E-raamat: Phenotypic Screening: Methods and Protocols

High-Content Screening Framework for Academic Early Drug Discovery.- The Cell Painting PLUS Assay: Phenotypic Profiling Using Iterative Staining-Elution Cycles.- Analyzing Cell Painting PLUS Data Using Cell Profiler and KNIME Analytics Platform.- Cell Painting Protocol to Characterize Morphological Profiles of Large Compound Collections Using the EU-OPENSCREEN Library.- The E-Morph Screening Assay: Phenotypic Screening for Estrogenic or Anti-Estrogenic Compound Activities.- Phenotypic Characterization Using Open-Source Deep Learning Tools.- Quality Control Measures and Statistical Strategies to Address the Challenges of High-Content Phenotypic Data.- Morphological Data Analysis: From Descriptor Development to Predictive Modeling.- Digital Holographic Microscopy for Phenotypic Profiling of Adherent Cells.- Semi-Automated Detection of Late Cytokinetic Bridges.- Phenotypic Drug Screening for Novel Antifibrotic Therapeutics in Lung Health.- Spinal Spheroids as Screening Platform for Peripheral Neuropathies.- A Head and Neck Cancer Spheroid Model for Phenotypic High-Content Screening of Chemoresistance.- Dissecting Bacterial Growth Variants by Cellular Phenotypic Profiling and Backtracing.- Large-Scale Mutagenesis Screening for Genetic Determinants of Plasmodium falciparum Sexual Development.- High-Throughput Phenotypic and Metabolic Screening of Wild Yeasts for Their Biotechnological Application.- Invertebrate Automated Phenotyping Platform (INVAPP): An Automated High-Throughput System with Applications in Understanding and Combating Human Diseases.- CRISPR/Cas9-Based Mutagenesis Strategies for Efficient Biallelic Gene Inactivation and Consistent Phenotypic Detection in F0 Zebrafish.