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E-raamat: Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary

  • Formaat: 333 pages
  • Ilmumisaeg: 26-Mar-2003
  • Kirjastus: National Academies Press
  • Keel: eng
  • ISBN-13: 9780309507462
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  • Formaat: 333 pages
  • Ilmumisaeg: 26-Mar-2003
  • Kirjastus: National Academies Press
  • Keel: eng
  • ISBN-13: 9780309507462

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The resistance topic is timely given current events. The emergence of mysterious new diseases, such as SARS, and the looming threat of bioterrorist attacks remind us of how vulnerable we can be to infectious agents. With advances in medical technologies, we have tamed many former microbial foes, yet with few new antimicrobial agents and vaccines in the pipeline, and rapidly increasing drug resistance among infectious microbes, we teeter on the brink of loosing the upperhand in our ongoing struggle against these foes, old and new. The Resistance Phenomenon in Microbes and Infectious Disease Vectors examines our understanding of the relationships among microbes, disease vectors, and human hosts, and explores possible new strategies for meeting the challenge of resistance.



Table of Contents



Front Matter Summary and Assessment 1. Introduction 2. Microbe Resistance 3. Vector Resistance 4. The Economics of Resistance 5. Factors Contributing to the Emergence of Resistance 6. Emerging Tools and Technology for Countering Resistance 7 Strategies to Contain the Development and Consquences of Resistance Appendix A: Publc Health Consquences of Use of Antimicrobial Agents in Agriculture Appendix B: Agenda: Issues of Resistance: Microbes,Vectors, and the Host Appendix C: Information Resources Appendix D: Executive Summary: WHO Report Appendix E: Executive Summary: GFHR Report Appendix F: Executive Summary: Interagency Task Force Report Appendix G: Forum Member, Speaker, and Staff Biographies
Summary and Assessment 1(19)
Stanley M. Lemon
Introduction
19(25)
Microbial Resistance: Adopting an Evolutionary Approach
19(2)
Arms Races and Antimicrobial Resistance: Using Evolutionary Science to Slow Evolution
21(11)
Stephen R. Palumbi
Antibiotic Resistance 1992-2002: A Decade's Journey
32(12)
Stuart B. Levy
Microbe Resistance
44(35)
Overview
44(2)
New Strategies Against Multi-Drug-Resistant Bacterial Pathogens
46(6)
Alexander Tomasz
Malaria and the Problem of Chloroquine Resistance
52(7)
Thomas E. Wellems
Drug Resistance in Treatment of Schistosomiasis
59(5)
Charles H. King
Bacterial Infection in Irradiated Mice: Therapy and Prophylaxis (Anthrax, a Special Consideration)
64(15)
Thomas B. Elliott
Vector Resistance
79(28)
Overview
79(2)
Insecticide Resistance in Insect Vectors of Human Disease
81(7)
Janet Hemingway
Managing the Emergence of Pesticide Resistance in Vectors
88(6)
William G. Brogdon
What Is the Role of Insecticide Resistance in the Re-Emergence of Major Arthropod-Borne Diseases?
94(13)
Donald R. Roberts
Paul B. Hshieh
The Economics of Resistance
107(23)
Overview
107(1)
What Does Economics Have to Offer in the War Against Antimicrobial Resistance?
108(10)
Richard D. Smith
Economic Instruments for the Control of Antimicrobial Resistance
118(3)
William Jack
Economic Responses to the Problem of Drug Resistance
121(9)
Ramanan Laxminarayan
Factors Contributing to the Emergence of Resistance
130(29)
Overview
130(2)
Antibiotic Use and Resistance in Developing Countries
132(7)
Iruka N. Okeke
Healthcare-Acquired Infections: Hospitals as a Breeding Ground for Antimicrobial Resistance
139(8)
Lindsay E. Nicolle
The Use of Antimicrobials in Food-Producing Animals
147(12)
Thomas R. Shryock
Emerging Tools and Technology for Countering Resistance
159(37)
Overview
159(1)
Evolution of Multiple Mechanisms of Resistance to β-Lactam Antibiotics
160(7)
Dasantila Golemi-Kotra
Sergei Vakulenko
Shahriar Mobashery
Using Phase Lytic Enzymes to Control Antibiotic-Resistant Pathogenic Bacteria on Mucous Membranes
167(7)
Vincent A. Fischetti
Roles for Pharmacokinetics and Pharmacodynamics in Drug Development for Resistant Pathogens
174(22)
Jerome J. Schentag
Alan Forrest
Strategies to Contain the Development and Consequences of Resistance
196(91)
Overview
196(2)
Development of the Public Health Action Plan to Combat Antimicrobial Resistance and CDC Activities Related to Its Implementation
198(8)
David M. Bell
Antibiotic Resistance: Encouraging the Development of New therapies, Preserving the Usefulness of Current Therapies
206(4)
Mark J. Goldberger
The Centers for Disease Control and Prevention's Campaign to Prevent Antimicrobial Resistance in Health Care Settings
210(5)
Julie L. Gerberding
Antimicrobial Resistance Containment Strategies of the Rational Pharmaceutical Management Plus Program
215(8)
Terry Green
Anthony Savelli
Antimicrobial Resistance and Future Directions
223(8)
Mary E. Torrence
APPENDIXES
A Public Health Consequences of Use of Antimicrobial Agents in Agriculture
231(13)
B Agenda: Issues of Resistance: Microbes, Vectors, and the Host
244(5)
C Information Resources
249(7)
D Executive Summary: Who Report
256(18)
E Executive Summary: GFHR Report
274(5)
F Executive Summary: Interagency Task Force Report
279(8)
G Forum Member, Speaker, and Staff Biographies
287


Stacey L. Knobler, Stanley M. Lemon, Marian Najafi, and Tom Burroughs, Editors, Forum on Emerging Infections