Increasing evidence indicates the role of natural killer (NK) cells in resistance to tumors and infections as well as in production of cytokines and regulation of hematopoiesis. Moreover, NK cells have been shown to be the major effector cells among interleukin-2 (IL-2) activated lymphocytes, mediating cytotoxic effect against many types of human tumors. Thus, NK cells may be responsible for therapeutic effects observed in cancer patients after adoptive therapy with IL-2 activated lymphocytes. This volume summarizes the known aspects of NK cell anticancer responses, providing state-of-the-art information in the field of NK cell-cancer cell interactions, activation, and oncolytic signaling. Annotation copyright Book News, Inc. Portland, Or.
This volume provides a state-of-the-art survey of developments in the field of NK cell-cancer cell interactions, activation, and oncolytic signaling
This volume provides a state-of-the-art survey of developments in the field of NK cell-cancer cell interactions, activation, and oncolytic signaling. Specific topics discussed include NK cell receptors and adhesion molecules, signal transduction and activation, and mechanisms of cytotoxicity. The book will be an excellent learning tool and reference resource for scientists, clinicians, and students.
NK CELL RECEPTORS AND ADHESION MOLECULES. Molecular Cloning of Human and
Murine Natural Killer Cell Tumor Recognition Proteins (Stephen K. Anderson).
Structure and Function of the CD16:z:g NK Receptor Complex (Paul Anderson and
Eric Viver). Molecular Characterization of a Novel NK Cell Signal
Transduction Molecule: NKR-P1 (Roberto Giorda, Edward P. Weisberg, Edward P.
Tagge, and Massimo M. Trucco). Modulation of Function-Associated Molecules on
Natural Killer Cells Alters Recognition and Cytotoxicity (David T. Harris,
Liliana Jaso-Friedmann, and Donald L. Evans). Bright Phenotype of Adhesion
Molecules on Lymphocytes with High Oncolytic Function (Eva Lotzová and C.A.
Savary). Human NK Cell Adhesion Molecules (CAMs) (Daniela Zarcone,
Giannamaria Cerruti, Claudya Tenca, Giuseppe Arancia, Walter Malorni,
Francesca Iosi, and Carlo E. Grossi). Fibronectin Receptors on NK Cells
(Angela Santoni, Angela Gismondi, Gabriella Palmieri, Stefania Morrone,
Fabrizio Mainiero, Giorgio Santoni, Martin J. Humphries, Mario Piccoli, and
Luigi Frati). Function of the Fibronectin Receptor on Human NK Cells (Eero
Saksela, Kristina Somersalo, Tamas Magyarlaki, and Ismo Virtanen).
Interaction of Human Natural Killer Cells with the Vascular Endothelium:
Characterization of Their Migratory Ability and Adhesive Molecules (Paola
Allavena, GianCarlo Bianchi, Carla Paganin, Ines Martin-Padura, Barbara
Bottazzi, Miranda Apiranthitou Drogari, Mirella Gaboli, PierCarlo Marchisio,
and Alberto Mantovani). SIGNAL TRANSDUCTION AND ACTIVATION. Signal
Transduction Mechanisms in NK Cell Cytotoxicity (Zacharie Brahmi). Signal
Transduction During NK Cell Activation (Paul J. Leibson). Shared Structural
and Functional Motifs for Signal Transduction in T Lymphocytes and Natural
Killer Cells (Ian C. S. Kennedy, John R. Ortaldo, and John J. O'Shea).
Characterization and Functional Significance of NKR-P1 (3.2.3 Antigen): A
Novel Triggering Molecule (William H. Chambers, Albert B. DeLeo, Nikola L.
Vujanovic, Ronald
Eva Lotzova
Lisainfo e-raamatute kohta