In 21 chapters, this volume describes manifold attempts to speed up the development of new and better agrochemicals. The first part discusses mainly general principles and techniques for the analysis of relationships between structure and activity. The traditional distinction of insecticides, herbicides, and fungicides is retained in the following sections covering applications of structure-activity analysis. Selected examples and diverse methods for their rational design are explained. The volume closes with two chapters dealing with the ecotoxicology of organophosphates and the application of quantum chemical methods to evaluate the environmental behavior of xenobiotics. Annotation copyright Book News, Inc. Portland, Or.
This book presents discussions of the most important aspects in the development of agrochemicals. The book covers such broad areas as structure activity and ecotoxicological analyses in comprehensive reviews for general methods and chronicles for individual examples. Topics in structure-activity relationships include how to combine submolecular structures of pharmacological interests and modify them according to chemorational models with computer-aided procedures such as the traditional Hansch-type QSAR, the sequential, simplex optimization, and molecular modeling. Topics in the ecotoxicology of organo phosphorus compounds are discussed in terms of the quantitative structure-toxicity relationship (QSTR). Chronicles of molecular orbital methodology in predicting environmental fates of agrochemicals are also provided.
This volume will be invaluable for researchers in the agrochemical and pharmaceutical industries.
GENERAL METHODS. Sequential Simplex Optimization Strategies in
Agrichemical/Drug Design (Ernest L. Plummer). Principles and Usage of Steric
Parameters in Correlation Analysis of Pesticides (Carlo Silipo and Antonio
Vittoria). Novel Ways to Factor the Bioresponse Data of Drugs, Toxicants and
Agrochemicals (Philip S. Magee). A Chemorational Approach to Agrochemicals:
The Trifluoromethylpyridinyl Group as a Building Block (Takahiro Haga).
APPLICATIONS. INSECTICIDES. QSAR and Rational Design of Insecticides (George
Holan and David A. Winkler). Rational Approaches to Finding Agrochemical
Leads (Morifuso Eto). Physical-Organic Concepts in Structure-Activity
Relationships in the Development of Insecticides (T.R. Fukuto and S.
Keadtisuke). Structure Evolutions of Synthetic Pyrethroid Insecticides in
Correlational Views Guided by Template Procedure as Applied to Natural
Product Models with High Structural Multiplicity (Hirosukle Yoshioka).
Transition State Analog Enzyme Inhibitors: Structure-Activity Relationships
of Trifluoromethyl Ketones (András Scékács, Barna Bordás, and Bruce D.
Hammock). Design of Proinsecticides (Noriharo Umetso). HERBICIDES.
Structure-Activity Studies of Photosynthesis Inhibitors (Wilfried Draber).
Application of the Hansch-Fujita Method to the Design of Amide and Urea
Herbicides (Chiyozo Takayama, Katsuzo Kamoshita, Akira Fujinami and Osuma
Kirino). Development and Analysis of QSAR Models for Generating Pesticidal
Synthesis Programs (Barrington Cross and David W. Ladner). Chemical Structure
and Activity of Herbicidal Inhibitors of Phytoene Desaturase (Gerhard
Sandmann and Peter Böger). Structure-Activity Relationships of Sulfonylurea
Herbicides (Tariq A. Andrea, Steven P. Artz, Thomas B. Ray, and Robert J.
Pasteris). Cyclohexanedione Herbicides: Their Activities and Properties (Isao
Iwataki). FUNGICIDES. Application of the Hansch-Fujita Method to the Design
of Imide and Carbamate Fungicides (Katsuzo Kamoshita, Chiyozo Takayama, Junya
Takahashi, and
Wilfried Draber, Toshio Fujita
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