| Preface |
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xvii | |
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1 Properties of Nanoparticulate Materials |
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1 | (38) |
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2 | (2) |
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1.2 Nanoparticulate Materials |
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4 | (1) |
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1.3 Common Characteristics of All Types of Nanoparticulate Materials |
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5 | (14) |
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5 | (1) |
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1.3.1.1 Specific surface area |
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5 | (1) |
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1.3.1.2 Melting point depression |
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6 | (1) |
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1.3.1.3 Solubility enhancement |
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7 | (1) |
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1.3.1.4 Reduced sintering temperature |
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8 | (1) |
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1.3.1.5 Thermodynamically metastable crystal structures |
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9 | (2) |
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1.3.1.6 Luminescent quenching |
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11 | (1) |
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1.3.1.7 Surface treatments |
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12 | (1) |
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1.3.2 Small Light-Scattering Power |
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13 | (1) |
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1.3.3 Phonon Confinement Effects |
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14 | (1) |
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1.3.4 Nanoparticle Suspension Systems |
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15 | (1) |
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1.3.4.1 Distance between particles |
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15 | (2) |
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1.3.4.2 Particle dispersion |
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17 | (1) |
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17 | (1) |
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18 | (1) |
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1.4 Characteristics of Specific Types of Nanoparticulate Materials |
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19 | (13) |
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1.4.1 Semiconductor Nanoparticles |
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20 | (2) |
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1.4.2 Metal Nanoparticles |
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22 | (2) |
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1.4.3 Carbon-Based Nanomaterials |
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24 | (1) |
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24 | (1) |
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25 | (1) |
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26 | (1) |
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1.4.4 Magnetic Nanomaterials |
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27 | (1) |
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1.4.4.1 Magnetic materials |
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27 | (2) |
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1.4.4.2 Finite size effect: single domain |
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29 | (1) |
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1.4.4.3 Finite size effect: superparamagnetism |
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30 | (1) |
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30 | (2) |
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32 | (7) |
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2 Applications and Market Opportunities of Nanoparticulate Materials |
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39 | (34) |
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39 | (2) |
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2.2 Nanotechnology Market |
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41 | (2) |
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2.3 Opportunities and Challenges |
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43 | (21) |
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44 | (1) |
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2.3.1.1 Energy production |
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44 | (1) |
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45 | (1) |
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2.3.1.3 Energy conservation |
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46 | (1) |
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2.3.1.4 Market for energy nanotechnology |
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47 | (2) |
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2.3.2 Medical, Personal Care and Pharmaceutical Sector |
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49 | (1) |
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2.3.2.1 Applications for medical nanotechnology |
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49 | (2) |
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2.3.2.2 Market for medical nanotechnology |
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51 | (2) |
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53 | (2) |
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55 | (2) |
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57 | (2) |
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2.3.6 Food and Agriculture Sectors |
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59 | (2) |
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2.3.7 Other Sectors Including Industrial Materials and Paints |
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61 | (3) |
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2.4 Nanoparticle Applications in Consumer Products |
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64 | (3) |
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67 | (6) |
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3 Production Techniques of Nanoparticles on a Laboratory Scale |
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73 | (66) |
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74 | (3) |
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3.2 Precipitation Methods |
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77 | (4) |
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3.3 Deposition-Precipitation (DP) Techniques |
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81 | (4) |
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85 | (7) |
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3.4.1 Aqueous Sol-Gel Method |
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86 | (2) |
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3.4.2 Non-Aqueous (or Non-Hydrolytic) Sol-Gel Method |
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88 | (4) |
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3.5 Microemulsion Techniques |
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92 | (6) |
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3.5.1 Oil-in-Water (O/W) Microemulsion Method |
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92 | (2) |
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3.5.2 Water-in-Oil (W/O) Microemulsion Method |
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94 | (3) |
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3.5.3 Water-in-scCO2 (W/scCO2) Microemulsion Method |
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97 | (1) |
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3.6 Hydrothermal and Solvothermal Methods |
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98 | (6) |
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3.6.1 Hydrothermal Method |
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98 | (4) |
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3.6.2 Solvothermal Method |
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102 | (2) |
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3.7 Microwave-Assisted Techniques |
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104 | (3) |
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107 | (3) |
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3.9 Liquid Feed Flame Spray Pyrolysis (LF-FSP) Methods |
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110 | (3) |
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3.10 Template-Directed Synthetic Techniques |
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113 | (3) |
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3.11 Mechanochemical Processing |
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116 | (2) |
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3.12 Ionic Liquid-Assisted Methods |
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118 | (2) |
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120 | (19) |
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4 Commercial-Scale Production of Nanoparticles |
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139 | (32) |
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139 | (1) |
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4.2 Methods Used in the Commercial-Scale Production of Nanoparticles |
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140 | (14) |
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4.2.1 Challenges in Production Scale-Up |
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140 | (2) |
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4.2.2 Inorganic Nanoparticles |
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142 | (1) |
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4.2.2.1 Mechanical grinding/milling (top-down) |
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143 | (1) |
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4.2.2.2 Vapour phase technique (bottom-up) |
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143 | (1) |
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4.2.2.3 Liquid-phase technique (bottom-up) |
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144 | (1) |
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4.2.2.4 Solid-phase technique; mechanochemical processing (bottom-up) |
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145 | (1) |
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4.2.2.5 Which methods and why? |
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146 | (2) |
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4.2.3 Carbon-Based Nanoparticles |
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148 | (1) |
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148 | (4) |
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152 | (1) |
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4.2.3.3 Diamond nanoparticles |
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153 | (1) |
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4.3 Effects of Production Methods on the Properties of Commercial Nanoparticles |
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154 | (10) |
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155 | (6) |
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161 | (3) |
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164 | (7) |
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5 The Commercialisation of Nanotechnology: The Five Critical Success Factors to a Nanotech-Enabled Whole Product |
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171 | (34) |
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172 | (4) |
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5.1.1 The Valley of Death |
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173 | (3) |
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5.2 Nanotechnology Commercialisation Critical Success Factors |
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176 | (24) |
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5.2.1 Product Orientation (and Not Technology Admiration) |
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176 | (1) |
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5.2.1.1 The need for focus on the single most commercially viable and attainable application |
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176 | (4) |
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5.2.1.2 The need to start with an exhaustive list of potential base markets and applications |
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180 | (4) |
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5.2.2 Continuous Market Interaction and Selection of a Beachhead Application |
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184 | (3) |
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5.2.3 Application of Spiral Product Development Methodology |
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187 | (4) |
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5.2.4 Attraction and Retention of Commercialisation Partners |
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191 | (7) |
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5.2.5 Mitigation of Nanotechnology-Specific Technology Risks |
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198 | (1) |
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5.2.5.1 Manufacturing methods and scale-up |
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198 | (1) |
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5.2.5.2 Quality control and specification tolerance of nanotechnology in the whole product |
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199 | (1) |
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5.2.5.3 Occupational and environmental health and safety |
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199 | (1) |
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200 | (5) |
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6 Overcoming Nanotechnology Commercialisation Challenges: Case Studies of Nanotechnology Ventures |
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205 | (34) |
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205 | (1) |
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206 | (17) |
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207 | (4) |
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6.2.2 NanoGram/NeoPhotonics Corp. |
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211 | (6) |
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6.2.3 Degussa Advanced Nanomaterials (AdNano) |
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217 | (6) |
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6.3 Analysis of Case Study Commercialisation Challenges |
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223 | (4) |
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6.4 Approaches to Nanotech Commercialisation Critical Success Factors |
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227 | (8) |
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6.4.1 Product Orientation (and Not Technology Admiration) |
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227 | (1) |
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6.4.2 Continuous Market Interaction and Selection of a Beachhead Application |
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228 | (2) |
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6.4.3 Application of Spiral Product Development Methodology |
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230 | (1) |
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6.4.4 Attraction and Maintenance of Commercialisation Partners |
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231 | (1) |
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6.4.5 Mitigation of Nanotechnology-Specific Technology Risks |
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232 | (2) |
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6.4.6 Licensing vs. Manufacturing Decision |
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234 | (1) |
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235 | (4) |
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7 Intellectual Property and Nanomaterials: Trend and Strategy |
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239 | (26) |
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239 | (1) |
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7.2 Background: Patent Application Trends within Each Strategic Priority Area in Japan |
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240 | (2) |
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7.3 Trend in Patent Applications in the Area of Nanotechnology |
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242 | (12) |
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242 | (4) |
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7.3.2 Trends in Nanotechnology Patents in the Four Largest Patent Organisations |
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246 | (1) |
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7.3.3 Trends in Nanotechnology Patent Application According to the Applicant's Nationality |
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247 | (2) |
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7.3.4 Number of Nanotechnology Patent Applications by Corporations, Universities and Public Research Organisations |
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249 | (3) |
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7.3.5 International Comparison of Nanotechnology-Related Patents in Nine Designated Technology Areas |
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252 | (2) |
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7.4 Examples of Applied Nanotechnology: Carbon Nanotube Technology |
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254 | (4) |
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7.4.1 Growth in the Patent Applications Related to CNT |
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254 | (1) |
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7.4.2 Level of the Maturity of CNT Technology from the Perspective of Patent Trends |
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255 | (3) |
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7.4.3 Trends in Patent Application Related to CNT, Based on the Type of Technological Fields |
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258 | (1) |
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7.5 Conclusion: Intellectual Property Strategy in the Field of Nanotechnology |
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258 | (5) |
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7.5.1 IP Strategy at the Stage of Basic Research |
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258 | (3) |
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7.5.2 IP Strategy at the Stage of Application Development |
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261 | (1) |
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7.5.3 Connecting Basic Research and Application Development |
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262 | (1) |
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263 | (2) |
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263 | (1) |
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263 | (2) |
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8 Government Regulation of Nanotechnologies |
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265 | (22) |
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266 | (1) |
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8.2 The World of Regulation: Unpacking Different Regulatory Models |
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267 | (4) |
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8.2.1 State-Based Regulation |
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268 | (1) |
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8.2.2 Civil-Based Regulation |
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269 | (1) |
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270 | (1) |
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8.3 Current Regulatory Frameworks and Their Effectiveness for Nanotechnologies |
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271 | (5) |
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8.4 Multi-Lateral and Multi-Party Initiatives |
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276 | (2) |
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8.5 Conclusion: Acknowledging the Elephant in the Room |
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278 | (9) |
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9 Metrology, Standards and Measurements Concerning Engineered Nanoparticles |
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287 | (44) |
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9.1 Metrology: The Science of Measurement |
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288 | (1) |
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289 | (12) |
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289 | (1) |
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9.2.2 Documentary Standards |
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290 | (5) |
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9.2.3 Reference Materials |
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295 | (2) |
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9.2.4 Nanoparticle Metrology |
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297 | (1) |
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9.2.4.1 Nanoparticle properties |
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297 | (2) |
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9.2.4.2 Nanoparticle size measurements |
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299 | (1) |
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9.2.5 Sampling and Dispersion |
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300 | (1) |
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9.3 Measurement Techniques for Nanoparticle Characterisation |
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301 | (1) |
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9.4 Selected Nanoparticle Size Measurement Techniques: Benefits and Limitations |
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302 | (21) |
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9.4.1 Dynamic Light Scattering |
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302 | (1) |
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302 | (1) |
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303 | (1) |
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304 | (1) |
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9.4.1.4 Instrument performance verification |
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304 | (1) |
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304 | (1) |
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304 | (1) |
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305 | (1) |
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306 | (1) |
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9.4.2.4 Instrument performance verification |
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306 | (1) |
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9.4.3 Small Angle X-Ray Scattering |
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306 | (1) |
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306 | (1) |
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306 | (1) |
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307 | (1) |
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9.4.3.4 Instrument performance verification |
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307 | (1) |
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9.4.4 Transmission Electron Microscopy |
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307 | (1) |
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307 | (1) |
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308 | (1) |
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308 | (1) |
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9.4.4.4 Instrument performance verification |
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309 | (1) |
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9.4.5 Scanning Electron Microscopy |
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309 | (1) |
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309 | (1) |
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310 | (1) |
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310 | (1) |
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9.4.5.4 Instrument performance verification |
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311 | (1) |
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9.4.6 Atomic Force Microscopy |
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311 | (1) |
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311 | (1) |
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312 | (1) |
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312 | (2) |
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9.4.6.4 Instrument performance verification |
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314 | (1) |
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9.4.7 Particle-Tracking Analysis |
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314 | (1) |
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314 | (2) |
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316 | (1) |
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316 | (1) |
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9.4.7.4 Instrument performance verification |
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316 | (1) |
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9.4.8 Differential Centrifugal Sedimentation |
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317 | (1) |
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317 | (1) |
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318 | (1) |
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319 | (1) |
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9.4.8.4 Instrument performance verification |
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319 | (1) |
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9.4.9 Field Flow Fractionation |
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320 | (1) |
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320 | (2) |
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322 | (1) |
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322 | (1) |
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9.4.9.4 Instrument performance verification |
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322 | (1) |
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323 | (8) |
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10 Safety of Engineered Nanomaterials and OH&S Issues for Commercial-Scale Production |
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331 | (50) |
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331 | (1) |
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10.2 Overview of Nanotoxicology |
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332 | (23) |
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10.2.1 Toxic Potential of Nanoparticles |
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333 | (2) |
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10.2.2 Toxicokinetic Characteristics of Nanoparticles |
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335 | (1) |
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335 | (2) |
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337 | (1) |
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337 | (1) |
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337 | (1) |
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10.2.3 Mechanisms of Nanoparticle Toxicity in Biological Systems |
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337 | (1) |
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10.2.3.1 Particle uptake pathways in cells |
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338 | (1) |
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10.2.3.2 Protein corona effects |
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339 | (2) |
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10.2.4 Summary of Nanoparticle Bioactivity |
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341 | (1) |
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10.2.4.1 Nanoparticle size, and surface area, charge and chemistry effects |
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341 | (1) |
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10.2.4.2 Nanoparticle shape and form effects |
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342 | (1) |
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10.2.4.3 Nanoparticle effects on target cells |
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342 | (1) |
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10.2.4.4 Contaminant effects |
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343 | (1) |
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10.2.4.5 Neurotoxicity potential of nanoparticles |
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343 | (1) |
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10.2.4.6 Immunotoxic potential of nanoparticles |
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344 | (1) |
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10.2.5 Potential Biomarkers of NP Exposure |
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345 | (1) |
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10.2.6 Toxicology of Specific Inorganic Engineered Nanomaterials |
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346 | (1) |
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10.2.6.1 Nano titanium dioxide |
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346 | (2) |
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10.2.6.2 Nano cerium dioxide |
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348 | (1) |
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348 | (2) |
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350 | (1) |
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351 | (1) |
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352 | (1) |
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353 | (1) |
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10.2.7 Latest Initiatives in Nanosafety Research |
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353 | (2) |
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10.3 Overview of Occupational Health and Safety Issues and Workplace Controls |
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355 | (26) |
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10.3.1 Occupational Health and Safety Issues Relating to Engineered Nanomaterials |
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355 | (2) |
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10.3.2 Nanomaterial Health Risk Assessment |
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357 | (3) |
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10.3.3 Hierarchy of Workplace Controls for Handling Nanomaterials |
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360 | (1) |
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10.3.3.1 Elimination controls |
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361 | (1) |
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10.3.3.2 Substitution and modification controls |
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361 | (3) |
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10.3.3.3 Enclosure controls |
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364 | (1) |
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10.3.3.4 Extraction controls |
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364 | (2) |
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10.3.3.5 Administrative controls |
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366 | (1) |
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10.3.3.6 Personal protective equipment |
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367 | (1) |
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10.3.4 Risk Management and Control Banding |
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368 | (13) |
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11 Managing Nanowaste: Concepts and Challenges for Nanomanufacturers |
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381 | (24) |
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381 | (1) |
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11.2 Conceptualising Nanowaste |
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382 | (4) |
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383 | (3) |
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386 | (2) |
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11.3.1 Indicators and Parameters |
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387 | (1) |
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11.3.2 Monitoring and Reporting |
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387 | (1) |
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388 | (4) |
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11.4.1 Corporate Nanowaste Management Policy |
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389 | (1) |
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11.4.2 Disclosure and Transparency |
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390 | (1) |
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11.4.3 Contract Nanowaste Management Services |
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391 | (1) |
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11.5 Nanowaste Risk Management |
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392 | (4) |
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11.5.1 Legal and Regulatory Drivers |
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392 | (1) |
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11.5.2 Risk Assessment Techniques |
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393 | (1) |
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11.5.3 Common Exposure Scenarios |
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394 | (1) |
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11.5.4 Corporate Social Responsibility |
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395 | (1) |
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11.5.5 Extended Producer Responsibility |
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395 | (1) |
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396 | (3) |
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11.6.1 Routine Nanowaste Handling |
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397 | (1) |
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11.6.2 Contingency Response |
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397 | (1) |
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11.6.3 Nanowaste Containment, Storage and Treatment |
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398 | (1) |
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399 | (6) |
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405 | (44) |
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405 | (3) |
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12.2 Nanotechnology in Society |
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408 | (2) |
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12.3 So What Does Good Engagement Look Like? |
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410 | (1) |
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12.4 Obstacles to Good Engagement |
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411 | (2) |
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12.5 A Short History of Public Engagement |
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413 | (1) |
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414 | (4) |
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12.7 Understanding NGOs and Affected Publics |
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418 | (1) |
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12.8 Public Attitude Research |
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419 | (3) |
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12.9 Engaging the Unengaged |
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422 | (8) |
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12.10 Public Perception Barriers to Good Engagement |
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430 | (1) |
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12.11 Examples of Engagement |
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430 | (10) |
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12.12 Public Engagement Models for the Future |
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440 | (2) |
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12.13 Online Communities and Online Community Engagement |
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442 | (1) |
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12.14 Areas for More Work |
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443 | (1) |
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12.15 So What Does It All Mean? |
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444 | (5) |
| Index |
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449 | |