This disorder transcends multiple disciplines and demands a team approach to improve knowledge and treatment. The highly experienced internationally recognized authors have updated every section and added many new chapters, including some on genetic abnormalities in virus and host seen in PTLDs. In this successor edition, there is a completely new section on PTLDs after hematopoietic stem cell transplantation. The newest PTLD classifications and current treatment paradigms that reflect recently conducted international trials are fully incorporated. As technologies have advanced, this book provided state-of-the-art new diagnostic and prognostic information.
Post-Transplant Lymphoproliferative Disorders 2nd Edition is designed to be a valuable reference for oncologists and all transplant professionals, such as surgeons, nephrologists, cardiologists, hepatologists/gastroenterologists, pulmonologists, infectious disease specialists, pathologists, as well as interns and residents in training in these specialists. It provides these professionals with comprehensive and up-to-date information that guides their management of transplant patients before and after transplant, with and without PTLD.
Introduction and History.- Definitions and Pathology of PTLD.- EBV
Biology in the Pathogenesis of PTLD.- Host genetic mutations and expression
analyses in PTLD.- Immune responses to EBV in the immunocompromised host.-
Technical aspects of Epstein-Barr viral load assays.- Epidemiology of PTLD
after SOT.- Clinical Features and Diagnostic Considerations.- Prognostic
Factors.- Management of PTLD.- Prevention of Epstein - Barr virus Infection
and Post-Transplant Lymphoproliferative Disorders Following Transplantation.-
Epidemiology and Prognosis of PTLD after HSCT.- Clinical Presentations and
Features of PTLD after Hematopoietic Stem Cell Transplantation.- Management
of PTLD after HSCT.- Preventative and preemptive strategies for EBV infection
and PTLD after hematopoietic stem cell transplantation.- Organ Specific
issues of PTLD Kidney.- Liver.- Post-transplantation Lymphoproliferative
Disorder in Intestinal Transplant Recipients.- PTLD After Heart
Transplantation.- Lung Transplantation.- Research Priorities and Future
Directions.
Vikas R. DharnidharkaDivision of Pediatric Nephrology Hypertension and PheresisWashington University School of MedicineSt. Louis, MOUSA Michael GreenDepartments of Pediatrics and SurgeryUniversity of Pittsburgh School of MedicineUPMC Children's Hospital of PittsburghPittsburgh, PAUSA Steven A. WebberDepartment of PediatricsVanderbilt University School of MedicineNashville, TNUSA Ralf Ulrich TrappeDepartment of Hematology and OncologyDIAKO Ev. Diakonie-Krankenhaus BremenBremen, Germany
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