"A useful handbook to guide laboratory staff in mastering the techniques of flow cytometry in diagnosing complex hematological malignancies. Practical and current, it presents comprehensive information, from instrument settings and panel construction to data interpretation. Will support users in recognizing relevant immunophenotypic abnormalities"--
A useful handbook to guide laboratory staff in mastering the techniques of flow cytometry in diagnosing complex hematological malignancies. Practical and current, it presents comprehensive information, from instrument settings and panel construction to data interpretation. Will support users in recognizing relevant immunophenotypic abnormalities.
Master the implementation of flow cytometry techniques in diagnosing complex hematologic diseases and malignancies in patients with this comprehensive and practical guide. Featuring updated recommendations on pre-analytical steps, instrument settings and panel construction, this manual offers invaluable support for those diagnosing, treating and researching hematologic malignancies. Written by leading experts in the field, this book puts flow cytometry into everyday context. Through engaging with differential diagnoses, the manual offers an accurate description of specific features of malignancies and mimicking conditions. It also places flow cytometry in the scope of integrated diagnosis according to WHO and ICC classifications. Fully updated throughout, this second edition provides new literature and concepts, and presents new AI-based analytical methods. Richly illustrated and in full colour, this book is an ideal resource for those working in flow cytometry laboratories.
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Practical manual in understanding how multiparameter flow cytometry helps in the integrated diagnosis of hematological malignancies.
1. Flow cytometry in clinical haematopathology: basic principles and
data analysis of multiparameter data sets Francis Lacombe and Marie-Christine
Béné;
2. Antigens Marie-Christine Béné and Anna Porwit;
3. Flow cytometry of
normal blood, bone marrow and lymphatic tissue Anna Porwit and
Marie-Christine Béné;
4. Reactive conditions and other diseases where flow
cytometric findings may mimic haematological malignancies Marie-Christine
Béné, Wolfgang Kern and Anna Porwit;
5. Examples of immunophenotypic features
in various categories of acute leukaemia Marie-Christine Béné and Anna
Porwit;
6. Acute lymphoid leukaemia (all) and minimal/measurable residual
disease in all Barbara Buldini, Elena Varotto and Andrea Zangrando;
7.
Immunophenotyping of mature b-cell lymphomas Olof Axler and Anna Porwit;
8.
Plasma cell myeloma and related disorders Anna Porwit and Marie Christine
Béné;
9. Mature t-cell neoplasms and natural killer-cell malignancies Anne
Tierens;
10. Flow cytometric diagnosis of classic hodgkin lymphoma in lymph
nodes Lori Soma and Jonathan R. Fromm;
11. Measurable residual disease in
acute myeloid leukaemia Jacqueline Cloos, Angèle Kelder, Dave de Leeuw and
Costa Bachas;
12. Ambiguous lineage and mixed phenotype acute leukaemia Anna
Porwit and Marie-Christine Béné;
13. Flow cytometry in myelodysplastic
syndromes Theresia M. Westers and Arjan A. van de Loosdrecht;
14. Future
applications of flow cytometry and related techniques Marie Christine Béné,
Anna Porwit and Francis Lacombe.
Anna Porwit MD PhD is Professor Emerita at the Division of Pathology, Lund University, Sweden. She has also held professor positions at the Karolinska Institute, Stockholm, Sweden, and at the University of Toronto, ON, Canada. She is a co-author of over 200 original papers and has contributed to the 'WHO Classification of Haematopoietic Malignancies' (2008 and 2016). Marie Christine Béné is Professor Emerita of Hematology, former Professor of Immunology, and lastly head of the Hematology Biology Department in Nantes University Hospital. She has been largely involved in flow cytometry applications in diagnosis and follow-up. She has co-authored over 500 publications, has contributed to the 'WHO Classification of Haematopoietic Malignancies' (2008 and 2016) and leads the European LeukemiaNet WP10 on morphology and flow cytometry.
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