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E-raamat: Self-powered SoC Platform for Analysis and Prediction of Cardiac Arrhythmias

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This book presents techniques necessary to predict cardiac arrhythmias, long before they occur, based on minimal ECG data. The authors describe the key information needed for automated ECG signal processing, including ECG signal pre-processing, feature extraction and classification. The adaptive and novel ECG processing techniques introduced in this book are highly effective and suitable for real-time implementation on ASICs.

Chapter 1 Introduction Chapter 2 Literature Review Chapter 3 System Design and Development Chapter 4 Hardware Design and Implementation Chapter 5 Performance and Result Chapter 6 Conclusions Bibliography Index
1 Introduction
1(10)
1.1 Remote Monitoring System (RMS)
2(2)
1.1.1 Key Enabling Technologies
3(1)
1.1.2 Economical Impact
4(1)
1.2 Electrocardiographic Signal
4(2)
1.3 Cardiac Arrhythmias
6(1)
1.4 The Problem with Existing Cardiac Arrhythmia Automatic Diagnostic Solutions
7(1)
1.5 Proposed Solutions and Book Contribution
7(1)
1.6 Goal of the Work
8(1)
1.7 Book Outline
9(2)
2 Literature Review
11(12)
2.1 Cardiovascular Diseases
12(1)
2.1.1 Mortality
12(1)
2.1.2 Prevalence
13(1)
2.2 ECG Filtering: A Review
13(2)
2.3 ECG Feature Extraction Techniques: A Review
15(1)
2.4 ECG Classification Techniques: A Review
15(5)
2.4.1 Support Vector Machine (SVM)
16(1)
2.4.2 Artificial Neural Network (ANN)
17(1)
2.4.3 Hidden Markov Model (HMM)
18(1)
2.4.4 Linear Discriminant Analysis (LDA)
18(1)
2.4.5 Naive Bayes
19(1)
2.4.6 Hybrid Methods
19(1)
2.5 Hardware Implementation of ECG Signal Processing Systems: A Review
20(3)
2.5.1 State-of-the-Art
20(3)
3 System Design and Development
23(16)
3.1 ECG Databases
26(1)
3.2 Analytical Methods for ECG Preprocessing
27(5)
3.2.1 QRS Complex Detection
27(1)
3.2.2 T and P Wave Delineation
28(4)
3.3 Feature Extraction
32(4)
3.3.1 Short-Term ECG Features
33(2)
3.3.2 Statistical Analysis
35(1)
3.3.3 Information Gain Attribute Evaluation
35(1)
3.4 Classification Using Naive Bayes
36(3)
3.4.1 Classification Procedure
37(2)
4 Hardware Design and Implementation
39(12)
4.1 System Architecture
39(1)
4.2 Design of the Preprocessing Stage
39(5)
4.2.1 Realization of QRS Complex Detection
40(3)
4.2.2 Realization of T and P Wave Delineation
43(1)
4.3 Design of the Classification Stage
44(1)
4.4 ASIC Implementation
45(6)
4.4.1 Set Specifications and Prepare the Golden Model
45(1)
4.4.2 RTL Coding and Testbench
46(1)
4.4.3 Synthesis
46(1)
4.4.4 IC Compiler (ICC)
47(1)
4.4.5 Chip Finishing
47(4)
5 Performance and Results
51(14)
5.1 Matlab Simulation Results
51(5)
5.1.1 Performance of the Preprocessing Stage: Part 1
51(2)
5.1.2 Performance of the Feature Extraction Stage
53(2)
5.1.3 Performance of the Classification Stage: Part 1
55(1)
5.1.4 Comparison to Published Work: Part 1
56(1)
5.2 ASIC Implementation Results
56(6)
5.2.1 Performance of the Preprocessing Stage: Part 2
58(1)
5.2.2 Performance of the Classification Stage: Part 2
58(1)
5.2.3 Comparison to Published Work: Part 2
58(4)
5.3 First Tapeout
62(3)
5.3.1 Testing and Implementation
62(3)
6 Conclusions
65(2)
Bibliography 67(6)
Index 73
Hani Saleh is an Associate professor of electronic engineering at Khalifa University (KU), he joined KU since Jan, 2012. He is a co-founder and an active member in KSRC (Khalifa University Research Center) where he leads a project for the development of wearable blood glucose monitor SOC and a mobile surveillance SOC and safe exercise monitoring device. Hani published 90 articles in peer-reviewed journals and conferences, he has 8 issued US patents and 9 pending patent applications. Hani has a total of 19 years of industrial experience in ASIC chip design, microprocessor design, DSP core design, graphics core design and embedded system design. His experience spans DSP core design, microprocessor peripherals design, microprocessors and graphics core deign. Prior to joining Khalifa University he worked as a Senior Chip Designer (Technical Lead) at Apple incorporation; where he worked on the design and implementation of Apple next generation graphics cores for its mobile products (iPad, iPhone, etc.), prior to joining Apple, he worked for several leading semiconductor companies including Intel (ATOM mobile microprocessor design), AMD (Bobcat mobile microprocessor design), Qualcomm (QDSP DSP core design for mobile SOCs), Synopsys (a key member of Synopsys turnkey design group where he taped out many ASICs and designed the I2C DW IP included in Synopys DesignWare library), Fujitsu (SPARC compatible high performance microprocessor design) and Motorola Australia (M210 low power microprocessor synthesizable core design).







Nourhan Bayasi (M13) received the B.S. degree in electrical and computer engineering from the Khalifa University of Science, Technology and Research, Abu Dhabi, United Arab Emirates, in 2013, where she is currently pursuing the M.S. degree in electrical and computer engineering. Her research project focuses on system-on-chip design and implementation of a fully integrated wearable biomedical system. Her currentresearch interests include designing analog and mixed-signals integrated circuits, low power circuit design, and digital signal processing and its application.

 

Baker Mohammad (M04SM13) received the B.S. degree from the University of New Mexico, Albuquerque, NM, USA, the M.S. degree from Arizona State University, Tempe, AZ, USA, and the Ph.D. degree from the University of Texas at Austin, Austin, TX, USA, in 2008, all in electrical and computer engineering. He was a Senior Staff Engineer and the Manager with Qualcomm, Austin, where he was involved in designing high performance and low power DSP processor used for communication and multimedia application. He was involved in a wide range of microprocessors design with Intel Corporation, Santa Clara, CA, USA, from high performance, server chips >100 W (IA-64), to mobile embedded processor low power sub-1 W (xscale). He has over 16 years of industrial experience in microprocessor design with an emphasis on memory, low power circuit, and physical design. He is currently an Associate Professor of Electronic Engineering with the Khalifa University of Science, Technology and Research, Abu Dhabi, United Arab Emirates, and a Consultant with Qualcomm Inc., San Diego, CA, USA. In addition, he is involved in microwatt range computing platform for WSN focusing on energy harvesting and power management, including efficient dc/dc and ac/dc converters. He holds ten issued U.S. patents and has several pending patent applications. He has authored one book entitled Embedded Memory Design for Multi-Core and SoC and co-authored several publications in digital system design, memory design and testing, energy harvesting, power management, and power conversion, in addition to emerging memory technology modeling and design. His current research interests include power efficient computing, high yield embedded memory, and emerging technology, such as memristor, STTRAM, and computer architecture.

 Mohammed Ismail a prolific author and entrepreneur in the field of chip design and test, spent over 25 years in academia and industry in the US and Europe .He obtained his BS and MS from Cairo University, Egypt and His PhD from the University of Manitoba, Canada in 1983, all in electrical engineering.

He is the Founder of the Ohio State University's (OSU) Analog VLSI Lab, one of the foremost research entities in the field of analog, mixed signal and RF integrated circuits and served as its Director. He also served on the Faculty of OSU's ElectroScience Lab. He held a Research Chair at the Swedish Royal Institute of Technology (KTH) where he founded the RaMSiS (Radio and Mixed Signal Integrated Systems) Research Group there. He had visiting appointments in Finland (Aalto university), Norway (NTH and University of Oslo), the Netherlands (Twente University) and Japan (Tokyo Institute of Technology).



He Joined KUSTAR, the UAE in 2011, where heheld the ATIC (now Mubadala Technology) Professor Chair and is Founding Chair of the ECE Department. He is the Founding Director of the Khalifa Semiconductor Research Center

(KSRC) and Co-Director of the ATIC-SRC  Center of Excellence on Energy Efficient Electronic systems (ACE4S) targeting self-powered chip sets for wireless sensing and monitoring, bio chips and power management solutions. He recently joined Wayne State University, Detroit, Michigan as Professor and Chair of the ECE Department. He maintained a  an appointment with KUSTAR as an Adjunct professor. His current research focuses on "self- healing" design techniques for CMOS RF and mm-wave ICs in deep nanometer nodes, energy harvesting and power management, wearable Biochips hardware security, and SoCs for IoTs.





Dr.Ismail served as a Corporate Consultant to over 30 companies and is a Co-Founder of Micrys Inc., Columbus, Ohio, Spirea AB, Stockholm, Firstpass Technologies Inc., Dublin, Ohio and ANACAD-Egypt (now part of Mentor Graphics/Siemens).

He advised the work of over 50 Ph.D. students and of over 100 M.S. students. He authored or co-authored over 20 books and over 170 journal publications, 300 conference papers and has 14 US patents issued and several pending.





He is the Founding Editor of the Springer Journal of Analog Integrated Circuits and Signal Processing and serves as the Journal's Editor-in-Chief. He served the IEEE in many editorial and administrative capacities. He is the Founder of the IEEE International Conference on Electronics, Circuits and Systems (ICECS), the flagship Region 8 Conference of the IEEE Circuits and Systems Society and a Co-Founder of the IEEE International Symposium on Quality Electronic Design (ISQED). He received the US Presidential Young Investigator Award, the Ohio State Lumley Research Award four times, in 1992, 1997, 2002 and 2007, IEEE 2016 CAS Society best paper award and the US Semiconductor Research Corporation's Inventor Recognition Award twice. He is a Fellow of IEEE.