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E-raamat: Molecular Biology and Pathogenesis of Peste des Petits Ruminants Virus

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  • Formaat: PDF+DRM
  • Sari: SpringerBriefs in Animal Sciences
  • Ilmumisaeg: 20-Aug-2012
  • Kirjastus: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • Keel: eng
  • ISBN-13: 9783642314513
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Molecular Biology and Pathogenesis of Peste des Petits Ruminants VirusSuurem pilt
  • Formaat: PDF+DRM
  • Sari: SpringerBriefs in Animal Sciences
  • Ilmumisaeg: 20-Aug-2012
  • Kirjastus: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • Keel: eng
  • ISBN-13: 9783642314513
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Peste de Petits Ruminants (PPR) is a highly contagious viral disease of domestic and wild small ruminants that can significantly affect economies. The authors are experts in the field and provide an up-to-date and comprehensive review covering all aspects of the disease. The book is divided into seven chapters highlighting genome organization, virus replication and the determinants of virulence, pathophysiology and clinical disease, immunology and immunopathogenesis, epidemiology, diagnostic assays and vaccines, and the challenges concerning global eradication. It is an invaluable reference work, presenting the latest information for virologists, microbiologists, immunologists, veterinarians, and scientists working in PPR research.

1 Genome Organization of Peste des Petits Ruminants Virus
1(22)
1.1 Introduction
1(1)
1.2 Morphology and Genome Structure
2(14)
1.2.1 Virion and Genomic Properties
2(2)
1.2.2 PPRV Structural Proteins
4(10)
1.2.3 PPRV Accessory Proteins
14(2)
1.3 Comparative Genome Analysis
16(2)
1.4 Conclusion
18(5)
References
18(5)
2 Replication and Virulence Determinants of Peste des Petits Ruminants Virus
23(10)
2.1 Introduction
24(1)
2.2 PPRV Replication and Life Cycle
24(3)
2.3 Viral Transmissions and Propagation
27(2)
2.3.1 Non-Host Factors
27(1)
2.3.2 Host Factors
28(1)
2.4 Host Determinants of Pathogenesis
29(1)
2.5 Conclusions
30(3)
References
30(3)
3 Pathophysiology and Clinical Assessment of Peste des Petits Ruminants
33(16)
3.1 Introduction
33(1)
3.2 PPRV Pathogenesis in Small Ruminants
34(10)
3.2.1 Clinical Manifestations
34(4)
3.2.2 Pathophysiology
38(1)
3.2.3 Gross Lesions
38(1)
3.2.4 PPRV in Lambs and Kids
39(1)
3.2.5 Histopathology
40(2)
3.2.6 Neuropathology
42(2)
3.3 Differential Diagnosis
44(3)
3.3.1 Rinderpest
44(1)
3.3.2 Foot-and-Mouth Disease
44(1)
3.3.3 Bluetongue
44(1)
3.3.4 Contagious Caprine Pleuropneumonia
45(1)
3.3.5 Contagious Ecthyma
45(1)
3.3.6 Nairobi Sheep Disease
45(1)
3.3.7 Diarrhea Complex
46(1)
3.3.8 Pneumonic Pasteurellosis
46(1)
3.3.9 Heartwater
46(1)
3.3.10 Mineral Poisoning
46(1)
3.4 Conclusions
47(2)
References
47(2)
4 Immunology and Immunopathogenesis of Peste des Petits Ruminants Virus
49(20)
4.1 Introduction
49(1)
4.2 Immunity Against PPRV
50(2)
4.2.1 Passive Immunity
50(1)
4.2.2 Active Immunity
50(2)
4.3 B- and T-cell Epitopes
52(4)
4.3.1 B Cell Epitopes
53(1)
4.3.2 T Cell Epitopes
54(2)
4.4 Apoptosis Induced by PPRV
56(2)
4.5 Cytokine Responses Against PPRV
58(2)
4.6 Immunosuppression Caused by PPRV
60(3)
4.7 Hematological Responses Against PPRV
63(1)
4.8 Biochemical Responses to PPRV
64(1)
4.9 Conclusions
65(4)
References
66(3)
5 Epidemiology and Distribution of Peste des Petits Ruminants
69(36)
5.1 Introduction
70(2)
5.2 Bases for PPRV Classification
72(2)
5.3 Prevalence and Distribution of PPRV in PPR Endemic Countries
74(22)
5.3.1 Distribution of PPRV in South Asia
74(5)
5.3.2 Distribution of PPRV in the Middle East
79(5)
5.3.3 Distribution of PPRV in West Africa
84(4)
5.3.4 Distribution of PPRV in East Africa
88(5)
5.3.5 Distribution of PPRV in Central Africa
93(1)
5.3.6 Distribution of PPRV in North Africa
94(2)
5.4 PPRV and Europe
96(1)
5.5 Conclusions
97(8)
References
98(7)
6 Current Advances in Molecular Diagnosis and Vaccines for Peste des Petits Ruminants
105(30)
6.1 Introduction
105(1)
6.2 Diagnosis of PPRV
106(8)
6.2.1 Serological Diagnosis of PPRV
106(3)
6.2.2 Serological Assays
109(1)
6.2.3 Antigen Detection for PPR Diagnosis
110(1)
6.2.4 Genome Detection for PPR Diagnosis
110(4)
6.3 Vaccines Against PPRV
114(4)
6.3.1 Heterologous Attenuated PPRV Vaccines
114(1)
6.3.2 Homologous Attenuated PPRV Vaccines
115(2)
6.3.3 Stability of Live Attenuated PPRV Vaccines
117(1)
6.4 Recombinant Marker PPRV Vaccines
118(5)
6.4.1 Heterologous Marker Vaccines for PPRV
118(1)
6.4.2 Homologous Marker Vaccines for PPRV
119(4)
6.5 Multivalent Vaccines
123(3)
6.6 DIVA Vaccines
126(1)
6.7 Control of PPRV Using RNA Interference
127(1)
6.8 Conclusions
127(8)
References
128(7)
7 Poverty Alleviation and Global Eradication of Peste des Petits Ruminants
135(14)
7.1 Introduction
136(1)
7.2 Economic Impact of PPR Disease
136(2)
7.3 Control and Eradication of PPRV: Where do We Stand?
138(7)
7.3.1 Factors Favoring the Possibility for Global Eradication of PPRV
138(5)
7.3.2 Factors Hindering the Possibility for Global Eradication of PPRV
143(2)
7.4 Roles of International Health Organizations in PPR Eradication Campaigns
145(1)
7.5 Conclusion and Prospects
146(3)
References
146(3)
Index 149
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