platinum Jubilee lecture award of Science Congress in 2001 and Silver medal of Chemical Research Society of India, Bangalore, 2002. He worked as a member of various committees, more notable being, IUPAC, and DST, programme advisory committee. Prof Bhattacharya is the author of three books, Group theory and its Chemical Applications, published by Himalaya Publishing House, Mumbai, Metal Ions in Biochemistry, First Edition, by Narosa Publisher, Delhi, and Threshold of Inorganic Chemistry, 1st edition, published by Himalaya Publishing House, Mumbai.
Prakash B Samnani obtained his MSc and PhD degrees from The Maharaja Sayajirao University of Baroda, Vadodara. After a 2 years stint as Research Officer in Analytical Division of the Advanced Research Center of Sun Pharmaceuticals, he joined the Department of Chemistry of the M S University of Baroda where he is presently working as Professor. With the industrial experience and more than 25 years of teaching and research experience in Chemistry in the University, the author has a number of research publications to his credit. He has published research papers in the area of Analytical Chemistry and Homogeneous Catalysis in journals of National and International repute. He has also authored five books titled Experiments in Chemistry, Chemical Companion, Teaching of Chemical Analysis, Quantitative Chemical Analysis, and Threshold of Inorganic Chemistry, all published by well known publishing houses in India. He has completed research projects funded by UGC, CSIR, DST. His teaching and research interests include Inorganic Chemistry, Analytical Chemistry, especially Chromatographic methods, Environmental Chemistry and Homogeneous Catalysis.
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