| Preface |
|
v | |
| Contributors |
|
xi | |
|
Mathematical Modeling of Stem Cells: A Complexity Primer for the Stem-Cell Biologist |
|
|
1 | (16) |
|
|
|
|
|
|
|
|
|
1 | (4) |
|
|
|
5 | (2) |
|
Complex Adaptive Systems with Multiple Interacting Agents |
|
|
7 | (1) |
|
Modeling Stem Cells and Cell Lineages as Complex Adaptive Systems |
|
|
8 | (5) |
|
Ramifications for Current Thinking |
|
|
13 | (1) |
|
|
|
13 | (1) |
|
|
|
14 | (3) |
|
Theoretical Concepts of Tissue Stem-Cell Organization |
|
|
17 | (20) |
|
|
|
|
|
|
|
|
|
17 | (1) |
|
Defining Tissue Stem Cells |
|
|
18 | (1) |
|
Conceptual Challenges in Tissue Stem-Cell Biology |
|
|
18 | (1) |
|
Predictive Theories and Quantitative Models |
|
|
19 | (1) |
|
A New Perspective on Stem-Cell Systems |
|
|
20 | (2) |
|
Modeling of the Dynamics of Clonal Competition in Hematopoietic Stem Cells |
|
|
22 | (4) |
|
Spatio-Temporal Stem-Cell Organization |
|
|
26 | (3) |
|
Conceptual Novelty and Achievements |
|
|
29 | (3) |
|
|
|
32 | (5) |
|
Mechanisms of Genetic Fidelity in Mammalian Adult Stem Cells |
|
|
37 | (18) |
|
|
|
Evolution of Mechanisms of Mammalian Tissue Cell Genetic Fidelity: The Needs of a Few |
|
|
37 | (2) |
|
An Exact Definition for the Long-Lived Nature of ASCs |
|
|
39 | (1) |
|
Mutagenesis Mechanisms in ASCs |
|
|
40 | (1) |
|
Immortal DNA Strand Co-Segregation and a Carpenter's Rule for Genetic Fidelity in ASCs |
|
|
41 | (2) |
|
Implications of the Carpenter's Rule for ASC Aging, Cell Kinetics, and DNA Repair Functions |
|
|
43 | (2) |
|
Estimation of the Mutation-Avoidance Effect of an Immortal DNA Strand Mechanism in ASCs |
|
|
45 | (2) |
|
Evidence for Immortal DNA Strand Co-Segregation in ASCs |
|
|
47 | (5) |
|
|
|
52 | (3) |
|
Neural Stem Cells: Isolation and Self-Renewal |
|
|
55 | (16) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
55 | (1) |
|
In Vivo Localization of NSCs |
|
|
55 | (5) |
|
Control of the Self-Renewal and Differentiation of NSCs |
|
|
60 | (6) |
|
Conclusion and Perspectives |
|
|
66 | (1) |
|
|
|
66 | (5) |
|
Stem Cells in Mammary Epithelium |
|
|
71 | (18) |
|
|
|
|
|
|
|
71 | (1) |
|
Aging and Reproductive Senescence |
|
|
72 | (1) |
|
|
|
72 | (4) |
|
Mammary Stem-Cell Markers |
|
|
76 | (6) |
|
Mammary Stem Cells in Carcinogenesis |
|
|
82 | (2) |
|
Pregnancy and Breast Cancer Risk |
|
|
84 | (1) |
|
|
|
84 | (1) |
|
|
|
85 | (4) |
|
Lineage Tracking, Regulation, and Behaviors of Intestinal Stem Cells |
|
|
89 | (28) |
|
|
|
|
|
|
|
89 | (1) |
|
|
|
89 | (7) |
|
Lineage Tracking as an Approach to Understanding the Stem-Cell Behavior |
|
|
96 | (5) |
|
Tracking Stem-Cell Fate Through Understanding What Regulates Their Proliferation and Differentiation |
|
|
101 | (8) |
|
Identifying Markers for Intestinal Stem Cells |
|
|
109 | (2) |
|
|
|
111 | (1) |
|
|
|
111 | (6) |
|
Stem Cell Populations in Skin |
|
|
117 | (32) |
|
|
|
|
|
|
|
117 | (18) |
|
|
|
135 | (1) |
|
|
|
135 | (14) |
|
A Perspective on In Vitro Clonogenic Keratinocytes: A Window into the Regulation of the Progenitor Cell Compartment of the Cutaneous Epithelium |
|
|
149 | (12) |
|
|
|
|
|
149 | (1) |
|
Cutaneous Epithelium as a Continually Renewing Tissue Containing In Vitro Clonogenic Keratinocytes |
|
|
149 | (1) |
|
Functional Evidence of Stem Cells in Epidermis and Hair Follicles |
|
|
150 | (7) |
|
In Mice, Keratinocyte Colony Number is Genetically Defined and Quantitatively Complex |
|
|
157 | (1) |
|
Keratinocyte Colony Size is Also Genetically Defined |
|
|
158 | (1) |
|
|
|
159 | (1) |
|
|
|
159 | (2) |
|
Hepatic Stem Cells and the Liver's Maturational Lineages: Implications for Liver Biology, Gene Expression, and Cell Therapies |
|
|
161 | (54) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
The Liver as a Maturational Lineage System |
|
|
161 | (7) |
|
General Comments on Stem Cells |
|
|
168 | (1) |
|
|
|
169 | (14) |
|
|
|
183 | (5) |
|
Reconstitution of Liver by Cell Transplantation |
|
|
188 | (5) |
|
Liver Cell Therapies---Clinical Programs |
|
|
193 | (5) |
|
|
|
198 | (1) |
|
|
|
199 | (16) |
|
Multistage Carcinogenesis: From Intestinal Stem Cell to Colon Cancer in the Population |
|
|
215 | (14) |
|
|
|
|
|
215 | (2) |
|
A Biologically Based Multistage Model for Colon Cancer |
|
|
217 | (4) |
|
Adenomatous Polyps---Observations and Model Predictions |
|
|
221 | (4) |
|
|
|
225 | (1) |
|
|
|
226 | (3) |
|
Intestinal Stem Cells and the Development of Colorectal Neoplasia |
|
|
229 | (42) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
229 | (1) |
|
Basic Structure and Function of the Intestinal Crypt |
|
|
230 | (4) |
|
|
|
234 | (2) |
|
|
|
236 | (2) |
|
Intestinal Stem-Cell Repertoire |
|
|
238 | (1) |
|
The Concept of Stemness and ``Immortal'' DNA Strands |
|
|
239 | (3) |
|
Molecular Regulation of Normal Intestinal Crypt Homeostasis |
|
|
242 | (8) |
|
Early Molecular Events in Colorectal Tumorigenesis |
|
|
250 | (2) |
|
Intestinal Stem Cells and the Origin of Colorectal Cancer |
|
|
252 | (1) |
|
Colorectal Tumor Morphogenesis |
|
|
253 | (3) |
|
Clinical Implications and Future Directions |
|
|
256 | (2) |
|
|
|
258 | (1) |
|
|
|
259 | (12) |
|
Stem Cells in Neurodegeneration and Injury |
|
|
271 | (34) |
|
|
|
|
|
|
|
|
|
271 | (1) |
|
|
|
272 | (13) |
|
The Use of Stem Cells in Brain Disease and Injury |
|
|
285 | (8) |
|
|
|
293 | (1) |
|
|
|
293 | (12) |
|
Adult Stem Cells and Gene Therapy |
|
|
305 | (34) |
|
|
|
|
|
|
|
305 | (1) |
|
Adult Stem Cells for Gene Therapy |
|
|
306 | (4) |
|
|
|
310 | (5) |
|
Hurdles to Stem-Cell Gene Therapy |
|
|
315 | (6) |
|
|
|
321 | (1) |
|
|
|
322 | (17) |
|
Clinical Applications of Hematopoietic Stem Cells |
|
|
339 | (50) |
|
|
|
|
|
|
|
339 | (1) |
|
Clinical Use of HSCs in Transplantation |
|
|
339 | (2) |
|
Autologous Stem-Cell Transplantation |
|
|
341 | (2) |
|
|
|
343 | (8) |
|
ASCT: Nonmalignant Diseases |
|
|
351 | (2) |
|
Allogeneic Stem-Cell Transplantation |
|
|
353 | (4) |
|
Specific Clinical Indications for Allogeneic Transplant |
|
|
357 | (6) |
|
Cord Blood Transplantation |
|
|
363 | (9) |
|
|
|
372 | (1) |
|
|
|
373 | (16) |
| Index |
|
389 | |
Lisainfo e-raamatute kohta