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E-raamat: Perinatal Stem Cells

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  • Ilmumisaeg: 05-Feb-2013
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  • Keel: eng
  • ISBN-13: 9781118497876
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  • Formaat: PDF+DRM
  • Ilmumisaeg: 05-Feb-2013
  • Kirjastus: Wiley-Blackwell
  • Keel: eng
  • ISBN-13: 9781118497876

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Cetrulo, Certulo Jr., and Taghizadeh compile 18 chapters that outline recent research and major advances in the clinical use of mesenchymal stem cells from pregnancy-related sources. Stem cell scientists, hematologists, surgeons, pathologists, and others from Europe, the US, Australia, and Hong Kong discuss specific stem cell isolation techniques and other strategies for collecting, processing, and using perinatal cell sources, and address clinical applications in areas like transplantation, traumatic brain injury, liver disease, and stroke therapy. They describe stem cells found in amniotic fluid, the clinical practice of cord blood transplantation, hematopoietic stem cell development in the placenta and transplantation, uses for preventing and treating complications after transplantation, cord tissue/Wharton's jelly-derived stem cells, immunogeniocity and immunomodulatory effects, uses in treating and preventing graft-versus-host disease in hematopoietic transplantation, the amnion and regenerative medicine applications, the role of stem cells in regenerative medicine, the amniotic membrane, and fetal stem cells in maternal circulation. This edition has a new industry section on stem cell banking and regenerative medicine and the patenting of stem cell innovations, and includes updates to some chapters. Annotation ©2013 Book News, Inc., Portland, OR (booknews.com)

Perinatal Stem Cells, 2nd Edition builds on the first edition to provide an updated tutorial on perinatal stem cells, including stem cells harvested from the amniotic fluid, placenta, maternal blood supply, umbilical cord and Wharton's Jelly. As in the first edition, coverage includes the underlying biology of each of the sources of pregnancy related stem cells, cell culture, and potential therapeutic uses, as well as insights on the impact of these stem cells from obstetricians and gynecologists, cardiologists, hematologists, tissue engineers, and cord blood bankers.

Normally discarded as medical waste, perinatal stem cells offer a powerful therapeutic tool box alternative to the controversial embryonic stem cells. Since publication of the first edition, a burgeoning commerical industry has developed around various sources of perinatal cells, and the second edition now includes an overview of this growing industry.

With contributions from some of the top academic stem cell laboratories in the United States as well as new chapters from international stem cell scientists, Perinatal Stem Cells presents an update on the cutting-edge research in the field while maintaining its signature clinical focus.

Arvustused

A classic text, focuses on recent research and advances in the clinical use of mesenchyme stem cells from pregnancy sources.  (Pediatric Endocrinology Reviews, 1 June 2014)

Contributors xi
Introduction xv
1 Amniotic Fluid Stem Cells
1(16)
Sean Vincent Murphy
Anthony Atala
Introduction
1(1)
Development of Gestational Stem Cells
2(1)
Isolation and Characterization of Amniotic Fluid Stem Cells
2(1)
Multipotency of Amniotic Fluid Stem Cells
3(5)
Clinical Application of Amniotic Fluid Stem Cells
8(5)
Conclusion
13(1)
References
13(4)
2 Cord Blood Transplants: Perinatal Stem Cells in Clinical Practice
17(20)
Richard L. Haspel
Karen K. Ballen
Introduction
17(1)
Hematopoietic Stem Cell Transplants: Adult Donor Collection
17(1)
Hematopoietic Stem Cell Transplants: HLA Matching
18(1)
Collection and Processing of Cord Blood Units
19(1)
Hematopoietic Stem Cell Transplants: Recipient Issues
20(1)
Bone Marrow versus Single Cord Blood: Pediatric
21(2)
Bone Marrow versus Cord Blood: Adults
23(1)
Cord Blood Transplant: Advantages and Disadvantages
23(1)
Double Cord Blood Transplants: Ablative Regimens
24(2)
Double Cord Blood Transplant: Non-Myeloablative Regimens
26(1)
Are Two Cords Better Than One?
27(1)
Chimerism
28(1)
Predicting the Winner
28(2)
Other Experimental Strategies
30(1)
Summary
31(1)
References
31(6)
3 Hematopoietic Stem Cell Development in the Placenta
37(16)
Katrin E.R. Ericson
Akanksha Chhabra
Hanna K.A. Mikkola
Introduction
37(1)
The Hematopoietic System
37(1)
Historical Perspective on Placental Hematopoiesis
38(1)
The Development and Structure of the Mouse Placenta
39(1)
Hematopoietic Activity in the Mouse Placenta
40(2)
Identification of Placental HSCs
42(1)
The Origin and Localization of Placental HSCs
43(2)
Hematopoietic Activity in the Human Placenta
45(1)
Hematopoietic Microenvironment in the Placenta
46(1)
Conclusions and Perspectives
47(2)
References
49(4)
4 Perinatal Mesenchymal Stem Cell Banking for Umbilical Cord Blood Transplantation and Regenerative Medicine
53(18)
Rouzbeh R. Taghizadeh
Introduction
53(1)
Hematopoiesis
54(1)
Hematopoietic Transplantations
54(2)
Umbilical Cord: Source of Perinatal HSCs and MSCs
56(1)
Hematopoietic Transplantations of Umbilical Cord Blood
57(1)
Strategies to Overcome the Transplant-Related Limitations of Umbilical Cord Blood
58(3)
Umbilical Cord Tissue MSC Banking
61(2)
References
63(8)
5 Making Organ and Stem Cell Transplantation Safer: The Role of Mesenchymal Stem Cells
71(6)
Hans Klingemann
Introduction
71(1)
MSC to Prevent Rejection After Solid Organ Transplantation
72(1)
MSC in the Treatment of Graft-versus-Host Disease
73(1)
MSC to Support Hematopoietic Recovery of Stem Cells After Stem Cell Transplantation
74(1)
References
75(2)
6 Wharton's Jelly Mesenchymal Stem Cells and Immune Modulation: Regenerative Medicine Meets Tissue Repair
77(12)
Rita Anzalone
Felicia Farina
Melania Lo Iacono
Simona Corrao
Tiziana Corsello
Giovanni Zummo
Giampiero La Rocca
Introduction
77(2)
Expression of Relevant Immunomodulatory Molecules in Vitro by MSCs
79(1)
Tolerance Induction by MSCs: Rediscovering the Embryo Immune Evasion Mechanisms
79(1)
Immune Modulation in Vivo: Contrasting Data on the Immune Privilege of MSCs
80(2)
WJ-MSC in in Vivo Models: Enhancing the Immunomodulatory Features of Adult MSC Populations
82(1)
Conclusions and Future Perspectives
83(1)
References
84(5)
7 Immunogenicity Versus Immunomodulation of Perinatal Stem Cells
89(16)
Bram Lutton
Raimon Duran-Struuck
Introduction
89(1)
Mechanisms of Immunomodulation by Umbilical Cord- and Bone Marrow-Derived MSCs
90(1)
Innate Immune System
90(2)
Adaptive Immune System
92(2)
Natural Tolerance and Umbilical Cord Tissues
94(1)
Tolerance versus Immunogenicity: The Yin and Yang of Host Responses to Umbilical Cord-Derived Cells
95(2)
Conclusions
97(1)
References
98(7)
8 The Translational Potential of Perinatal Stem Cells in Clinical Medicine: Mesenchymal Stem Cells
105(14)
Radbeh Torabi
Vincenzo Villani
Christopher A. Mallard
Curtis L. Cetrulo, Jr.
Introduction
105(1)
Graft-versus-Host Disease
106(1)
Acute GVHD
107(1)
Chronic GVHD
108(1)
GVHD Prevention
109(1)
Hematopoetic Recovery and HCT Engraftment
109(1)
Hematopoietic Recovery
110(1)
HCT Engraftment
111(1)
MSC Potential Uses
111(2)
References
113(6)
9 Newborn Stem Cells: Identity, Function, and Clinical Potential
119(20)
Anthony Park
Louis Chan
Mayur Danny I. Gohel
Sean Murphy
Ursula Manuelpillai
Ann Chidgey
Richard Boyd
Introduction
120(1)
The Newborn Offers an Enormous Opportunity for Stem Cells
120(1)
Amnion
120(1)
Isolation and Phenotypic Characterization of Amnion Cells
121(2)
Therapeutic Potential of Amnion Membrane
123(2)
Mechanisms of AEC-Enhanced Wound Repair
125(2)
Therapeutic Potential of Amnion as Single Cells
127(1)
Amnion Immunogenicity and Immunosuppressive Properties
127(1)
Amnion-Derived Mesenchymal Stromal Cells
128(2)
Umbilical Cord Mesenchymal Stromal Cells
130(1)
Chorion MSCs
131(2)
References
133(6)
10 Biomedical Potential of Human Perinatal Stem Cells
139(16)
Oleg V. Semenov
Christian Breymann
Role of Stem Cells in Regenerative Medicine
139(1)
Perinatal Stem Cell Sources
140(3)
Properties of Perinatal Mesenchymal Stem Cells
143(1)
Properties of Perinatal Hematopoietic Stem Cells
144(1)
Biomedical Applications of Human Perinatal Stem Cells
145(2)
Perspectives and Obstacles
147(1)
References
148(7)
11 Progenitor Cell Therapy for the Treatment of Traumatic Brain Injury
155(22)
Alex Bryan Olsen
Robert A. Hetz
Supinder S. Bedi
Charles S. Cox, Jr.
Introduction
155(4)
Cellular Therapy for the Treatment of TBI
159(1)
Neural Stem Progenitor Cells
159(1)
Human Multipotent Adult Progenitor Cells
160(3)
Mesenchymal Stem Cells
163(2)
Umbilical Cord Blood
165(1)
Wharton's Jelly
166(1)
Amniotic Fluid-Derived Stem Cells
167(1)
The Inflammatory Reflex
168(2)
Conclusion
170(1)
References
171(6)
12 The Human Amniotic Membrane: A Tissue with Multifaceted Properties and Different Potential Clinical Applications
177(20)
Maddalena Caruso
Antonietta Silini
Ornella Parolini
Introduction
177(1)
Structure and Histology of the Human Amniotic Membrane
178(1)
Preparation, Preservation, and Sterilization of the Human Amniotic Membrane
179(1)
Biological and Structural Properties of the Human Amniotic Membrane Generally Invoked to Explain Its Effects in Vivo
180(3)
Established Clinical Applications of the Human Amniotic Membrane
183(4)
Prospective Applications of the Human Amniotic Membrane: Lessons from Preclinical Studies
187(3)
Conclusions and Perspectives
190(1)
References
190(7)
13 Advances and Possible Applications of Human Amnion for the Management of Liver Disease
197(12)
Fabio Marongiu
Maria Paola Serra
Marcella Sini
Ezio Laconi
Marc C. Hansel
Kristen J. Skvorak
Roberto Gramignoli
Stephen C. Strom
Introduction
197(1)
Human Amnion for the Management of Liver Fibrosis
198(1)
Amnion-Derived Hepatocytes and Their Possible Applications
199(5)
Conclusions
204(1)
References
205(4)
14 Amnion-Derived Cells for Stroke Restorative Therapy
209(12)
Naoki Tajiri
Loren E. Glover
Cesar V. Borlongan
Introduction
209(1)
Stem Cell Therapy: Beyond Stroke Neuroprotection
210(1)
Therapeutic Potential of Adult Stem Cells
210(1)
The Biology of Amnion-Derived Cells
211(1)
Amnion-Derived Cells for Cell Therapy
212(3)
Conclusion
215(1)
References
216(5)
15 Pregnancy-Acquired Fetal Progenitors as Natural Cell Therapy
221(16)
Elke Seppanen
Nicholas M. Fisk
Kiarash Khosrotehrani
Introduction
221(1)
Fetal Cell Microchimerism, a Widespread Phenomenon
222(1)
The Kinetics of Fetal Cell Detection
222(1)
Factors Modifying the Level of Microchimerism
222(1)
Detecting FMC
223(1)
Homing and Plasticity of FMC
224(1)
Hematopoietic Capacity of FMC
224(4)
Epithelial, Neuronal and Hepatic Capacity of FMC
228(1)
Mesenchymal Capacity of FMC
228(1)
FMC Includes Functional Endothelial Progenitor Cells that Contribute to Tissue Repair
229(1)
FMC Likely Includes Cells of Placental Origin
230(1)
Conclusions
230(1)
References
231(4)
Industry Review
235(2)
16 Perinatal Stem Cells: An Industry Perspective
237(12)
Kyle J. Cetrulo
Introduction
237(1)
The Public Cord Blood Banking Industry
238(1)
The Private Banking Industry
239(1)
Research and Cord Blood Clinical Trials
240(1)
The Mesenchymal Stem Cell Regenerative Medicine Industry
241(1)
Wharton's Jelly/Cord Tissue
242(1)
Placental Stem Cells and Placental Tissue
243(1)
Amniotic Fluid
244(1)
Conclusion
245(1)
References
245(4)
17 Patent Protection of Stem Cell Innovations
249(10)
John R. Wetherell
The Role of Patents in Commercialization
249(1)
Background of the Patent System
250(1)
Patentable Subject Matter
251(1)
Statutory Requirements for a Patent
252(2)
Written Description/Enablement/Best Mode
254(2)
Important Future Changes
256(3)
18 Interview with Frances Verter, Founder of Parent's Guide to Cord Blood Foundation
259(12)
Frances Verter
Kyle J. Cetrulo
References
269(2)
19 Umbilical Cord Blood Banking: An Obstetrician's Perspective
271(8)
Jordan H. Perlow
References
277(2)
Index 279
Kyle J. Cetrulo is the founder and CEO of Auxocell Laboraties, Inc, as well as the founder and Director of the Perinatal Stem Cell Society.?Co-editor of the first edition of Perinatal Stem Cells, Dr. Cetrulo is an active member of the stem cell research community, serving as Director of the International Cord Blood Society since 1998.

Curtis Cetrulo Jr., M.D. is Assistant Professor of Surgery at Harvard Medical School, Boston. A co-editor of the first edition of Perinatal Stem Cells, he is also Director of the Reconstructive Transplantation Service in the Divisions of Transplant Surgery and Plastic and Reconstructive Surgery at Massachusetts General Hospital, and a senior investigator for the Composite Tissue Allograft Laboratory at Massachusetts General.