This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.
Chapter
1. A Historical and Technological Background to
Organs-on-a-Chip.
Chapter
2. Applications of microfluidics.-
Chapter
3.
Microfluidics based Organ-on-a-chip for cell biology studies.-
Chapter
4.
Microfluidics in Chemical biology.
Chapter
5. Role of microfluidics in drug
delivery.- Chapter
6. Microfluidics in drug discovery.
Chapter
7.
Microfludic based sensors.
Chapter
8. Background and
Organs-on-a-Chip.- Chapter
9. Culture and co-culture of cells for multi organ
on chip.-
Chapter 10.Cells and organs on a chip in biomedical sciences.-
Chapter
11. Futuristic aspects of organ on a chip.- Chapter
12. Development
of Human on a chip.
Chapter
13. Multi-organ on a chip for personalized
medicine.
Chapter
14. Development and application of Microfluids in organoid
formation.- Chapter
15. Liver on a chip.-
Chapter
16. Placenta on Chip: A
Modern approach to probe feto-maternal interface.
Chapter
17. Microfluidic
retina-on-chip.
Chapter
18. Heart on a chip.
Chapter
19. Kidney on a
chip.-
Chapter
20. Lungs on a chip.- Chapter
21. Brain on a chip.-
Chapter
22. Skin on a chip.-
Chapter
23. Organs-on-a-chip in preclinical studies.-
Chapter
24. Application of organ on chip in blood brain barrier model.-
Chapter
25. Multi organs on a chip in disease modeling.- Chapter
26.
Prospects of Medical device on a chip.
Chapter
27. Lab on a chip for
precision Medicine.
Chapter
28. Tumour-on-a-chip : Perfusion systems to
model the extracellular breast tumour microenvironment:from tumour
progression to metastasis formation.
Chapter
29. Building Human In Vitro 3D
Models to Replace Animal Studies: During Drug Discovery Reearch: Scientific,
Ethical and Regulatory Considerations.
Dr. PV. Mohanan is a Fellow of the National Academy of Science and Royal Society of Biologists, UK. He was a JSPS Post-Doctoral Fellow at the University of Tsukuba, Japan, in the field of Neurotoxicity. He joined Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Govt. of India, in 1989. As a toxicologist, he has been intimately associated with all the medical devices/technologies developed at SCTIMST. Currently, he heads the Division of Toxicology and a visiting professor and visiting researcher at Toyo University, Japan, and a Certified Biological Safety Specialist. He received a lifetime achievement award from the Society of Toxicology India for the outstanding contribution to toxicology research. Dr. Mohanan made significant contributions to the development of medical device regulations in India. He received a certificate of appreciation from the Hon. Minister of Science and Technology, Govt. of India, contributed to getting full adherent status on GLP from the OECD. He has authored more than 250 publications and edited 4 books. Presently, he is the Secretary-General of Society of Toxicology, India, and General Secretary of Indian JSPS Alumni Association.
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