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E-raamat: Oncofertility: Fertility Preservation for Cancer Survivors

  • Formaat: PDF+DRM
  • Sari: Cancer Treatment and Research 138
  • Ilmumisaeg: 11-Sep-2007
  • Kirjastus: Springer-Verlag New York Inc.
  • Keel: eng
  • ISBN-13: 9780387722931
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  • Formaat: PDF+DRM
  • Sari: Cancer Treatment and Research 138
  • Ilmumisaeg: 11-Sep-2007
  • Kirjastus: Springer-Verlag New York Inc.
  • Keel: eng
  • ISBN-13: 9780387722931
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It has been our pleasure to edit the first book on an interdisciplinary science we call oncofertility. Oncofertility bridges traditional areas of basic science and medical research, brings together oncologists and fertility specialists, and hopes to provide real options to young people who survive life-preserving but fertility-threatening treatments for cancer. The chapters in this book range from basic discovery research to reproductive medicine and from social science and the humanities to a section on stories from those who have survived cancer and have faced issues of fertility deprivation or restoration. Specifically, we have addressed three main areas: the underlying biological questions surrounding follicle growth and cryo-preservation of tissue; the application of the new technology to medical practice; and, the psychosocial implications of cancer-related infertility and oncofertility research for patients and their families. These questions are interlinking and require teams of investigators working in concert to solve a major unmet need. The book is a comprehensive initial definition of the field and we anticipate a great many more breakthroughs that will eventually provide a menu of options to those with fertility-threatening conditions. The editors thank the Specialized Cooperative Centers Program in Reproduction and Infertility Research (U54 HD041857) and the Institute for Womens Health Research of Northwestern University for funding and support of this book. Teresa K.

Arvustused

From the reviews:





"This is a compilation of current research on the preservation of fertility in young cancer patients facing gonadotoxic treatment regimens. While they have targeted this book at helping to train and educate oncologists and reproductive specialists caring for young cancer patients, it may also be interesting and important to people in a variety of other fields including those in reproductive biology, biomedical ethics, sociology, and health policy. an interesting and important book for anyone involved in the care of young cancer patients." (Emily S. Jungheim, Doodys Review Service, January, 2008)

 

"This book is the first of its kind on the topic of oncofertility - a new discipline uniting reproductive biologists with oncologists to provide options for men, women, and children with a fertility-threatening cancer diagnosis. The book spans disciplines from cutting edge research to clinical care, bioethics, and medical guidelines. There are chapters for the specialists and chapters for patients who wish to read stories about those who have faced fertility-impacting diseases."

This is a terrific book and a must read!

Linda C. Giudice, MD, PhD, MSc Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Sciences The Robert B. Jaffe, MD, Endowed Professor in Reproductive Sciences University of California, San Francisco

Foreword v
Teresa K. Woodruff and Karrie Ann Snyder
Foreword vii
Lindsay Beck and Joyce Reinecke
Contributors xvii
Part I Introduction
1. The Emergence of a New Interdiscipline: Oncofertility
3
Teresa K. Woodruff
Oncofertility: The New Offensive in the War on Cancer
3
Secondary Effects of Treatment on the Health and Quality of Life of Young Survivors of Cancer
4
Fertility Threats Due to Cancer Treatment
5
An Emerging Urgent Unment Need for Young Cancer Patients: Balancing Life-Preserving but Fertility-Threatening Cancer Treatments
6
Information GAP
9
Data GAP
10
Option GAP
10
Conclusion
11
Part II Fertility Risk and Treatment Options
2. Fertility Management for Women With Cancer
15
Sanjay K. Agarwal and R. Jeffrey Chang
Ovarian Physiology
15
Impact of Cancer Therapies on Ovarian Function
18
Current Techniques of Fertility Preservation
20
Embryo Freezing
20
Ovarian Tissue Freezing
22
Oocyte Freezing
23
Future Directions
25
Summary
25
References
26
3. Fertility Preservation in Adult Male Cancer Patients
28
Robert E. Brannigan
The Impact of Cancer on Male Reproductive Health
28
Endocrine Effects of Tumors
29
Cytotoxic Autoimmune Response
30
Systemic Physiological Changes
31
Psychological Changes Associated with Cancer
31
The Impact of Cancer Treatment on Male Reproductive Health
32
Effects of Radiation Therapy
32
Effects of Chemotherapy
36
Effects of Surgery
38
Effects of Opiods
39
Fertility Preservation in Male Cancer Patients
39
American Society of Clinical Oncology Guidelines
40
Sperm Cryopreservation
41
Overview of Sperm Collection Techniques
42
Testicular Tissue Cryopreservation (ONCO-TESE)
42
Future Directions in Fertility Preservation in Male Cancer Patients
45
Conclusion
45
References
46
4. Managing Fertility in Childhood Cancer Patients
50
Kimberley J. Diller
Follow-up Guidelines Related to Male Fertility
51
Risk Factors
51
Surveillance and Screening
51
Additional Management Issues
52
Follow-up Guidelines Related to Female Fertility
52
Risk Factors
52
Surveillance and Screening
53
Additional Management Issues
54
Optimal Care for Pediatric Cancer Patients
54
References
55
5. Fertility Risk in Pediatric and Adolescent Cancers
57
Clarisa R. Gracia and Jill P. Ginsberg
Scope of the Problem
57
The Importance of Fertility to Cancer Patients
57
Common Cancers in Children and their Treatment
58
Fertility Risks for Young Females
58
Gonadotoxicity of Cancer Treatments
58
Chemotherapy
59
Radiation
59
Effects on the Hypothalamic-Pituitary-Ovarian Axis
61
Pregnancy Outcomes in Cancer Survivors
63
Options for Preserving Fertility in Girls and Young Women
63
Fertility Risks for Young Men
64
Chemotherapy
65
Radiotherapy
65
Options for Preserving Fertility in Boys and Young Men
66
Ethical Issues in Pediatric Patients
67
Conclusion
67
References
68
Part III Oncofertility Techniques and Research
6. Bioengineering and the Ovarian Follicle
75
Min Xu, Teresa K. Woodruff and Lonnie D. Shea
Follicle Growth In Vivo
76
Culture Systems for Follicle Growth
77
Hydrogels for Three-Dimensional Culture In Vitro
78
Ovarian Transplantation Using Biomaterials
79
Conclusion
80
References
80
7. The Science of Cryobiology
83
Steven F. Mullen and John K. Critser
Introduction
83
Anatomy of Cryopreservation
83
The Effects of Water Precipitation (as Ice) During Cooling
84
Ice Nucleation, Crystallization, Vitrification, and Devitrification
84
Solute Concentration as a Result of Ice Crystallization, The Associated Osmotic Effects, and Cell Death at Supra-Optimal Cooling Rates
86
Cell Death at Sub-Optimal Cooling Rates and the Role of Cryoprotectants in Mitigating Cell Damage
90
Cryoprotectants: Beneficial Effects
91
Cryoprotectants: Detrimental Effects
94
Cell Death at Sub-Optimal Cooling Rates
98
Cooling and Cooling Injury/Cold Shock
99
Vitrification as an Alternate to Equilibrium cryopreservation
102
References
103
8. Ovarian Tissue Cryopreservation and Transplantation: Banking Reproductive Potential for the Future
110
David Lee
Indications for Ovarian Tissue Banking
110
Scope of the Clinical Problem and Incidence of Ovarian Failure
110
Gonadotoxicity of Chemotherapy
111
Gonadotoxicity of Radiation Therapy
112
Limitations of Fertility: Preserving Techniques
113
The Promise of Ovarian Tissue Banking
115
Cryopreservation of Ovarian Tissue has been Successful
116
Autotransplantation of Ovarian Tissue has been Successful
117
Problems with Ovarian Transplantation: Re-Introduction of Cancer
123
Xenografting as a Potential Solution
124
Conclusion
126
References
126
9. Progress, History and Promise of Ovarian Cryopreservation and Transplantation for Pediatric Cancer Patients
130
Yasmin Gosiengfiao
References
132
Part IV Health Care Decision-Making
10. Oncofertility and the Social Sciences
137
Karrie Ann Snyder
Studying Cancer Within the Social Sciences
138
Gender and Oncofertility
139
Gender and Patient-Physician Interactions
140
Gender and the Experience of Infertility
141
Race/Ethnicity and Oncofertility
142
Race/Ethnicity and Patient–Physician Interactions
143
Race/Ethnicity and Family and Community Involvement
144
The Digitial Divide and Race/Ethnicity
145
Conclusion
146
References
147
11. Shared Decision Making: Fertility and Pediatric Cancers
149
Marla L. Clayman, Kathleen M. Galvin, and Paul Arnston
The Current State of Pediatric Oncofertility
150
Family Communication in Context
151
Shared Decision Making in Theory and in Practice
152
Decision Making in Pediatrics and Cancer
152
References
158
Part V Ethical and Psychosocial Impact of Cancer-Related Infertility
12. Today's Research, Tomorrows Cures: The Ethical Implications of Oncofertility
163
Leilah E. Backhus and Laurie Zoloth
Expanding Options for Women – Follicle Preservation and Maturation
165
A Prairie Horizon: The Long View of Research on Fertility
165
The Role of Oncologists and Infertility Specialists
168
Ethical Issues in the Case of Childhood Cancers
170
The Special Case of Young Girls
170
Research in Children
171
Assessing the Intervention: A Community Consent Process in Action
173
The Ethical Implications for a New Terrain: Therapy or Enhancement?
174
Recalling a Complex History
176
Conclusion
178
References
178
13. The Psychosocial Context of Cancer-Related Infertility
180
Matthew J. Loscalzo and Karen L. Clark
The Social Context
180
Psychosocial Screening for Infertility Concerns
183
Biopsychosocial Screening Instrument: How Can We Help You and Your Family 2
183
Discussion and Implications
188
References
190
14. Childhood Cancer: Fertility and Psychosocial Implications
191
Karen E. Kinahan, Aarati Didwania, and Carrie L. Nieman
Recent Research on Late Effects and Infertility
191
Addressing the Threat of Infertility
193
Childhood Cancer Survivors and Fertility Preservation
194
Male Infertility
196
Access to Care
197
Conclusion
198
References
198
15. Fertility Preservation and Adolescent Cancer Patients: Lessons from Adult Survivors of Childhood Cancer and Their Parents
201
Carrie L. Nieman, Karen E. Kinahan, Susan E. Yount, Sarah K. Rosenbloom, Kathleen J. Yost, Elizabeth A. Hahn, Timothy Volpe, Kimberley J. Dilley, Laurie Zoloth, and Teresa K. Woodruff
Methods
203
Study Design and Sample Recruitment
203
Data Collection and Analysis
203
Results
204
Sample Characteristics
204
Content Analysis
204
Discussion
211
Conclusion
215
References
216
Part VI Training in a New Medical Discipline and Medical Guidelines
16. Oncofertility: A New Medical Discipline and the Emerging Scholar
221
Laymi A. Kondapalli
Infertility: An Unmet Clinical Need for Young Cancer Patients
222
Oncofertility and the Oncofertility Scholar
226
Reproductive Endocrinology and Infertility as the Springboard to a New Oncofertility Scholar
226
Research Directions
229
Future Directions
230
Conclusion
231
References
233
17. Oncofertility Consortium Consensus Statement: Guidelines for Ovarian Tissue Cryopreservation
235
Leilah E. Backhus, Laxmi A. Kondapalli, R. Jeffrey Chang, Chrislos Cottiifitris, Ralph Kazer and Teresa K. Woodruff
References
239
Part VII Patient Stories and Oncofertility
18. Personal Accounts of Cancer and Infertility
243
Provided by Fertile Hope
A New Generation of Hope: Antoinette's Story
243
Starting a Family One Day: Adriatic's Story
244
An Improvised Script: Beverley's Story
245
Life is Worth Living: Brian's Story
246
Young and Hopeful for the Future: Dorothy's Story
246
Hope, from Texas to Panama: Elia's Story
247
Appendix A: Oncofertility Options 249
Provided by Fertile Hope
Index 257