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E-raamat: Microdialysis Techniques in Neuroscience

  • Formaat: EPUB+DRM
  • Sari: Neuromethods 75
  • Ilmumisaeg: 06-Nov-2012
  • Kirjastus: Humana Press Inc.
  • Keel: eng
  • ISBN-13: 9781627031738
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  • Formaat: EPUB+DRM
  • Sari: Neuromethods 75
  • Ilmumisaeg: 06-Nov-2012
  • Kirjastus: Humana Press Inc.
  • Keel: eng
  • ISBN-13: 9781627031738

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Since its first application, microdialysis has become incredibly popular to study brain function and has been applied with success in different fields from psychopharmacology, neurobiology, and physiology in animals and also humans. Microdialysis Techniques in Neuroscience focuses on the practical aspects of microdialysis in animal and human, highlighting current technical limitations and providing a vision of what is yet to come for the determination of the most disparate compounds in the brain. The book’s contents range from new techniques for detection and quantifying the release of several different neurotransmitters in vitro and in vivo, even in freely moving animals, to sophisticated use of reverse dialysis and the application of microdialysis in pharmacokinetic studies. Each of the sixteen chapters, in fitting with the spirit of the Neuromethods series, contain an introduction that gives a broad overview of a focused topic, followed by an extensive protocol on how the experiments are performed along with invaluable practical advice. Detailed and authoritative, Microdialysis Techniques in Neuroscience will be a valuable reference for students, neuroscientists, and physicians for the use of microdialysis in the study of brain functions and its clinical applications.

This book covers practical aspects of microdialysis in animals and humans, highlighting current technical limitations and offering a vision of what's to come in the determination of the most disparate compounds in the brain. Offers practical tips and more.
Foreword vii
Preface to the Series ix
Preface xi
Contributors xv
1 Cerebral Microdialysis: Research Technique or Clinical Tool?
1(22)
Anouk Borg
Martin Smith
2 In Vivo Microdialysis to Study Striatal Dopaminergic Neurodegeneration
23(20)
Giuseppe Di Giovanni
Massimo Pierucci
Mauro Pessia
Vincenzo Di Matteo
3 Application of Reverse Microdialysis in Neuropharmacological Studies
43(20)
Christian Hocht
Facundo Martin Bertera
Carlos Alberto Taira
4 Microdialysis and Advances for Sampling Synaptic and Extrasynaptic Pools
63(26)
Cheng-fu Chen
Brian T. Rasley
Benjamin P.E. Warlick
Tom K. Green
Kristian E. Swearingen
Kelly L. Drew
5 In Vivo Microdialysis for Measurement of Oxidative Metabolism in the Living Brain
89(14)
H. Ronald Zielke
Carol L. Zielke
Peter J. Baab
6 Quantitative In Vivo Microdialysis in Pharmacokinetic Studies
103(18)
Teodoro Zornoza
Maria Jose Cano-Cebrian
Ana Polache
Luis Granero
7 Combination of In Vivo Microdialysis with Selective Electrochemical Detection for Online Continuous Monitoring of Brain Chemistry
121(36)
Yuqing Lin
Zipin Zhang
Lanqun Mao
8 Application of Spinal Microdialysis in Freely Moving Rats
157(18)
Vincent Umbrain
Lin Shi
Jan Poelaert
Ilse Smolders
9 Monitoring Extracellular Monoamines with In Vivo Microdialysis in Awake Rats: A Practical Approach
175(34)
Roberto W. Invernizzi
10 Intracerebral Human Microdialysis in Parkinson's Disease
209(16)
Salvatore Galati
Giuseppe Di Giovanni
11 Monitoring Extracellular Amino Acid Neurotransmitters and hROS by In Vivo Microdialysis in Rats: A Practical Approach
225(24)
Maria Alessandra Colivicchi
Chiara Stefanini
Wolfhardt Freinbichler
Chiara Ballini
Loria Bianchi
Keith F. Tipton
Laura Della Corte
12 Measurement of Neuropeptides in Dialysate by LC-MS
249(12)
Omar S. Mabrouk
Robert T. Kennedy
13 Achieving High Temporal Resolution for In Vivo Measurements by Microdialysis
261(14)
Neil D. Hershey
Robert T. Kennedy
14 Indirect Analysis of Nitric Oxide and Quantitation of Selective Nitric Oxide Synthase Inhibitors in Microdialysate Samples
275(24)
Gary M. Pollack
15 Determination of Histamine in Microdialysis Samples from the Rodent Brain by Column Liquid Chromatography
299(22)
Jan Kehr
Takashi Yoshitake
16 Intracerebral Microdialysis in the Study of Limbic Seizure Mechanisms and Antiepileptic Drug Action Using Freely Moving Rats
321(18)
Jeanelle Portelli
Ilse Smolders
Index 339