Beginning with the Underwood Memorial Lecture, Integrative Aspects of Zinc Metabolism and Function, by Robert U. Cousins (nutrition sciences, U. of Florida-Gainesville), the 347 papers report on recent research into the functional role, metabolism, and molecular and cellular biology of trace elements. They provide new data on zinc and copper transport mechanisms, enabling a global view of the molecular metabolism of the metals in the human body; new perspectives on the epidemiology of trace-element deficiency and supplementation; the results of recent major trials demonstrating the beneficial effect of selenium on human health; information on new selenoproteins and biological roles; research into boron and chromium; and other perspectives. The title suggests that their terminology may be some decades out of date. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Proceedings of the 10th International Symposium on Trace Elements in Man and Animals (TEMA 10), held May 2-7, 1999, in Evian, France. This volume containing the proceedings of the tenth of the highly successful TEMA meetings, presents recent progress in the research on the functional role and metabolism of trace elements, and new developments in the understanding of molecular and cellular biology. Various contributions providing new data on zinc and copper transport mechanisms, enable a global view of the molecular metabolism of these metals in the human body, whilst other particularly dramatic results presented here offer new perspectives on the epidemiology of trace elements deficiency and supplementation. Also included are the results of recent major trials demonstrating the beneficial effect of selenium on human health. The spectacular growth of interest in the field of selenium, with the discovery of new selenoproteins and biological roles, is represented here along with the other areas of particular progress the research into boron and chromium, which have marked this year's meeting.
This volume, containing the proceedings of the tenth of the highly successful TEMA meetings, presents recent progress in the research on the functional role and metabolism of trace elements, and new developments in the understanding of molecular and cellular biology.
UNDERWOOD MEMORIAL LECTURE Integrative Aspects of Zinc Metabolism and Function 1(8) Robert J. Cousins I. CELLULAR AND MOLECULAR BIOLOGY OF TRACE ELEMENTS Trace Elements Cellular Metabolims The Copper Transporting ATPases in Human Disease 9(6) Jonathan D. Gitlin Regulation and Function of the Copper Ion Transport Machinery 15(6) Jaekwon Lee Dennis J. Thiele Control of Gene Expression of Glutathione Peroxidase-1 and Other Selenoproteins in Rats and Cultured Cells 21(8) Roger A. Sunde Jacqueline K. Evenson Cellular and Subcellular Distribution of Selenium and Selenium-Containing Proteins in the Rat 29(6) Dietrich Behne Henning Pfeifer Doris Rothlein Antonios Kyriakopoulos The Mechanism and Regulation of Zinc Transport in Yeast 35(8) David J. Eide Metallothionein Facilitates Zinc Absorption in Zinc Deficient Mice but Limits Absorption in Zinc Replete Mice 43(4) P. Coyle J. C. Philcox A. M. Rofe Metallothionein and Innate Activation of Primary Human and Mouse Monocytes 47(4) James Koropatnick Suzanne Dale Rudolfs K. Zalups Role of Metallothionein on Zn, Cu, Cd Au, and Ag Accumulation in Hepatic Cytosol of Heavy Metal-Injected Rats 51(4) S. Saito K. Yoshida Molecular Cloning of a Human cDNA Regulated by Heavy Metals 55(4) M. G. Pagliuca S. Cigliano R. Lerose A. Leone Distribution of Copper Transported ATP7B in Embryo and New Born Rat 59(4) T. Hosokawa M. Okabe M. Kurasaki A. Hata F. Endo K. Nagano I. Matsuda K. Urakami T. Saito Interaction between Copper and Iron Metabolism in the Human Intestinal Caco-2 Cells 63(2) I. Gabrielli Y. Sambuy S. Ferruzza M. L. Scarino Induction of Metallothioneins by Zinc (Zn) Supplementation Quantification in Young Rat Tissues 65(2) G. S. Henriques S. M. F. Cozzolino Trace Elements and Oxidative Stress Iron, Oxidative Stress, the HFE Gene, and Lung Cancer 67(4) J. M. McCord S. K. Bose B. Gao Selenium and the Protection against Peroxynitrite 71(6) Helmut Sies Lars-Oliver Klotz Stefan M. Schieke Karlis Briviba Gavin E. Arteel Cooperative Effects of Zinc/Selenium and Thiols in the Protection against UV-Induced Genomic DNA Damage 77(6) Marie-Jeanne Richard Nathale Emonet-Piccardi Christine Didier Eric Jourdan Marie-Therese Leccia Marie-Odile Parat Jean Cadet Jean C. Beani Alain Favier Trace Elements and Enzyme Redox Centers 83(6) Marc Fontecave Importance of Trace Elements in Transcription Factor NF-κB Activation 89(8) Jacques Piette Trace Elements: Metabolism and Oxidative Modifications of Lipoproteins 97(8) Y. Rayssiguier A. Mazur Co-localization of Cu/Zn-Superoxide Dismutase (SOD-1), Nitric Oxide Synthase (NOS), and Zn/Cu-Metallothionein (MT) in Rat Brain 105(6) Masashi Okabe Toshiyuki Hosokawa Shigeru Saito Takeshi Saito Masaaki Kurasaki Hidesuke Shimizu Effect of Dolomite and Thiamine Supplementation on Serum Total Antioxidant Status and Bioelements Concentration in Lead-Intoxicated Rats 111(4) Z. Krejpcio R. Wojciak Protective Effects of Antioxidants on Iron-Induced Free Radical-Mediated Damaging Processes in Humans and Animals 115(4) Igor Afanasev Elena Ostrachovich Irina Deeva Ludmila Korkina Complexes of Flavonoids with Iron and Copper as a New Way of Decreasing the Oxidative Damage Induced by Transition Metal Supplementation 119(4) L. G. Korkina E. A. Ostrachovich G. A. Ibragimova I. B. Afanasev Oncogene Activation and Apoptosis as Possible Mechanism of Antitumour Effect of Ferric-Sorbitol-Citrate 123(4) Marija Poljak-Blazi Marijeta Kralj Marijana Popovic-Hadzija Changes in Oxidant and Antioxidant Status in Rats Fed Different Amounts of Selenium and Exposed to NOx 127(2) J. Gromadzinska W. Wasowicz K. Rydzynski J. Neve Zinc Protects Genomic DNA from Solar Light Injury: A Possible Role for Zinc-Induced Metallothionein? 129(2) E. Jourdan N. Emonet-Piccardi A. Favier J. C. Beani M. J. Richard The Effect of Carbamylation on Glutathione Peroxidase and Copper-Zinc Superoxide Dismutase 131(2) Heather E. Roxborough Cheryl Reid Jane McEneny Caroline Mercer Dorothy McMaster Maireard OHare Ian S. Young Anthracyclin Resistance of GLC4 Tumoral Cells and Intracellular Selenium Metabolism 133(2) M. Andriollo P. Guiraud M. J. Richard A. Favier Antiproliferative Ability of Ferric-Sorbitol-Citrate and Ferrocenes for Malignant Cell Line, Hep2 and F10 135(2) M. Poljak-Blazi A. Ferle Vidovic V. Rapic D. Skare Modulation of SP1 and NFκB Binding Activity by Aluminum in HeLa Cells 137(1) C. Garrel M. Osman A. Favier Antioxidant Micronutriments Insulin-Sensitivity 138(1) P. Faure F. Couzy D. Barclay E. Rossini M. J. Richard J. Arnaud A. Favier S. Halimi Exacerbated Immune Stress Response in Early Magnesium Deficiency in the Rat 139(1) A. Mazur C. Malpuech-Brugere W. Nowacki E. Rock Y. Rayssiguier Zinc Protects Human Endothelial Vascular Cells against the Glucose Induced Cytotoxicity 140(1) K. Lalanne S. Bouvard N. Wiernsperger P. Faure A. Favier S. Halimi Effects of Elevated Dietary Cu and Cd Concentrations on Oxidative Stress, Cell Proliferation, and Apoptosis in Atlantic Salmon (Salmon Salar L.) Parr 141(1) Marc H. G. Berntssen Sjoerd E. Wendelaar Bonga Amund Maage Modulation of Copper Deficiency Induced Oxidative Stress by Dietary Polyphenol in the Rat 142(1) I. Bureau C. Feillet-Coudray E. Gueux E. Rock A. Mazur Y. Rayssiguier Thioredoxin/Thioredoxin Reductase System: Their Roles in DNA Stability and Cell Adaptation to Ultraviolet Radiation 143(1) C. Didier M.-J. Richard J. C. Beani A. Favier Toxic Effect of Ciprofloxacin May be the Result of a Free Radical Pathway 144(1) A. Gurbay B. Gonthier D. Daveloose F. Hincal A. Favier Transport, Speciation and distribution of Trace Elements Trace Element Speciation in Human Body Fluids 145(8) Peter Bratter Andrea Raab Andrea N. Richarz Gelfiltration and Anion-Exchange Chromatography for the Separation of Vanadium Binding Proteins in Plasma of Rats, Rabbits, and Humans 153(4) K. De Cremer K. R. Cornelis Metabolism of Selenate Administered into Rats: Speciation of Selenium by HPLC-ICP MS 157(4) Kazuo T. Suzuki Yamato Shiobara Fractionation of Soluble Selenium Compounds from Fish using Size-Exclusion Chromatography with On-Line Detection by Inductively Coupled Plasma Mass Spectrometry: Comparison with other Techniques 161(4) Gunilla Onning Ingvar A. Bergdahl Metabolism of Arsenic from Seaweed by Man and Animals: Speciation in Body Fluids using Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry 165(4) Jorg Feldmann Speciation of Selenium in Food and Animal Feed using Ion Chromatography On-Line Microwave Pretreatment Hydride Generation Atomic Absorption Spectrometry 169(4) Magnus Johansson Guy Bordin Adela R. Rodriguez Selenium True Absorption and Tissue Concentration of Rats at Dietary Selenite, Seleno Cysteine, and Seleno Methionine 173(2) W. Windisch M. Kirchgeßner Effects of Selenium Status on Selenium Incorporation into Plasma Fractions and Excretion in Urine in Men Infused with 74Se Selenite 175(2) Y. Xia J. Butler M. Janghorbani P. Ha P. Whanger J. Olesik L. Daniels Magnesium Excretion and Redistribution in Rat Tissues after Disulfiram Experimental Administration 177(1) L. Kovatsi M. Tsougas H. Tsoukali D. Psaroulis Selenium and Arsenic Distribution in Soluble Protein Fractions in Liver of Hens Fed with Added As2O3 178(2) V. Stibilj I. Falnoga D. Cestnik R. Jacimovic Metal Distribution in Metallothioneins of Cytosols from Human Cirrhotic Livers 180(1) C. Wolf P. Bratter U. Rosick Effect of Retinol Deficiency on Liver Concentration of Fe, Cr, Zn, Mn, Co, Cd, and Pb in Rat 181(2) A. C. Anzulovich L. B. Oliveros L. D. Martinez M. Roura M. S. Gimenez Vitamin A Deficiency Modify the Antioxidant Defenses and the Trace Elements Level in Rat Liver 183(1) A. C. Anzulovich L. Oliveros D. Martinez M. Baucells M. S. Gimenez Transport of Silver and Its Potential Interactions with Copper Metabolism in the Rat 184(2) S. Hanson S. Donley H. Rim M. C. Linder Dietary Vanadium, P-ATPase-7a Expression and the Influence on Lysyl Oxidase and Cu Accumulation in Rat Skin and Liver 186(3) Robert B. Rucker Chang Tai Cui Eskouhie H. Tchaparian Alyson E. Mitchell Michael Clegg Janet Y. Uriu-Hare Carl L. Keen II. HUMAN PHYSIOLOGY AND STATUS OF TRACE ELEMENTS Trace Elements in Food Chain, Diets and Intakes Recommended Dietary Intakes for Trace Elements: New Trends 189(6) Janet C. King Trace Element Addition to Foods: Technological and Nutritional Aspects 195(6) Denis Barclay Trace Elements in Intravenous Nutrition 201(8) A. Shenkin Trace Element Intake and Balance in Adults in Central Europe 209(6) M. Anke M. Glei W. Dorn R. Muller J. Vormann M. Muller M. Jahritz M. Seifert S. Holzinger S. Drobner B. Rohrig C. Rother L. Angelow G. O. Latunde-Dada Nutrient Risk Assessment: Implications for Food Fortification Policy 215(6) Mary R. LAbbe Kevin A. Cockell Sheila Dubois William H. Ross Vanadium---An Essential Element for Animals and Humans? 221(6) M. Anke H. Illing-Gunther H. Gurtler S. Holzinger M. Jaritz S. Anke U. Schafer Effect of Iron Fortification of Infant Weaning Foods on Mineral Absorption 227(1) C. Martinez G. Lopez G. Ros T. Fox S. J. Fairweather-Tait An Approach to Assessing the Safety of Trace Element Supplementation 228(1) D. H. Shrimpton Strontium Transfer in the Food Chain of Humans 229(2) M. Anke M. Seifert M. Jaritz E. Losch E. Hartmann Content of the Mineral Elements in the Light Diets Used for Alimentation of the Pensioner House Residents in Warsaw 231(1) A. Klos J. Bertrandt Determination of Mineral Levels in Walnut Cultivars after Microwave Mineralisation 232(1) F. Lavedrine A. Ravel A. Villet V. Ducros J. Alary Average Intake of Trace Elements in Military Food Services in France 233(2) P. Le Francois D. Argaud Use of Haem Iron Concentrate in the Fortification of Weaning Foods 235(2) C. Martinez G. Ros M. J. Periago G. Lopez Mineral Content in Four Spanish Fish after Bone Addition 237(2) Isabel Martinez Maria Jesus Periago Marina Santaella y Gaspar Ros Trace Elements in Austrian Food 239(1) A. Sima M. Wilplinger S. Zochling S. Heumann U. Schaller W. Pfannhauser Trace Element (Cu, Fe, Zn) Intakes in Cuba 240(2) T. Verdura J. Arnaud P. Fleites M. Chassagne A. Favier R. Perez-Cristia J. Barnouin Distribution of Trace Elements and Minerals in Pulp and Peel of Apples and of Persimmons 242(2) Z. Zachwieja J. Piotrowicz M. Folta H. Barton S. Gorinstein M. Zemser S. Traktenberg Mineral Elements in the Diet Planned for Consumption for Residents of the Pensioner House in Warsaw 244(1) J. Bertrandt A. Klos Zinc is Scarce and Expensive 245(2) N. Darmon A. Briend Estimated Daily Intakes and Concentrations of Essential Trace Elements in Infant Formulas 247(1) I. Navarro J. I. Alvarez A. Martin Clinical Evaluation of ``Designer Eggs as a Source of Essential Micronutrients for Humans 248(2) P. Surai A. MacPherson Plasma Levels of Selenium, Selenoprotein P, and Glutathione Peroxidase and Their Correlations to Fish Intake and Serum Levels of Thyropropin and Thyroid Hormones---A Study on Latvian Fish Consumers 250(2) L. Hagmar M. Persson-Moschos B. Akesson A. Schutz Interlaboratory Comparison Studies into Determination of Metals Content in Foods, Organized by the National Institute of Hygiene 252(3) Krystyna Starska Maria Wojciechowska-Mazurek Elzbieta Brulinska-Ostrowska Kazimierz Karlowski Trace Elements Bioavailability Bioavailability of Trace Elements in Human Diet 255(6) Susan J. Fairweather-Tait The Influence of Various Food Ingredients and Their Combinations on in Vitro Availability of Iron and Zinc in Cereal Based Vegetarian Meals 261(6) V. V. Agte K. V. Tarwadi S. A. Chiplonkar Is Increasing Ascorbic Acid Intake from Foods an Effective Strategy for Improving Dietary Iron Bioavailability? An Evaluation Using Dietary Algorithms, Iron Isotopes, and a Food-Based Community Intervention Trial in Rural Mexico 267(4) Lindsay H. Allen Olga Garcia Obregon Margarita Diaz Steven Abrams Suzanne Murphy Jorge L. Rosado Iron Intake from Mixed Meals in Cameroon 271(4) A. Bell F. Ndigui P. Effa Bioavailability of Calcium and Zinc from Various Infant Formulae with and without Thickening Agents 275(4) Douwina Bosscher Kristien Van Dyck Harry Robberecht Micheline Van Caillie-Bertrand Hendrik Deelstra Absorption of Selenium from Biosynthetically Labelled Foods in Humans 279(4) C. Atherton T. Fox S. Fairweather-Tait J. Dainty J. Lewis M. Baxter H. Crews N. Langford Tissue Zinc Uptake as a Measure of the Relative Bioavailability of Supplemental Zinc Sources for Domestic Animals 283(4) C. B. Ammerman M. Sandoval P. R. Henry R. C. Littell R. D. Miles Effects of Whole Wheat Flour and Fermentable Carbohydrates on Intestinal Absorption of Trace Elements in Rats 287(6) C. Coudray H. W. Lopez M. A. Levrat-Verny J. Bellanger C. Remesy Y. Rayssiguier Bioavailability of Different Sources of Protected Zinc 293(6) Daniel D. Gallaher Cynthia M. Gallaher Stephanie Shulman Andrea McElhome Kyle A. Brokken Gerry Shurson Cobalt Deficiency Induced Hyperhomocysteinemia and Oxidative Status of Cattle 299(6) G. I. Stangl F. J. Schwarz M. Kirchgessner Role of Diet Related Habits and Cooking Practices on Bioavailability of Iron, Copper, and Zinc and Status of Iron in Vegetarians 305(1) V. V. Agte M. Indumadhavi V. Kakade S. Palkar S. Girigosavi K. Tarwadi S. A. Chiplonkar Dialysability of Calcium, Iron, and Zinc in Beans, Chick Peas, and Lentils 306(2) V. Sebastia R. Barbera R. Farre M. J. Lagarda Effect of Zinc Depletion on Iron Transport across Isolated Duodenal Sacs 308(1) Peter W. F. Fischer Bartholomeus Belonge Mineral Element Status in Rats Fed Diets with Extruded or not Extruded Evening Primrose (Oenothera Paradoxa) 309(2) M. A. Gralak H. Leontowicz M. Leontowicz A. Bogucka-Sciezynska G. W. Kulasek Combined Effects of Complex Carbohydrates and a Resistant Protein on Intestinal Absorption and Status of Iron and Zinc in the Rat 311(2) D. Grizard C. Coudray M. Tahiri J. C. Tressol Y. Van Doesum Y. Rayssiguier C. Barthomeuf Nutrient Risk Assessment: Implications for Food Fortification Policy 313(1) Mary R. LAbbe Kevin A. Cockell Sheila Dubois William H. Ross Design of Product as Source of Variance in ``in Vitro Mineral Availability of Homogenised Weaning Foods 314(1) A. B. Olivares C. Martinez G. Ros Iron Dialysability in Enteral Diets 315(2) C. H. Azevedo A. P. Galhardo C. Colli Trace Element Status New Indices for Assessment of Trace Element Status and Requirement, with a Special Focus on Selenium 317(6) Jean Neve Are Young Women with Low Iron Stores at Risk of Zinc as Well as Iron Deficiency? 323(6) R. S. Gibson A-L Heath N. Prosser W. Parnell U. M. Donovan T. Green K. E. McLaughlin D. L. OConnor W. Bettger C. M. Skeaff Assessment of Femurs and Testis as Parameters for Zinc Bioavailability from Different Food Sources 329(1) G. S. Henriques L. F. C. Pedrosa E. L. Dantas J. M. de Moura C. L. Araujo S. M. F. Cozzolino The Effects of Low Protein Diet and Light Deprivation on Zinc Status and Gonad Function in Adult Male Rats 330(1) N. Virgona M. Kamiyama T. Yano T. Esashi Zinc Nutritional Status in Obese Children and Adolescents 331(1) D. N. Marreiro M. Fisberg S. M. F. Cozzolino Reference Values of Selected Trace Elements in the Serum of Term Newborns from the Urban Area of Rome 332(1) Alessandro Alimonti Francesco Petrucci Francesco Laurenti Sergio Caroli Haptoglobin Polymorphism Association with Magnesium and Lipid Profile in Healthy Teenagers 333(2) M. Bicho C. P. Monteiro L. Sardinha S. Llobet P. Marques Vidal M. J. Halpern M. J. Laires Urinary Lithium: Distribution Shape, Reference Values, and Evaluation of Exposure Based on Inductively Coupled Plasma Argon Emission Spectrometry 335(1) K. Usuda K. Kono T. Watanabe T. Dote H. Nishiura M. Shimahara N. Hashiguchi H. Takeishi Assessment of Nonheme Iron Status in the Whole Blood, Plasma, and Serum: Healthy Neonates and Patients with Iron Overload 336(2) O. M. Mykhaylyk N. A. Dudchenko T. A. Orlova N. M. Pyasetska I. P. Lubyanova Lipid Peroxidation and Zinc and Copper Status in Healthy Adults after Ginseng Ingestion 338(1) A. Sanchez-Mayoral R. De Miguel Romera L. Perez Gallardo Variability of Multiple Nutritional Elements in Hair of One Man Over Two Decades 339(1) L. M. Klevay D. M. Christopherson T. R. Shuler Effect of Magnesium Deficiency on Enterocyte Ca, Fe, Cu, and Zn Content 340(1) E. Planells N. Sanchez-Morito P. Aranda J. Llopis Serum Copper, Zinc, and Selenium Levels with Regard to Psychological Stress in Men 341(2) A. Pizent J. Jurasovic M. Pavlovic S. Telisman Urinary Iodine and Thyroid Status of New Zealand Residents 343(2) C. D. Thomson S. Woodruffe A. Colls T. D. Doyle Serum Silicon Concentration of Healthy Persons in the Antwerp Region (Belgium) 345(2) K. Van Dyck H. Robberecht R. Van Cauwenbergh H. Deelstra Trace Elements in Pregnancy, Lactation, Growth Zinc and Human Pregnancy 347(6) Michael Hambidge Nancy Krebs Laura Caulfield Trace Element Nutrition during Pregnancy and Lactation---Effect on Milk Trace Elements 353(6) Bo Lonnerdal Glutathione Peroxidase is Not a Functional Marker of Selenium Status in the Neonatal Period 359(6) L. A. Daniels R. A. Gisbon K. Simmer Trace Element Transfer from the Mother to the Newborn---Investigations on Triplets of Colostrum, Maternal, and Umbilical Cord Sera 365(4) Michael Krachler Erich Rossipal Dusanka Micetic-Turk Relationship between Trace Elements, Activities of Antioxidant Enzymes in Maternal and Umbilical Cord Blood in Poland 369(4) W. Wasowicz J. Gromadzinska K. Szram K. Rydzynski P. Wolkanin Zb Pietrzak J. Tomczak Compensatory Changes in Selenoenzymes in Full Term Human Placentae Induced by Environmental Conditions 373(2) P. Zagrodzki L. Zamorska M. Zadrozna Maternal Anemia at Delivery, Outcome of Pregnancy and Infant Birth Weight, in a Group of Low Socioeconomic Level, in Greater Buenos Aires 375(2) M. L. de Portela L. Lopez S. H. Langini S. Fleischman A. Weisstaub M. Garcia O. Moreno C. R. Ortega Soler Trace Element and Vitamin Deficiencies in French Pregnant Women 377(2) I. Hininger M. Favier H. Faure J. Arnaud F. Khatir J. Thoulon E. Hariveau A. Favier A. M. Roussel Vinegar Drink to Improve Iron Status during Pregnancy 379(2) U. Heins C. Koebnick C. Leitzmann Evolution of Copper Contents from Colostrum to Transitional Human Milk 381(2) M. D. Silvestre M. J. Lagarda R. Farre C. Martinez-Costa J. Brines G. Clemente Ceruloplasmin Oxidase Expression in the Rowett Hooded Rat and Human Placenta during Pregnancy 383(2) L. Gambling W. Bruce-Johnson R. G. Lea M. J. Bingham H. J. McArdle Anemia and Its Therapy with Peroral Antianemics in Pregnancy and Puerperium 385(2) M. Mara V. Eretova J. Zivny J. Kvasnicka A. Umlaufova E. Marova Requirements for the Essential Trace Elements Iron and Zinc during Pregnancy 387(1) Shahla M. Wunderlich Urinary Selenium in Preterm Infants: Effect of Inorganic Versus Organic Selenium Intake 388(2) L. A. Daniels R. A. Gibson K. Simmer Trace Element Balance Study in Very Low Birthweight Infants 390(1) Andrea Raab Andrea Loui Peter Bratter Michael Obladen Nutritional Status of Iron of Pre-School Children from the City of Juiz de Fora, MG, Brazil 391(2) E. L. Chicourel A. F. Pinto Ae. C. Lassance M. Fisberg S. M. F. Cozzolino Trace Elements in Exercise and Extreme Conditions Exercise Effects on Trace Element Metabolism 393(6) Richard A. Anderson Altitude Related Changes in Red Blood Cell Membrane Lipids and Proteins. Possible Links with Redox 399(6) Claus Behn Manuel Ivan Estrada Eliseo Hibert Davila Oscar Araneda Max Gonzalez Alejandro Carrasco Rudy Soria Mauricio Araos Mercedes Villena Wilma Tellez Hilde Spielvogel Enrique Vargas Jorge Cajigal Gloria Celedan Gustavo Gonzolez Effect of Supplementation with Brazil Nuts (CP, Bertholletia excelsa H. B. R.), in Capoeira Players on Selenium (Se) Concentration and Glutathione Peroxidases Activity (GSH-Px, E.C.1.11.1.9) 405(2) V. F. Coutinho V. B. Bittencourt S. M. F. Cozzolino Effects of Weight Loss and Weight-Bearing Exercise on Blood and Organ Concentrations of Lead and Some Essential Metals 407(2) Francis W. Kemp Shenggao Han Wenjie Li David Tiber Chenzang Wang David Sepulveda Justin Holmes John D. Bogden Trace Elements in Aging Trace Element Deficiencies and Supplementations in the Elderly 409(8) Anne-Marie Roussel Serum and Urine Selenium Changes in a Group of Elderly during One Year of Selenium Supplementation 417(4) J. Kvicala V. Zamrazil J. Jiranek Blood and Skin Antioxidant Status in Werner Syndrome (4 patients) 421(4) M. T. Leccia M. J. Richard G. Borla Darve J. C. Beani A. Favier P. Amblard Effects of Aluminum on Glutamate Metabolism: A Possible Explanation for Its Toxicity in the Aged Rats and in an Experimental Model of Aluminum Overload 425(4) Cecile Struys-Ponsar Olivier Guillard Phillippe van den Bosch de Aguilar Zinc-Induced Excessive Glutamate Release May Cause Accelerated Senescence with Defect in Learning and Memory in Senescence Accelerated Mouse 429(4) Takeshi Saito Noriko Nakagawa Kyoko Takahashi Dan Li Yuwako Yamamoto Hiroko Sasaki Nozomu Nakamura Kazuhiro Ogawa Hiroyoshi Fujita Masaaki Kurasaki Masaski Okabe Toshiyuki Hosokawa Serum Selenium and Glutathione Peroxidase Activity in Octogenarian and Nonagenarian Subjects in Belfast 433(4) I. M. Rea D. McMaster A. Murphy C. Mercer Long Term Tropical Antioxidant Treatment Provides Protection against Clinical Signs of Photoaging 437(4) L. Vaillant L. Declercq D. Malvy J. C. Beani J. Bazex D. Maes S. Hercberg Lactulose Stimulates Calcium Absorption in Postmenopausal Women Dose-Dependently 441(1) E. G. H. M. van den Heuvel Th. Muijs W. van Dokkum G. Schaafsma Selenium and Cognitive Decline in the Elderly---The EVA Study 442(1) C. Berr B. Balansard J. Arnaud A. M. Roussel A. Alperovitch Does Hormonal Replacement Therapy Influence Antioxidant Status and LDL Oxidizability in Post-Menopausal Women? 443(1) I. Bureau F. Laporte V. Ducros H. Faure Y. Rayssiguier A. Favier A. M. Roussel Metallothionein Expression and Its Significance in the Brain Aging of Dog 444(2) Akinori Shimada Masahiko Satoh Chiharu Tohyama Vitamin and Mineral Intakes and Biochemical Status in a Spanish Aged Women Group. Effects of Body Mass Index 446(2) P. Valera P. Garcia-Garcia R. M. Ortega A. Lopez-Sobaler A. M. Requejo Biomarkers of Mouse Aging: Modifications of Minerals and Antioxidant Enzymes 448(1) Heng-Kuan Wong Jacqueline Riondel Alain Favier Does Hormonal Replacement Therapy Influence Trace Element Status in Post-Menopausal Women? 449(1) I. Bureau J. Arnaud R. Anderson M. J. Richard F. Laporte A. Favier A. M. Roussel Relationship between Serum Selenium and Red Cell and Plasma Glutathion Peroxidase Levels: Effect of Supplementation with Nutritional Doses of Antioxidants in Elderly and Adult Subjects 450(3) Paul Preziosi Josiane Arnaud Marie-Jeanne Richard Pilar Galan Denis Malvy Serge Briancon Anne-Marie Roussel Alain Favier Serge Hercberg Epidemiology of Trace Elements Intervention Studies on Antioxidant Trace Elements. Special Focus on Selenium 453(10) Serge Hercberg Selenium Status in Northern Ireland and France: The Prime Study 463(4) Dorothy McMaster Pedro Marques-Vidal Pierre Ducimetiere Phillipe Amouyel Dominique Arveiler Alun Evans Determinants of Blood Selenium Concentrations in France (SU VI MAX Study) 467(2) J. Arnaud A. M. Roussel P. Preziosi P. Galan S. Hercberg A. Favier Selenium Status and Antioxidant Enzyme Activities in High School Children from an Endemic Goiter Area 469(2) B. Giray T. Tezic Y. Gedik A. Oktem F. Hincal Iodine Content of Water and Selenium Level in Corn and Wheat Consumed in an Endemic Goiter Area 471(2) B. Giray F. Hincal Selenium Deficiency in South-West Bohemia 473(2) J. Kvicala V. Zamrazil V. Jiranek Effect of Copper Supplementation in Middle Aged People on Plasma Anti-Oxidants and Red Blood Cell Oxidizability: Foodcue Study 475(2) E. Rock A. Mazur Y. Rayssiguier C. Kehoe J. M. OConnor M. P. Bonham J. J. Strain Plasma and Urine Selenium of Cows from Various Regions of the Czech Republic and Its Comparison with Corresponding Human Population Selenium Indexes 477(2) J. Kvicala V. Kroupova A Comparative Study of Blood Antioxidant Parameters in Two Portuguese Urban Populations 479(2) A. M. Viegas-Crespo M. C. Santos M. L. Pavao P. A. Lopes J. Neve Comparison of Trace Elements and Macronutrients in Breast Milk of Women from Eight Different Geographical Locations 481(1) G. M. Radzanowski J. Jackson K. Pramuk S. M. Kaup Selenium Concentration in Human Milk and the Daily Se Intake by Breast-Fed Infants in the Western Part of Poland 482(2) B. A. Zachara A. Pilecki Effect on Biochemical Markers of Two-Years Supplementation with Antioxidants in the SU.VI.MAX Study: Interest of Nutritional Doses 484(2) Serge Hercberg Henri Faure Paul Preziosi Josiane Arnaud Marie-Jeanne Richard Pilar Galan Denis Malvy Serge Briancon Anne-Marie Roussel Alain Favier Iodine Nutrition of French Adults Issued from the SU.VI.MAX Cohort 486(2) Pierre Valeix Marjorie Zarebska Paul Preziosi Bruno Pelletier Pilar Galan Dietary Iron Intake and Iron Status of French Adults Participating in the SU.VI.MAX Cohort 488(3) Pilar Galan Paul Preziosi Bernadette Fieux Marjorie Zarebska Serge Briancon Denis Malvy Anne-Marie Roussel Alain Favier Serge Hercberg III. Trace Elements in Human Diseases Diabetes Insulin Enhancing Effects of Vanadium 491(6) John H. McNeill Is Zinc Essential to Modulate Insulin Sensitivity? 497(6) Patrice Faure Serge Halimi Sophie Bouvard Olivier Ramon Karine Lalane Anne Marie Roussel Alain Emile Favier Role of Chromium in Glucose Intolerance, Diabetes, Total Parenteral Nutrition, and Body Composition 503(8) Richard A. Anderson William Cefalu Khursheed N. Jeejeebhoy Gilbert R. Kaats Evaluation of Zinc in Children with Type 1 Diabetes Mellitus 511(4) L. P. C. Pedrosa A. Spinola-Castro M. Matsumoto J. Len F. Schwartzman L. P. Camargo S. M. F. Cozzolino Zinc Sulphate Induced Metallothionein in Pancreatic Islets of Mice and Protected from Streptozotocin-Induced Diabetes 515(4) Patricia Ohly Claudia Dohle Josef Abel Helga Gleichmann Water Content of Minerals Associated with Type 2 Diabetes Mellitus of Samples Collected on the Navajo Reservation 519(4) Judith Hallfrisch Claude Veillon Kristine Patterson A. David Hill Irene Benn Bessie Holiday Ruby Ross Sylvia Zhonnie Frances Price Ann Sorenson Dietary Copper Deficiency Causes Elevation of Early and Advanced Glycation End-Products 523(4) J. T. Saari G. M. Dahlen The Use of Stable Isotope Tracers to Explorate Zinc and Selenium Metabolism in Insulin Dependent Patients 527(1) M. Bertouze P. Faure V. Ducros S. Halimi A. Favier Zinc Modulates the Glucose Induced Rat Aortic Smooth Cell Proliferation 528(2) S. Bouvard P. Faure A. Favier M. Leconte S. Halimi Metabolic Effects of Dietary Chromium-L-Methionine in Horses and Beef Cattle 530(2) M. T. Socha S. L. Ralston R. Raub E. B. Kegley C. K. Swenson A. B. Johnson T. M. Fakler Zinc Protects HeLa Cells against the Glucose Induced Cytotoxic Effect 532(2) P. Faure S. Bouvard A. Favier S. Halimi Oxidative Stress and Antioxidant Trace Element Status in Patients with Non Insulin-Dependent Diabetes 534(2) A. Kerkeni A. M. Roussel A. Othmane S. Majhoub N. Zouari F. Najjar J. Arnaud A. Favier R. A. Anderson Zinc Deficiency Increases the Deleterious Effect of High Fructose Diet on Fetal Development and Free Radical Activity in Rats 536(2) B. Lachil P. Faure C. Ribuot J. Arnaud M. J. Richard M. Seve A. Favier Zinc 100 ppm Does Not Improve Insulin Sensitivity of High Fructose Fed Rats Leading to Insulin Resistance 538(1) E. Rossini S. Bouvard M. J. Richard S. Halimi A. Favier Design of New Oxovanadium (IV) Complexes for Treatment of Diabetes. Bioavailability, Speciation, and Tissue Targeting Considerations 539(1) K. H. Thompson J. H. McNeill C. Orvig The Metallic Component of the Glucose Tolerance Factor, G. T. F.: Cobalt against Chromium 540(3) F. Silio A. Santos B. Ribas Cardiovascular Diseases and Oxidative Stress The Interaction between Dietary Copper and Excess Iron---Increases the Risk of Heart Disease 543(4) Meira Fields Charles G. Lewis Selenium and Chronic Heart Failure 547(4) Michel de Lorgeril Patricia Salen Michele Accominotti Antioxidant Status of Patients with Unstable Angina Pectoris and Acute Myocardial Infarction 551(4) Momcilo B. Mihailovic Zorana Vasiljevic Sladjana Sobajic Ivan B. Jovanovic Olivera Pesut Gordana Matic The Effect of Zinc Deficiency on Parameters of Lipoprotein Metabolism and Lipolysis in Rats Fed Different Fats 555(4) K. Eder S. Wild M. Kirchgessner Plasma Level of Antioxidant Minerals (Cu, Zn, Mn, and Se) and Fe: A Comparison of Patients with Cerebro-vascular Disease and Healthy Adults in Korea 559(4) I. S. Kwun H. S. Jang C. S. Kwon Trace Elements as Determined by ICP-MS Analysis in Patients with Coronary Artery Disease 563(2) Ellen Burgess Robert Audette Merril Knudtson George Wyse The Effect of Zinc Deficiency on Some Key Enzymes of Lipid Metabolism in Rats Fed Olive Oil or Linseed Oil 565(1) K. Eder K. Waldhauser M. Kirchgessner Lipid Concentrations of Low-Density Lipoproteins and Their Oxidative Susceptibility in Zinc-Deficient Rats 566(2) K. Eder M. Kirchgessner Comparative Evaluation of Trace Elements Contents in Aortic Wall and in Hair Samples of Young Males 568(1) A. V. Skalny A. A. Zhavoronkov A. L. Chernyaev A. V. Koudrine Heart Disease Risk in the UK as Influenced by Environmental Factors and Defined by Hair Calcium Concentration 569(2) A. MacPherson J. Bacso Regulation of Hepatic Cholesterol and Lipoprotein Metabolism in Copper-Deficient Rats 571(2) A. Mazur C. Serougne C. Moundras B. Bayle F. Millat Y. Rayssiguier Copper Body Status and Cardiovascular Diseases 573(1) G. Mielcarz Increased Plasma Glutathione Peroxidase Activity in Patients with Acute Myocardial Infarction 574(1) B. A. Zachara M. Ukleja-Adamowicz J. Lecka E. Nartowicz Other Human Diseases Selenium in Cancer Prevention 575(6) M. P. Rayman L. C. Clark Trace Elements in Hypertension 581(6) Gianfranco Vivoli Margherita Bergomi Paola Borella Sergio Rovesti Persistence of Goiter Despite Oral Iodine Supplementation in Goitrous Children with Iron-Deficiency Anemia in the Cote dIvoire 587(4) Michael Zimmermann Pierre Adou Toni Torresani Christophe Zeder Richard Hurrell Trace Elements in Patients Treated by On-Line Hemodiafiltration. The Blood Chromium Behaviour 591(6) A. Baj G. Bregante R. DAngelo G. Bonforte F. Toffoletto M. Surian Relationships between Trace Element Nutriture and Progression of Human Immunodeficiency Virus Infection 597(4) John D. Bogden Joan H. Skurnick Francis W. Kemp Shenggao Han Joan Lloyd Herman Baker Donald B. Louria Iron and Manganese Homeostasis in Chronic Liver Disease: Relationship to Pallidal T1-Weighted Magnetic Resonance Signal Hyperintensity 601(6) Elise A. Malecki Attila G. Devenyi Todd F. Barron Timothy J. Mosher Paul Eslinger Claire V. Flaherty-Craig Lorenzo Rossaro Effect of Depression and of Antidepressant Therapy on Serum Zinc Levels---A Preliminary Clinical Study 607(4) Malgorzata Schlegel-Zawadzka Andrzej Zieba Dominika Dudek Miroslaw Krosniak Maria Szymaczek Gabriel Nowak Abnormalities of Iron Homeostasis in the Pregnancy Syndrome Pre-Eclampsia 611(6) M. P. Rayman J. Barlis S. Sokari R. W. Evans C. W. G. Redman L. J. King Lipid Peroxidation in Patients with Diseases Known to Affect Trace Element Status 617(6) Mariana Vlad P. J. Porr G. Uza Maria Zirbo Selenium Status of Breast and Gastroinstestinal Cancer Patients in Turkey 623(2) B. Avsar I. G. Gokmen Zinc and Selenium Intake in Nondialysed Patients with Chronic Renal Failure 625(1) D. Mafra D. I. T. Favaro S. M. F. Cozzolino Zinc Nutritional Status in Patients with Chronic Renal Failure, Residents in Sao Paulo, Brazil 626(1) D. Mafra L. Cuppari S. M. F. Cozzolino Iron, Zinc, Copper Levels of Thalassemia Patients of Northern Cyprus 627(2) R. Oktekin G. Gokmen Blood Markers of Oxidative Stress in Patients with Amyotrophic Lateral Sclerosis 629(2) D. Bonnefont-Rousselot M. C. Jaudon L. Lacomblez B. Bourely V. Doppler C. Bizard F. Salachas G. Bensimon J. Delattre V. Meininger Glutathione Peroxidase Activity Is Reduced in Haemodialysis Patients 631(2) H. E. Roxborough C. M. Loughrey C. Mercer D. McMaster I. S. Young Copper and Zinc Levels in Patients with Colorectal Polyps 633(1) K. Linke G. Mielcarz K. Zietek Total Superoxide Dismutase Activity and Glutathione Peroxidase Activity in Plasma of Phenylketonuric Subjects Supplemented with Selenium 634(2) M. Calomme P. Cos V. Ramaekers B. Francois M. Van Caillie-Bertrand D. Vanden Berghe The Content of Selected Bioelements in Hair of Children with Infantile Cerebral Palsy (Paralysis Cerebralis Infantilis, Diplegia) 636(2) R. W. Wojciak Z. Krejpcio Serum Copper in Juvenile Rheumatoid Arthritis 638(1) O. M. S. Amancio D. M. A. Chaud M. O. E. Hilario Serum Copper in Juvenile Rheumatoid Arthritis: Influence of Dietary Copper 639(1) D. M. A. Chaud O. M. S. Amancio Hilario M. O. E. Gallium Nitrate and Zinc Content in Peripheral Blood Lymphocytes of Patients with Lung Cancer 640(1) A. V. Koudrine A. V. Skalny Antioxidant Systems in Normal and Preeclamptic Algerian Pregnant Women 641(2) Brahim Lachili Josiane Arnaud Henri Faure Marie Jeanne Richard Anwar Bouabsa Anne Marie Roussel Alain Favier Effect of Erythropoietin Therapy and Selenium Supplementation on Some Antioxidant Parameters in Blood of Uremic Patients on Long-Term Hemodialysis 643(2) B. A. Zachara A. Adamowicz U. Trafikowska A. Pilecki A. Trafikowska E. Nartowicz J. Manitius Trace Element Toxicity and Environmental Exposure Arsenic Groundwater Contamination and Sufferings of People in West Bengal-India and Bangladesh 645(6) U. K. Chowdhury B. K. Biswas T. Roy Chowdhury B. K. Mandal G. Samanta G. K. Basu C. R. Chanda D. Lodh K. C. Saha D. Chakraborti S. C. Mukherjee S. Roy S. Kabir Q. Quamruzzaman Heavy Metals and Persistent Organic Pollutants in Newborn Correlated with Maternal Smoking 651(4) Bente Deutch Jens C. Hansen Copper and Early Childhood Cirrhosis (ECC)---A Retrospective Study in Germany 655(8) H. H. Dieter W. Schimmelpfenning E. Meyer M. Tabert Difference in Penetration of Metals into the Brain 663(4) Takeshi Minami Yuko Sakita Yuko Okazaki Ryouhei Amano Exposure to Platinum-Group Metals Released by Automotive Catalytic Converters: The Case of Urban Youngsters 667(4) S. Caroli F. Petrucci B. Bocca M. Krachler F. Forastiere A. Alimonti Urinary Copper and Mortality among Inhabitants Living in a Cadmium Polluted Area in Japan 671(4) M. Nishijo H. Nakagawa Y. Morikawa M. Tabata K. Miura K. Higashiguchi T. Seto T. Kido K. Nogawa K. Mizukoshi M. Nishi Serum Selenium in Relation to Biomarkers of Lead in Men 675(4) J. Jurasovic A. Pizent S. Telisman Hepatotoxic Effects Associated to Short and Long Term Exposure to Excess Dietary Copper in Rats 679(6) E. Aburto A. Cribb C. Fuentealba The Biological and Medical Importance of the Interactions between Nickel and Zinc, Magnesium and Manganese in Vivo 685(2) M. Anke A. Trupschuch G. Gunstheimer Effect of Aluminum on Manganese Superoxide Dismutase (MnSOD) Expression 687(1) C. Garrel C. Carron A. Favier Indicators for Sensitisation to Ni, Co, and Cr, a Eu-Project 688(2) Olof Vesterberg Fish Consumption and Mercury Speciation in Hair of Indigenous Population of the Amazon 690(1) Antonio C. Barbosa Jose G. Dorea Jurandir R. Souza Glauce L. Oliveira Metabolism of Phospholipids in Pituitary Gland: Effect of Ion Cadmium 691(2) Ana Maria Calderoni Maria Sofia Gimenez Investigations on the Elements Status Markers in Humans. Lead Significant Correlation between Pb Content in Milk Teeth and Blood of 6-Year-Old Children 693(2) H. Barton Z. Zachwieja M. Folta Morphologic and Biochemical Assessment of the Role of Lipid Peroxidation in the Pathogenesis of Copper Toxicity in Copper-Loaded Rats 695(2) E. Aburto A. Cribb I. C. Fuentealba Effect of Dolomite and Thiamine Supplementation on Tissue Trace Elements Concentrations in Lead-Intoxicated Rats 697(2) Z. Krejpcio D. Olejnik R. W. Wojciak J. Gawecki Acute Human Molybdenum Toxicity from a Dietary Molybdenum Supplement---A New Member of the ``Lucor Metallicum Family 699(2) Berislav Momcilovic Effects of Lead on the Maturation of the Female Gamete and Fertility 701(2) B. Lefevre J. Poupon A. Pesty V. Machelon J. Testart Rhamnogalacturonan II (RG-II), a Prectic Polysaccharide Present in the Vegetable-Derived Products, Strongly Decreases Lead Tissue Accumulation: Potential Interest in Chronic Lead Exposure 703(2) M. Tahiri P. Pellerin J. C. Tressol T. Doco Y. Rayssiguier C. Coudray Dietary Exposures to the Platinum Group Elements 705(2) G. E. Ysart P. F. Miller H. Crews P. Robb M. Baxter C. De Largy S. Lofthouse C. Sargent N. Harrison Acute and Chronic Effects of Acid Phenol Compounds on Aluminum Retention in Rats 707(2) Z. Deng L. Gouzoux C. Coudray A. Mazur Y. Rayssiguier D. Pepin Determination of Total and Soluble Titanium in Soft Tissues Covering Titanium Microplates in Stomatology: An Analytical Study 709(2) J. Poupon J. P. Meningaud C. Chenevier M. Galliot-Guilley J. Ch. Bertrand IV. TRACE ELEMENTS IN ANIMALS Tissue Selenium Levels in Laying Hens Are Influenced by Dietary Oils and Fatty Acids Including Trans Fatty Acids 711(6) Klaus Schafer Dietary Mo as an Antagonist to Cu Absorption: Stable Isotope (65Cu) Measurements in Grazing Sheep 717(6) S. O. Knowles N. D. Grace J. R. Rounce A. Litherland D. M. West J. Lee Copper-Associated Cirrhosis in North Ronaldsay Sheep: A Possible Model for Idiopathic Copper Toxicosis 723(6) S. Haywood T. Muller W. Muller Z. Dincer Dietary Copper Affects Lipid and Cholesterol Metabolism in Finishing Steers 729(4) T. E. Engle J. W. Spears C. L. Wright T. A. Armstrong A Comparison of Two Methods of Copper Supplementation for Grazing Red Deer (Cervus Elaphus) 733(4) D. V. Illingworth D. W. Jackson N. R. Kendall S. B. Telfer Trace Elements and Vitamins in Blood of Alpacas (Lama pacos) and Sheep Grazing the Same Pasture 737(4) G. J. Judson B. A. McGregor A. M. Howse A Comparison of the Efficacy of Proprietary Products in the Treatment of Molybdenum Induced Copper Deficiency 741(8) N. R. Kendall C. Middlemas H. Maxwell F. Birch D. V. Illingworth D. W. Jackson S. B. Telfer The Effect of a Copper, Cobalt, and Selenium Bolus on Sheep from Three Upland Scottish Farms 749(4) A. M. Mackenzie N. R. Kendall D. V. Illingworth D. W. Jackson I. M. Gill S. B. Telfer Selenium and Fluoride Toxicology---Water Quality Guidelines for Dohne Merino Sheep in Southern Africa 753(6) J. A. Meyer N. H. Casey Effect of Dietary Copper Level and High Sulfate Water on Copper Metabolism and Growth in Cattle 759(4) C. L. Wright J. W. Spears T. E. Engle T. A. Armstrong Apparent Trace Element Absorption in Growing Pigs Fed Rations of Increasing Calcium Carbonate Content 763(4) Torben Larsen Jose A. Fernandez Ricarda M. Engberg Heat Processing of Protein Sources on the Faecal Excretion of Their Selenium in Dairy Cows 767(1) J. B. J. van Ryssen G. E. Schroeder Dietary Antagonists to Copper Absorption: Stable Isotope Measurements in Grazing Ruminants 768(1) J. Lee N. D. Grace J. R. Rounce S. O. Knowles The Effect of a Zinc, Cobalt, and Selenium Bolus on Ram Semen Quality and Trace Element Status 769(3) N. R. Kendall A. Green S. McMullen R. G. Rodway The Effect of Lead on the Rate of Fermentation of Herbage by Rumen Micro-Organisms 772(3) S. T. Strojan C. J. C. Phillips Effects of Intraruminal Monensin and Selenium Capsules on Glutathion Peroxidase, Calcaemia, Phosphatemia, and Live Weight Gain in Heifers on Pasture with Solanum Malacoxylon 775(2) Bruna E. Ruksan Laura Marangunich L. Barry Lowe Trace Element Content in Natural and Commercial Cats Food and Trace Element Status of Cats Depending on Sex and Disease 777(2) S. Anke H. Gurtler M. Anke Validation and Normal Ranges of Plasma Ceruloplasmin Concentration in Cats and Dogs 779(2) C. J. Charlton S. L. Wattam N. D. Skinner Current AAFCO and NRC Recommendations for Selenium Are Too Low for Puppies 781(1) K. J. Wedekind J. DeBraekeleer G. F. Combs The Effect of a Zinc, Cobalt, and Selenium Bolus on Sheep from Nine Upland Scottish Farms 782(2) N. R. Kendall A. M. Mackenzie D. V. Illingworth D. W. Jackson I. M. Gill S. B. Telfer Field Trials of A Copper, Cobalt, and Selenium Soluble Glass Bolus 784(2) N. R. Kendall A. M. Mackenzie S. B. Telfer Evaluation of the Trace Mineral Status of Lactating Dairy Cattle in Trans NZOIA District Western Kenya 786(1) F. D. O. Oduor I. O. Jumba S. O. Wandiga Canine Ferritin: Assay Validation and Normal Range for Serum 787(2) N. D. Skinner C. J. Charlton S. L. Ebbrell V. INDIVIDUAL TRACE ELEMENTS Iron Iron in Infancy: Absorption, Erythrocyte Incorporation, Loss 789(6) Robert E. Serfass Transport of Iron in Health and Diseases 795(4) Andreas Rolfs Matthias A. Hediger Benefits and Problems Associated with Iron Supplementation and Fortification 799(10) Serge Hercberg Low Iron Diet and Cadmium Exposure Disrupt Steroidogenesis in the Rat 809(4) Martina Piasek John W. Laskey Krista Kostial Maja Blanusa Janet M. Ferrell Peculiarities of Nonheme Iron Metabolism upon Experimental Modelling of Rat Glial Brain Tumour. Perspectives for Diagnosis and Treatment 813(6) Olga M. Mykhaylyk Natalie A. Dudchenko Eugene A. Lebedev Bogdan S. Shurunov Iron Bioavailability from Iron Amino Acid Chelate or Ferrous Sulfate for Treatment of Iron Deficiency Anemia 819(1) Oscar Pineda H. DeWayne Ashmead Alain Bourdonnais The Effect of a High Intake of Whole Wheat Bread Produced with and without Phytase on Iron Status in Young Women 820(1) M. Hansen B. A. Jorgensen S. Sandstrom Zinc Status in Pregnancy Assessed by Hair Analysis---Nutritional Influences 821(2) U. Heins C. Koebnick C. Leitzmann In Vitro Properties of Ferrous and Ferric Ions with Phytate 823(2) D. Oberleas Iron Metabolism in Rats Consuming Olive Oil or Sunflower Oil Unused or Used in Repeated Potato Frying 825(2) A. M. Perez-Granados M. P. Vaquero M. P. Navarro The Ferritin Secreted by Cultured Hepatoma Cells in Response to Iron and Inflammatory Cytokines Strongly Resembles the Ferritin in Serum and Has Homology to Intracellular Ferritins as Well as Immunoglobulins 827(2) L. Butcher M. Hazegh-Azam A. Nguyen P. Nguyen K. Vu L. Rezaee C. Juska K. Schaffer M. Zamany L. Estevez M. Hallock M. C. Linder Two Levels of Iron Supplementation and Developmental Outcome, Iron Nutrition, and Adverse Results in Low Birth Weight Infants 829(2) J. K. Friel P. F. Kwa B. Simmons K. Aziz C. Mercer A. MacDonald W. L. Andrews Selenium Some Functions of the Essential Trace Element, Selenium 831(6) Thressa C. Stadtman Characteristics and Function of Selenoprotein P 837(6) Raymond F. Burk Kristina E. Hill Some Biochemical Functions of Selenium in Animals and Man 843(6) J. R. Arthur G. J. Beckett The Secis Element in Selenoprotein mRNAS. A Rosetta Stone for Decoding the UGA Selenocysteine Codon and a Molecular Tag for Unveiling New Selenoproteins 849(6) Alain Lescure Daniel Gautheret Robert Walczak Philippe Carbon Alain Krol Prolonged Stimulation of Rats with Adrenocorticotrophic Hormone (ACTH) Alters Concentration of Selenium in the Kidney: Reversibility and Possible Mechanism 855(4) B. Cheng T. S. Srikumar F. M. Al-Awadi J. Thakkar F. Sequeira Dietary Selenium Intake and Antioxidant Defenses in Tissues of Peripuberal Rats 859(6) Maria Cristina Santos Jean Neve Maria Leonor Pavao Ana Maria Viegas-Crespo Selenoprotein P in Plasma in Relation to Cancer Morbidity in Middle-Aged Swedish Men 865(4) Marie Persson-Moschos Lars Stavenow Bjorn Akesson Folke Lindgarde Effect of Selenium Supplementation on Plasma Selenoprotein P of New Zealanders 869(4) Christine D. Thomson Anna J. Duffield Kristina E. Hill Tracking the Metabolism and Excretion of Selenium in Real Time in Humans 873(4) G. Bellisola M. Colombatti G. Fracasso F. Pasti M. Valdes A. Torboli Changes in Indices of Selenium Status in Men on Low, Medium, and High Intakes 877(6) T. Fox C. Atherton S. Fairweather-Tait J. Dainty J. Lewis M. Baxter H. Crews True Absorption, Excretion, and Tissue Retention of Selenium at Widely Varying Selenium Supply to Rats 883(4) W. Windisch M. Kirchgessner The Oral Intake of Antioxidant Nutrient Associated with Selenium Does Protect Skin against Actinic Exposure 887(4) Jean Pierre Cesarini S. Demanneville Bioavailability of Selenium from Untreated and Processed Selenomethionine-Enriched Fillets of Atlantic Salmon (Salmosalar) 891(1) R. Oernsrud M. Lorentzen Stability of Glutathione Peroxidase Activity during Storage and Heat Treatment of Whey 892(1) H. Lindmark Mansson J. Chen B. Akesson Purification and Enzyme-Linked Immunoassay of Bovine Extracellular Glutathione Peroxidase 893(2) H. Lindmark Mansson B. Akesson Selenium Distribution in Liver of Hens Fed with Sunflower Oil 895(2) I. Falnoga V. Stibilj D. Mazej M. Tusek Znidaric Selenium and Lipoproteins: Preliminary in Vivo and in Vitro Observations in Humans 897(2) V. Ducros F. Laporte N. Belin A. David A.-M. Roussel A. Favier Transforming Growth Factor-β1 Inhibits Selenoprotein P Expression in Cultured Human Liver Cells 899(2) V. Mostert I. Dreher J. Kohrle J. Abel Experimentally Induced Selenium and Vitamin E Deficiency in Growing Rabbits 901(2) J. Pallauf A. Muller Erika Most Identification of 5 Novel Selenoproteins Based on RNA Structural Tags 903(1) A. Lescure D. Gautheret P. Carbon A. Krol Tat Protein of HIV1 Decreases Selenoglutathione Peroxidase and Increases Uv-A Cytotoxicity Independently of Selenium Supplementation 904(2) M. J. Richard P. Guiraud A. Favier Serum Selenium Concentrations and the Acute Phase Response 906(3) T. M. T. Sheehan Aleha Khatun Copper Neurochemical Alterations following Perinatal Copper Deficiency in Rodents 909(8) Joseph R. Prohaska Molecular Analysis of Wilson Disease Gene in French Patients 917(6) I. Ceballos-Picot A. Nicole B. Aral C. Franvel C. Soulie H. Lassal F. Woimant M. Haguenau P. Chappuis Defining Optimal Copper Status in Humans: Concepts and Problems 923(6) J. J. Strain Dietary Copper, Vanadate, Lysyl Oxidase Activity, and Lysine Tyrosyl Quinone Formation 929(4) Robert B. Rucker Changtai Cui Eskouhie H. Tchaparian Alyson E. Mitchell Michael Clegg Janet Y. Uriu-Hare Brian Rucker Tracy Stites Carl L. Keen Copper Metabolism in the Rodent Kidneys 933(4) Masaaki Kurasaki Masashi Okabe Mika Suzuki-Kurasaki Shigeru Saito Toshiyuki Hosokawa Osamu Yamanoshita Takeshi Saito Effect of Copper in the Food Chain on Human Health (FOODCUE: Fair Ct95-0813) 937(6) E. Rock J. J. Strain J. M. OConnor M. P. Bonham Y. Rayssiguier A. Mazur B. Sandstrom S. Hodjberg-Bugel S. J. Fairweather-Tait I. J. Harvey G. Majsak-Newman A. Flynn K. Cashman A. Baker F. Ginty J. H. Beattie I. Bremner M. D. Reid G. Rotilio M.-L. Scarino Y. Sambuy S. Ferruzza M. R. Ciriolo A. DeMartino The Effect of Copper Supplementation on Putative Indices of Body Copper Status and on Oxidative and Inflammatory Measures (FOODCUE Project) 943(4) J. M. OConnor M. P. Bonham E. Turley C. Kehoe J. S. Coulter M. S. Faughnan A. McKeown V. J. McKelvey-Martin E. Rock Y. Rayssiguier A. Mazur A. Flynn K. Cashman A. Baker J. J. Strain Role of Ceruloplasmin in Fe Efflux from Placenta; Identification of an Endogenous Cu Oxidase in Human Placental Cells (BeWo) 947(4) Ruth Danzeisen Harry J. McArdle Dietary Molybdenum: Effect on Copper Absorption, Excretion, and Status in Young Men 951(4) Judith R. Turnlund William R. Keyes Identity and Regulation of the Copper Transport Protein, Transcuprein 955(2) N. Liu L. Lo T. Tran L. Jones M. C. Linder Response of Diamine Oxidase and Other Copper Status Biomarkers to Modifications in Dietary Copper in the Rat 957(2) C. Feillet-Coudray A. Mazur C. Coudray E. Rock Y. Rayssiguier Effect of Dietary Copper Intake on Biochemical Indices Associated with Copper Metabolism 959(2) L. Harvey G. Majsak-Newman S. Fairweather-Tait A. Baker K. Cashman A. Flynn Zinc Metallothioneins: Their Cellular Function and Relationship with Zinc 961(8) John H. Beattie Ian Bremner Zinc as a Cellular Regulator of Apoptosis 969(8) Alain Favier Zinc and Growth 977(4) Michael Hambidge Nancy Krebs Zinc Nutriture as Related to Brain 981(6) Harold H. Sandstead Christopher J. Frederickson James G. Penland Zinc in Preterm and Term Infants---Parallel Studies on Metabolic Balances and Plasma Concentrations 987(4) E. Sievers U. Schleyerbach T. Arpe D. Garbe-Schonberg J. Schaub Activity of Calmodulin-Regulated Enzymes in Tissues of Zinc-Deficient Rats 991(4) H.-P. Roth S. Schmidmayer M. Kirchgessner Zinquin Ester---A Reagent for the Investigation of the Role of Available Zn(II) in Living Systems 995(4) David Ward Stephen Lincoln Henry Betts Peter Zalewski Ian Forbes Indumathy Mahadevan Marc Kimber Kym Hendrickson Cognitive Effects of Adaptation to a Low Zinc Diet in Healthy Men 999(4) M. J. Kretsch A. K. H. Fong J. G. Penland B. Sutherland J. C. King Intracellular Zinc Chelation Induces Apoptosis, Caspases Activation, and Transcription Factors Degradation in Jurkat and HeLa Cells 1003(6) Seve Michel Chimienti Fabrice Richard Sandrine Mathieu Jacques Favier Alain Effect of Zinc Supplementation on Biological Parameters of Bone Turnover in Healthy Men 1009(4) Anne Peretz Pierre Bergmann Theodore Papadopoulos Vania Siderova Jean Neve Betaine-Homocysteine S-Methyltransferase is an Abundant Zinc Metalloenzyme in Liver 1013(4) Andrew P. Breska III Timothy A. Garrow Nourishment: To Moderate Constantly or to Indulge Occasionally---The Message of Zinc Dose-Rate Idiorrhythm to the Needy 1017(4) Berislav Momcilovic Concentration of Growth Hormone, IGF-1, Insulin and C-Peptide in Rat Serum during Development of Alimentary Zinc Deficiency 1021(4) H.-P. Roth M. Kirchgessner Moderately High Zinc Intake Impairs Verbal Memory of Healthy Postmenopausal Women on a Low Copper Diet 1025(6) James G. Penland David B. Milne Cindy W. Davis Identification of the Zinc Binding Protein in a Child with Hyperzincaemia as Calprotectin (MRP8/MRP14) 1031(4) B. Sampson P. Richmond B. E. Golden M. K. Fagerhol J. H. Beattie I. Z. Kovar Characterisation of the Different Steps during Zinc Chelation Induced Apoptosis in Jurkat and HeLa Cells 1035(1) F. Chimienti M. Seve S. Richard J. Mathieu A. Favier Effect of Ion Zinc on the Metabolism of Phosphatidylcholine and Sphingomielin in Lung of Rat 1036(2) N. N. Gomez M. R. Fernandez M. S. Ojeda M. S. Gimenez Metallothionein, Calmodulin, and Trace Elements in Healing Skin Wounds 1038(1) B. Sampson A. Lansdown A. Rowe Zinc Modulation of Macrophages Interleukin 1 Gene Expression and Secretion 1039(1) A. E. Aguilar R. Pastelin S. Perez M. D. Lastra Assessment of Zn Role in Murine Experimental Cysticercosis Caused by Taenia crassiceps 1040(3) M. D. Lastra E. Sciutto R. Pastelin A. E. Aguilar G. Fragoso Boron The Dogged Path to Acceptance of Boron as a Nutritionally Important Mineral Element 1043(6) Forrest H. Nielsen Homing in on the Molecular Basis of Boron Essentiality Using Differential Display, Gene Arrays, and Northern Blots 1049(4) C. D. Eckhert A. Bennett K. Becker D. Luo Estimation of Dietary Boron Intake in Six Countries: Egypt, Germany, Great Britain, Kenya, Mexico, and the United States 1053(4) Charlene Rainey Leslie Nyquist Jennifer Casterline Dena Herman Nutritional Essentiality of Boron for Development, Maturation, and Reproduction in Frogs---A Review 1057(4) D. J. Fort R. L. Rogers E. L. Stover P. L. Strong F. J. Murray Effects of Boron in Wound Healing: Experiments on Nude Mice 1061(6) Brigitte Dousset Mohamed Benderdour Ketsia Hess Rosine Mayap-Nzietchueng Francine Belleville Andre Duprez Effect of Dietary Boron on Bone Characteristics and Plasma Parameters in Young Pigs 1067(4) T. A. Armstrong J. W. Spears T. E. Engle C. L. Wright Dietary Boron Is a Physiological Regulator of the Normal Inflammatory Response 1071(6) Curtiss D. Hunt Boron Stimulated Yeast Differential Gene Expression 1077(1) A. Bennett V. Gilman N. Soch D. Luo C. D. Eckhert Identification by Gene Arrays of Boron Responsive Genes in Yeast 1078(1) K. Becker A. Bennett C. D. Eckhert Limb Teratogenesis Induced by Chronic Boron or Copper Deficiency in Xenopus 1079(1) D. J. Fort E. L. Stover F. J. Murray P. L. Strong An Assessment of Fertility in Boron-Exposed Turkish Subpopulations: An Epidemiological Approach 1080(2) M. Col B. S. Sayli Y. Genc E. Ercevik A. H. Elhan A. Keklik Photoreceptor Dystrophy in Boron Depleted Zebrafish 1082(1) S. Dohs C. D. Eckhert Adverse in Vitro Development of Preimplantation Mouse Embryos Exposed to Low Boron Diet and Low Boron 1083(2) L. Lanoue F. J. Murray P. L. Strong C. L. Keen The Temporal Effects of Low Dietary Boron (B) on Tissue B Concentrations in Rats 1085(2) J. Y. Uriu-Adams B. J. Horwath F. J. Murray G. Downing P. Strong C. L. Keen Boron Stimulates Yeast Growth 1087(1) A. Bennett N. Soch R. Rowe C. D. Eckhert Does Boron Act on Transcription and Translation of Proteins? 1088(3) M. Dzondo-Gadet R. Mayap Nzietchueng K. Hess P. Nabet F. Belleville B. Dousset VI. TRACE ELEMENT ANALYSIS New Sensitive Methods in the Determination of Trace Elements 1091(8) P. Schramel Distribution of Selenium, Arsenic, Iron, and Scandium in Selenium-Deficient Rats Using the Multitracer Technique 1099(4) Rieko Hirunuma Shuichi Enomoto Shizuko Ambe Fumitoshi Ambe Separation of Metallothionein Isoforms and Identification of Complexed Metals by Capillary Zone Electrophoresis Using Diode Array Detection 1103(4) V. Virtanen G. Bordin A.-R. Rodriguez Inductively Coupled Plasma Time of Flight Mass Spectrometry for Trace Element---and Speciation Analysis 1107(4) Hakan Emteborg Xiaodan Tian Monika Heisterkamp Freddy C. Adams Silicon Absorption from Stabilized Orthosilicic Acid and Other Supplements in Healthy Subjects 1111(4) M. Calomme P. Cos P. DHaese R. Vingerhoets L. Lamberts M. De Broe C. Van Hoorebeke D. Vanden Berghe Preparation and ICP-MS Measurements of Magnesium Stable Isotopes in Human Samples 1115(1) M. Sabatier W. R. Keyes M. J. Arnaud J. R. Turnlund Characterization of Zinc Metallothioneins Using Electroanalytical Methods 1116(1) M. Dabrio A. R. Rodriguez Hepatic Metallothionein Isoforms Induction by Cadmium and Its Detection Using Capillary Electrophoresis 1117(2) B. Ribas Ozonas O. Garcia Arribas M. Perez Calvo Recent Developments in HPLC-ICP-MS for the ``Difficult Elements 1119(1) F. Abou-Shakra P. Booker Determination of Heavy Metals in Calcium and Herbal Supplements Utilizing Inductively Coupled Plasma Mass Spectrometry (ICP-MS) 1120(1) Elzbieta (Ela) Bakowska Overview of Biomedical Applications of Inductively Coupled Plasma Mass Spectrometry (ICP-MS) 1121(1) Elzbieta (Ela) Bakowska Determination of Serum Cobalt at the Nanomolar Level by Direct Electrothermal Atomic Absorption Spectrometry 1122(3) J. Poupon V. Gleizes G. Saillant M. Galliot-Guilley List of Participants 1125(24) Author Index 1149(8) Subject Index 1157
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