This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers.
The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinicalbiochemistry.
Chapter 1. Obesity induced chronic low-level inflammation and
cancers.- Chapter 2. Adipose tissue produced estrogen as risk factor for
cancers.- Chapter 3. Insulin and Insulin-like growth factor-1 associated
cancers.-Chapter 4. Adipokines play important role in cell proliferation and
antiproliferation.- Chapter 5. mTOR and AMP-activated protein kinase in
obesity and cancer.- Chapter 6. Immune response and oxidative stress in
obesity induced cancer.- Chapter 7. Role of gene polymorphism in obesity and
cancer.- Chapter 8. Therapeutic role of green tea in obesity and
cancer.- Chapter 9. Effect of dietary phytochemicals in obesity and
cancer.- Chapter 10. Resveratrol as anti-obesity and anticancer
agent.- Chapter 11. EGCG as anti-obesity and anticancer agent.
Chapter
12. miRNAs as therapeutic target in obesity and cancer.- Chapter 13. In
silico updates on lead identificationfor obesity and cancer.- Chapter
14. In
vivo models for obesity and obesity related carcinogenesis.
Chapter
15.
Estrogen signaling based current and potential therapies against obesity and
related diseases.
Chapter 16. Autophagy at the crossroad of obesity mediated
cancer progression.
Dr. Shashank Kumar is working as Assistant Professor at the Department of Biochemistry, Central University of Punjab, Punjab, India. He has been alumni of the Department of Biochemistry, King Georges Medical University, and the Department of Biochemistry, University of Allahabad, India. Dr. Kumar edited many books including, Concepts in Cell Signaling, Secondary Metabolites and Functional Food Components, and Carbohydrate Metabolism Theory and Practical Approach, Phytochemistry: An in silico and in vitro updates, etc. Dr. Shashanks basic research focuses on understanding the role of miRNAs in breast cancer pathophysiology and developing appropriate biomarkers for early detection and prognosis of the disease. The translational research focus is to identify novel synthetic and natural inhibitors of signaling pathways related to disease pathophysiology. Dr. Kumar has more than 50 published scientific papers/reviews/editorial articles in various National/International peer-reviewed journals of repute. He has been a member of various national/international academic bodies.
Prof. Sanjay Gupta is a Professor & Research Director and holds Carter Kissell Endowed Chair in Urologic Oncology in the Department of Urology at Case Western Reserve University and The Urology Institute at the University Hospitals Case Medical Center. He also holds secondary appointments in the Departments of Nutrition and Division of General Medical Sciences at Case Comprehensive Cancer Center. Dr. Gupta has a joint appointment as Research Scientist at the Louis Stokes VA Medical Center, Cleveland, Ohio. Dr. Gupta has authored some 150 publications, including book chapters, research articles and reviews, and has spoken on several occasions in cancer prevention symposiums, seminars, and meetings. He has been serving in various study sections at National Cancer Institute (NCI) and Department of Defense (DOD), and other councils worldwide. He also serves on the Editorial Board as well as a reviewer for several prestigious scientific journals.
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