In this manual, the authors compare the range of applications for phosgene with that of the alternative compounds, dealing in detail with the possible uses of diphosgene, triphosgene, carbon dioxide, organic carbonates, oxalylchloride and many other alternative materials used in synthesis. However, they clearly point out those cases where phosgene continues to have the advantage. The result is a mine of information for synthetic chemists working in industry and academia faced with the question of where the toxic phosgene can be replaced by an unproblematic compound - including the safety phosgenation.
Arvustused
"The encyclopaedic nature of this book, combined with its critical, informed, and comprehensive approach, makes it a very valuable source for synthetic chemists in academia and in industry."
Peter L. Spargo Organic Research Process and Development
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Classification of Phosgene Organic Reactions. |
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Structural Properties of Phosgene and 'Pseudophosgene' Compounds. |
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Thermodynamic of Phosgene Reactions. |
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Thermal, Chemical (Nucleophilic) and Catalytic Induced Dissociation. |
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Phosgenes vs. Phosgene Substitutes Reactivity. |
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Phosgenes vs. Phosgene Substitutes Reactions. |
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Specific Synthetic Applications of Phosgene vs. Phosgene Substitutes. |
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Synthesis of Phosgene Substitutes. |
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Safety Aspects and Environmental Impact. |
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Monitoring of Phosgene and Phosgene Substitutes. Analytical Methods. |
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Livius Cotarca was born in Romania (1951) where he received his M .Sc. and PhD degrees in Industrial Organic Chemistry from the Polytechnic University of Timisoara. He holds also a M. Sc. Degree in Chemical Engineering from the Milan Polytechnic University (Italy). He was successively Associate Professor of Organic Chemistry at Timisoara and Senior Chemist at Caffaro-Sinia, Italy. In 1999 he joined the Zamban Group where he is now Manager of Research and Industrial Development. Dr. Cotarca is a recipient of the Nicolae Teclu Award for Chemistry of Romanian Academy and is a member of the American Chemical Society. He is author of numerous patents and publications and co-author of two books. Currently, his scientific interest is devoted to the process chemistry of active pharmaceutical ingredients. Heiner Eckert was born in Munich, Germany, where he gained his diploma in Chemistry at the Technical University of Munich (TUM) in 1973, going on to receive his PhD with summa cum laude under Professor I. Ugi three years later. In 1977, he founded Dr. Eckert GmbH, a company specializing in developing fine chemicals and processes for chemicals production, particularly in the field of phosgenation reactions. At present he is working as an Academic Director at the TUM, with his research focused on new methods in organic syntheses development. Dr. Eckert has published numerous scientific publications and patents, and indeed the Eckert hydrogenation catalysts are named for him.
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