Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine addresses the key concepts involved in the interactions between cells and biomaterials in the musculoskeletal tissue engineering and regenerative medicine field. The updated developments and challenges of the mechanisms/mechanobiology and structure-function properties of those interactions, as well as emerging technologies underlying tissue-engineered scaffolding, are carefully discussed. Lastly, cell engineering and cell-based therapies, growth factors/drugs properties, vascularization, immunomodulation are also outlined.
Given the large number of musculoskeletal disorders and related injuries that can affect muscles, bones and joints and lead to severe complications of the neuromuscular system, it is imperative to develop new treatment strategies to delay or repair associated diseases and to promote optimal long-term health.
- Presents the fundamentals of the complex interplay of cells with biomaterials in musculoskeletal tissue engineering
- Includes coverage of stem cells and cell-based therapies, in vitro and in vivo models, nanotechnology, bioprinting, computational modeling, regulatory and clinical translation, and much more
- Written by global leaders in the field
Section 1: Fundamentals of cell-biomaterials interactions
1. Introduction
2. Fundamentals and mechanisms
3. Cellular signaling processes
4. Cell-protein interactions
5. The microenvironment: Recreate the ECM
6. Surface modifications topography, porosity
7. Chemotaxis: Soluble morphogens and Growth factors
8. Cell-biomaterials: Vascularization
9. Cell-biomaterials in Immunomodulation
10. Mechanobiology regulation
11. Electrical/Magnetic stimulation
Section 2: Multiscale design, structure/function and processing
technologies
12. Introduction
13. Design of polymeric biomaterials at multiscale
14. Design of Calcium phosphates cements: Structure/function
15. Biomimetic micro-/nano- scales design
16. Cells-biomaterials structure-function at different length scales
17. Computational modelling involved in multiscale design
18. Hydrogel systems design: Structure/function
19. Scaffolding design and structure/function: Electrospinning
20. Scaffolding design and structure/function: Advanced manufacturing
21. Scaffolding design and structure/function: Bioprinting
22. Dynamic models for investigating structure/function of biomaterials:
Bioreactors
23. Dynamic models for investigating cell-biomaterials interactions:
Microfluidics
24. Complex in vitro models for studying cell-biomaterials interactions
25. In vivo animal models
26. Regulatory and clinical translation
J. Miguel Oliveira, BSc, PhD is the Director of Pre-Clinical Research at the FIFA MEDICAL CENTER, Estádio do Dragão, Porto, PT since Fev. 2013. Currently, he is a Lecturer in Doctoral Programme in Tissue Engineering, Regenerative Medicine and Stem Cells at UMinho, PT. He is also an Invited lecturer at the Faculty of Medicine, U. Porto (since Sept. 2013) and Dept. of Polymer Eng., UM, PT. Dr. Oliveira has published over 220 scientific contributions in scientific journals. Miguel Oliveira was approved 17 patents, published 5 books, 3 special issue in scientific journals, and more than 90 book chapters in books with international circulation. In addition, he is member of the advisory board of the Journal of Materials Science: Materials in Medicine, International Journal of Tissue Engineering, Journal ISRN Biomaterials, The Journal of Experimental Orthopaedics, Journal Recent Patents on Corrosion Science”, and referee in more than 40 international journals. Dr. Rui Reis is Vice-President for Research and Innovation of University of Minho, Portugal, Director of 3Bs Research Group and Director of ICVS/3B´s Associate Laboratory, both of UMinho. Hes the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global Past-President of the Tissue Engineering and Regenerative Medicine International Society and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. Hes edited 18 books, 10 special issue journals, 280 book chapters and has more than 1225 published works listed on ISI Web of Knowledge, being an inventor of around 70 patents. Hes been awarded many important international prizes, including the TERMIS-EU contributions to the literature Award and the TERMIS-EU Career Achievement Award, and recently the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize. Sandra Pina is Assistant Researcher at 3Bs Research Group, Institute 3Bs, University of Minho, Barco, Portugal.
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