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E-raamat: Nutrition and Skeletal Muscle

Edited by (Professor in Biochemistry, Molecular Biology and Nutrition, Clermont-Auvergne University, Clermont-Ferrand University Hospital)
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  • Ilmumisaeg: 24-Oct-2018
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128104101
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  • Formaat: PDF+DRM
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  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128104101
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Nutrition and Skeletal Muscle provides coverage of the evidence of dietary components that have proven beneficial for bettering adverse changes in skeletal muscle from disuse and aging. Skeletal muscle is the largest tissue in the body, providing elements of contraction and locomotion and acting as an important contributor to whole body protein and amino metabolism, glucose disposal and lipid metabolism. However, muscle loss, atrophy or weakness can occur when there are metabolic imbalances, disuse or aging. This book addresses the topic by providing insight and research from international leaders, making it the go-to reference for those in skeletal muscle physiology.

  • Provides an understanding of the crucial role of skeletal muscle in global metabolic homeostasis regulation
  • Delivers the information needed to understand the utilization of crucial supplements for the preservation of skeletal muscle
  • Presents insights on research from international leaders in the field
List of Contributors xi
Part I General Aspects: Skeletal Muscle Physiology And Nutrition
1 Skeletal Muscle Mass Indices in Healthy Adults
Heliodoro Aleman-Mateo
Roxana E. Ruiz Valenzuela
Introduction
3(1)
The Biological Bases That Underlie the Indices
4(2)
Different Skeletal Muscle Indices Generated Worldwide
6(4)
Clinical Implications of the Indiscriminate Use of Different Published Indices
10(2)
Conclusions
12(1)
References
12(6)
2 Reduced Skeletal Muscle Mass and Lifestyle
David Scott
Physical Activity
18(1)
Nutrition
19(3)
Combining Physical Activity and Nutrition
22(3)
Smoking, Alcohol Use and Socioeconomic Status
25(1)
Conclusions
26(2)
References
28(8)
3 Molecular Mechanisms of Postmeal Regulation of Muscle Anabolism
Olivier Le Bacquer
Cellular Processes Under mTORC1
36(2)
Upstream mTOR Signaling
38(2)
Conclusion
40(1)
References
40(8)
4 Adaptation of Skeletal Muscle Mass and Metabolism to Physical Exercise
Xavier Bigard
The Muscular Adaptation to Endurance Training
48(5)
The Muscular Adaptation to Resistance Training (RT)
53(4)
The Specific Responses to Concurrent Training
57(2)
References
59(8)
Part II Pathophysiology Of Skeletal Muscle: The Important Role Of Diet And Nutrients
Section 1: Ageing and Sarcopenia
5 The Role of Specific Nutriments in Sarcopenia Associated With Chronic Diseases: A Focus on Cancer
Sami Antoun
Sarcopenia in Chronic Diseases
67(1)
Impact of Sarcopenia on Disease Outcomes in the Chronic Setting
68(2)
Muscle Anabolism in Cancer Patients
70(1)
The Role of Total and Specific Amino Acids in Promoting Muscle Anabolism in Cancer
71(5)
Role of Total and Specific Amino Acids in Promoting Muscle Anabolism in Chronic Disease Other Than Cancer
76(1)
Role of Omega-3 Fatty Acid Supplementation in Promoting Muscle Anabolism in Cancer Patients
77(1)
Conclusion
78(1)
References
78(4)
Further Reading
82(1)
6 Sarcopenic Obesity
Andrea P. Rossi
Sofia Rubele
Mauro Zamboni
Introduction
83(1)
Sarcopenic Obesity (SO) Definition
83(2)
Pathogenesis of SO
85(1)
Clinical implications of SO
86(1)
Clinical implications of DAO
87(1)
Treatment
88(1)
Conclusion
89(1)
References
90(2)
Further Reading
92(1)
7 Effects of Sarcopenic Obesity on Cardiovascular Disease and All-Cause Mortality
Janice L. Atkins
Introduction
93(1)
Defining Sarcopenic Obesity
94(1)
Sarcopenic Obesity and Cardiovascular Risk Factors in Older Age
95(1)
Sarcopenic Obesity and Cardiovascular Disease in Older Age
96(1)
Sarcopenic Obesity and All-Cause Mortality in Older Age
96(5)
Conclusions
101(1)
References
101(7)
Section 2: Obesity, High Fat, and Overfeeding
8 Skeletal Muscle in Obesity and Chronic Overfeeding
Christelle Guillet
Muscle Strength
108(1)
Muscle Mass
109(1)
Skeletal Muscle Protein Metabolism and Obesity
109(2)
Muscle Typology
111(1)
Conclusion
112(1)
References
112(5)
9 Skeletal Muscle Mitochondrial, Obesity, and High-Fat Feeding
Christelle Guillet
Introduction
117(1)
Mitochondrial Content
118(1)
Muscle Oxidative Capacities
118(2)
Factors Involved in Mitochondria Dysfunction
120(1)
Conclusion
121(1)
References
121(4)
10 Muscle Immune Cells, Obesity, and High-Fat Feeding
Carla Domingues-Faria
Nicolas Goncalves-Mendes
Marie-Chantal Farges
Introduction
125(1)
Obesity, High-Fat Feeding, Muscle Immune Cell Infiltration, and Activation
125(3)
Obesity, High-Fat Feeding, and Muscle Regeneration Capacity
128(4)
Conclusion
132(1)
References
132(7)
Section 3: Physical Exercise
11 Physiological Regulation of Skeletal Muscle Mass: Resistance Exercise-Mediated Muscle Hypertrophy
Joaquin Perez-Schindler
Christoph Hantwhin
Introduction
139(1)
Resistance Exercise and Protein Synthesis
140(3)
Resistance Exercise and Ribosomal Biogenesis
143(2)
Resistance Exercise and Satellite Cells
145(1)
Conclusions and Outlook
146(1)
Key Points
147(1)
Acknowledgments
147(1)
References
147(4)
12 Training, Changes in Nutritional Requirements and Dietary Support of Physical Exercise
Irene Margaritis
Introduction Into the Role of Nutrition on Adaptive Effects of Exercise
151(1)
Acute and Chronic Exercise: Stress and Adaptation
152(5)
Energetic Macronutrients
157(8)
Does Exercise-Related Requirement Justify Micronutrient Supplement Use?
165(7)
Health Claims and the "Beneficial" Expected Effects
172(2)
Discussion
174(3)
Conclusion and Key Messages
177(1)
References
177(6)
13 Proteins and Amino Acids and Physical Exercise
Stephen D. Patterson
Mark Waldron
Owen Jeffries
Introduction
183(1)
Sources of Protein Intake
184(1)
Protein Requirements
184(1)
Endurance Exercise Performance
184(3)
Resistance Exercise Performance
187(2)
Recovery From Exercise
189(3)
References
192(5)
14 Physical Exercise in Chronic Diseases
Bente K. Pedersen
Introduction
197(1)
Methods
197(1)
Metabolic Diseases
198(12)
Cardiovascular and Pulmonary Diseases
210(19)
Perspective
229(1)
Acknowledgment
229(1)
References
229(22)
Part III Nutrition As A Therapeutical Tool For Skeletal Muscle
Section 4: Amino Acid Supplements
15 Whey Protein and Muscle Protection
Yves Boirie
Skeletal Muscle Loss and Protein Nutrition
251(2)
Interest of "Fast" Proteins for Muscle Anabolic Response
253(3)
Conclusion
256(1)
References
256(7)
16 Branched-Chain Amino Acids (Leucine, Isoleucine, and Valine) and Skeletal Muscle
Stefan H.M. Gorissen
Stuart M. Phillips
List of Abbreviations
263(1)
Introduction
263(2)
BCAA Requirement and Tolerable Upper Intake Level
265(1)
Catabolism of BCAAs
266(1)
mTOR Signaling and Muscle Protein Synthesis
267(3)
Acute Effects of BCAA Intake on Muscle Protein Synthesis
270(1)
The Leucine Content of Dietary Protein: A Determinant of the Anabolic Potential?
271(1)
Chronic Effects of BCAA Supplementation and Muscle Growth
272(2)
BCAAs and Insulin Resistance
274(1)
Key Facts
275(1)
Summary Points
275(1)
Acknowledgments
275(1)
References
276(3)
17 Glutamine and Skeletal Muscle
Vinicius F. Cruzat
An Introduction to Glutamine Metabolic Biochemistry
279(1)
Glutamine Metabolic Biochemistry in Skeletal Muscles
280(4)
Glutamine Nutritional Properties in Skeletal Muscles
284(4)
Important Considerations of Glutamine Supplementation
288(2)
Conclusion
290(1)
References
290(5)
18 Arginine and Skeletal Muscle
Jean-Pascal De Bandt
List of Abbreviations
295(1)
Arginine Metabolism
296(2)
Arginine and Muscle Creatine
298(1)
Arginine and Endothelial Function
299(1)
Arginine and Muscle Protein Homeostasis
299(3)
Arginine and Muscle Function
302(1)
Arginine and Tissue Healing
303(1)
Arginine and Muscle Protein Homeostasis in Acute Injury
304(1)
Conclusion
305(1)
References
305(7)
19 Citrulline and Skeletal Muscle
Charlotte Breuillard
Arthur Goron
Christophe Moinard
Conclusion
312(1)
References
313(2)
20 Sulfur Amino Acids and Skeletal Muscle
Isabelle Papet
Didier Remond
Dominique Dardevet
Laurent Mosoni
Sergio Polakof
Marie-Agnes Peyron
Isabelle Savary-Auzeloux
General Biochemical Aspects on Sulfur Amino Acids
315(9)
Sulfur Amino Acids and Related Compounds in Skeletal Muscle
324(8)
Sulfur Amino Acids Requirements and Supplementations
332(4)
References
336(11)
Section 5: Dietary Lipids
21 Regulation of Skeletal Muscle Metabolism by Saturated and Monounsaturated Fatty Acids
Cedric Moro
Frederic Capel
Introduction
347(2)
Mechanisms of Action of SFA and MUFA in Skeletal Muscle
349(5)
Lifestyle Interventions to Alleviate SFA-Mediated Lipotoxicity in Skeletal Muscle
354(1)
Conclusions
354(1)
References
355(4)
22 Polyunsaturated Omega-3 Fatty Acids and Skeletal Muscle
Gordon I. Smith
List of Abbreviations
359(1)
Introduction
359(1)
What Are Polyunsaturated Omega-3 Fatty Acids?
359(2)
Regulation of Muscle Mass
361(1)
Effect of Omega-3 Fatty Acids on Muscle Protein Turnover
362(2)
Muscle Mass and Volume
364(2)
Strength and Physical Function
366(1)
Conclusions
367(1)
Acknowledgments
367(1)
References
367(8)
Section 6: Vitamin D
23 Vitamin D Signaling and Skeletal Muscle Cells
Carla Domingues-Faria
Stephane Walrand
Introduction
375(1)
Vitamin D and Skeletal Muscle Function
376(2)
Vitamin D and Skeletal Muscle Morphology
378(1)
Vitamin D Status and Skeletal Muscle Development and Regeneration
379(2)
Effect of Vitamin D on Skeletal Muscle Cell Signaling
381(2)
Genetic Contribution to Vitamin D Effects
383(1)
The Complex Action of Vitamin D
383(1)
Conclusion
384(1)
References
384(5)
24 Vitamin D Deficiency and Myopathy
Christian M. Girgis
Introduction
389(1)
Vitamin D
389(1)
Muscle Weakness and Vitamin D Deficiency
390(1)
Muscle Pain and Vitamin D Deficiency
391(1)
Vitamin D and Physical Performance Measures
392(1)
Falls and Vitamin D Deficiency
393(1)
Conclusions
394(1)
References
395(6)
Section 7: Nutraceuticals and Phytochemicals
25 Phytochemicals, Their Intestinal Metabolites, and Skeletal Muscle Function
Kazumi Yagasaki
List of Abbreviations
401(1)
Introduction
401(1)
Cultured Skeletal Muscle Cells and Incubated Muscle Tissues as Useful Bioassay Systems to Search for Novel Bioactive Factors
402(1)
Glucose Uptake Assay in Cultured L6 Myotubes for Initial Screening of Novel Phytochemicals
403(2)
Phytochemicals, Glucose Metabolism in Skeletal Muscle Cells and Their Effects on T2D Model Animals
405(8)
Plant Hormones and Muscle Function
413(1)
Direct Molecular Target of Phytochemicals that Activate AMPK
414(1)
Bromacology: Pharmacology of Food and Their Components
414(1)
Acknowledgments
414(1)
References
415(4)
26 Antioxidants and Polyphenols Mediate Mitochondrial Mediated Muscle Death Signaling in Sarcopenia
Stephen E. Alway
List of Abbreviations
419(1)
Introduction
420(1)
Mitochondrial Function in Aging Muscles and Motor Neurons
421(2)
Potential Sources of Mitochondrial Dysfunction in Aging
423(2)
PGC-LCS Regulation of Mitochondria in Sarcopenia
425(2)
Mitochondria are Initiators of Cell Death Signaling in Aging Muscles
427(3)
Autophagy
430(4)
Linking Autophagy and Apoptosis
434(1)
Ubiquitin Proteasome System
435(2)
Mitochondria, Mitophagy, and the Ubiquitin Proteasome System (UPS)
437(1)
Localized Apoptotic Signaling Spreads to Remove the Entire Fiber in Sarcopenia
438(2)
Potential for Nutritional Strategies to Reverse Mitochondrial Death Signaling
440(19)
Conclusions
459(2)
References
461(14)
27 β-Conglycinin and Skeletal Muscle
Satoshi Wanezaki
Nobuhiko Tachibana
List of Abbreviations
475(1)
Introduction
475(1)
Effects of β-Conglycinin on Lowering of Blood Triglycerides
476(1)
Promotion of Adiponectin Production
476(1)
β-Conglycinin Influence Glucose Metabolism in Skeletal Muscle
477(1)
Peptides Derived from β-Conglycinin Modulate GLUT4 Translocation
478(1)
A Novel Protein Similar to β-Conglycinin: Mung Bean Protein
478(1)
Conclusions
479(3)
References
482(3)
28 Effects of Quercetin on Mitochondriogenesis in Skeletal Muscle: Consequences for Physical Endurance and Glycemic Control
Alfredo Fernandez-Quintela
Inakiaki Milton-Laskibar
Leixuri Aguirre
Saioa Gomez-Zorita
Marcela Gonzalez
Maria P. Portillo
List of Abbreviations
485(1)
Introduction
486(2)
Quercetin and Physical Endurance
488(3)
Quercetin and Glucose Tolerance
491(4)
Concluding Remarks
495(1)
Acknowledgments
495(1)
References
495
Part IV Adverse Effects Due To Drugs And Alcohol
29 Statins and Muscle Damage
Matthew J. Sorrentino
Scope of the Problem
499(1)
Definition of Muscle Toxicity
499(1)
Myalgias
500(2)
Myopathy
502(1)
Myositis and Myonecrosis
502(1)
Rhabdomyositis
502(1)
Autoimmune-Mediated Necrotizing Myositis
503(1)
Risk Factors for Muscle Toxicity
504(1)
Mechanism of Muscle Toxicity
504(1)
Management
505(1)
Conclusions
506(1)
References
506(3)
30 Alcoholic Myopathy
Emilio Gonzalez-Reimers
Geraldine Quintero-Platt
Emilio Gonzalez-Arnay
Candelaria Martin-Gonzalez
Lucia Romero-Acevedo
Francisco Santolaria-Fernandez
Concept and Prevalence
509(1)
Histologic Features
510(1)
Clinical Features
511(3)
Pathogenesis
514(6)
Future Prospects. Effects on Distant Organs
520(2)
Concluding Remarks
522(1)
References
522(7)
Index 529
Stéphane Walrand, MSc, PhD is research director at the French National Institute for Agricultural Research (INRA), in the Human Nutrition Department. Professor Walrand graduated in 1990 with an Honours Degree in Biological Sciences. He received his Master's degree in 1996 and he gained his PhD in 2000 in the specialty "Clinical Research, Technological Innovation and Public Health". In 2002, Professor Walrand joined the Laboratory of Molecular Endocrinology in Bratislava (Slovak Republic) as a post-doctoral fellowship under the direction of Professor Julius Brtko. He then joined INRA in 2002 as a research fellow. In 2004-2005, Professor Walrand joined the Endocrine Research Unit (Prof. KS Nair), Mayo Clinic and Foundation in Rochester, Minnesota. He was appointed as Director of Research at INRA in 2010 and since then performs the function of Deputy Director of the Human Nutrition Unit (Clermont-Ferrand, France) and co-leader of the Nutrition, Metabolism and Muscle Mass team (NuTrim). Professor Walrand has collaborations with research groups in Australia, the US, Belgium, Switzerland and the Netherlands. It has a lot of expertise on muscle metabolism in various pathophysiological conditions and under different dietary constraints. Professor Walrand is a member of the Scientific Board of the French Society of Clinical Nutrition and Metabolism. He is also one of the experts on the board of experts of French Agency for Food, Environmental and Occupational Health & Safety. He has lectured nationally and internationally. To his credit, Professor Walrand has published over 150 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.