Contributor contact details |
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xii | |
Woodhead Publishing Series in Biomaterials |
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xvi | |
About the editors |
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xx | |
Preface |
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xxi | |
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Part I Fundamentals of microfluidic technologies for biomedical applications |
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1 | (164) |
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1 Materials and methods for the microfabrication of microfluidic biomedical devices |
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3 | (60) |
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3 | (1) |
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1.2 Microfabrication methods |
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4 | (6) |
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1.3 Materials for biomedical devices |
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10 | (9) |
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19 | (24) |
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1.5 Conclusion and future trends |
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43 | (1) |
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44 | (18) |
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62 | (1) |
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2 Surface coatings for microfluidic-based biomedical devices |
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63 | (37) |
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63 | (2) |
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2.2 Covalent immobilization strategies: polymer devices |
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65 | (8) |
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2.3 Covalent immobilization strategies: glass devices |
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73 | (3) |
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2.4 Adsorption strategies |
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76 | (6) |
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2.5 Other strategies utilizing surface treatments |
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82 | (2) |
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2.6 Examples of applications |
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84 | (6) |
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2.7 Conclusion and future trends |
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90 | (1) |
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2.8 Sources of further information and advice |
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91 | (1) |
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92 | (8) |
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3 Actuation mechanisms for microfluidic biomedical devices |
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100 | (39) |
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100 | (1) |
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101 | (17) |
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118 | (10) |
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3.4 Limitations and future trends |
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128 | (2) |
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130 | (9) |
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4 Digital microfluidics technologies for biomedical devices |
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139 | (26) |
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139 | (3) |
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4.2 On-chip microdrop motion techniques |
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142 | (13) |
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155 | (6) |
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161 | (1) |
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161 | (1) |
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162 | (3) |
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Part II Applications of microfluidic devices for drug delivery and discovery |
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165 | (116) |
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5 Controlled drug delivery using microfluidic devices |
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167 | (18) |
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167 | (2) |
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5.2 Microreservoir-based drug delivery systems |
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169 | (6) |
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5.3 Micro/nanofluidics-based drug delivery systems |
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175 | (6) |
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181 | (1) |
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182 | (1) |
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182 | (3) |
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6 Microneedles for drug delivery and monitoring |
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185 | (46) |
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185 | (2) |
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6.2 Fabrication of microneedles (MNs) |
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187 | (3) |
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6.3 MN design parameters and structure |
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190 | (6) |
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6.4 Strategies for MN-based drug delivery |
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196 | (6) |
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6.5 MN-mediated monitoring using skin interstitial fluid (ISF) and blood samples |
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202 | (11) |
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213 | (5) |
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218 | (1) |
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219 | (12) |
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7 Microfluidic devices for drug discovery and analysis |
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231 | (50) |
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231 | (2) |
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7.2 Microfluidics for drug discovery |
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233 | (24) |
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7.3 Microfluidics for drug analysis and diagnostic applications |
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257 | (11) |
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7.4 Conclusion and future trends |
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268 | (1) |
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7.5 Sources of further information and advice |
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269 | (1) |
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269 | (12) |
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Part III Applications of microfluidic devices for cellular analysis and tissue engineering |
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281 | (162) |
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8 Microfluidic devices for cell manipulation |
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283 | (68) |
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283 | (2) |
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8.2 Microenvironment on cell integrity |
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285 | (2) |
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8.3 Microscale fluid dynamics |
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287 | (6) |
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8.4 Manipulation technologies |
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293 | (36) |
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8.5 Manipulation of cancer cells in microfluidic systems |
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329 | (5) |
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8.6 Conclusion and future trends |
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334 | (1) |
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8.7 Sources of further information and advice |
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334 | (1) |
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335 | (16) |
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9 Microfluidic devices for single-cell trapping and automated micro-robotic injection |
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351 | (12) |
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351 | (2) |
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9.2 Device design and microfabrication |
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353 | (2) |
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9.3 Experimental results and discussion |
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355 | (5) |
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360 | (1) |
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361 | (1) |
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361 | (2) |
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10 Microfluidic devices for developing tissue scaffolds |
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363 | (25) |
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363 | (1) |
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10.2 Key issues and technical challenges for successful tissue engineering |
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364 | (6) |
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10.3 Microfluidic device platforms |
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370 | (9) |
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10.4 Conclusion and future trends |
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379 | (2) |
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381 | (7) |
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11 Microfluidic devices for stem cell analysis |
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388 | (55) |
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388 | (4) |
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11.2 Technologies used in stem cell analysis |
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392 | (10) |
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11.3 Examples of microfluidic platform for stem cell analysis: stem cell culture platform -- mimicking in vivo culture conditions in vitro |
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402 | (8) |
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11.4 Examples of microfluidic platform for stem cell analysis: single stem cell analysis |
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410 | (4) |
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11.5 Microdevices for label-free and non-invasive monitoring of stem cell differentiation |
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414 | (6) |
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11.6 Microfluidics stem cell separation technology |
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420 | (8) |
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11.7 Conclusion and future trends |
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428 | (3) |
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11.8 Sources of further information and advice |
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431 | (1) |
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431 | (12) |
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Part IV Applications of microfluidic devices in diagnostic sensing |
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443 | (191) |
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12 Development of immunoassays for protein analysis on nanobioarray chips |
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445 | (20) |
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445 | (2) |
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447 | (4) |
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12.3 Immobilization chemistry |
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451 | (1) |
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452 | (2) |
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454 | (8) |
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12.6 Conclusion and future trends |
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462 | (1) |
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462 | (3) |
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13 Integrated microfluidic systems for genetic analysis |
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465 | (27) |
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465 | (2) |
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13.2 Integrated microfluidic systems |
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467 | (1) |
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13.3 Development of integrated microdevices |
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468 | (2) |
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13.4 Applications of fully integrated systems in genetic analysis |
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470 | (12) |
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13.5 Conclusion and future trends |
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482 | (1) |
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483 | (9) |
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14 Low-cost assays in paper-based microfluidic biomedical devices |
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492 | (35) |
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492 | (1) |
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14.2 Fabrication techniques for paper-based microfluidic devices |
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493 | (13) |
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14.3 Detection and read-out technologies |
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506 | (7) |
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14.4 Application of paper-based microfluidic devices |
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513 | (8) |
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14.5 Conclusion and future trends |
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521 | (1) |
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522 | (5) |
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15 Microfluidic devices for viral detection |
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527 | (30) |
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527 | (2) |
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15.2 Microfluidic technologies used for viral detection |
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529 | (15) |
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15.3 Examples of applications |
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544 | (6) |
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15.4 Conclusion and future trends |
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550 | (1) |
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551 | (1) |
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551 | (6) |
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16 Microfluidics for monitoring and imaging pancreatic islet and β-cells for human transplant |
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557 | (37) |
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557 | (3) |
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16.2 Insulin secretory pathway: how glucose sensing and metabolic coupling translates to insulin kinetics |
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560 | (2) |
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16.3 Technologies: the emergence of microfluidics applied to islet and β-cell study |
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562 | (3) |
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16.4 Design and fabrication of the University of Illinois at Chicago (UIC) microfluidic device |
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565 | (4) |
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569 | (4) |
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16.6 Protocol: procedures |
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573 | (12) |
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585 | (4) |
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589 | (1) |
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589 | (5) |
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17 Microfluidic devices for radio chemical synthesis |
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594 | (40) |
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594 | (1) |
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17.2 Medical applications of microfluidic radiochemistry: positron emission tomography (PET) and single photon emission computed tomography (SPECT) |
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595 | (2) |
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17.3 Advantages and disadvantages of microfluidic devices |
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597 | (4) |
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17.4 Realization of promises: the superiority of microfluidic systems |
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601 | (20) |
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17.5 Current problems for microfluidic technology |
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621 | (5) |
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17.6 Recent developments with potential impact |
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626 | (3) |
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629 | (1) |
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629 | (5) |
Index |
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634 | |