Aging of somatic stem cells reduces stem cell function and results in dysfunctional organs and tissues. Aging of stem cells is thus an underlying cause for aging associated diseases. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis like skin, blood, intestine. Understanding molecular and cellular mechanisms of aging of stem cells is critical for developing approaches to attenuate stem cell aging and it might pave avenues for a healthier life in the elderly. This book presents our current knowledge on mechanisms of aging of stem cells, written by highly prominent experts in the field. It gives insight into stem cell function, comprehensively explains the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches on how to attenuate stem cell aging or attain rejuvenation. The book is written for scientists and clinicians working with stem cells, aging mechanism and age related diseases.
This book offers insight into stem cell function, comprehensively exploring the mechanisms of stem cell aging in model organisms and mammalian systems, and describing related diseases and approaches for attenuating stem cell aging or attaining rejuvenation.
Arvustused
This book discusses the impact of aging on the many stem cell populations, the pathologies associated with the decline of stem cell functions, and the use of stem cells to attenuate stem cell aging. The purpose is to provide a reference for researchers working in the field of healthy aging. The audience is clinicians and all scientists working in the field of aging, stem cells, and regenerative medicine. (Michele Fornaro, Doody's Book Reviews, October, 2015)
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1 Stem Cell Aging: An Overview |
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3 | (16) |
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Part II Mechanisms of Stem Cell Aging: Lessons from Model Organisms |
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2 Aging in the Single-Celled Eukaryote, S. cerevisiae |
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19 | (32) |
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3 Germline Stem Cells and Their Roles in the Regulation of Organism Longevity |
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51 | (20) |
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4 Age-Related Changes to Drosophila m. Male Germline Stem Cells |
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71 | (14) |
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5 Aging of Intestinal Stem Cells in Drosophila Melanogaster |
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85 | (22) |
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Part III Mechanisms of Stem Cell Aging in Mammalian Tissues |
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6 Aging of Murine Hematopoietic Stem Cells |
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107 | (20) |
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7 Aging of Human Haematopoietic Stem Cells |
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127 | (22) |
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8 Aging of Stem Cells in Skin: What Is Driving the Aging Process? |
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149 | (26) |
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9 Aging of Mammalian Intestinal Stem Cells |
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175 | (20) |
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10 Aging of Muscle Stem Cells |
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195 | (32) |
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11 Aging of Human Mesenchymal Stem Cells |
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227 | (18) |
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12 Aging of the Hematopoietic Stem Cell Niches |
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245 | (14) |
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Part IV Stem Cells, Diseases of Aging and Rejuvenation |
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13 Hematopoietic Stem Cell Aging and Leukemogenesis |
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259 | (28) |
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14 Mesenchymal Stem Cells in Wound Repair, Tissue Homeostasis, and Aging |
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287 | (32) |
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Karin Scharffetter-Kochanek |
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15 Retinal Repair Using Stem Cells |
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319 | (24) |
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16 Closing the Circle: Stem Cell Rejuvenation and Longevity |
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343 | |
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Hartmut Geiger studied chemistry and biochemistry at the Universities of Karlsruhe and Witten/Herdecke in Germany. He received his PhD from the Max-Planck-Institute for Immunobiology in Freiburg, Germany in 1999. From 1999 to 2002 he was scientific research fellow at the University of Kentucky, USA with expertise in stem cells, genetics and aging. From 2002 to 2008 he was Assistant Professor at the Division of Experimental Hematology, Cincinnati Childrens Hospital Medical Center, University of Cincinnati, USA. Since 2008 he has been Associate Professor at the University of Cincinnati, USA and Professor at the University of Ulm, Division of Dermatology and Allergic Diseases, Germany. His main research interest lies in the molecular biology of aging.
Lisainfo e-raamatute kohta