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E-raamat: Microarrays: Principles, Applications and Technologies

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  • Formaat: 347 pages
  • Ilmumisaeg: 01-Jan-2014
  • Kirjastus: Nova Science Publishers Inc
  • ISBN-13: 9781629487137
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  • Formaat: 347 pages
  • Ilmumisaeg: 01-Jan-2014
  • Kirjastus: Nova Science Publishers Inc
  • ISBN-13: 9781629487137
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The sequencing of the human genome was a pivotal event in science that opened the door to exploring the structure and function of genes and their regulation. The activation or suppression of transcribed genes is critical to the orchestration of everyday biological processes at the cellular, tissue, and physiological levels. The rapid advance of science and technology has yielded the development of the microarray technique, which has propelled a much deeper understanding of the genome. By combining these technological advances in microarrays with statistical and bioinformatics software, investigators are now able to perform scientific investigations geared towards answering unique biological problems that encompass many fields of research from genetics and evolution to molecular medicine, health, and disease. This book provides an overview of the use and application of microarrays throughout the life sciences to address diverse complex biological questions. In this collection, authors present information on using microarrays to unlock molecular mechanisms and gene expression patterns associated with research areas ranging from biodefense, pathological changes, and monitoring antimicrobial resistance genes to diagnostics, marine biodiversity, and dermal toxicology.
Preface vii
Chapter 1 Microarray Technology for Category `A' Bioterrorism Agent Research: Current Status and Perspectives
1(22)
Lauren Huettner
Eric M. Vela
Chapter 2 Similarity Threshold Selection Tools for Gene Co-Expression Networks
23(14)
Liliana Lopez-Kleine
Luis Guillermo Leal
Chapter 3 Mining Gene Expression Microarrays for Long Non-Coding RNAs
37(12)
L. Zhang
D. R. Wagner
Y. Devaux
Chapter 4 An In Situ Electroporation and Flow Device for Mechanotransduction Studies
49(20)
Zoltan Kis
Leila Towhidi
Henry Ip
Emmanuel Drakakis
Anil Bharath
Rob Krams
Chapter 5 A New Application for Microarrays: Analysis of Global MicroRNA Expression Profiles in the Extracellular Microvesicles of Human Macrophage-Like Cells
69(12)
Tadayoshi Kagiya
Masayuki Taira
Chapter 6 Identification of Reference Genes by Meta-Microarray Analyses
81(20)
Issac H. K. Too
Sean S. J. Heng
Oliver Y. W. Chan
Bryan M. H. Keng
Ching-Yee Chia
Claudia W. X. Lim
Wan-Ting Leong
Qinghao Chu
Ernest J. G. Ang
Yongjie Lin
Maurice H. T. Ling
Chapter 7 Invertebrate DNA Chip: Opportunities and Challenges in the Development and Application of Microarrays for Marine Biodiversity Studies
101(34)
Srujana Chitipothu
Alessia Cariani
Fabio Bertasi
Marco Stagioni
Marc Kochzius
Dietmar Blohm
Fausto Tinti
Monica Landi
Chapter 8 Using Microarrays to Decipher the Virus-Host Interactions in HCV Infected Patients: Implications for Viral Resistance, Drug Development and Personalized Medicine
135(12)
Jing Sun
Jianguo Yuan
Bing Liu
Shilin Li
Yujia Li
Xiaoqiong Duan
Chunhui Yang
Peibing Zeng
Limin Chen
Chapter 9 Microarray Diagnostics for Orthopoxviruses, Filoviruses, Arenaviruses and Type A Influenza Virus
147(40)
Alexander N. Sinyakov
Vladimir A. Ryabinin
Chapter 10 Using DNA Microarray Technology to Monitor the Distribution of Antimicrobial Resistance Genes in Escherichia Coli Isolated from Animal Colibacillosis Outbreaks
187(24)
Pietro Badagliacca
Luke Masson
Alfreda Tonelli
Giacomo Migliorati
Josee Harel
Chapter 11 Phenotypic Anchoring of Liver Injury in Rats by Gene Expression Profiling
211(20)
Minjun Chen
Reagan Kelly
Lillian Tong
Jurgen Borlak
Weida Tong
Chapter 12 Application of Microarray Technology in Toxicology
231(20)
Abir T. El-Alfy
Chapter 13 Microarray Analysis of Gene Transcription Profiles in Chronic Rhinosinusitis
251(18)
Marcin Fraczek
Beata Rostkowska-Nadolska
Malgorzata Kapral
Chapter 14 Transcriptomic Analysis of Oligomeric Amyloid-β Treated Primary Cortical Neurons Reveals Dysregulation of Genes Involved in the Biosynthesis of Steroids and Cholesterol
269(28)
Bilal Malik
Cathy Fernandes
Richard Killick
Alessia Usardi
Ritchie Williamson
Stuart Kellie
Brian H. Anderton
C. Hugh Reynolds
Chapter 15 Application of Microarrays to Cutaneous Chemical Exposures
297(18)
James V. Rogers
Jennifer A. Price
Index 315