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E-raamat: Stimulated Raman Scattering Microscopy: Techniques and Applications

Edited by (Department of Chemistry, Department of Biomedical Engineering and Kavli Institute for Brain Science, Columbia University, USA), Edited by (Professor, Department of Electrical Engineering and Informati), Edited by , Edited by (Professor, Boston University, Boston, USA)
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  • Ilmumisaeg: 04-Dec-2021
  • Kirjastus: Elsevier - Health Sciences Division
  • Keel: eng
  • ISBN-13: 9780323903370
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  • Formaat: PDF+DRM
  • Ilmumisaeg: 04-Dec-2021
  • Kirjastus: Elsevier - Health Sciences Division
  • Keel: eng
  • ISBN-13: 9780323903370
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Stimulated Raman Scattering Microscopy: Techniques and Applications describes innovations in instrumentation, data science, chemical probe development, and various applications enabled by a state-of-the-art stimulated Raman scattering (SRS) microscope. Beginning by introducing the history of SRS, this book is composed of seven parts in depth including instrumentation strategies that have pushed the physical limits of SRS microscopy, vibrational probes (which increased the SRS imaging functionality), data science methods, and recent efforts in miniaturization.

This rapidly growing field needs a comprehensive resource that brings together the current knowledge on the topic, and this book does just that. Researchers who need to know the requirements for all aspects of the instrumentation as well as the requirements of different imaging applications (such as different types of biological tissue) will benefit enormously from the examples of successful demonstrations of SRS imaging in the book.

Led by Editor-in-Chief Ji-Xin Cheng, a pioneer in coherent Raman scattering microscopy, the editorial team has brought together various experts on each aspect of SRS imaging from around the world to provide an authoritative guide to this increasingly important imaging technique. This book is a comprehensive reference for researchers, faculty, postdoctoral researchers, and engineers.
  • Includes every aspect from theoretic reviews of SRS spectroscopy to innovations in instrumentation and current applications of SRS microscopy
  • Provides copious visual elements that illustrate key information, such as SRS images of various biological samples and instrument diagrams and schematics
  • Edited by leading experts of SRS microscopy, with each chapter written by experts in their given topics
Contributors xv
Foreword xix
Part 1 Theory
1 Coherent Raman scattering processes
Herve Rigneault
1.1 Introduction
3(1)
1.2 Molecular resonances
3(2)
1.2.1 Harmonic oscillator
3(1)
1.2.2 Damped harmonic oscillator
4(1)
1.2.3 Driven harmonic oscillator
4(1)
1.2.4 Study at resonance
4(1)
1.3 Molecular vibrational resonances
5(6)
1.3.1 Vibrational modes
5(1)
1.3.2 Modeling a diatomic molecule
6(1)
1.3.3 Infrared (IR) absorption
6(1)
1.3.4 Spontaneous Raman scattering
7(2)
1.3.5 Coherent Raman scattering
9(2)
1.4 The CARS process
11(5)
1.4.1 Resonant and nonresonant CARS processes
11(1)
1.4.2 Nonlinear polarization and susceptibility
12(1)
1.4.3 Anti-Stokes field generation and propagation
12(2)
1.4.4 X in the spectral domain
14(2)
1.5 The SRS process
16(3)
1.5.1 Coherence and interferometry
16(1)
1.5.2 Field propagation
17(2)
1.6 Conclusion
19(2)
References
19(2)
2 Sensitivity and noise in SRS microscopy
Herve Rigneault
Yasuyuki Ozeki
2.1 Introduction
21(1)
2.2 Definitions and laser intensity noise model
21(4)
2.2.1 Model
21(1)
2.2.2 Definitions
22(2)
2.2.3 Calculations
24(1)
2.3 Low-noise SRS detection through lock-in amplification
25(4)
2.3.1 System and model description
25(2)
2.3.2 Average current and DC power
27(1)
2.3.3 Power spectral density (PSD)
27(1)
2.3.4 Signal-to-noise ratio (SNR)
28(1)
2.3.5 SNR optimization
29(1)
2.4 Shot-noise-limited SNR in SRS, CARS, and spontaneous Raman scattering: A comparison
29(4)
2.4.1 Shot-noise-limited SNR of SRS
30(2)
2.4.2 Shot-noise-limited SNR of CARS
32(1)
2.4.3 Shot-noise-limited SNR of spontaneous Raman scattering
32(1)
2.4.4 Comparison between SRS, CARS, and spontaneous Raman scattering in the shot-noise limit
33(1)
2.5 Conclusion
33(1)
Appendix
34(7)
Appendix A Photocurrent power spectral density
34(1)
Appendix B Modulation at half the repetition rate
34(1)
Appendix C Power spectral density of the lock-in output
35(1)
Appendix D Estimation of the area of focus
36(1)
Appendix E Estimation of the depth of focus
36(1)
Appendix F Derivation of the spectral overlap of vibrational resonance
37(1)
Appendix G Raman scattering cross section
38(1)
Appendix H Quantum mechanical description of Raman scattering
39(1)
References
39(2)
3 Stimulated Raman scattering: Ensembles to single molecules
Richard C. Prince
Eric O. Potma
3.1 The birth and evolution of stimulated Raman scattering
41(5)
3.1.1 The birth of SRS: Light conversion and early spectroscopy
41(2)
3.1.2 First wave: Picosecond time-resolved spectroscopy
43(1)
3.1.3 Second wave: Ultrafast and impulsive regimes
43(1)
3.1.4 Third wave: Diffraction-limited microscopy
44(1)
3.1.5 Fourth wave: Nanoscale and single-molecule spectroscopy
45(1)
3.1.6 Toward SRS nanoscopy
45(1)
3.2 Probing molecules with SRS spectroscopy
46(5)
3.2.1 SRS spectroscopy in the time domain
47(1)
3.2.2 Features of time-domain SRS
48(1)
3.2.3 Femtosecond stimulated Raman scattering (FSRS)
49(2)
3.3 Probing smaller samples: The transition to microscopy
51(4)
3.3.1 Shrinking the probing volume
51(1)
3.3.2 Phase matching in coherent Raman microscopy
51(1)
3.3.3 Instrumentation for SRS microscopy
52(1)
3.3.4 Applications of SRS microscopy
53(2)
3.4 From ensembles to single molecules
55(14)
3.4.1 Enhancing SRS with electronic resonances
55(1)
3.4.2 Enhancing SRS with plasmonic resonances
56(1)
3.4.3 Advanced techniques: Nonoptical detection
57(1)
References
58(7)
Further readings
65(4)
Part 2 Advanced Instrumentation and emerging modalities
4 Hyperspectral SRS imaging via spectral focusing
Bryce Manifold
Benjamin Figueroa
Dan Fu
4.1 Introduction
69(1)
4.2 Principles of spectral focusing SRS
69(2)
4.3 Implementation of spectral focusing SRS
71(1)
4.4 Improving the speed of spectral focusing SRS
72(1)
4.5 Improving the spectral resolution and spectral coverage of spectral focusing SRS
73(2)
4.6 Variations of spectral focusing SRS
75(1)
4.7 Summary and outlook
76(5)
References
77(4)
5 Balanced detection SRS microscopy
Dario Polli
Giulio Cerullo
5.1 Introduction
81(1)
5.2 Balanced detection
81(2)
5.3 Modulation transfer and lock-in amplification
83(1)
5.4 Beyond balanced detection
84(1)
5.5 Auto-balanced detection (ABD)
85(1)
5.6 In-line balanced detection (IBD)
86(1)
5.7 Dual-color spectral-focusing IBD
87(2)
5.8 Collinear balanced detection
89(1)
5.9 Summary
90(1)
References
90(1)
6 Multiplex stimulated Raman scattering microscopy via a tuned amplifier
Mikhail N. Slipchenko
Ji-Xin Cheng
6.1 Introduction
91(1)
6.2 Resonant circuit
92(1)
6.3 Tuned amplifier
92(2)
6.4 Spectral multiplexing
94(1)
6.4.1 Spectrally multiplexed SRS microscopy
94(1)
6.4.2 Spectrally multiplexed SRS cytometry
94(1)
6.5 Spatial multiplexing
95(1)
6.5.1 Line scan transient absorption microscopy
95(1)
6.5.2 Collinear multiple beams SRS (COMB-SRS) microscopy
96(1)
6.6 Conclusions and outlook
96(3)
References
97(2)
7 Impulsive SRS microscopy
Dan Oron
Dekel Raanan
Yahel Softer
7.1 Introduction
99(1)
7.2 Requirements for impulsive excitation and detection
100(1)
7.3 Schemes
101(6)
7.3.1 Time-domain ISRS
101(2)
7.3.2 Frequency-domain ISRS
103(1)
7.3.3 Single-beam impulsive configurations
104(1)
7.3.4 Delay scanning techniques
105(2)
7.4 Implementations of impulsive Raman microscopy
107(3)
7.5 Resonant effects
110(1)
7.6 Impulsive multidimensional spectroscopy
111(1)
7.7 Conclusion
112(3)
References
112(3)
8 Multicolor SRS imaging with wavelength-tunable/switchable lasers
Yasuyuki Ozeki
8.1 Introduction
115(1)
8.2 Multicolor SRS imaging with a high-speed wavelength-tunable laser
115(6)
8.2.1 Setup of multicolor SRS imaging system
115(1)
8.2.2 Operation of the wavelength-tunable pulse source
116(2)
8.2.3 Laser synchronization
118(1)
8.2.4 Electronic circuits
118(1)
8.2.5 Multicolor SRS imaging
119(2)
8.3 Multicolor SRS imaging with a wavelength-switchable laser
121(3)
8.3.1 Operation of wavelength-switchable lasers
121(1)
8.3.2 Electronics for the wavelength-switchable laser
122(1)
8.3.3 Multicolor SRS imaging in flow
122(2)
8.4 Discussions
124(1)
8.5 Summary
124(3)
References
124(3)
9 Pulse-shaping-based SRS spectral imaging and applications
Ping Wang
Zhiliang Huang
9.1 Introduction
127(1)
9.2 Principle of pulse shaping
127(1)
9.3 Methods of SRS spectral imaging based on pulse shaping
128(2)
9.4 Applications of pulse-shaping-based SRS imaging
130(6)
9.5 Summary and outlook
136(1)
References
136(1)
10 Background-free stimulated Raman scattering imaging by manipulating photons in the spectral domain
Hanlin Zhu
Hyeon Jeong Lee
Delong Zhang
10.1 Introduction
137(2)
10.2 Principle
139(1)
10.3 Removing the non-Raman background in SRS imaging
140(3)
10.4 Enabling applications by background-free SRS imaging
143(2)
10.5 Conclusions
145(2)
Acknowledgments
145(1)
References
145(2)
11 Coherent Raman scattering microscopy for superresolution vibrational imaging: Principles, techniques, and implementations
Li Gong
Wei Zheng
Zhiwei Huang
11.1 Introduction
147(3)
11.2 SSRS microscopy
150(5)
11.2.1 Principle of SSRS processes
150(2)
11.2.2 Virtual sinusoidal modulation (VSM) method for superresolution SSRS imaging
152(1)
11.2.3 Experimental observation of SSRS processes and SSRS super-resolution imaging
153(2)
11.3 HO-CARS microscopy
155(4)
11.3.1 Principle of HO-CARS process
155(2)
11.3.2 Experimental observation of HO-CARS
157(1)
11.3.3 Superresolution HO-CARS imaging
158(1)
11.4 Discussion and outlook
159(2)
11.5 Conclusions
161(4)
References
161(4)
12 Quantum-enhanced stimulated Raman scattering
Rayssa Bruzaca de Andrade
Tobias Gehring
Ulrik Lund Andersen
12.1 Introduction
165(1)
12.2 The process of SRS
165(2)
12.3 Advancing SRS beyond the shot-noise limit
167(2)
12.3.1 Fundamental limits to the sensitivity
167(1)
12.3.2 Sensitivity limit for pure states
168(1)
12.3.3 Examples
169(1)
12.3.4 Sensitivity using intensity detection
169(1)
12.4 Noise sources in SRS spectroscopy
169(4)
12.4.1 Noise processes
170(1)
12.4.2 Shot-noise calibration of the detector
170(1)
12.4.3 Noise reduction techniques
170(2)
12.4.4 Optical loss
172(1)
12.5 Experimental test of quantum-enhanced SRS
173(3)
12.5.1 Experimental scheme
173(2)
12.5.2 Discussion
175(1)
12.6 Conclusion
176(3)
References
176(3)
13 Stimulated Raman excited fluorescence (SREF) microscopy: Combining the best of two worlds
Hanqing Xiong
Wei Min
13.1 Introduction
179(1)
13.2 Pioneering work of double-resonance fluorescence spectroscopy
179(1)
13.3 Realization of stimulated Raman excited fluorescence in 2019
180(1)
13.4 Main physical considerations
181(3)
13.5 Remaining technical challenges
184(1)
13.6 Outlook
185(4)
Acknowledgment
186(1)
References
186(3)
14 Instrumentation and methodology for volumetric stimulated Raman scattering imaging
Xueli Chen
Nan Wang
Lin Wang
Peng Lin
14.1 Introduction
189(1)
14.2 Volumetric stimulated Raman scattering imaging by projection tomography
190(4)
14.2.1 Instrumentation
190(1)
14.2.2 Methodology
191(3)
14.3 Volumetric stimulated Raman scattering imaging by tissue clearing
194(3)
14.4 Volumetric stimulated Raman scattering imaging by remote focusing
197(2)
14.5 Outlook
199(4)
Acknowledgments
199(1)
References
199(4)
15 SRS flow and image cytometry
Chi Zhang
15.1 Introduction
203(1)
15.2 Raman flow cytometry and cell sorting
204(1)
15.3 Coherent Raman scattering flow cytometry
205(4)
15.4 Stimulated Raman imaging cytometry and cell sorting
209(3)
15.5 Outlook
212(3)
Acknowledgment
212(1)
References
212(3)
16 Widely and rapidly tunable fiber laser for high-speed multicolor SRS
Carsten Fallnich
Maximilian Brinkmann
Tim Hellwig
16.1 The demand for widely and rapidly tunable fiber-based lasers in coherent Raman imaging
215(1)
16.2 Different concepts for tunable fiber-based lasers in SRS
216(2)
16.3 Concept for widely and rapidly tunable fiber-based four-wave mixing
218(4)
16.4 Rapidly and widely tunable fiber optical parametric oscillator
222(2)
16.5 Applicability to coherent anti-stokes Raman scattering
224(2)
16.6 Applicability to stimulated Raman scattering
226(3)
16.7 Conclusions on widely and rapidly tunable fiber-based lasers in coherent Raman imaging
229(4)
References
230(3)
17 Compact fiber lasers for stimulated Raman scattering microscopy
Khanh Kieu
17.1 Introduction
233(2)
17.2 High-power picosecond fiber source for coherent Raman microscopy
235(3)
17.3 All-fiber laser source providing two synchronized ps, narrowband pulse trains for SRS microscopy
238(6)
17.3.1 Laser design
238(1)
17.3.2 Characterization
239(2)
17.3.3 Auto-balanced detection for suppression of laser excess noise
241(1)
17.3.4 SRS imaging with the fiber laser source
241(2)
17.3.5 Conclusion
243(1)
17.4 Widely tunable all-fiber laser source based on four-wave mixing
244(4)
17.4.1 Phase-matching of FWM in the optical fiber
244(4)
17.5 All-fiber laser source for coherent Raman microscopy based on spectral focusing
248(4)
17.6 Summary
252(5)
References
254(3)
18 Synchronized time-lens source for coherent Raman scattering microscopy
Ke Wang
Chris Xu
18.1 Introduction
257(1)
18.2 Basic principles of the time-lens source
258(1)
18.3 Experimental realization of the time-lens source
259(2)
18.4 Basic principles of the synchronized time-lens source
261(1)
18.5 Experimental realization of the synchronized time-lens source and its performance
262(2)
18.6 Applications to CRS microscopy and various implementations of the synchronized time-lens source
264(5)
18.6.1 Application to video-rate CRS microscopy
264(1)
18.6.2 Fiber-delivered two-color picosecond source and its application to CARS microscopy
265(1)
18.6.3 Direct-current-modulated synchronized time-lens source for hyperspectral SRS microscopy and spectroscopy
265(1)
18.6.4 Multicolor synchronized time-lens source for nonresonant-background-suppressed CARS microscopy
266(3)
18.7 Conclusion and perspective
269(6)
References
269(6)
Part 3 Vibrational probes
19 Spontaneous Raman and SERS microscopy for Raman tag imaging
Hiroyuki Yamakoshi
Katsumasa Fujita
19.1 Introduction
275(1)
19.2 Spontaneous Raman and SERS microscopy
275(2)
19.3 Introduction of Raman-tag imaging
277(3)
19.4 Raman-tag cellular analysis by spontaneous Raman microscopy
280(1)
19.5 Raman-tag sensor for spontaneous Raman microscopy
281(2)
19.6 Raman-tag cellular analysis by SERS
283(2)
19.7 Conclusions
285(4)
References
286(3)
20 Stimulated Raman scattering imaging with small vibrational probes
Haomin Wang
Jiajun Du
Dongkwan Lee
Lu Wei
20.1 Introduction
289(1)
20.2 Principle
290(4)
20.2.1 Triple-bond vibrational probes
290(1)
20.2.2 Isotope-based vibrational probes
291(3)
20.2.3 Raman-active monomers for nanoparticles
294(1)
20.2.4 Raman-active targeted probes and chemical sensors
294(1)
20.3 Applications
294(10)
20.3.1 Small vibrational probes in metabolisms
294(5)
20.3.2 SRS imaging of drug pharmacokinetics
299(3)
20.3.3 Vibrational probes in chemical sensing
302(2)
20.3.4 Screening and interrogating the metabolic flux with vibrational probe sets
304(1)
20.4 Outlook
304(7)
References
306(5)
21 Supermultiplexed vibrational imaging: From probe development to biomedical applications
Naixin Qian
Wei Min
21.1 Introduction
311(1)
21.2 Vibrational probe development
312(6)
21.2.1 Vibrational modes in the bio-silent region enable bioorthogonality
312(1)
21.2.2 Frequency tuning based on k and μ
313(2)
21.2.3 Enhancing sensitivity
315(1)
21.2.4 Establishment of supermultiplexed palettes
316(2)
21.3 Biomedical applications
318(7)
21.3.1 Supermultiplexed imaging of structures and organizations
321(1)
21.3.2 Supermultiplexed imaging of metabolic activity
322(2)
21.3.3 Supermultiplexed barcoding
324(1)
21.4 Outlook
325(4)
References
325(3)
Further reading
328(1)
22 Raman beads for bio-imaging
Jing Wang
Qingqing Jin
Xinjing Tang
22.1 Introduction
329(1)
22.2 Principle
330(2)
22.3 Methods
332(2)
22.3.1 Preparation of Raman beads
332(1)
22.3.2 Raman spectroscopy and SRS imaging of Raman beads
333(1)
22.3.3 The applications of Raman beads for bio-imaging
334(1)
22.4 Results
334(6)
22.5 Outlook
340(3)
References
341(2)
23 Plasmon-enhanced stimulated Raman scattering microscopy
Cheng Zong
Chen Yang
Ji-Xin Cheng
23.1 Introduction
343(1)
23.2 Principle of plasmon-enhanced stimulated Raman scattering
344(1)
23.3 Experimental system for PESRS measurements
344(4)
23.3.1 Instrumentation
344(2)
23.3.2 Plasmonic nanostructures
346(2)
23.4 Line shapes of PESRS spectra
348(3)
23.4.1 PESRL versus PESRG
348(1)
23.4.2 Wavelength dependence
348(2)
23.4.3 Theoretical description of the PESRS line shapes
350(1)
23.5 From ensembles to single molecules
351(1)
23.5.1 Ensemble detection
351(1)
23.5.2 Single-molecule (SM) detection
351(1)
23.6 PESRS versus PECARS
352(1)
23.6.1 Line shape
352(1)
23.6.2 Enhancement factor (EF)
353(1)
23.7 Outlook
353(6)
References
353(6)
Part 4 Data science
24 Converting hyperspectral SRS into chemical maps
Haonan Lin
Ji-Xin Cheng
24.1 Introduction
359(1)
24.2 Unsupervised methods
360(6)
24.2.1 Principal component analysis
360(1)
24.2.2 Spectral phasor approach
361(2)
24.2.3 Multivariate curve resolution (MCR)
363(1)
24.2.4 Factorization into susceptibilities and concentrations of chemical components (FSC3)
364(1)
24.2.5 Independent component analysis (ICA)
364(1)
24.2.6 Determine the number of components
365(1)
24.3 Supervised methods
366(1)
24.3.1 Least-square fitting with spectral profiles
366(1)
24.3.2 Supervised classification
367(1)
24.4 Conclusions and outlook
367(4)
References
368(3)
25 Compressive Raman microspectroscopy
Haonan Lin
Hilton B. de Aguiar
25.1 Introduction to the compressive microspectroscopy framework
371(2)
25.2 Compressive SRS microspectroscopy
373(3)
25.2.1 Unsupervised methods
373(2)
25.2.2 Supervised methods
375(1)
25.3 Beyond SRS: Compressive microspectroscopy in spontaneous Raman and CARS
376(4)
25.3.1 Spontaneous Raman
377(1)
25.3.2 CARS
378(2)
25.4 Conclusions and perspectives
380(3)
References
380(3)
26 Denoise SRS images
Chien-Sheng Liao
26.1 Introduction
383(1)
26.2 Denoise spectroscopic images by PCA
383(4)
26.2.1 Principle: PCA and the connection to SVD
384(1)
26.2.2 Using SVD to denoise SRS spectroscopic images
385(1)
26.2.3 Using SVD to denoise CARS spectroscopic images
386(1)
26.3 Denoise by spectral total variation
387(4)
26.3.1 Principle of STV
387(3)
26.3.2 Procedure to denoise 3D SRS images by STV
390(1)
26.3.3 Using STV to denoise SRS images
390(1)
26.4 Denoise by the deep learning algorithm
391(6)
26.4.1 Principle of neural network
391(2)
26.4.2 Denoise a single SRS image by U-net of CNN
393(1)
26.4.3 Denoise a single CARS images by fine-tuned and ensemble learning
393(1)
26.4.4 Denoise spectroscopic SRS images by spatial-spectral Res-Net
394(3)
26.4.5 SRS image restoration by deep learning algorithms
397(1)
26.5 Outlook
397(6)
References
398(5)
Part 5 Applications to life science and materials science
27 Use of SRS microscopy for imaging drugs
Craig F. Steven
Elisabetta Chiarparin
Alison N. Hulme
Valerie G. Brunton
27.1 Introduction
403(4)
27.1.1 The necessity for drug imaging
403(1)
27.1.2 Techniques in drug imaging
403(1)
27.1.3 Imaging drugs using SRS microscopy
404(3)
27.2 Cancer therapeutics
407(2)
27.3 Dermatological drugs
409(3)
27.4 Drug formulations and delivery systems
412(3)
27.4.1 Drug formulations
412(2)
27.4.2 Drug delivery systems
414(1)
27.5 Conclusions
415(6)
References
416(5)
28 Isotope-probed SRS (ip-SRS) imaging of metabolic dynamics in living organisms
Yajuan Li
Lingyan Shi
28.1 Introduction
421(1)
28.2 DO-SRS imaging of metabolic dynamics in living organisms
422(9)
28.2.1 Rationale of using heavy water for SRS metabolic imaging
422(1)
28.2.2 Strategies to distinguish and unmix C---D signals of SRS imaging
422(2)
28.2.3 DO-SRS imaging of lipid metabolism in living C. elegans and mice
424(4)
28.2.4 DO-SRS imaging of de novo protein synthesis in mice
428(1)
28.2.5 Simultaneous imaging of lipid and protein metabolism in living C. elegans and zebrafish
428(1)
28.2.6 DO-SRS imaging to identify tumor boundary and metabolic heterogeneity in mice
429(2)
28.3 Spectral tracing of deuterium (STRIDE) for SRS imaging of glucose metabolism in mice
431(4)
28.3.1 Principle of STRIDE for SRS imaging
431(1)
28.3.2 Multiplex imaging with STRIDE for macromolecule synthesis
431(1)
28.3.3 STRIDE imaging of protein and lipid dynamics in mouse
431(2)
28.3.4 STRIDE imaging of lipid absorption in neonatal mouse intestine
433(1)
28.3.5 STRIDE imaging of glucose isotopologues for temporally resolved metabolic dynamics
434(1)
28.4 Volumetric clearing-enhanced SRS imaging
435(4)
28.4.1 Raman-tailored tissue clearing for SRS imaging
435(1)
28.4.2 Volumetric clearing-enhanced SRS imaging of entire tumor spheroids
436(1)
28.4.3 Volumetric clearing-enhanced SRS imaging of mouse brain
437(1)
28.4.4 Volumetric clearing-enhanced SRS imaging of tumors
437(1)
28.4.5 Metabolic volumetric imaging of tumor with DO-SRS
438(1)
28.5 SRS imaging of protein metabolism in mice via intracarotid injection of D-AA
439(1)
28.5.1 Rationale of intracarotid injection of D-AA for SRS imaging
439(1)
28.5.2 SRS imaging of protein metabolic in mouse brain
439(1)
28.5.3 SRS imaging of protein metabolic in mouse choroid plexus
440(1)
28.5.4 SRS imaging of protein metabolic in mouse pancreas
440(1)
28.5.5 SRS imaging of protein metabolic heterogeneity in liver and tumor
440(1)
28.6 Summary
440(5)
References
441(4)
29 Rapid determination of antimicrobial susceptibility by SRS single-cell metabolic imaging
Weill Hong
Meng Zhang
Ji-Xin Cheng
29.1 Introduction
445(1)
29.2 Rapid AST in bacteria by SRS imaging of glucose-oV incorporation
446(3)
29.2.1 Glucose-oV incorporation
446(1)
29.2.2 Antibiotic susceptibility determination within one cell cycle
446(1)
29.2.3 MIC determination
447(2)
29.3 Rapid AST in bacteria by SRS imaging of DzO incorporation
449(7)
29.3.1 D20 incorporation
449(1)
29.3.2 Metabolism in the presence of antibiotics
450(1)
29.3.3 Quantitation of single-cell metabolism inactivation concentration (SC-MIC)
450(2)
29.3.4 AST for bacteria in complex environments
452(4)
29.4 Rapid AST in fungi by SRS imaging of de novo lipogenesis
456(3)
29.4.1 Aberrant lipid accumulation in resistant C. albicans
457(1)
29.4.2 De novo lipogenesis as a signature for rapid AST
458(1)
29.5 Conclusion and outlook
459(4)
References
459(4)
30 Stimulated Raman scattering imaging of cancer metabolism: New avenue to precision medicine
Shuhua Yue
30.1 Introduction
463(1)
30.2 Deciphering cancer metabolism by SRS microscopy
464(3)
30.2.1 Lipid droplet in cancer
464(2)
30.2.2 Lipids on membranes in cancer
466(1)
30.2.3 Glucose metabolism in cancer
466(1)
30.2.4 Nucleic acid metabolism in cancer
466(1)
30.3 Deciphering drug metabolism in cancer by SRS microscopy
467(1)
30.4 SRS microscopy opens new avenue to precision diagnosis of cancer
467(3)
30.5 SRS microscopy opens new avenue to precision treatment of cancer
470(1)
30.6 Concluding remarks and future perspectives
470(5)
References
471(4)
31 Biomedical applications of SRS microscopy in functional genetics and genomics
Dinghuan Deng
Tao Chen
Meng C. Wang
31.1 Introduction
475(1)
31.2 Principle
476(3)
31.2.1 Physical basis of CARS and SRS microscopy
476(2)
31.2.2 Instrumental overview of single-frequency and hyperspectral SRS microscopy systems
478(1)
31.3 Methods and results
479(4)
31.3.1 Maintenance of worms
479(1)
31.3.2 Genetic screens in Celegans
479(1)
31.3.3 Genetic screens using SRS microscopy
479(1)
31.3.4 Lipid composition profiling by SRS microscopy
480(2)
31.3.5 SRS-based imaging flow cytometry
482(1)
31.4 Outlook
483(4)
References
484(3)
32 Stimulated Raman voltage imaging for quantitative mapping of membrane potential
Hyeon Jeong Lee
Delong Zhang
32.1 Introduction
487(1)
32.2 Principle
488(1)
32.3 Methods
489(2)
32.3.1 Biological systems
489(1)
32.3.2 Imaging setup
490(1)
32.4 Applications
491(5)
32.5 Outlook
496(5)
Acknowledgments
497(1)
References
497(4)
33 Neurodegenerative disease by SRS microscopy
Minbiao Ji
Wenlong Yang
33.1 ALS disease
501(5)
33.2 Alzheimer's disease
506(6)
33.3 Conclusions
512(3)
References
512(3)
34 Applications of stimulated Raman scattering (SRS) microscopy in materials science
Qian Cheng
Yupeng Miao
Ruiwen Zhang
Wei Min
Yuan Yang
34.1 Introduction
515(1)
34.2 Application of the SRS microscopy in materials sciences
516(7)
34.2.1 Static material structures
517(3)
34.2.2 Transport of chemical species
520(1)
34.2.3 Transformation in chemical reactions
521(2)
34.3 Perspectives
523(6)
References
525(4)
35 Resolving molecular orientation by polarization-sensitive stimulated Raman scattering microscopy
Pu-Ting Dong
Cheng Zong
Ji-Xin Cheng
35.1 Introduction
529(1)
35.2 Principle of polarization-sensitive SRS microscopy
529(1)
35.3 A polarization-sensitive hyperspectral SRS microscope
530(1)
35.4 Recent applications of polarization-sensitive SRS microscopy
530(3)
35.4.1 Early diagnosis of dental caries
531(1)
35.4.2 Investigating biomolecule vibrational modes in HeLa cells
532(1)
35.4.3 Mapping cholesterol crystals in lipid-rich plaques
532(1)
35.5 AmB orientation in single fungal cellmembrane resolved by polarization-sensitive SRS microscopy
533(3)
35.6 Conclusion
536(5)
References
536(5)
Part 6 Miniaturization and translation to medicine
36 Stimulated Raman histology
Anzhela Moskalik
Yosef Dastagirzada
Daniel Orringer
36.1 Introduction: Gold standard of cancer diagnosis---Histology
541(1)
36.2 Principle: How can SRS microscopy be used to supplement/improve histology
541(1)
36.3 Methods
541(2)
36.4 Results: Comparison of standard and SRS histology
543(4)
36.4.1 Tumors of the central nervous system
544(2)
36.4.2 Pediatric brain tumors
546(1)
36.4.3 Cancers of the head and neck
546(1)
36.4.4 Gastrointestinal tumors
546(1)
36.4.5 Laryngeal squamous cell carcinoma
547(1)
36.5 Outlook
547(1)
36.6 Future directions
547(4)
References
548(3)
37 Miniaturized handheld stimulated Raman scattering microscope
Peng Lin
Hongli Ni
Chien-Sheng Liao
Rongguang Liang
Ji-Xin Cheng
37.1 Introduction
551(1)
37.2 Challenges in miniaturization of SRS microscope
552(2)
37.2.1 Parasitic nonlinear background in fiber delivery
552(1)
37.2.2 Miniaturization of an objective lens
553(1)
37.2.3 Detection of epi-SRS signal
553(1)
37.2.4 Laser steering technology
554(1)
37.3 A state-of-the-art handheld SRS microscope and itsperformance
554(2)
37.3.1 Design of the handheld SRS microscope
554(1)
37.3.2 Background removal through the time domain approach
555(1)
37.3.3 Performance of the handheld SRS microscope
555(1)
37.4 Applications of handheld SRS microscope
556(1)
37.4.1 In situ detection of pesticide residues on crop product
556(1)
37.4.2 Discrimination of brain cancerous tissues from normal tissues
556(1)
37.4.3 Monitoring in vivo drug delivery into human skin
557(1)
37.5 Outlook
557(4)
References
559(2)
38 Intraoperative multimodal imaging
Arnica Karuna
Tobias Meyer
Michael Schmitt
J'urgen Popp
38.1 Introduction
561(1)
38.2 Optical imaging
562(12)
38.2.1 Fluorescence imaging
563(2)
38.2.2 Molecular spectroscopy
565(9)
38.3 Summary
574(1)
References 575(8)
Index 583
Dr. Ji-Xin Cheng attended University of Science and Technology of China (USTC) from 1989 to 1994. He carried out his PhD study on bond-selective chemistry at USTC. As a graduate student, he worked as a research assistant at Universite Paris-sud on vibrational spectroscopy and the Hong Kong University of Science and Technology (HKUST) on quantum dynamics theory. After postdoctoral training on ultrafast spectroscopy at HKUST, he joined Sunney Xies group at Harvard University as a postdoc and worked on the development of CARS microscopy. Cheng joined Purdue University as Assistant Professor in 2003, promoted to Associate Professor in 2009 and Full Professor in 2013. He joined Boston University as the Inaugural Theodore Moustakas Chair Professor in Photonics and Optoelectronics in 2017. For his pioneering contributions to the chemical imaging field, Cheng received the 2020 Pittsburg Spectroscopy Award, the 2019 Ellis R. Lippincott Award, and the 2015 Craver Award. Dr. Wei Min graduated from Peking University in 2003. He received his Ph.D. from Harvard University in 2008 studying single-molecule biophysics with Prof. Sunney Xie. After continuing his postdoctoral work in the Xie group, Dr. Min joined the faculty at Columbia University in 2010 and was promoted to Full Professor there in 2017. Dr. Mins current research interests focus on developing novel optical spectroscopy and microscopy technology to address biomedical problems. His group has made important contributions to the development of stimulated Raman scattering (SRS) microscopy and its broad application in biomedical imaging. Dr. Mins contribution has been recognized by a number of honors, including Scientific Achievement Award from Royal Microscopical Society (2021), Pittsburgh Conference Achievement Award (2019), Coblentz Award of Molecular Spectroscopy (2017), ACS Early Career Award in Experimental Physical Chemistry (2017), and NIH Directors New Innovator Award (2012). Dr. Yasuyuki Ozeki received B.S., M.S. and Dr. Eng. Degrees in Electronic Engineering from the University of Tokyo, Tokyo, Japan, in 1999, 2001, and 2004, respectively. In 2004, he joined Furukawa Electric Co., Ltd., as a postdoctoral researcher of Japan Science and Technology Agency (JST). In 2006, he joined Department of Material and Life Science, Osaka University, Osaka, Japan, as an assistant professor. From 2009 to 2013, he was also PRESTO researcher of JST. In 2013, he was appointed as an Associate Professor of Department of Electrical Engineering and Information Systems, the University of Tokyo, Tokyo, Japan, and was promoted to a Full Professor in 2021. His work covers millimeter-wave photonics, nonlinear fiber optics, ultrafast lasers, and their application to microprocessing and biomedical microscopy. His current research focuses on biomedical imaging by stimulated Raman scattering (SRS) microscopy, and its related technologies including highly functional ultrafast laser sources, detection electronics, image processing, etc. Dario Polli is Associate Professor of Physics at Politecnico di Milano (Italy) since 2014, where he is heading a research group of more than 10 people including post-docs, Ph.D. and diploma students. He is affiliated with the Center for Nano Science and Technology of the Italian Institute of Technology in Milan, Italy. His main research focus is on coherent Raman spectroscopy and microscopy, ultrafast and non-linear optics, Fourier-transform spectroscopy and time-resolved pump-probe spectroscopy and microscopy. He is the recipient of many research grants, including an ERC Consolidator grant on the development of high-speed broadband coherent Raman microscopy for fast and reliable tumour identification. He also devotes to technology transfer: he filed several patents and has founded two start-up companies in the field of photonics. Finally, he is passionate about Science divulgation to the public.
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