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E-raamat: Novel Therapeutic Approaches Targeting Oxidative Stress

Edited by (Assistant Professor, School of Biotechnology, Gautam Buddha University, Greater Noida, Gautam Buddha Nagar, Uttar Pradesh, India), Edited by (Central University of Haryana, Mahendergarh (Haryana), India)
  • Formaat: EPUB+DRM
  • Ilmumisaeg: 18-Feb-2022
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780323909068
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Novel Therapeutic Approaches Targeting Oxidative StressSuurem pilt
  • Formaat: EPUB+DRM
  • Ilmumisaeg: 18-Feb-2022
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780323909068
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Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored.

The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives.

  • Explores oxidative stress in a variety of diseases, including neurological disorders, cardiovascular diseases, age-related diseases, and cancer
  • Covers a range of therapeutic approaches to target oxidative stress
  • Includes chapters on the application of novel drug delivery systems and diagnostic biosensors to oxidative stress
  • Features case studies illustrating the targeting of oxidative stress
Contributors xi
Preface xiii
Acknowledgments xv
1 Novel therapeutic approaches targeting oxidative stress in mood disorders
Alexander Bambokian
Fabiano A. Gomes
Calvin Sjaarda
Claudio N. Soares
Roumen Milev
Elisa Brietzke
1 Introduction
1(2)
2 The production of ROS in the brain
3(1)
3 The elimination of ROS in the brain
4(2)
4 Oxidative stress in the brain
6(1)
5 Markers of oxidative stress and mood disorders
7(1)
6 Antioxidant treatments in mood disorders
8(4)
7 Conclusions
12(7)
References
13(6)
2 Ferroptosis: Oxidative stress and pathophysiology
Haseeb Ahsan
Mohammad Yusuf Hasan
Rizwan Ahmad
1 Introduction
19(3)
2 Immunology
22(1)
3 Conclusion
23(4)
Acknowledgment
24(1)
References
24(3)
3 Oxidative stress and its biological significance
Mari Uyeda
1 Introduction
27(1)
2 Oxidative stress in 4-hydroxynonenal (HNE) leading to apoptosis
28(1)
3 Antioxidant supplementation increasing tumorigenesis
29(1)
4 Regulation of the cell cycle in the oxidative state
30(1)
5 Viral infections and oxidative stress
31(1)
6 Epigenetic factors and carcinogenesis
31(1)
7 Extracellular superoxide angles and apoptosis
32(11)
8 Extreme oxidative stress with T cells
43(1)
9 Oxidative stress in lung cancer
43(1)
10 Inflammation and lung cancer
44(14)
11 Oxidative stress in breast cancer
58(6)
12 Response to therapy
64(13)
References
67(10)
4 Novel therapeutic approaches targeting oxidative stress in aging
Akshay Kumar
Pawan Kumar Maurya
1 Introduction
77(1)
2 Hallmarks of aging
78(1)
3 Causes of aging
78(1)
4 Age-associated diseases
79(3)
5 Novel therapeutic approaches
82(3)
6 Liposomes
85(3)
7 Conclusion
88(5)
References
88(5)
5 Novel therapeutic approaches targeting oxidative stress in neurodegenerative diseases
Somu Yadav
Akshay Kumar
Deepika
Pawan Kumar Maurya
1 Introduction
93(1)
2 Dimensions of aging in the investigation of neurodegeneration
94(11)
3 Clinical implications
105(7)
4 Implications for research
112(7)
Acknowledgment
112(1)
References
112(7)
6 The role of oxidative stress in kidney diseases
Vikas Saini
1 Introduction
119(1)
2 Kidney architecture at the cellular level
120(2)
3 Nephrotoxicity and renal pathology
122(1)
4 Classification of kidney diseases
123(1)
5 The chemical species of oxidative stress
124(2)
6 Cellular antioxidant defense system
126(1)
7 Sources of ROS in the kidneys
127(1)
8 Reactive oxygen species and kidney diseases
128(1)
9 Oxidative stress in the renal tubules
129(4)
10 Oxidative stress in the glomerulus
133(1)
11 Oxidative stress in the renal vasculature
133(2)
12 Role of ROS in ischemia and reperfusion (I/R)-induced acute kidney injury
135(8)
References
135(8)
7 The role of oxidative stress and antioxidants across the spectrum of acute coronary syndrome
Wahid All
Neha Srivastava
Priyanka Sharma
1 Introduction
143(1)
2 Oxidative stress
144(1)
3 Endothelial dysfunction and oxidative stress
145(1)
4 Molecular effects of oxidative stress
145(1)
5 Oxidative stress in coronary artery disease
146(1)
6 Coronary microvascular dysfunction
147(1)
7 Oxidative stress and lipids, protein, and DNA damage
147(1)
8 Therapies for oxidative stress-associated cardiovascular diseases
148(4)
9 Conclusions
152(3)
References
152(3)
8 Biosensors in the detection of oxidative stress using discovered biomarkers
Swaraj Mohanty
Yasmin Ahmad
1 Introduction
155(1)
2 Biosensors
156(4)
3 Biomarkers
160(2)
4 Overview of discovered biomarkers for oxidative stress
162(1)
5 Management of oxidative stress conditions
163(2)
6 Research trends and future challenges in development of biosensors
165(1)
7 Conclusion
166(5)
Acknowledgments
166(1)
References
166(5)
9 Biochemical approaches/methods in the detection of free radicals
Imteyaz Qamar
Uditi
1 Introduction
171(1)
2 In vitro methods
172(1)
3 Chemiluminescence-derived methods using luciferine derivatives
173(3)
4 Reduction of cytochrome c
176(1)
5 NBT tests
177(1)
6 Aconitase inactivation
177(1)
7 Boronates
178(1)
8 In vivo methods
179(1)
9 Redox potential of the GSH/GSSG couple
179(1)
10 Measurement of F2-isoprostanes as indicators of lipid peroxidation
180(1)
11 Reporter assays
180(1)
12 Fluorescent protein-based methods
181(2)
13 Analytical methods
183(1)
14 Fluorescence-dependent methods
184(1)
15 Electron spin resonance (ESR) or electron paramagnetic resonance (EPR) spectroscopy
185(1)
16 Spin trapping technique
186(1)
17 Immuno-spin trapping of macromolecules
186(2)
18 Combined 1ST and mMRI detection
188(1)
19 Pulse radiolysis
188(2)
20 Chromatography-based techniques
190(1)
21 Other biochemical methods
191(2)
22 Summary
193(7)
References
193(7)
10 Novel therapeutic approaches targeting oxidative stress in breast and lung cancer
Pooja Kaushik
Medha Kaushik
Suhel Parvez
1 Introduction
200(1)
2 Epidemiology and risk factors
201(8)
3 Role of oxidative stress in cancer pathophysiology
209(4)
4 Classification of breast and lung cancer
213(5)
5 Conventional therapies for cancer treatment
218(14)
6 Novel approaches for cancer therapeutics
232(8)
7 Therapeutic approaches targeting oxidative stress in cancer
240(5)
8 Conclusion
245(1)
9 Future perspective
245(6)
Acknowledgments
246(1)
References
246(5)
11 Advancements in novel drug delivery systems: Providing a challenge and threat to oxidative stress in various diseases
Sumira Malik
Shilpa Prasad
Archna Dhasmana
1 Introduction
251(2)
2 Antioxidants working principle and pathways
253(2)
3 Types of antioxidants and their mode of action
255(3)
4 Traditional approaches
258(1)
5 Innovative approaches in nano delivery of natural and synthetic antioxidants
259(1)
6 Limitations and future perspectives of novel drug delivery systems at clinical translation level
260(3)
7 Summary
263
References
264(2)
Further reading
266
Prof. Pawan Kumar Maurya is Dean, School of Life Long Learning & Head of Department of Biochemistry, Central University of Haryana, India. He has done a PhD from the University of Allahabad (A Central University), India & post-doctoral training from Universidade Federal de Sao Paulo-UNIFESP, Brazil; Taipei Medical University (TMU) and National Taiwan University (NTU), Taiwan. He has more than 14 years of teaching and research experience. He is working on biochemical diagnostics, nanomedicine, and clinical biochemistry. He has published over 75 research articles in reputed journals. He has also edited of six books published from Elsevier, USA and Springer-Nature, Singapore. He is recipient of prestigious fellowships: Science without Borders (Government of Brazil) and National Science Council, Taiwan. Dr. Imteyaz Qamar is working as an assistant professor at School of biotechnology, Gautam Buddha University, Greater Noida, India. His area on interest is Stress biology, and Cancer Genetics

He earned his Ph.D. in Molecular Endocrinology from Chonnam National University, South Korea with an emphasis on gene regulation and physiological function of an androgen receptor corepressor-19kD using mice model. He has written various manuscripts, grants, progress reports, pre-IND protocols, animal protocols and published in well reputed international journals. He has also received various awards such as Brain Korea-21 Best Research presenter award 2007, Bharath Vikas award 2016, Young Scientist Award 2017 & 2019, STE meritorious award 2019 etc. He serves as a member of editorial boards of various peer reviewed journals. He is also a member of the endocrinology society, United States of America (USA).
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