Foreword |
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v | |
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Teresa K. Woodruff and Karrie Ann Snyder |
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Foreword |
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vii | |
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Lindsay Beck and Joyce Reinecke |
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Contributors |
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xvii | |
Part I Introduction |
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1. The Emergence of a New Interdiscipline: Oncofertility |
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3 | |
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Oncofertility: The New Offensive in the War on Cancer |
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3 | |
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Secondary Effects of Treatment on the Health and Quality of Life of Young Survivors of Cancer |
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4 | |
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Fertility Threats Due to Cancer Treatment |
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5 | |
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An Emerging Urgent Unment Need for Young Cancer Patients: Balancing Life-Preserving but Fertility-Threatening Cancer Treatments |
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6 | |
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9 | |
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10 | |
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10 | |
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11 | |
Part II Fertility Risk and Treatment Options |
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2. Fertility Management for Women With Cancer |
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15 | |
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Sanjay K. Agarwal and R. Jeffrey Chang |
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15 | |
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Impact of Cancer Therapies on Ovarian Function |
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18 | |
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Current Techniques of Fertility Preservation |
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20 | |
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20 | |
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22 | |
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23 | |
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25 | |
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25 | |
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26 | |
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3. Fertility Preservation in Adult Male Cancer Patients |
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28 | |
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The Impact of Cancer on Male Reproductive Health |
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28 | |
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Endocrine Effects of Tumors |
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29 | |
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Cytotoxic Autoimmune Response |
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30 | |
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Systemic Physiological Changes |
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31 | |
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Psychological Changes Associated with Cancer |
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31 | |
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The Impact of Cancer Treatment on Male Reproductive Health |
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32 | |
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Effects of Radiation Therapy |
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32 | |
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36 | |
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38 | |
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39 | |
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Fertility Preservation in Male Cancer Patients |
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39 | |
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American Society of Clinical Oncology Guidelines |
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40 | |
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41 | |
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Overview of Sperm Collection Techniques |
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42 | |
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Testicular Tissue Cryopreservation (ONCO-TESE) |
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42 | |
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Future Directions in Fertility Preservation in Male Cancer Patients |
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45 | |
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45 | |
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46 | |
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4. Managing Fertility in Childhood Cancer Patients |
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50 | |
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Follow-up Guidelines Related to Male Fertility |
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51 | |
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51 | |
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Surveillance and Screening |
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51 | |
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Additional Management Issues |
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52 | |
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Follow-up Guidelines Related to Female Fertility |
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52 | |
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52 | |
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Surveillance and Screening |
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53 | |
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Additional Management Issues |
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54 | |
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Optimal Care for Pediatric Cancer Patients |
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54 | |
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55 | |
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5. Fertility Risk in Pediatric and Adolescent Cancers |
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57 | |
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Clarisa R. Gracia and Jill P. Ginsberg |
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57 | |
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The Importance of Fertility to Cancer Patients |
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57 | |
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Common Cancers in Children and their Treatment |
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58 | |
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Fertility Risks for Young Females |
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58 | |
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Gonadotoxicity of Cancer Treatments |
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58 | |
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59 | |
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59 | |
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Effects on the Hypothalamic-Pituitary-Ovarian Axis |
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61 | |
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Pregnancy Outcomes in Cancer Survivors |
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63 | |
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Options for Preserving Fertility in Girls and Young Women |
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63 | |
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Fertility Risks for Young Men |
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64 | |
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65 | |
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65 | |
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Options for Preserving Fertility in Boys and Young Men |
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66 | |
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Ethical Issues in Pediatric Patients |
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67 | |
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67 | |
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68 | |
Part III Oncofertility Techniques and Research |
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6. Bioengineering and the Ovarian Follicle |
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75 | |
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Min Xu, Teresa K. Woodruff and Lonnie D. Shea |
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76 | |
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Culture Systems for Follicle Growth |
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77 | |
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Hydrogels for Three-Dimensional Culture In Vitro |
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78 | |
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Ovarian Transplantation Using Biomaterials |
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79 | |
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80 | |
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80 | |
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7. The Science of Cryobiology |
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Steven F. Mullen and John K. Critser |
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83 | |
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Anatomy of Cryopreservation |
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83 | |
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The Effects of Water Precipitation (as Ice) During Cooling |
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84 | |
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Ice Nucleation, Crystallization, Vitrification, and Devitrification |
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84 | |
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Solute Concentration as a Result of Ice Crystallization, The Associated Osmotic Effects, and Cell Death at Supra-Optimal Cooling Rates |
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86 | |
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Cell Death at Sub-Optimal Cooling Rates and the Role of Cryoprotectants in Mitigating Cell Damage |
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Cryoprotectants: Beneficial Effects |
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91 | |
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Cryoprotectants: Detrimental Effects |
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Cell Death at Sub-Optimal Cooling Rates |
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98 | |
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Cooling and Cooling Injury/Cold Shock |
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99 | |
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Vitrification as an Alternate to Equilibrium cryopreservation |
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102 | |
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103 | |
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8. Ovarian Tissue Cryopreservation and Transplantation: Banking Reproductive Potential for the Future |
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110 | |
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Indications for Ovarian Tissue Banking |
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110 | |
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Scope of the Clinical Problem and Incidence of Ovarian Failure |
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110 | |
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Gonadotoxicity of Chemotherapy |
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111 | |
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Gonadotoxicity of Radiation Therapy |
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112 | |
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Limitations of Fertility: Preserving Techniques |
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113 | |
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The Promise of Ovarian Tissue Banking |
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115 | |
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Cryopreservation of Ovarian Tissue has been Successful |
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116 | |
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Autotransplantation of Ovarian Tissue has been Successful |
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117 | |
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Problems with Ovarian Transplantation: Re-Introduction of Cancer |
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123 | |
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Xenografting as a Potential Solution |
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124 | |
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126 | |
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126 | |
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9. Progress, History and Promise of Ovarian Cryopreservation and Transplantation for Pediatric Cancer Patients |
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130 | |
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132 | |
Part IV Health Care Decision-Making |
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10. Oncofertility and the Social Sciences |
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137 | |
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Studying Cancer Within the Social Sciences |
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138 | |
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139 | |
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Gender and Patient-Physician Interactions |
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140 | |
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Gender and the Experience of Infertility |
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141 | |
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Race/Ethnicity and Oncofertility |
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142 | |
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Race/Ethnicity and Patient–Physician Interactions |
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143 | |
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Race/Ethnicity and Family and Community Involvement |
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144 | |
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The Digitial Divide and Race/Ethnicity |
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145 | |
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146 | |
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147 | |
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11. Shared Decision Making: Fertility and Pediatric Cancers |
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149 | |
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Marla L. Clayman, Kathleen M. Galvin, and Paul Arnston |
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The Current State of Pediatric Oncofertility |
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150 | |
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Family Communication in Context |
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151 | |
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Shared Decision Making in Theory and in Practice |
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152 | |
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Decision Making in Pediatrics and Cancer |
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152 | |
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158 | |
Part V Ethical and Psychosocial Impact of Cancer-Related Infertility |
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12. Today's Research, Tomorrows Cures: The Ethical Implications of Oncofertility |
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163 | |
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Leilah E. Backhus and Laurie Zoloth |
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Expanding Options for Women – Follicle Preservation and Maturation |
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165 | |
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A Prairie Horizon: The Long View of Research on Fertility |
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165 | |
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The Role of Oncologists and Infertility Specialists |
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168 | |
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Ethical Issues in the Case of Childhood Cancers |
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170 | |
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The Special Case of Young Girls |
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170 | |
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171 | |
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Assessing the Intervention: A Community Consent Process in Action |
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173 | |
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The Ethical Implications for a New Terrain: Therapy or Enhancement? |
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174 | |
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Recalling a Complex History |
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176 | |
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178 | |
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178 | |
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13. The Psychosocial Context of Cancer-Related Infertility |
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180 | |
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Matthew J. Loscalzo and Karen L. Clark |
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180 | |
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Psychosocial Screening for Infertility Concerns |
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183 | |
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Biopsychosocial Screening Instrument: How Can We Help You and Your Family 2 |
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183 | |
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Discussion and Implications |
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188 | |
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190 | |
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14. Childhood Cancer: Fertility and Psychosocial Implications |
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191 | |
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Karen E. Kinahan, Aarati Didwania, and Carrie L. Nieman |
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Recent Research on Late Effects and Infertility |
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191 | |
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Addressing the Threat of Infertility |
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193 | |
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Childhood Cancer Survivors and Fertility Preservation |
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194 | |
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196 | |
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197 | |
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198 | |
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198 | |
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15. Fertility Preservation and Adolescent Cancer Patients: Lessons from Adult Survivors of Childhood Cancer and Their Parents |
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201 | |
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Carrie L. Nieman, Karen E. Kinahan, Susan E. Yount, Sarah K. Rosenbloom, Kathleen J. Yost, Elizabeth A. Hahn, Timothy Volpe, Kimberley J. Dilley, Laurie Zoloth, and Teresa K. Woodruff |
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203 | |
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Study Design and Sample Recruitment |
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203 | |
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Data Collection and Analysis |
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203 | |
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204 | |
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204 | |
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204 | |
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211 | |
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216 | |
Part VI Training in a New Medical Discipline and Medical Guidelines |
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16. Oncofertility: A New Medical Discipline and the Emerging Scholar |
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221 | |
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Infertility: An Unmet Clinical Need for Young Cancer Patients |
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222 | |
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Oncofertility and the Oncofertility Scholar |
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226 | |
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Reproductive Endocrinology and Infertility as the Springboard to a New Oncofertility Scholar |
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226 | |
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229 | |
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230 | |
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231 | |
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233 | |
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17. Oncofertility Consortium Consensus Statement: Guidelines for Ovarian Tissue Cryopreservation |
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235 | |
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Leilah E. Backhus, Laxmi A. Kondapalli, R. Jeffrey Chang, Chrislos Cottiifitris, Ralph Kazer and Teresa K. Woodruff |
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239 | |
Part VII Patient Stories and Oncofertility |
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18. Personal Accounts of Cancer and Infertility |
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243 | |
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A New Generation of Hope: Antoinette's Story |
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243 | |
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Starting a Family One Day: Adriatic's Story |
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244 | |
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An Improvised Script: Beverley's Story |
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245 | |
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Life is Worth Living: Brian's Story |
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246 | |
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Young and Hopeful for the Future: Dorothy's Story |
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246 | |
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Hope, from Texas to Panama: Elia's Story |
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247 | |
Appendix A: Oncofertility Options |
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249 | |
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Index |
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257 | |