This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field.
The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research.
Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.
Part. I. History, Recollections, And Homages.- Paradigm Shifts in the
History of Nox2 and Its Regulators: An Appreciative Critique.- The Phagocyte
Oxidase: The Early Years.- Reflections on My Life in Noxes.- The Discovery
and Characterisation of Nox2, a Personal Journey.- Reminiscences on
Positional Cloning of X-CGD Gene (Aka CYBB, gp91phox, Nox2).- On Katsuko
Kakinuma: Spectroscopic Studies of Redox Centers in NADPH Oxidase
Identifying and Observing the Key Players That Pass an Electron to Oxygen.-
Pierre Vignais, from One Respiratory Chain to Another.- Gary M. Bokoch, the
Rac-n-Rho Man: His fascination with Rho-GTPases.- History and Discovery of
the Noxes: From Nox1 to the DUOXes.- Part. II. Canonical NADPH Oxidases.-
NADPH Oxidase 1: At the Interface of the Intestinal Epithelium and Gut
Microbiota.- Physiological Functions and Pathological Significance of NADPH
Oxidase 3.- Nox 4: From Discovery to Pathophysiology.- Nox5 - Molecular
Regulation and Pathophysiology.-DUOX1 and DUOX2, DUOXA1 and DUOXA2.- Part.
III. NADPH Oxidase Regulators.- p47phox and NOXO1, the Organizer Subunits of
the NADPH Oxidase 2 (Nox2) and NADPH Oxidase 1 (Nox1).- The NADPH Oxidase
Activator p67phox and Its Related Proteins.- p40phox: Composition, Function
and Consequences of Its Absence.- Rho Family GTPases and their Modulators.-
Part IV. Tools, Inhibitors, and Neighbors.- Tools to Identify Noxes and their
Regulators.- Methods to Measure Reactive Oxygen Species Production by NADPH
Oxidases.- Isoform-Selective Nox Inhibitors: Advances and Future
Perspectives.- Proteins Cross-talking with Nox Complexes: The Social Life of
Noxes.- Part V. Non-Mammalian NADPH Oxidases.- NADPH Oxidase-Dependent
Processes in the Social Amoeba Dictyostelium Discoideum.- Discovery and
Functional Analysis of the Single-Celled Yeast NADPH Oxidase, Yno1.- NADPH
Oxidases in Fungi.- Plant NADPH Oxidases.- Nematode Noxes: The DUOXes of
Caenorhabditis elegans.- NADPH Oxidases in Arthropods.- NADPH Oxidases in
Zebrafish.- Part VI. Structure.- Structural Insights into the Mechanism of
DUOX1-DUOXA1 Complex.- Structure, Function and Mechanism of Six-Transmembrane
Epithelial Antigen of the Prostate (STEAP) Enzymes.- Part VII. Pathology.-
Chronic Granulomatous Disease.- Definitive Treatments for Chronic
Granulomatous Disease with a Focus on Gene Therapy.- Part VIII. Future.- Quo
Vadis NADPH Oxidases: Perspectives on Clinical Translation.
Edgar Pick, MD, PhD is Professor Emeritus of Immunology at the Sackler Faculty of Medicine at Tel Aviv University, Israel. He was Director of the Julius Friedrich Cohnheim-Minerva Center for Cellular and Molecular Phagocyte Research, Head of the Kodesz Institute of Host Defense against Infectious Diseases, and Incumbent of the Roberts-Guthman Chair in Immunopharmacology.
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