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E-raamat: Ranking Vaccines: A Prioritization Software Tool: Phase II: Prototype of a Decision-Support System

  • Formaat: 160 pages
  • Ilmumisaeg: 30-Sep-2013
  • Kirjastus: National Academies Press
  • Keel: eng
  • ISBN-13: 9780309266390
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  • Formaat: 160 pages
  • Ilmumisaeg: 30-Sep-2013
  • Kirjastus: National Academies Press
  • Keel: eng
  • ISBN-13: 9780309266390

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SMART VaccinesStrategic Multi-Attribute Ranking Tool for Vaccinesis a prioritization software tool developed by the Institute of Medicine that utilizes decision science and modeling to help inform choices among candidates for new vaccine development. A blueprint for this computer-based guide was presented in the 2012 report Ranking Vaccines: A Prioritization Framework: Phase I.



Ranking Vaccines: A Prioritization Software Tool,Phase II extends the proof-of-concept presented in the Phase I report, which was based on multi-attribute utility theory. This report refines a beta version of the model developed in the Phase I report and presents its next iteration, SMART Vaccines 1.0.



Ranking Vaccines: Phase II discusses the methods underlying the development, validation, and evaluation of SMART Vaccines 1.0. It also discusses how SMART Vaccines shouldand, just as importantly, should notbe used. The report also offers ideas for future enhancements for SMART Vaccines as well as for ideas for expanded uses and considerations and possibilities for the future.







Table of Contents



Front Matter Summary 1 Introduction: New Vaccines and SMART Vaccines 2 Refinements to the SMART Vaccines Model 3 Data Synthesis, Software Redesign, and Evaluation 4 Observations and Looking Forward References Appendix A: Computational Modeling for SMART Vaccines Appendix B: Candidate Disease Profiles Appendix C: Data Sources and Methodology for SMART Vaccines Appendix D: Verification and Analyses of the SMART Vaccines Computational Model Appendix E: Stakeholder Speakers Appendix F: Biographical Information
Disclaimer xvii
Summary 1(12)
1 Introduction: New Vaccines and Smart Vaccines
13(12)
Study Context and Scope
17(2)
Study Process and Feedback from Stakeholders
19(6)
2 Refinements to the Smart Vaccines Model
25(8)
A Brief Review of the Modeling Framework
25(3)
Setting Ranges for Attributes: A Heuristic Process
28(1)
Weights and Ranks: Attention to the Ranges of the Attributes
28(3)
Comparison of SMART Scores
31(2)
3 Data Synthesis, Software Redesign, and Evaluation
33(28)
Selection of Vaccine Candidates
33(2)
Data Sourcing and Quality
35(1)
Development of a Test Model to Inform Software Redesign
36(2)
Interface Redesign for SMART Vaccines 1.0
38(9)
Representative Use Case Scenarios
47(4)
Users' Evaluation of the Prototype
51(10)
4 Observations and Looking Forward
61(10)
Guiding Principle and Strategy
61(1)
A Vision for the Future
62(1)
Future Steps
63(3)
Enhanced Applications of SMART Vaccines
66(3)
Next Phase
69(2)
REFERENCES
71(2)
APPENDIXES
A Computational Modeling for SMART Vaccines
73(12)
B Candidate Disease Profiles
85(14)
C Data Sources and Methodology for SMART Vaccines
99(12)
D Verification and Analyses of the SMART Vaccines Computational Model
111(14)
E Stakeholder Speakers
125(2)
F Biographical Information
127