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E-raamat: Recent Advancement in Prodrugs

Edited by , Edited by , Edited by (Drugs Testing Laboratory Avam Anusandhan Kendra, Raipur), Edited by
  • Formaat: 350 pages
  • Ilmumisaeg: 13-May-2020
  • Kirjastus: CRC Press
  • Keel: eng
  • ISBN-13: 9781000057997
  • Formaat - EPUB+DRM
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  • Formaat: 350 pages
  • Ilmumisaeg: 13-May-2020
  • Kirjastus: CRC Press
  • Keel: eng
  • ISBN-13: 9781000057997

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Recent Advancement in Prodrugs

Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations.

Key features











Covers recent advancements in development of prodrugs





Presents balanced synthesis and applications of prodrug chemistry





Discusses broad spectrum of prodrug categories and outlines industrial applications





Reviews prodrugs in cancer nanomedicine, its therapy and treatment





Elucidates mathematical models to study the kinetics of prodrugs

This book covers recent advances in the design of prodrugs. It contains all the significant recent examples of prodrug chemistry developments and will aid academics and researchers seeking to generate new projects in the field.
Preface vii
Editors ix
Contributors xi
1 Recent Advancements in New Drug Design and Development of Prodrugs
1(20)
Kamal Shah
Gaurav Krishna
Jeetendra Kumar Gupta
Durgesh Nandini Chauhan
Nagendra Singh Chauhan
Pradeep Mishra
2 Codrugs: Optimum Use through Prodrugs
21(46)
Suneela Dhaneshwar
Poorvashree P. Joshi
Shubham Pawar
3 Role of Prodrugs in Drug Design
67(26)
Asadullah Madni
Sobia Noreen
Afifa Shafique
Abdur Rahim
Muhammad Sarfraz
Attia Afzal
4 Prodrugs for Enhancement of Lipophilicity
93(20)
Suneela Dhaneshwar
Neha V. Bhilare
5 Lipidic Prodrugs for Drug Delivery: Opportunities and Challenges
113(20)
Milica Markovic
Shimon Ben-Shabat
Arik Dahan
6 The Progress of Prodrugs in Drug Solubility
133(32)
Guilherme Felipe dos Santos Fernandes
Igor Muccilo Prokopczyk
Chung Man Chin
Jean Leandro dos Santos
7 Prodrugs for CNS Drug Delivery
165(20)
Katalin Prokai-Tatrai
8 Prodrugs for Cancer Treatment
185(16)
William L. Stone
Victoria E. Palau
K. Krishnan
9 Prodrugs in Cancer Nanomedicine and Therapy
201(26)
Vikas Pandey
Tanweer Haider
Vishal Gour
Vandana Soni
Prem N. Gupta
10 Nitroreductases in Prodrug Therapies
227(26)
Tugba Giingor
Ferah Comert Onder
Mehmet Ay
11 Prodrug Approach Using Carboxylesterase: Different Substrate Specificities of Human Carboxylesterase Isozymes
253(16)
Masato Takahashi
Masakiyo Hosokawa
12 Mathematical Models for ADME of Prodrugs
269(16)
Vipin Bhati
Navyashree V.
Shamsher Singh
Pooja Chawla
Anoop Kumar
13 Prodrug Approaches for Natural Products
285(32)
Sudhir Kumar Thukral
Pooja Chawla
Alok Sharma
Viney Chawla
14 Biotechnology-Based Prodrug Approach for Cell-Specific Targeting: Its Theoretical Basis and Application
317(16)
Sunita Minz
Manju Rawat Singh
Deependra Singh
Arun Singh Parihar
Madhulika Pradhan
Index 333
Kamal Shah, Durgesh Nandini Chauhan, Nagendra Singh Chauhan, Pradeep Mishra