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E-raamat: Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes

Edited by , Edited by (Professor, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara (Punjab) India), Edited by (Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India), Edited by (Professor, Centre for )
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  • Ilmumisaeg: 23-May-2017
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128097182
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  • Formaat: PDF+DRM
  • Ilmumisaeg: 23-May-2017
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128097182

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Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genesprovides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology.

The book is organized into three sections, beginning with an introduction to nanomedicine and its associated

issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field.

By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner.

  • Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies
  • Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery
  • Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery
  • Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more

Muu info

A detailed look at the latest technologies and strategies in nanomedicine for drug delivery that includes achievements, challenges, and solutions
List of Contributors
xiii
Biographies xvii
Preface xix
Acknowledgments xxi
Section I Introduction and Issues in Nanomedicine
1 Nanotechnology for the Development of Nanomedicine
3(59)
Rakesh K. Tekade
Rahul Maheshwari
Namrata Soni
Muktika Tekade
Mahavir B. Chougule
1.1 Nanotechnology and Nanomedicine: Approaching the Ideal Scale
4(2)
1.2 Approaches of Nanomedicines
6(1)
1.3 History of Nanomedicines
7(1)
1.4 Rationale for the Development of Nanomedicine
8(1)
1.5 Advantages of Nanomedicine Over Conventional Drug Delivery Systems
8(1)
1.6 Impact of Nanomedicine Applications on Healthcare Costs
9(1)
1.7 Nanomaterials Used for the Development of Nanomedicines
10(14)
1.8 Nanotechnology and Medicinal Applications
24(13)
1.9 Nanomedicine Research, Development, and Current Clinical Status
37(11)
1.10 Current Clinical Status and Regulatory Considerations
48(3)
1.11 Challenges in Commercialization of Nanotherapeutics
51(3)
1.12 Summary and Conclusion
54(8)
Acknowledgments
55(1)
References
55(7)
2 Current Update on the Role of Enhanced Permeability and Retention Effect in Cancer Nanomedicine
62(48)
Anfal Jasim
Sara Abdelghany
Khaled Greish
2.1 Introduction
63(1)
2.2 Enhanced Permeability and Retention Effect
63(5)
2.3 Desired Physiochemical Nanoconstructs
68(5)
2.4 Enhanced Permeability and Retention-Based Drug Delivery Systems
73(7)
2.5 Exosomes
80(1)
2.6 Bacterial and Viral Delivery Systems
81(5)
2.7 Beyond Enhanced Permeability and Retention
86(9)
2.8 Limitations of the Enhanced Permeability and Retention Effect
95(4)
2.9 Future Prospects
99(11)
References
100(10)
3 Systematic Development of Nanocarriers Employing Quality by Design Paradigms
110(41)
Bhupinder Singh
Sumant Saini
Shikha Lohan
Sarwar Beg
3.1 Introduction
111(6)
3.2 Experimental Designs Employed During Formulation by Design of Drug Delivery System
117(7)
3.3 Optimum Search
124(2)
3.4 Overall Formulation by Design Strategy for Development of Nanostructured Drug Delivery System
126(1)
3.5 Software Usages During Formulation by Design
127(1)
3.6 Formulation by Design Optimization of Nanostructured Drug Delivery System: Literature Update
127(14)
3.7 Conclusions
141(10)
References
142(9)
Section II Current Technologies in Nanomedicine
4 Liposomal-Based Therapeutic Carriers for Vaccine and Gene Delivery
151(16)
Mahfoozur Rahman
Sarwar Beg
Amita Verma
Firoz Anwar
Abdus Samad
Vikas Kumar
4.1 Introduction
151(1)
4.2 Introduction to Liposomes and Their Therapeutic Applications in Vaccine Delivery
152(4)
4.3 Archaeosomes
156(1)
4.4 Transfersomes
156(1)
4.5 Immunopotentiating Reconstituted Influenza Virosomal Carriers
157(1)
4.6 Liposomal-Based Gene Delivery
158(4)
4.7 Conclusion
162(5)
References
162(5)
5 Polymeric Micelles for Drug Targeting and Delivery
167(36)
Mohd Cairul Iqbal Mohd Amin
Adeel M. Butt
Muhammad W. Amjad
Prashant Kesharwani
5.1 Introduction
167(1)
5.2 Mechanism of Micelle Formation
168(1)
5.3 Morphology of Polymeric Micelles
169(1)
5.4 Types of Polymeric Micelles
169(2)
5.5 Polymers Commonly Used to Fabricate Polymeric Micelles
171(4)
5.6 Advantages of Polymeric Micelles as Drug Delivery Carriers
175(1)
5.7 Polymeric Micelle Targeting Approaches
175(17)
5.8 Polymeric Micelles for Drug Delivery: Future Prospects
192(11)
References
193(10)
6 Nanoparticle-Homing Polymers as Platforms for Theranostic Applications
203(20)
Rimesh Augustine
Johnson V. John
II Kim
6.1 Introduction
203(2)
6.2 Noble Metal Nanoparticles Supported on Different Polymers
205(9)
6.3 Other Metal Nanoparticles Supported on Different Polymers
214(5)
6.4 Conclusions
219(4)
References
219(4)
7 Polymeric Nanoparticles in Targeting and Delivery of Drugs
223(33)
Sarita Rani
Ashok K. Sharma
Iliyas Khan
Avinash Gothwal
Sonam Chaudhary
Umesh Gupta
7.1 Introduction
224(2)
7.2 Methods of Preparation
226(7)
7.3 Physiochemical and Surface Properties
233(1)
7.4 Drug Loading and Drug Release of Nanoparticles
234(1)
7.5 Release Kinetics
235(3)
7.6 Polymeric Nanoparticles in Targeted Drug Delivery
238(3)
7.7 Clinical Application of Polymeric Nanoparticles
241(7)
7.8 Conclusion and Future Prospects
248(8)
Acknowledgment
249(1)
References
249(7)
8 Solid Lipid Nanoparticles for Targeting and Delivery of Drugs and Genes
256(31)
Rakesh K. Tekade
Rahul Maheshwari
Muktika Tekade
Mahavir B. Chougule
8.1 Introduction
257(2)
8.2 Morphology and Structure of Solid Lipid Nanoparticles
259(1)
8.3 Ingredients and Preparation of Solid Lipid Nanoparticles
260(5)
8.4 Production of Solid Lipid Nanoparticles-Based Hybrid Preparations
265(1)
8.5 Characterization of Solid Lipid Nanoparticles
265(1)
8.6 Limitations of Solid Lipid Nanoparticles and Approaches to Overcome
266(2)
8.7 Route of Administration, Biopharmaceutic and Pharmacokinetic of Solid Lipid Nanoparticles
268(2)
8.8 Medical Applications of Solid Lipid Nanoparticles
270(7)
8.9 Marketed Products and Patents
277(3)
8.10 Summary and Conclusion
280(7)
Acknowledgment
280(1)
References
281(6)
9 Lipid-Based Nanoparticles for Targeted Drug Delivery of Anticancer Drug
287(35)
Ranjita Shegokar
Rajani Athawale
Nalini Kurup
Rongbing Yang
Mahavir B. Chougule
9.1 Introduction
287(5)
9.2 Nanoparticles for Cancer Therapy
292(1)
9.3 Challenges in Delivery of a Promising Anticancer Agent---Paclitaxel
293(2)
9.4 Drug Delivery Carriers Based on Lipids (Solid and/or Liquid)
295(12)
9.5 Marketed Paclitaxel Products
307(6)
9.6 Conclusion
313(9)
Acknowledgment
314(1)
References
314(8)
10 Bioadhesive Polymers for Targeted Drug Delivery
322(41)
Lalit Kumar
Shivani Verma
Bhuvaneshwar Vaidya
Vivek Gupta
10.1 Introduction
323(1)
10.2 Mucus: A Basic Need for Physiological Functioning and Bioadhesion
324(1)
10.3 Theories of Bioadhesion
325(2)
10.4 Effect of Polymer Properties on Bioadhesion Process
327(2)
10.5 Bioadhesive Polymers Used for Delivery of Therapeutic Molecules
329(3)
10.6 Evaluation Parameters of Bioadhesive Polymer-Based Drug Delivery Systems
332(2)
10.7 Utility of Bioadhesive Polymers in Drug Delivery
334(22)
10.8 Conclusions
356(7)
References
356(7)
11 Dendrimers in Targeting and Delivery of Drugs
363(26)
Prashant Kesharwani
Mohd Cairul Iqbal Mohd Amin
Namita Giri
Ashay Jain
Virendra Gajbhiye
11.1 Introduction
364(1)
11.2 Properties of Dendrimers
364(5)
11.3 Synthesis of Dendrimers
369(2)
11.4 Types of Dendrimers
371(4)
11.5 Applications of Dendrimers
375(3)
11.6 Dendrimers in Targeted Drug Delivery
378(3)
11.7 Dendrimers as Imaging Agents
381(1)
11.8 Toxicity of Dendrimers
381(2)
11.9 Conclusion and Future Prognosis
383(6)
References
383(6)
12 Carbon Nanotubes in Targeting and Delivery of Drugs
389(38)
Rakesh K. Tekade
Rahul Maheshwari
Namrata Soni
Muktika Tekade
12.1 Introduction
390(1)
12.2 History
391(1)
12.3 Methods of Preparation
392(3)
12.4 Functionalization of CNTs
395(3)
12.5 Properties and Pharmacokinetics of CNTs
398(6)
12.6 Classification of CNTs
404(1)
12.7 Applications of CNTs in Drug Delivery
405(13)
12.8 Biosafety/Toxicity Profile of CNTs
418(2)
12.9 Regulatory Aspects
420(1)
12.10 Conclusion and Future Perspective
421(6)
References
422(5)
13 Quantum Dots in Targeted Delivery of Bioactives and Imaging
427(26)
Vijay Mishra
Ekta Gurnany
Mohammad H. Mansoori
13.1 Introduction
427(2)
13.2 Historical Background of Quantum Dots
429(1)
13.3 Design of Quantum Dots
429(1)
13.4 Properties of Quantum Dots
430(2)
13.5 Methods of Quantum Dots Fabrication
432(4)
13.6 Characterization Techniques of Quantum Dots
436(1)
13.7 Surface Engineering of Quantum Dots
436(1)
13.8 Quantum Dots Related Toxicity and Its Remedial Strategies
437(3)
13.9 Quantum Dots in Drug Delivery
440(2)
13.10 Quantum Dots in Drug Targeting
442(1)
13.11 Quantum Dots in Diagnostic Imaging
443(2)
13.12 Concluding Remarks and Future Perspectives
445(8)
References
446(7)
Section III Future Developments and Challenges in Nanomedicine
14 Toxicity Concerns of Nanocarriers
453(32)
Shima Tavakol
Vali Kiani
Behnaz Tavakol
Mohammad A. Derakhshan
Mohammad Taghi Joghataei
Seyed Mahdi Rezayat
14.1 Nanoemulsion
454(1)
14.2 Genotoxicity
454(2)
14.3 Hemocompatibility and Immunotoxicity in Micelles and Nanoemulsion
456(2)
14.4 Pulmonary Toxicity Considerations
458(1)
14.5 Cardiovascular Toxicity
458(1)
14.6 Liposome
459(1)
14.7 Cytotoxicity and Genotoxicity
459(1)
14.8 Hemocompatibility and Immunotoxicity of Liposomes
460(2)
14.9 Histocompatibility
462(1)
14.10 Solid Lipid Nanoparticles
462(2)
14.11 Preparation
464(1)
14.12 Solvent Emulsification--Diffusion
464(1)
14.13 Heated Microemulsion
465(1)
14.14 Characterization
465(1)
14.15 Proton Nuclear Magnetic Resonance
465(1)
14.16 Microscopy Techniques
465(1)
14.17 Toxic Effects of Solid Lipid Nanoparticles In Vivo
466(2)
14.18 Effect of the Size on the Cytotoxicity and Genotoxicity
468(1)
14.19 Comments and Future Perspectives
469(1)
14.20 Polymeric Nanoparticles
469(2)
14.21 Genotoxicity
471(1)
14.22 Hemocompatibility
471(1)
14.23 Poly (Ethylene Imine)
472(1)
14.24 Albumin Nanoparticles
473(2)
14.25 Nanofibers as Drug Delivery Systems
475(10)
References
476(9)
15 Microporation and Nanoporation for Effective Delivery of Drugs and Genes
485(30)
Bhupinder Singh
Rajneet K. Khurana
Atul Jain
Ripandeep Kaur
Rajendra Kumar
15.1 Introduction
485(1)
15.2 Microporation as an Upcoming Approach to Transfer Drug via Skin
486(1)
15.3 Microporator
487(8)
15.4 Other Techniques to Create Micropores
495(1)
15.5 Nanoporation
496(13)
15.6 Emerging and Future Prospects
509(6)
Acknowledgments
510(1)
References
510(5)
Index 515
Dr. Vijay Mishra, PhD, is a Professor at the School of Pharmaceutical Sciences, Lovely Professional University, Phagwara (Punjab), India. He earned his doctoral degree in Pharmaceutical Sciences from Dr. H.S. Gour Central University, Sagar (MP), India. He has 15+ years of academic and research experience. Dr. Mishra has authored more than 160 research and review articles in various peer-reviewed international journals of high repute, 25 book chapters, 9 books, 10 Indian patents (filed and published), 1 Australian and 1 Indian patent (granted) and 5 Indian Copyrights (Granted). He has an h-index 43 and 6400+ citations to his credit. He has been a recipient of several internationally acclaimed fellowships and awards including Graduate Research Fellowship (AICTE, New Delhi), UGC-BSR Senior Research Fellowship (UGC, New Delhi) and International Travel Award/Grant (DBT, New Delhi). He is a life member of Indian Science Congress Association, Kolkata, India. He serves as an Editorial Board Member of various peer-reviewed journals. Dr. Mishra has been selected as the Worlds Top 2% scientists in 2021, 2022, 2023, and 2024 as per Stanford University, USA report. His current research interests encompass nanomedicine, cancer, phytotherapeutics, dendrimers, carbon nanotubes, and novel drug delivery systems. Dr. Prashant Kesharwani is assistant professor of Pharmaceutics at Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India. He has more than 12 years of teaching, research, and industrial experience at international levels from various countries, including the United States, Malaysia, and India. An overarching goal of his current research is the development of nanoengineered drug delivery systems for various diseases. He has more than 350 international publications in well-reputed journals and more than 25 international books (Elsevier). He is a recipient of many research grants from various funding bodies. He is also the recipient of several internationally acclaimed awards, such as USERN Laureate award”, most prestigious SERB-Ramanujan Fellowship Award”. He actively participates in outreach and scientific dissemination for the service of the wider community. His Number of citations is = 26779; h-index = 85; i-10 index = 370 (According to google scholar on March 2025). He has more than 30 international publications published in very high impact factor journals (Progress in Polymer Sciences IF 32.063, Molecular Sciences IF 41.444, Progress in Material Sciences IF 48.580, Advanced Materials IF 29.4, Drug Resistance Update IF 22.841 and Material Todays IF 32.072). He has presented many invited talks and oral presentations at prestigious scientific peer-conferences, received international acclaims and awards for research contribution, supervised students/junior researchers and actively participated in outreach and scientific dissemination for the service of the wider community.

Dr. Mohd Cairul Iqbal Mohd Amin is a Professor of Pharmaceutics in the Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM) in Kuala Lumpur, Malaysia. He is the youngest professor appointed in the faculty and the only expert in the area of pharmaceutics in UKM. He earned his BSc (Hons) in Pharmacy in 1996 and PhD in 2001 both from the University of Manchester, United Kingdom. He is currently the Head of Drug Delivery and Novel Targeting Research Group in UKM. He also serves as panel expert in nanocellulose for drug delivery for the National Nanotechnology Centre, Ministry of Science, Technology and Innovation, Malaysia. His current research interests encompass responsive-hydrogel biomaterials for oral protein and peptide delivery, cell delivery in tissue engineering and nano drug delivery systems in particular polymeric micellar conjugates for cancer research. Dr. Amin has authored more than 60 publications in high impact factor journals, a number of book chapters, has five patents issued/pending and has routinely consulted in the area of drug delivery and pharmaceutical technology. He has wide expertise in biomaterials, nanomedicine, polymer chemistry, micro- and nanotargeting delivery systems as well as oral and transdermal formulations and delivery systems. Dr. Iyer is the Director of Use-inspired Biomaterials and Integrated Nano Delivery (U-BiND) Systems Laboratory and an Associate Professor with Tenure in the Department of Pharmaceutical Sciences at Wayne State University in Detroit, Michigan, USA. He also serves as a Scientific Member of the Molecular Imaging Program (MIP) at the Barbara Ann Karmanos Cancer Institute in Detroit, Michigan, USA. Dr. Iyer received his PhD in 2008, in Polymer Engineering, under the mentorship of world-renowned scientist and 2016 Nobel Prize in Chemistry Nominee, Prof. Hiroshi Maeda at Sojo University in Kumamoto, Japan. Dr. Iyer was the recipient of the Controlled Release Societys (CRS) T. Nagai Research Achievement Award in 2012. Dr. Iyer completed his postdoctoral training in Cancer Radiology at the University of California, San Francisco (UCSF) in California, USA. In 2018 Dr. Iyer received an Early Career Investigator Award from the US Department of Defense (DoD). Dr. Iyer has authored more than 100 publications in peer reviewed International Journals (H-index:45), and books of high repute. He has more than 200 scientific presentations and invited talks at International Conferences and Workshops. He has five patents issued/pending. His areas of research are broadly focused on designing use-inspired bio- and nano-medical technologies aimed towards clinical translation using biocompatible delivery systems that have enhanced disease targeting with reduced toxicity burden to patients. He has wide expertise in biomaterials and nanomedicine, polymer chemistry and formulation development, drug and gene delivery systems, molecular and functional imaging, micro and nanoparticles for treating diseases such as infection,cancerand age-related dementia. His laboratory is funded by agencies such as National Institutes of Health and the US Department of Defense.