Specialists in the UK, France, Germany, Italy, and the Netherlands are the contributors to this volume of 17 chapters on new technologies and methods in diagnostic cellular pathology. The volume is a revised edition of Molecular biology in histopathology , published by Wiley in 1994. The chapter topics include blotting techniques, in-situ hybridization, DNA flow cytometry, interphase cytogenetics, oncogenes, molecular and immunological aspects of cell proliferation, interphase nucleolar organizer regions in tumor pathology, apoptosis and cell senescence, polymerase chain reaction, and laser capture microdissection. Gene expression using microarrays, proteomics, and the human genome project receive separate chapters. Graduate students and specialists will be the volume's audience. Annotation (c) Book News, Inc., Portland, OR (booknews.com)
The latest edition of this highly successful text, covers the major advances in the methods used in cellular and molecular pathology. In recent years, knowledge of the molecular organization of the cell has led to the development of powerful new techniques that bring greater accuracy and objectives to the diagnosis, prognosis and management of many diseases and to the study of pathological states. This book describes the latest molecular techniques available for the analysis of diseases. In particular it includes new techniques using fluorescent dyes, DNA microarrays, protein chemistry, and mass spectrometry. It also incorporates information from the Human Genome Project, and the new disciplines of genomics and proteomics, where relevant to pathology. Color plates are a new feature of this edition, illustrating the advances in fluorescence labeling of cells.
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