Regenerative Engineering and Developmental Biology: Principles and Applications examines cutting-edge developments in the field of regenerative engineering. Specific attention is given to activities that embrace the importance of integrating developmental biology and tissue engineering, and how this can move beyond repairing damage to body parts to instead regenerate tissues and organs. The text furthermore focusses on the five legs of the field of regenerative engineering, including: materials, developmental biology, stem cells, physics, and clinical translation. This book was written by leading developmental biologists; each chapter examines the processes that these biologists study and how they can be advanced by using the tools available in tissue engineering/biomaterials. Individual chapters are complete with concluding remarks and thoughts on the future of regenerative engineering. A list of references is also provided to aid the reader with further research. Ultimately, this book achieves two goals. The first encourages the biomedical community to think about how inducing regeneration is an engineering problem. The second goal highlights the discoveries with animal regeneration and how these processes can be engineered to regenerate body parts. Regenerative Engineering and Developmental Biology: Principles and Applications was written with undergraduate and graduate-level biomedical engineering students and biomedical professionals in mind.
Arvustused
"I strongly recommend that engineering- and medical-oriented people, as well as young generations who are interested in the future of regenerative medicine, should read this book." Kiyokazu Agata, Gakushuin University, Tokyo, Japan
"The book presents an outstanding collection of thought-provoking chapters that will accomplish the goal of bringing developmental biologists and tissue engineers closer together. This will certainly be a welcome addition to my book shelf." Randal Voss, University of Kentucky, USA
| Preface |
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ix | |
| Acknowledgments |
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xiii | |
| Editor |
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xv | |
| Contributors |
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xvii | |
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1 Introduction to regenerative engineering and developmental biology |
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1 | (22) |
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| Section I Signals Associated With Injury That Inititate Regeneration |
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2 Reactive oxygen species and neuroepithelial interactions during wound healing |
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23 | (16) |
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3 Controlling both the constructive power and the destructive power of inflammation to promote repair and regeneration |
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39 | (16) |
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4 Bioelectrical coordination of cell activity toward anatomical target states: An engineering perspective on regeneration |
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55 | (58) |
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5 The role of nerves in the regulation of regeneration |
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113 | (26) |
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6 Physiological aspects of blastema formation in mice |
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139 | (24) |
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| Section II How Cells Communicate To Remake The Pattern And Restore Function |
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7 Retinoic acid and the genetics of positional information |
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163 | (20) |
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8 MicroRNA signaling during regeneration |
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183 | (24) |
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9 Recovering what was lost: Can morphogens scale to enable regeneration? |
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207 | (22) |
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10 Environmental factors contribute to skeletal muscle and spinal cord regeneration |
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229 | (40) |
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11 Engineered flies for regeneration studies |
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269 | (22) |
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12 Positional information in the extracellular matrix: Regulation of pattern formation by heparan sulfate |
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291 | (18) |
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Md. Ferdous Anower-E-Khuda |
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13 Organ shaping by localized signaling centers |
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309 | (18) |
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14 The positional information grid in development and regeneration |
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327 | (24) |
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15 Theorizing about gene expression heterogeneity patterns after cell dedifferentiation and their potential value for regenerative engineering |
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351 | (12) |
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| Section III Integration Of New Structures With The Old |
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16 Directed differentiation of pluripotent stem cells in vitro |
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363 | (10) |
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17 Dedifferentiation as a cell source for organ regeneration |
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373 | (22) |
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18 Epigenetic control of cell fate and behavior |
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395 | (16) |
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19 Developmental plasticity and tissue integration |
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411 | (22) |
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| Section IV Principles Of Organ Development And Regeneration |
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20 Functional ectodermal organ regeneration based on epithelial and mesenchymal interactions |
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433 | (30) |
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21 Blastema formation in mammalian digit-tip regeneration |
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463 | (14) |
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22 Spinal cord repair and regeneration |
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477 | (22) |
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499 | (24) |
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24 Eye tissue regeneration and engineering |
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523 | (20) |
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25 Skin development and regeneration, and the control of fibrosis |
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543 | (12) |
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26 Programming cells to build tissues with synthetic biology: A new pathway toward engineering development and regeneration |
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555 | (40) |
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595 | (14) |
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| Index |
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609 | |
David M. Gardiner is a professor in the Department of Developmental and Cell Biology at the University of California Irvine. He received his BA in Biology from Occidental College, his Ph.D. from the Scripps Institution of Oceanography at UCSD, and postdoctoral training at UC Davis. His research has been focused discovering the mechanisms regulating limb regeneration in salamanders. He pioneered the use of the axolotl (Ambystoma mexicanum) as a model system for studies of vertebrate regeneration, and developed the Accessory Limb Model as an assay for bioactive compounds that induce dedifferentiation, blastema formation and limb regeneration. This novel assay is the basis for ongoing studies to identify molecular pathways that regulate regeneration in humans. Professor Gardiner is a Fellow of the American Association for the Advancement of Science, a recipient of the Marcus Singer Medal for Excellence in Regeneration Research, and a recipient of the Frontiers in Stem Cell and Regeneration Biology Pioneer Award. He is an author on more than 100 articles, and has served on numerous peer review committees, journal editorial boards, and scientific advisory boards. At UCI he serves as the Associate Dean for Research and Academic Affairs for the Francisco J. Ayala School of Biological Sciences.
Lisainfo e-raamatute kohta