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E-raamat: Molecular Imaging in Oncology

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This book discusses the most significant recent advances in oncological molecular imaging, covering the full spectrum from basic and preclinical research to clinical practice. The content is divided into five sections, the first of which is devoted to standardized and emerging technologies and probe designs for different modalities, such as PET, SPECT, optical and optoacoustic imaging, ultrasound, CT, and MRI. The second section focuses on multiscale preclinical applications ranging from advanced microscopy and mass spectroscopy to whole-body imaging. In the third section, various clinical applications are presented, including image-guided surgery and the radiomic analysis of multiple imaging features. The final two sections are dedicated to the emerging, crucial role that molecular imaging can play in the planning and monitoring of external and internal radiotherapy, and to future challenges and prospects in multimodality imaging. Given its scope, the handbook will benefit all readers who are interested in the revolution in diagnostic and therapeutic oncology that is now being brought about by molecular imaging.


The impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing steadily. This handbook addresses all aspects of molecular imaging in oncology, from basic research to clinical applications in the era of evidence-based medicine.

Part I Technology and Probe Design
1 Advanced X-ray Imaging Technology
3(28)
Daniela Pfeiffer
Franz Pfeiffer
Ernst Rummeny
2 Computed Tomography and Magnetic Resonance Imaging
31(80)
Monique R. Bernsen
Marcel van Straten
Gyula Kotek
Esther A. H. Warnert
Joost C. Haeck
Alessandro Ruggiero
Piotr A. Wielopolski
Gabriel P. Krestin
3 (Hybrid) SPECT and PET Technologies
111(24)
Teresa Nolte
Nicolas Gross-Weege
Volkmar Schulz
4 Ultrasound Imaging
135(20)
Georg Schmitz
Stefanie Dencks
5 Optical and Optoacoustic Imaging
155(34)
Daniel Razansky
Vasilis Ntziachristos
6 Multifunctional Magnetic Resonance Imaging Probes
189(38)
Philipp Biegger
Mark E. Ladd
Dorde Komljenovic
7 Single Photon Emission Computed Tomography Tracer
227(56)
Hans-Jurgen Pietzsch
Constantin Mamat
Cristina Muller
Roger Schibli
8 18F-Labeled Small-Molecule and Low-Molecular-Weight PET Tracers for the Noninvasive Detection of Cancer
283(36)
Christopher M. Waldmann
Klaus Kopka
Stefan Wagner
9 Ultrasound Molecular Imaging of Cancer: Design and Formulation Strategies of Targeted Contrast Agents
319(18)
Alexander L. Klibanov
10 Optical and Optoacoustic Imaging Probes
337(22)
Michel Eisenblatter
Moritz Wildgruber
Part II Preclinical Studies
11 Preclinical SPECT and SPECT-CT in Oncology
359(46)
Benjamin L. Franc
Youngho Seo
Robert Flavell
Carina Mari Aparici
12 Preclinical Applications of Magnetic Resonance Imaging in Oncology
405(34)
Wilfried Reichardt
Dominik von Elverfeldt
13 Optical and Optoacoustic Imaging
439(54)
Joanna Napp
Andrea Markus
Frauke Alves
14 Applications of Small Animal PET
493(16)
Sonja Schelhaas
15 Molecular Ultrasound Imaging
509(24)
Jasmin Baier
Anne Rix
Fabian Kiessling
16 Molecular Imaging in Oncology: Advanced Microscopy Techniques
533(32)
Dimitrios Kapsokalyvas
Marc A. M. J. van Zandvoort
Part III Clinical Applications
17 Quantitative SPECT/CT--Technique and Clinical Applications
565(26)
Philipp Ritt
Torsten Kuwert
18 Fluorescence Imaging of Breast Tumors and Gastrointestinal Cancer
591(34)
Dirk Grosenick
Christoph Bremer
19 FDG PET Hybrid Imaging
625(44)
Juliane Becker
Sarah M. Schwarzenbock
Bernd J. Krause
20 Non-FDG PET/CT
669(50)
Egesta Lopci
Stefano Fanti
21 Clinical MR Biomarkers
719(28)
Daniel Paech
Heinz-Peter Schlemmer
22 Clinical PET/MR
747(18)
Wolfgang Weber
23 Advanced Ultrasound Imaging for Patients in Oncology: DCE-US
765(8)
Nathalie Lassau
24 Image-Guided Radiooncology: The Potential of Radiomics in Clinical Application
773(22)
Jan C. Peeken
Benedikt Wiestler
Stephanie E. Combs
25 Non-invasive Imaging Techniques: From Histology to In Vivo Imaging
795(18)
Thomas Bocklitz
Anja Silge
Hyeonsoo Bae
Marko Rodewald
Fisseha Bekele Legesse
Tobias Meyer
Jiirgen Popp
26 Image-Guided Brain Surgery
813(32)
Stephanie Schipmann-Miletic
Walter Stummer
Part IV Image Guided Radiooncology
27 Molecular Imaging in Photon Radiotherapy
845(20)
Jamina Tara Fennell
Eleni Gkika
Anca L. Grosu
28 Molecular Imaging for Particle Therapy: Current Approach and Future Directions
865(16)
Katharina Seidensaal
Semi Ben Harrabi
Jiirgen Debus
29 Internal Radiation Therapy
881(24)
Uwe Haberkorn
Clemens Kratochwil
Frederik Giesel
Part V Future Challenges
30 Future Challenges of Multimodality Imaging
905
Diego Alfonso Lopez-Mora
Luis Alarcon Lagos
Montserrat Estorch
Ignasi Carrio
Otmar Schober was Director of the Department of Nuclear Medicine at the University of Münster from 1988 to 2013 and Deputy Rector of the university from 1994 to 1998. He has extensive expertise in the natural sciences and clinical medicine and has focused on imaging methods and their implementation in preclinical and clinical applications. Professor Schober completed his studies in laser physics with Herbert Welling and in surface physics with Nobel Laureate Gerhard Ertl at the Universities of Hanover and Munich. He received his medical training in Frankfurt, Hanover, and London; Heinz Hundeshagen was his mentor. From 1995 to 2003, he was a German Research Foundation expert reviewer for Radiology, Nuclear Medicine, and Radiation Biology. He has served as Editor-in-Chief of the Journal Nuklearmedizin (20012011) and as a coeditor of various international journals. Professor Schober served as coordinator of the Collaborative Research Center on Molecular Cardiovascular Imaging from 1999 to 2013. As a founder of the European Institute for Molecular Imaging, he was the principal investigator at the Cluster of Excellence Cells in Motion.







Fabian Kiessling leads the Institute for Experimental Molecular Imaging at the RWTH University in Aachen, where he is working to develop novel diagnostic and theranostic concepts, probes, and technologies. Professor Kiessling studied medicine at Heidelberg University and subsequently worked as a resident at the Department of Radiology, German Cancer Research Center (until the end of 2002). In 2003, he moved to the Department of Medical Physics in Radiology as leader of a Molecular Imaging Group. At the same time, he pursued his clinical training, becoming a board-certified radiologist in 2007. He is the author of more than 300 publications and book chapters and has been an editorial board member for various journals, including Radiology, European Radiology, Molecular Imaging and Biology, and Nanotheranostics. In 2019he was featured as Highly Cited Researcher by Clarivate Analytics, as World Expert in nanomedicine and molecular imaging by Expertscape, and he has won a number of awards, including the Emil Salzer Prize for Cancer Research and the Richtzenhain Prize. Together with Professor Matthias Bräutigam, he founded invivo Contrast GmbH, which distributes diagnostic probes for the preclinical market.