This book covers conventional clinical treatment methods for handling bone, cartilage, and related disorders along with their limitations and highlights the current state of art of tissue engineering as an alternative for regenerating defective tissue. Potential biomimetic scaffolding materials and their desired properties, modifications, optimizations, and interactions are described. It reviews the design, development, characterization, properties, and biological functions of biomaterials, various bioreactor systems, and involved translational challenges.
Features:
- Discusses the key aspects of generating engineered bone, cartilage, and associated tissues.
- Covers integration of stem cells and biomaterials including assessment of tissue graft, and translational strategy.
- Reviews multiple engineering principles involved in the various stages of developing biomaterials and scaffold.
- Explores key factors influencing tissue graft generation and challenges involved in various stages.
- Includes several exercises including review questions, numerical problems, for better understanding of the subject.
This book is aimed at researchers, students, professionals in biomedical engineering, tissue engineering, biomaterials, and orthopaedics.
This book covers conventional clinical treatment methods for handling bone, cartilage, and related disorders along with their limitations and highlights the current state of art of tissue engineering as an alternative for regenerating defective tissue. Biomimetic scaffolding materials, and translational challenges are covered.
1. Basic biology of bone, cartilage and surrounding tissues.
2. Tissue engineering as an alternative approach for bone & cartilage regeneration.
3. Basic biomaterial for repairing bone, cartilage and associated joint tissue defects.
4. Advances in fabrication of scaffold.
5. Scaffold properties & characterization.
6. Stem cells for cartilage, bone and related tissue regeneration.
7. Bioreactor and tissue graft generation.
8. In vitro assessment of bone & cartilage tissue grafts.
9. In vivo assessment of regenerated bone, cartilage and joint tissue.
10. Translational approaches & regulatory aspects.
Krishna Pramanik obtained her Ph.D in Chemical Technology in the year 1995 from the University of Calcutta , India. She has 30 years of experience in Industry, research and teaching in the field of Chemical Engineering, Biotechnology and Biomedical Engineering. She is presently a Professor in the Department of Biotechnology & Medical Engineering and Heading the Center of Excellence in Tissue Engineering, National Institute of Technology Rourkela, India. Her current major research activity in the field of tissue engineering with the main focus on the developing bio polymeric and polymer-composite based tissue scaffold with nano- features, integration of scaffold with stem cell to generate tissue constructs and tissue grafts for bone, cartilage, skin, and corneal tissue defects. She has published nearly 150 papers, 16 book chapters of international publications, and edited three books. She has supervised 20 doctoral and 5 Post Doctoral Fellows, most of which in the area of Biomaterial and Tissue Engineering. She has been serving as the Editor and Editorial Board Member of international Journals including the Associate-Editor of Biocell and currently Associate Editor of in Biomaterials (specialty section of Frontiers in Materials, Frontiers in Bioengineering and Biotechnology and Frontiers in Molecular Biosciences).
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