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E-raamat: Potential Therapeutic Applications of Nano-antioxidants

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  • Formaat: PDF+DRM
  • Ilmumisaeg: 27-Aug-2021
  • Kirjastus: Springer Verlag, Singapore
  • Keel: eng
  • ISBN-13: 9789811611438
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Potential Therapeutic Applications of Nano-antioxidantsSuurem pilt
  • Formaat: PDF+DRM
  • Ilmumisaeg: 27-Aug-2021
  • Kirjastus: Springer Verlag, Singapore
  • Keel: eng
  • ISBN-13: 9789811611438
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This book highlights the nano-antioxidants and their potential therapeutic applications. The chapters start with basic information on free radicals and antioxidants, through natural antioxidants, mechanisms of their action, ending with the use of nano-antioxidants particularly its potential therapeutic applications. Nano-antioxidant therapy has a promising future that has to be explored. It is a bridge topic to connect the already existing literature with potential therapeutic highlights. This book is designated for students and researchers interested in Biochemistry, Chemistry, Physics, Food Science and nutrition, Pharmaceutical Science and Medicine. It would also be interesting to global audiences from human and animal nutrition to food preservation and packaging.

 


1 Free Radicals Versus Antioxidants
1(18)
1 Introduction
1(1)
2 Free Radicals
2(5)
2.1 Formation and Definition of Free Radicals
2(1)
2.2 How Free Radicals Are Destructive
3(2)
2.3 Production of Reactive Organic Species
5(1)
2.4 Not Always Damaging
6(1)
2.5 When it Is Alarming?
6(1)
3 Antioxidants
7(12)
3.1 Definition
8(1)
3.2 The Locations where Free Radicals and Antioxidants Counteract
8(1)
3.3 Classification of Antioxidants
9(7)
References
16(3)
2 Chemistry of Natural Super-antioxidants
19(12)
1 Introduction
19(6)
1.1 Phytochemicals
19(1)
1.2 Polyphenols
20(1)
1.3 Classification and Chemical Structure of Polyphenols
21(4)
2 Color of Fruits and Vegetables
25(2)
3 Antioxidant Activity of Polyphenols
27(4)
References
28(3)
3 Nano-antioxidants
31(52)
1 Introduction
31(5)
1.1 A Brief Introduction of Nanoparticles
32(1)
1.2 Unique Traits of Nanomaterials
33(1)
1.3 Synthesis of Nanoparticles
33(1)
1.4 Characterization of Nanoparticles
34(2)
2 Nanoparticles as Nano-antioxidants
36(4)
2.1 Need of Antioxidants
36(2)
2.2 Role of Nanoparticles as Antioxidants
38(2)
3 Metal/Metal Oxide Nanoparticles
40(16)
3.1 Gold(Au)
40(3)
3.2 Silver(Ag)
43(1)
3.3 Ceria(CeO2)/Yttria(Y2O3)
44(3)
3.4 Copper/Copper Oxide (CuO)
47(2)
3.5 Titanium Dioxide (TiO2) Nanoparticles
49(1)
3.6 Platinum Nanoparticles
50(2)
3.7 Iron/Iron Oxide Nanoparticles
52(2)
3.8 Zinc Oxide Nanoparticles
54(2)
4 Non-metallic Nano-antioxidants
56(3)
4.1 Silica Nanoparticles as Nano-antioxidant
56(1)
4.2 Fullerenes(C6O)
57(2)
5 Polymeric Nano-antioxidants
59(5)
5.1 Vanillin
60(1)
5.2 Curcumin
61(1)
5.3 Quercetin, Catechin, and Resveratrol
62(1)
5.4 Zein
63(1)
5.5 Chitosan
63(1)
5.6 Gallic Acid
64(1)
6 Nanoemulsions and Nanocarriers
64(1)
7 Determination of Antioxidant Activity
65(8)
7.1 Parameters to Measure Antioxidant Ability
66(1)
7.2 Hydrogen Atom Transfer (HAT) Methods
66(1)
7.3 Single Electron Transfer (SET) Methods
67(6)
8 Cytotoxicity
73(1)
9 Conclusion
73(10)
References
74(9)
4 Mechanism of Antioxidant Activity
83(18)
1 Introduction
83(3)
1.1 Pathways for the Free Radical Production Activity
84(1)
1.2 Promulgation Mechanism for Free Radical Productivity
85(1)
2 Antioxidant Activity
86(1)
3 Mechanism of Antioxidant Activity
86(7)
3.1 Hydrogen Atom Transfer (HAT) Mechanism
87(2)
3.2 The SET: Single Electron Transfer Mechanism
89(1)
3.3 SET-PT: Single Electron Transfer Accompanied with Proton Transfer
90(1)
3.4 SPLET: Sequential Proton Loss Electron Transfer
90(1)
3.5 Transition Metals Chelation (TMC)
91(2)
4 Mechanism for the Functioning of Nano-Antioxidants
93(8)
4.1 Electron-Hole Excitonic Pairs (e-,H+)Theory
93(2)
4.2 n-n Stacking Interactions Theory
95(1)
4.3 Electron Abstraction Theory (EAT)
95(1)
4.4 Hydrogen Abstraction Theory (HAT)
96(1)
4.5 Electrostatic Attraction Theory
97(1)
References
97(4)
5 Quantification of Antioxidants
101(10)
1 Introduction
102(1)
2 WhatisQSAR?
102(1)
3 Molecular Descriptors
103(3)
4 Operations for QSAR/QSPR Modelling
106(1)
4.1 Progression Through Stepwise Regression
106(1)
4.2 Factor Analysis Followed by Multiple Linear Regression (FA-MLR) (Linear Regression with Many More Variables)
107(1)
4.3 Partial Least Squares Analysis (PLSA)
107(1)
5 QSAR for Phytochemicals
107(1)
6 QSAR Modelling Patterns for Nanomaterials
108(3)
7 Pros and Cons of QSAR Modelling
111(1)
References 111
Dr. Sharda Sundaram Sanjay

Dr.Sharda Sundaram Sanjay is Associate Professor in Chemistry at Ewing Christian College, Prayagraj, India. She has done her B.Sc., M.Sc. (Chemistry) and D.Phil. from the University of Allahabad. In addition to journal publications, she also has to her credit, a reference book and many book chapters in many edited volumes in different areas such as Nanomaterials, Medicine, Food Science. Dr. Sundaram has completed research projects and presented her research at different national and international events. Dr. Sundaram is on the reviewer panel and Editorial Board for national and international journals. She is a member of the National Academy of Sciences, India (NASI), Indian Chemical Society (ICS), The Institute of Applied Sciences (IAS), Indian Science Congress Association (ISCA), and The Society for Material Chemistry (SMC), BARC.

Dr. Ashutosh Kumar Shukla





Dr.Ashutosh Kumar Shukla is Associate Professor in Physics at Ewing Christian College, Prayagraj, India. He received his B.Sc., M.Sc. (Physics) and D.Phil. from the University of Allahabad. In addition to journal publications, he also has to his credit, a textbook and several edited volumes in different areas such as Medicine, Food Science, Crude Oil and Archaeological and cultural heritage research in collaboration with experts globally. Dr. Shukla has completed research projects and presented his research at different international meetings. Dr. Shukla is on the reviewer panel and Editorial Board for international journals. He is a member of the International EPR Society (IES) and a web member of the International Society of Magnetic Resonance (ISMAR).
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