This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.
Arvustused
This is a well-written book that I highly recommend to anyone interested in any aspect of personalized medicine. (Doodys, 24 August 2012)
Preface vii
Contributors ix
1. Pharmacogenetics: A Historical Perspective 1
Ann K. Daly
Part I Pharmacogenetics: Relationship to Pharmacokinetics and
Pharmacodynamics
2. Pharmacogenetics in Drug Metabolism: Role of Phase I Enzymes 15
Vita Dol˛an
3. Pharmacogenetics of Phase II Drug Metabolizing Enzymes 81
Ingolf Cascorbi
4. Pharmacogenetics of Drug Transporters 101
Henriette E. Meyer zu Schwabedissen, Markus Grube, and Heyo K. Kroemer
5. Pharmacogenetics of Drug Targets 149
Ann K. Daly and Maria Arranz
Part II Pharmacogenetics: Therapeutic Areas
6. Cardiovascular Pharmacogenetics 185
Bas J. M. Peters, Anthonius de Boer, Tom Schalekamp, Olaf H. Klungel, and
Anke-Hilse Maitland-van der Zee
7. Pharmacogenetics in Psychiatry 215
Evangelia M. Tsapakis, Sarah Curran, Ruth I. Ohlsen, Nora S. Vyas, Katherine
J. Aitchison, and Ann K. Daly
8. Pharmacogenetics in Cancer 251
Sharon Marsh
9. Pharmacogenetics of Asthma and COPD 271
Ellen S. Koster, Jan A. M. Raaijmakers, Anke-Hilse Maitland-van der Zee, and
Gerard H. Koppelman
10. Pharmacogenetics of Adverse Drug Reactions 295
Ann K. Daly, Martin Armstrong, and Munir Pirmohamed
11. Pharmacogenomics of Inflammatory Bowel Diseases 323
Alexander Teml, Susanne Karner, Elke Schaeffeler, and Matthias Schwab
12. Pharmacogenetics of Pain Medication 353
Jörn Lötsch
Part III Pharmacogenetics: Implementation in Clinical Practice
13. Ethical and Social Issues in Pharmacogenomics Testing 377
Susanne Vijverberg, Toine Pieters, and Martina Cornel
Part IV Developments in Pharmacogenetic Research
14. High-Throughput Genotyping Technologies for Pharmacogenetics 403
Beatriz Sobrino and Angel Carracedo
15. Developments in Analyses in Pharmacogenetic Datasets 415
Alison A. Motsinger-Reif
Part V Pharmacogenetics: Industry and Regulatory Affairs
16. Applications of Pharmacogenetics in Pharmaceutical Research and
Development 439
Daniel K. Burns and Scott S. Sundseth
17. Role of Pharmacogenetics in Registration Processes 461
Myong-Jin Kim, Issam Zineh, Shiew-Mei Huang, and Lawrence J. Lesko
Part VI Conclusions
18. Pharmacogenetics: Possibilities and Pitfalls 479
Anke-Hilse Maitland-van der Zee and Ann K. Daly
Index 485
ANKE-HILSE MAITLAND-VAN DER ZEE, PHD, is Associate Professor of Pharmacogenetics/Pharmacogenomics at Utrecht University, the Netherlands.
ANN K. DALY, PHD, is Professor of Pharmacogenetics at Newcastle University, UK.
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