E-raamat: Pathway Analysis for Drug Discovery: Computational Infrastructure and Applications

The use of pathway analysis as a method for drug discovery and development has resulted in an acceleration in research results, and this textbook for molecular biology and biochemistry students and practitioners offers fundamental understanding of new computational approaches in the field. Yuryev (application science, Ariadne Genomics, Inc.) has edited research articles that include new methods of pathway reconstruction for diseases and toxic states, and analysis techniques for the selection of drug targets, lead compound validation and the prediction of compound ADMET properties. The adoption of pathway analysis as the leading method of future drug discovery is emphasized throughout this volume. Annotation ©2009 Book News, Inc., Portland, OR (booknews.com)

This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.