E-raamat: Transgenic Animals

A systematic study of transgenesis and its techniques considering the challenges of gene transfer which is currently confined to a small number of animal species, issues of biosafety and bioethics, and the limits of animal transgenesis in the medical and pharmaceutical fields. The collected 83 research papers detail topics in the techniques for gene transfer into mammal embryos, in vitro mammal embryo manipulation, gene transfer into bird embryos, fish, lower vertebrates and invertebrates, gene targeting, the integration and modification of foreign DNA, trangenesis vectors, gene function, animal models for biomedical and pharmaceutical studies, animal protection against disease, the introduction of new genetic traits in domestic animals and associated problems and issues posed by transgenic animals. Annotation c. by Book News, Inc., Portland, Or.

During the past 20 years, transgenesis has become a popular technique and a crucial tool for molecular geneticists and biologists. Transgene expression is now better-controlled and even specifically inducible by exogenous factors. While these techniques have quite significantly transformed the experimental approaches taken by biologists, the applications are more limited than expected and concerns have arisen regarding biosafety as well as physiological, social, and philosophical issues.

Transgenic Animals: Generation and Use contains articles on the techniques used to generate transgenic animals and a section on the preparation of vectors for the optimally controlled expression of transgenes. It also examines the use of transgenic animals in the study of gene function and human diseases, the preparation of recombinant proteins and organs for pharmaceutical and medical use, and the improvement of genetic characteristics of farm animals. Finally, it discusses more recent problems generated by transgenic animals including conservation of transgenic lines, specific database patenting, biosafety, and bioethics.

Drawn from both academia and industry, the contributors to this monograph present in one concise volume all the relevant information on the different aspects of transgenesis. This book can be used as both a reference book and a textbook for specialized university courses and will be of interest to everyone involved in basic research in animal biology, molecular genetics, animal biotechnology, pharmaceutical science, and medicine.